WO PCT/EP2023/061297 2023-04-28 2943.218PC02 US 63/336,332 2022-04-29 US 63/371,454 2022-08-15 AstraZeneca UK Limited Taylor Cohen SARS-COV-2 ANTIBODIES AND METHODS OF USING THE SAME ANTICUERPOS CONTRA EL SARS-COV-2 Y MÉTODOS PARA UTILIZARLOS 82 1273 AA PAT source 1..1273 mol_type protein organism constructo sintético MFVFLVLLPLVSSQCVNLTTRTQLPPAYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTQTNSPRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKWPWYIWLGFIAGLIAIVMVTIMLCCMTSCCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT 5 AA PAT source 1..5 mol_type protein note CDR1 organism constructo sintético TSAVQ 17 AA PAT source 1..17 mol_type protein note CDR2 organism constructo sintético WIAVGSGNTNYAQKFQD 14 AA PAT source 1..14 mol_type protein note CDR3 organism constructo sintético PHCDRTSCHDGFDI 12 AA PAT source 1..12 mol_type protein note CDR1 organism constructo sintético RASQSVRSSYLA 7 AA PAT source 1..7 mol_type protein note CDR2 organism constructo sintético GASRRGT 9 AA PAT source 1..9 mol_type protein note CDR3 organism constructo sintético QQYGSSPWT 5 AA PAT source 1..5 mol_type protein note CDR1 organism constructo sintético TYVFT 17 AA PAT source 1..17 mol_type protein note CDR2 organism constructo sintético GIIPFFGTADYAQKFQG 9 AA PAT source 1..9 mol_type protein note CDR3 organism constructo sintético LSQWDLLPM 12 AA PAT source 1..12 mol_type protein note CDR1 organism constructo sintético RASQSFTSSYLA 11 AA PAT source 1..11 mol_type protein note CDR3 organism constructo sintético QQYGTSPRMYT 7 AA PAT source 1..7 mol_type protein note CDR1 organism constructo sintético SSNHYWV 16 AA PAT source 1..16 mol_type protein note CDR2 organism constructo sintético SMYYSGSTAYNPSLTN 16 AA PAT source 1..16 mol_type protein note CDR3 organism constructo sintético QIGPKRPSQVADWFDP 11 AA PAT source 1..11 mol_type protein note CDR1 organism constructo sintético RASQGISSYLA 7 AA PAT source 1..7 mol_type protein note CDR2 organism constructo sintético AASTLQS 9 AA PAT source 1..9 mol_type protein note CDR3 organism constructo sintético QQLNSYPLT 16 AA PAT source 1..16 mol_type protein note CDR3 organism constructo sintético QIGPKRPSQVADWFEP 5 AA PAT source 1..5 mol_type protein note CDR1 organism constructo sintético SYAIN 17 AA PAT source 1..17 mol_type protein note CDR2 organism constructo sintético GIIPIFRTPHYAQKFQG 22 AA PAT source 1..22 mol_type protein note CDR3 organism constructo sintético PSCGGDCPQYLKSSKLDWYFDL 12 AA PAT source 1..12 mol_type protein note CDR1 organism constructo sintético RASQSVSSTYLA 9 AA PAT source 1..9 mol_type protein note CDR3 organism constructo sintético QHYGSSPLT 5 AA PAT source 1..5 mol_type protein note CDR1 organism constructo sintético RNYMS 16 AA PAT source 1..16 mol_type protein note CDR2 organism constructo sintético VIYSGGSTFYADSVKG 10 AA PAT source 1..10 mol_type protein note CDR3 organism constructo sintético DLDVVGGTDY 12 AA PAT source 1..12 mol_type protein note CDR1 organism constructo sintético RASQSVSSSYLA 10 AA PAT source 1..10 mol_type protein note CDR3 organism constructo sintético QQYGSSPGYT 10 AA PAT source 1..10 mol_type protein note CDR3 organism constructo sintético DLEVVGGTDY 5 AA PAT source 1..5 mol_type protein note CDR1 organism constructo sintético DYAIH 17 AA PAT source 1..17 mol_type protein note CDR2 organism constructo sintético SISWDSGSIGYADSVKG 16 AA PAT source 1..16 mol_type protein note CDR3 organism constructo sintético GAFPGYSSGWYYGLDV 14 AA PAT source 1..14 mol_type protein note CDR1 organism constructo sintético TGTSSDVGGYNYVS 7 AA PAT source 1..7 mol_type protein note CDR2 organism constructo sintético EVSKRPS 9 AA PAT source 1..9 mol_type protein note CDR3 organism constructo sintético SSYAGNKGV 16 AA PAT source 1..16 mol_type protein note CDR3 organism constructo sintético GAFPGYSSGWYYGLEV 123 AA PAT source 1..123 mol_type protein note H Variable Sequence Region organism constructo sintético QVQLVESGPEMKKPGTSVKVSCKASGFTFITSAVQWVRQARGQRLEWMGWIAVGSGNTNYAQKFQDRVTINRDMSTSTAYMELSSLRSEDTAVYYCAAPHCDRTSCHDGFDIWGQGTMVTVSS 108 AA PAT source 1..108 mol_type protein note L Variable Sequence Region organism constructo sintético DIVMTQSPGTLSLSPGERATLSCRASQSVRSSYLAWYQQKPGQAPRLLIYGASRRGTGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPWTFGQGTKVEIK 123 AA PAT source 1..123 mol_type protein note H Variable Sequence Region organism constructo sintético QVQLVQSGPEVKKPGTSVKVSCKASGFTFITSAVQWVRQARGQRLEWMGWIAVGSGNTNYAQKFQDRVTITRDMSTSTAYMELSSLRSEDTAVYYCAAPHCDRTSCHDGFDIWGQGTMVTVSS 108 AA PAT source 1..108 mol_type protein note L Variable Sequence Region organism constructo sintético EIVMTQSPGTLSLSPGERATLSCRASQSVRSSYLAWYQQKPGQAPRLLIYGASRRGTGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPWTFGGGTKVEIK 118 AA PAT source 1..118 mol_type protein note H Variable Sequence Region organism constructo sintético EVQLVQSGAEVKKPGSSVKVSCKASRGTFNTYVFTWVRQAPGQGLEWMGGIIPFFGTADYAQKFQGRVTITADDSTSTAYMELSSLRSEDTAVYYCSRLSQWDLLPMWGQGTLVTVSS 110 AA PAT source 1..110 mol_type protein note L Variable Sequence Region organism constructo sintético DIVMTQSPGTLSLSPGERATLSCRASQSFTSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGTGSGTDFTLTISRLEPEDFAVYYCQQYGTSPRMYTFGQGTKVDIK 118 AA PAT source 1..118 mol_type protein note H Variable Sequence Region organism constructo sintético QVQLVQSGAEVKKPGSSVKVSCKASRGTFNTYVFTWVRQAPGQGLEWMGGIIPFFGTADYAQKFQGRVTITADESTSTAYMELSSLRSEDTAVYYCSRLSQWDLLPMWGQGTLVTVSS 110 AA PAT source 1..110 mol_type protein note L Variable Sequence Region organism constructo sintético EIVMTQSPGTLSLSPGERATLSCRASQSFTSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGTSPRMYTFGQGTKLEIK 126 AA PAT source 1..126 mol_type protein note H Variable Sequence Region organism constructo sintético QVQLQESGPGLVKPSETLSLTCTVFGGSITSSNHYWVWIRQPPGKGLEWIGSMYYSGSTAYNPSLTNRVTISVDTSKNQFSLKLSSVTAADTAVYYCARQIGPKRPSQVADWFDPWGQGTLVTVSS 107 AA PAT source 1..107 mol_type protein note L Variable Sequence Region organism constructo sintético DIQLTQSPSFLSASVGDRVTITCRASQGISSYLAWYQQKPGKAPKLLIYAASTLQSGVPSRFSGSGSGTEFTLTISSLQPEDFATYYCQQLNSYPLTFGGGTKVEIK 126 AA PAT source 1..126 mol_type protein note H Variable Sequence Region organism constructo sintético QVQLQESGPGLVKPSETLSLTCTVSGGSITSSNHYWVWIRQPPGKGLEWIGSMYYSGSTAYNPSLTNRVTISVDTSKNQFSLKLSSVTAADTAVYYCARQIGPKRPSQVADWFDPWGQGTLVTVSS 126 AA PAT source 1..126 mol_type protein note H Variable Sequence Region organism constructo sintético QVQLQESGPGLVKPSETLSLTCTVSGGSITSSNHYWVWIRQPPGKGLEWIGSMYYSGSTAYNPSLTNRVTISVDTSKNQFSLKLSSVTAADTAVYYCARQIGPKRPSQVADWFEPWGQGTLVTVSS 131 AA PAT source 1..131 mol_type protein note H Variable Sequence Region organism constructo sintético EVQLVESGAEVKKPGSSVKVSCKASGGTFSSYAINWVRQAPGQGLEWMGGIIPIFRTPHYAQKFQGRVTITADESTGTAYMELSSLRSEDTAVYYCASPSCGGDCPQYLKSSKLDWYFDLWGRGTLVTVSS 108 AA PAT source 1..108 mol_type protein note L Variable Sequence Region organism constructo sintético VIWMTQSPGTLSLSPGERATLSCRASQSVSSTYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQHYGSSPLTFGQGTRLEIK 131 AA PAT source 1..131 mol_type protein note H Variable Sequence Region organism constructo sintético QVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYAINWVRQAPGQGLEWMGGIIPIFRTPHYAQKFQGRVTITADESTSTAYMELSSLRSEDTAVYYCASPSCGGDCPQYLKSSKLDWYFDLWGRGTLVTVSS 108 AA PAT source 1..108 mol_type protein note L Variable Sequence Region organism constructo sintético EIVMTQSPGTLSLSPGERATLSCRASQSVSSTYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQHYGSSPLTFGQGTRLEIK 118 AA PAT source 1..118 mol_type protein note H Variable Sequence Region organism constructo sintético EVQLVESGGGLIQPGGSLRLSCAASEIIVSRNYMSWVRQAPGKGLEWVSVIYSGGSTFYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDLDVVGGTDYWGQGTLVTVSS 109 AA PAT source 1..109 mol_type protein note L Variable Sequence Region organism constructo sintético EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPGYTFGQGTKVDIK 118 AA PAT source 1..118 mol_type protein note H Variable Sequence Region organism constructo sintético EVQLVETGGGLIQPGGSLRLSCAASEIIVSRNYMSWVRQAPGKGLEWVSVIYSGGSTFYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDLDVVGGTDYWGQGTLVTVSS 109 AA PAT source 1..109 mol_type protein note L Variable Sequence Region organism constructo sintético EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPGYTFGPGTKVDIK 117 AA PAT source 1..117 mol_type protein note H Variable Sequence Region organism constructo sintético EVQLVETGGGLIQPGGSLRLSCAASEIIVSRNYMSWVRQAPGKGLEWVSVIYSGGSTFYADSVKGRFTISRDNSKNLYLQMNSLRAEDTAVYYCARDLEVVGGTDYWGQGTLVTVSS 118 AA PAT source 1..118 mol_type protein note H Variable Sequence Region organism constructo sintético EVQLVESGGGLIQPGGSLRLSCAASEIIVSRNYMSWVRQAPGKGLEWVSVIYSGGSTFYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDLEVVGGTDYWGQGTLVTVSS 125 AA PAT source 1..125 mol_type protein note H Variable Sequence Region organism constructo sintético EVQLLETGGGLVQPGRSLRLSCAASGFPFDDYAIHWVRLAPGKGLEWVSSISWDSGSIGYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTALYYCAKGAFPGYSSGWYYGLDVWGQGATVTVSS 109 AA PAT source 1..109 mol_type protein note L Variable Sequence Region organism constructo sintético QSVVTQPPSASGSLGQSVTISCTGTSSDVGGYNYVSWYQQHPGKAPKLMIFEVSKRPSGVPDRFSGSKSGNTASLTVSGLQAEDEADYYCSSYAGNKGVFGGGTKLTVL 125 AA PAT source 1..125 mol_type protein note H Variable Sequence Region organism constructo sintético EVQLVESGGGLVQPGRSLRLSCAASGFPFDDYAIHWVRLAPGKGLEWVSSISWDSGSIGYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTALYYCAKGAFPGYSSGWYYGLDVWGQGTTVTVSS 125 AA PAT source 1..125 mol_type protein note H Variable Sequence Region organism constructo sintético EVQLVESGGGLVQPGRSLRLSCAASGFPFDDYAIHWVRLAPGKGLEWVSSISWDSGSIGYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTALYYCAKGAFPGYSSGWYYGLEVWGQGTTVTVSS 109 AA PAT source 1..109 mol_type protein note L Variable Sequence Region organism constructo sintético QSAVTQPASVSGSPGQSITISCTGTSSDVGGYNYVSWYQQHPGKAPKLMIFEVSKRPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCSSYAGNKGVFGSGTKVTVL 106 AA PAT source 1..106 mol_type protein organism constructo sintético GQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS 330 AA PAT source 1..330 mol_type protein organism constructo sintético ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEFEGGPSVFLFPPKPKDTLYITREPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPASIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 7 AA PAT source 1..7 mol_type protein note CDR2 organism constructo sintético GASSRAT 123 AA PAT source 1..123 mol_type protein note H Variable Sequence Region organism constructo sintético QMQLVQSGPEVKKPGTSVKVSCKASGFTFMSSAVQWVRQARGQRLEWIGWIVIGSGNTNYAQKFQERVTITRDMSTSTAYMELSSLRSEDTAVYYCAAPYCSSISCNDGFDIWGQGTMVTVSS 8 AA PAT source 1..8 mol_type protein note CDR1 organism constructo sintético GFTFMSSA 8 AA PAT source 1..8 mol_type protein note CDR2 organism constructo sintético IVIGSGNT 16 AA PAT source 1..16 mol_type protein note CDR3 organism constructo sintético AAPYCSSISCNDGFDI 109 AA PAT source 1..109 mol_type protein note L Variable Sequence Region organism constructo sintético EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQHYGSSRGWTFGQGTKVEIK 7 AA PAT source 1..7 mol_type protein note CDR1 organism constructo sintético QSVSSSY 000 10 AA PAT source 1..10 mol_type protein note CDR3 organism constructo sintético QHYGSSRGWT 461 AA PAT source 1..461 mol_type protein note H organism constructo sintético EVQLVESGGGLVKPGGSLRLSCAASGFTFRDVWMSWVRQAPGKGLEWVGRIKSKIDGGTTDYAAPVKGRFTISRDDSKNTLYLQMNSLKTEDTAVYYCTTAGSYYYDTVGPGLPEGKFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEFEGGPSVFLFPPKPKDTLYITREPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPASIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 219 AA PAT source 1..219 mol_type protein note L organism constructo sintético DIVMTQSPDSLAVSLGERATINCKSSQSVLYSSNNKNYLAWYQQKPGQPPKLLMYWASTRESGVPDRFSGSGSGAEFTLTISSLQAEDVAIYYCQQYYSTLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 14 AA PAT source 1..14 mol_type protein organism constructo sintético NNLDSKVGGNYNYL 16 AA PAT source 1..16 mol_type protein organism constructo sintético EGFNCYFPLQSYGFQP 19 AA PAT source 1..19 mol_type protein organism constructo sintético RGDEVRQIAPGQTGKIADY 7 AA PAT source 1..7 mol_type protein organism constructo sintético YRLFRKS 17 AA PAT source 1..17 mol_type protein organism constructo sintético YQAGSTPCNGVEGFNCY