WO 01146-0114-00PCT US 63/337,945 2022-05-03 GENENTECH, INC. ANTI-Ly6E ANTIBODIES, IMMUNOCONJUGATES, AND USES THEREOF 34 131 AA PAT source 1..131 mol_type protein organism Homo sapiens MKIFLPVLLAALLGVERASSLMCFSCLNQKSNLYCLKPTICSDQDNYCVTVSASAGIGNLVTFGHSLSKTCSPACPIPEGVNVGVASMGISCCQSFLCNFSAADGGLRASVTLLGAGLLLSLLPALLRFGP 131 AA PAT source 1..131 mol_type protein organism Macaca sp. MKIFLPVLLAALLGVERASSLMCFSCLNQKSNLYCLKPTICSDQDNYCVTVSTSAGIGNLVTFGHSLSKTCSPACPLPEGINVGVASMGISCCQSFLCNFSAADGGLRASATLLGAGLLLSLLPALLRFGP 213 AA PAT source 1..213 mol_type protein note Humanized light chain amino acid sequence of anti-Ly6E antibody clone 3A3.v2.D92E organism synthetic construct DIQMTQSPSSLSASVGDRVTITCKASQNVGSNVDWYQQKPGKAPKLLIYKASNRYTGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCMQSETKYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 213 AA PAT source 1..213 mol_type protein note Chimeric variable light chain amino acid sequence of anti-Ly6E antibody clone 3A3 organism synthetic construct DIVMTQSPTSISISVGERVTMNCKASQNVGSNVDWYQQKTGQSPELLIYKASNRYTGVPGRFTGSGSGTDFTFTISNLQAEDLAVYYCMQSDTKYTFGAGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 453 AA PAT source 1..453 mol_type protein note Humanized heavy chain amino acid sequence of anti-Ly6E antibody clone 3A3 organism synthetic construct EVQLVESGGGLVQPGGSLKLSCAASGFTFSTVAMHWVRQASGKGLEWVGRIRTKPVNYETYYADSVKGRFTISRDDSKSTVYLQMNSLKTEDTAVYYCSAPNYYDGTYSFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 453 AA PAT source 1..453 mol_type protein note Chimeric heavy chain amino acid sequence of anti-Ly6E antibody clone 3A3 organism synthetic construct AVQLVEFGGGLVQPKESLKISCAASGFTFSTVAMHWVRQAPGKGLEWIARIRTKPVNYETYYADSVKGRFTISRDDSKSMVYLQMDNLKTEDAAMYYCSAPNYYDGTYSFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 11 AA PAT source 1..11 mol_type protein note Humanized variable light chain CDR 1 amino acid sequence of anti-Ly6E antibody clone 3A3.v2.D92E organism synthetic construct KASQNVGSNVD 7 AA PAT source 1..7 mol_type protein note Humanized variable light chain CDR 2 amino acid sequence of anti-Ly6E antibody clone 3A3.v2.D92E organism synthetic construct KASNRYT 8 AA PAT source 1..8 mol_type protein note Humanized variable light chain CDR 3 amino acid sequence of anti-Ly6E antibody clone 3A3.v2.D92E organism synthetic construct MQSETKYT 10 AA PAT source 1..10 mol_type protein note Humanized variable heavy chain CDR 1 amino acid sequence of anti-Ly6E antibody clone 3A3 organism synthetic construct GFTFSTVAMH 19 AA PAT source 1..19 mol_type protein note Humanized variable heavy chain CDR 2 amino acid sequence of anti-Ly6E antibody clone 3A3 organism synthetic construct RIRTKPVNYETYYADSVKG 14 AA PAT source 1..14 mol_type protein note Humanized variable heavy chain CDR 3 amino acid sequence of anti-Ly6E antibody clone 3A3 organism synthetic construct SAPNYYDGTYSFAY 1419 DNA PAT source 1..1419 mol_type other DNA note Humanized heavy chain nucleotide sequence of anti-Ly6E antibody clone 3A3 with signal sequence organism synthetic construct atgggatggtcatgtatcatcctttttctagtagcaactgcaaccggtgtacattcagaggtgcagctggtggagtctgggggaggcttggtccagcctggggggtccctgaaactctcctgtgcagcctctgggttcaccttcagtaccgttgctatgcactgggtccgccaggcttccgggaaagggctggagtgggttggccgtattagaaccaaacctgtcaattacgagacatactatgctgactcggtgaaaggcaggttcaccatctccagagatgattcaaagtccacggtgtatctgcaaatgaacagcctgaaaaccgaggacacggccgtgtattactgttctgcaccaaattactacgacggtacttactcttttgcctactggggccaaggaaccctggtcaccgtctcgagtgcctccaccaagggcccatcggtcttccccctggcaccctcctccaagagcacctctgggggcacagcggccctgggctgcctggtcaaggactacttccccgagccggtgacggtgtcgtggaactcaggcgccctgaccagcggcgtgcacaccttcccggctgtcctacagtcctcaggactctactccctcagcagcgtggtgactgtgccctctagcagcttgggcacccagacctacatctgcaacgtgaatcacaagcccagcaacaccaaggtggacaagaaagttgagcccaaatcttgtgacaaaactcacacatgcccaccgtgcccagcacctgaactcctggggggaccgtcagtcttcctcttccccccaaaacccaaggacaccctcatgatctcccggacccctgaggtcacatgcgtggtggtggacgtgagccacgaagaccctgaggtcaagttcaactggtacgtggacggcgtggaggtgcataatgccaagacaaagccgcgggaggagcagtacaacagcacgtaccgtgtggtcagcgtcctcaccgtcctgcaccaggactggctgaatggcaaggagtacaagtgcaaggtctccaacaaagccctcccagcccccatcgagaaaaccatctccaaagccaaagggcagccccgagaaccacaggtgtacaccctgcccccatcccgggaagagatgaccaagaaccaggtcagcctgacctgcctggtcaaaggcttctatcccagcgacatcgccgtggagtgggagagcaatgggcagccggagaacaactacaagaccacgcctcccgtgctggactccgacggctccttcttcctctacagcaagctcaccgtggacaagagcaggtggcagcaggggaacgtcttctcatgctccgtgatgcatgaggctctgcacaaccactacacgcagaagagcctctccctgtctccgggtaaatga 699 DNA PAT source 1..699 mol_type other DNA note Humanized light chain nucleotide sequence of anti-Ly6E antibody clone 3A3.v2.D92E with signal sequence organism synthetic construct atgggatggtcatgtatcatcctttttctagtagcaactgcaaccggtgtacattcagacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcaccatcacttgcaaggcgagtcagaacgttggctccaatgtagattggtatcagcagaaaccagggaaagcccctaagctcctgatctacaaggcatccaatcggtacacaggggtcccatcaaggttcagtggaagtggatctgggacagattttactttcaccatcagcagcctgcagcctgaagatattgcaacatattactgtatgcagtctgagactaagtacacttttggccagggtaccaaggtggagatcaaacgaactgtggctgcaccatctgtcttcatcttcccgccatctgatgagcagttgaaatctggaactgcttctgttgtgtgcctgctgaataacttctatcccagagaggccaaagtacagtggaaggtggataacgccctccaatcgggtaactcccaggagagtgtcacagagcaggacagcaaggacagcacctacagcctcagcagcaccctgacgctgagcaaagcagactacgagaaacacaaagtctacgcctgcgaagtcacccatcagggcctgagctcgcccgtcacaaagagcttcaacaggggagagtgttaa 699 DNA PAT source 1..699 mol_type other DNA note Chimeric light chain nucleotide sequence of anti-Ly6E antibody clone 3A3 with signal sequence organism synthetic construct atgggatggtcatgtatcatcctttttctagtagcaactgcaaccggtgtacattcagacattgtgatgactcagtctcccacatccatttccatatcagtaggagagagggtcaccatgaactgcaaggccagtcagaatgtgggttctaatgttgactggtatcaacagaaaacagggcagtctcctgaactgcttatctacaaggcatccaatcggtacactggcgtccctggtcgcttcacaggcagtggatctggaacagatttcactttcaccatcagcaacttgcaggctgaagacctggctgtttattactgtatgcagtctgacaccaagtacacgtttggagctggtaccaaggtggagatcaaacgaactgtggctgcaccatctgtcttcatcttcccgccatctgatgagcagttgaaatctggaactgcttctgttgtgtgcctgctgaataacttctatcccagagaggccaaagtacagtggaaggtggataacgccctccaatcgggtaactcccaggagagtgtcacagagcaggacagcaaggacagcacctacagcctcagcagcaccctgacgctgagcaaagcagactacgagaaacacaaagtctacgcctgcgaagtcacccatcagggcctgagctcgcccgtcacaaagagcttcaacaggggagagtgttaa 1419 DNA PAT source 1..1419 mol_type other DNA note Chimeric heavy chain nucleotide sequence of anti-Ly6E antibody clone 3A3 with signal sequence organism synthetic construct atgggatggtcatgtatcatcctttttctagtagcaactgcaaccggtgtacattcagcggtacaacttgttgagtttggtggaggattggtgcagcctaaggagtcattgaaaatctcatgtgcagcctctggattcaccttcagtactgttgccatgcactgggtccgccaggctccaggaaagggtctggaatggattgctcgcattagaactaaacctgttaattatgaaacatattatgctgattcagtgaaaggcagattcaccatctcccgagatgattcaaagagcatggtctacctacaaatggataacttgaaaactgaggacgcagccatgtattactgttcagctcctaattattatgatggtacttattcctttgcttactggggccaaggcactctggtaactgtctcgagtgcctccaccaagggcccatcggtcttccccctggcaccctcctccaagagcacctctgggggcacagcggccctgggctgcctggtcaaggactacttccccgagccggtgacggtgtcgtggaactcaggcgccctgaccagcggcgtgcacaccttcccggctgtcctacagtcctcaggactctactccctcagcagcgtggtgactgtgccctctagcagcttgggcacccagacctacatctgcaacgtgaatcacaagcccagcaacaccaaggtggacaagaaagttgagcccaaatcttgtgacaaaactcacacatgcccaccgtgcccagcacctgaactcctggggggaccgtcagtcttcctcttccccccaaaacccaaggacaccctcatgatctcccggacccctgaggtcacatgcgtggtggtggacgtgagccacgaagaccctgaggtcaagttcaactggtacgtggacggcgtggaggtgcataatgccaagacaaagccgcgggaggagcagtacaacagcacgtaccgtgtggtcagcgtcctcaccgtcctgcaccaggactggctgaatggcaaggagtacaagtgcaaggtctccaacaaagccctcccagcccccatcgagaaaaccatctccaaagccaaagggcagccccgagaaccacaggtgtacaccctgcccccatcccgggaagagatgaccaagaaccaggtcagcctgacctgcctggtcaaaggcttctatcccagcgacatcgccgtggagtgggagagcaatgggcagccggagaacaactacaagaccacgcctcccgtgctggactccgacggctccttcttcctctacagcaagctcaccgtggacaagagcaggtggcagcaggggaacgtcttctcatgctccgtgatgcatgaggctctgcacaaccactacacgcagaagagcctctccctgtctccgggtaaatga 213 AA PAT source 1..213 mol_type protein note Humanized light chain amino acid sequence of anti-Ly6E antibody clone 3A3 organism synthetic construct DIQMTQSPSSLSASVGDRVTITCKASQNVGSNVDWYQQKPGKSPKLLIYKASNRYTGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCMQSDTKYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 698 DNA PAT source 1..698 mol_type other DNA note Humanized light chain nucleotide sequence of anti-Ly6E antibody clone 3A3 with signal sequence organism synthetic construct atgggatggtcatgtatcatcctttttctagtagcaactgcaaccggtgtacattcagacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcaccatcacttgcaaggcgagtcagaacgttggctccaatgtagattggtatcagcagaaaccagggaaatcccctaagctcctgatctacaaggcatccaatcggtacacaggggtcccatcaaggttcagtggaagtggatctgggacagattttactttcaccatcagcagcctgcagcctgaagatattgcaacatattactgtatgcagtctgatactaagtacacttttggccagggtaccaaggtggagatcaaacgaactgtggctgcaccatctgtcttcatcttcccgccatctgatgagcagttgaaatctggaactgcttctgttgtgtgcctgctgaataacttctatcccagagaggccaaagtacagtggaaggtggataacgccctccaatcgggtaactcccaggagagtgtcacagagcaggacagcaaggacagcacctacagcctcagcagcaccctgacgctgagcaaagcagactacgagaaacacaaagtctacgcctgcgaagtcacccatcagggcctgagctcgcccgtcacaaagagcttcaacaggggagagtgtta 213 AA PAT source 1..213 mol_type protein note Humanized light chain amino acid sequence of anti-Ly6E antibody clone 3A3.K149C organism synthetic construct DIQMTQSPSSLSASVGDRVTITCKASQNVGSNVDWYQQKPGKSPKLLIYKASNRYTGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCMQSDTKYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWCVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 699 DNA PAT source 1..699 mol_type other DNA note Humanized light chain nucleotide sequence of anti-Ly6E antibody clone 3A3.K149C with signal sequence organism synthetic construct atgggatggtcatgtatcatcctttttctagtagcaactgcaaccggtgtacattcagacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcaccatcacttgcaaggcgagtcagaacgttggctccaatgtagattggtatcagcagaaaccagggaaatcccctaagctcctgatctacaaggcatccaatcggtacacaggggtcccatcaaggttcagtggaagtggatctgggacagattttactttcaccatcagcagcctgcagcctgaagatattgcaacatattactgtatgcagtctgatactaagtacacttttggccagggtaccaaggtggagatcaaacgaactgtggctgcaccatctgtcttcatcttcccgccatctgatgagcagttgaaatctggaactgcttctgttgtgtgcctgctgaataacttctatcccagagaggccaaagtacagtggtgcgtggataacgccctccaatcgggtaactcccaggagagtgtcacagagcaggacagcaaggacagcacctacagcctcagcagcaccctgacgctgagcaaagcagactacgagaaacacaaagtctacgcctgcgaagtcacccatcagggcctgagctcgcccgtcacaaagagcttcaacaggggagagtgttaa 131 AA PAT source 1..131 mol_type protein organism Macaca mulatta MKIFLPVLLAALLGVERASSLMCFSCLNQKSNLYCLKPTICSDQDNYCVTVSTSAGIGNLVTFGHSLSKTCSPACPLPEGINVGVASMGISCCQSFLCNFSAADGGLRASATLLGAGLLLSLLPALLRFGP 136 AA PAT source 1..136 mol_type protein organism Mus sp. MSATSNMRVFLPVLLAALLGMEQVHSLMCFSCTDQKNNINCLWPVSCQEKDHYCITLSAAAGFGNVNLGYTLNKGCSPICPSENVNLNLGVASVNSYCCQSSFCNFSAAGLGLRASIPLLGLGLLLSLLALLQLSP 136 AA PAT source 1..136 mol_type protein organism Rattus sp. MSAASSMRVFLPVLLAALLGVEQVHSLMCFSCTDQKNNINCLWPVSCSSTDNYCITLSAAAGFGNVNLGYTLNKGCSPTCPRENININLGVASVNSYCCQSSFCNFSTAGLGLRASIPLLGLGLLLSLLAVLRLSP 111 AA PAT source 1..111 mol_type protein organism Homo sapiens LMCFSCLNQKSNLYCLKPTICSDQDNYCVTVSASAGIGNLVTFGHSLSKTCSPACPIPEGVNVGVASMGISCCQSFLCNFSAADGGLRASVTLLGAGLLLSLLPALLRFGP 111 AA PAT source 1..111 mol_type protein organism Macaca fascicularis LMCFSCLNQKSNLYCLKPTICSDQDNYCVTVSTSAGIGNLVTFGHSLSKTCSPACPLPEGINVGVASMGISCCQSFLCNFSAADGGLRASATLLGAGLLLSLLPALLRFGP 111 AA PAT source 1..111 mol_type protein organism Macaca mulatta LMCFSCLNQKSNLYCLKPTICSDQDNYCVTVSTSAGIGNLVTFGHSLSKTCSPACPLPEGINVGVASMGISCCQSFLCNFSAADGGLRASATLLGAGLLLSLLPALLRFGP 110 AA PAT source 1..110 mol_type protein organism Mus sp. LMCFSCTDQKNNINCLWPVSCQEKDHYCITLSAAAGFGNVNLGYTLNKGCSPICPSENVNLNLGVASVNSYCCQSSFCNFSAAGLGLRASIPLLGLGLLLSLLALLQLSP 110 AA PAT source 1..110 mol_type protein organism Rattus sp. LMCFSCTDQKNNINCLWPVSCSSTDNYCITLSAAAGFGNVNLGYTLNKGCSPTCPRENININLGVASVNSYCCQSSFCNFSTAGLGLRASIPLLGLGLLLSLLAVLRLSP 213 AA PAT source 1..213 mol_type protein note Humanized light chain amino acid sequence of anti-Ly6E antibody clone 3A3.v2.D92S organism synthetic construct DIQMTQSPSSLSASVGDRVTITCKASQNVGSNVDWYQQKPGKAPKLLIYKASNRYTGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCMQSSTKYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 728 DNA PAT source 1..728 mol_type other DNA note Humanized light chain nucleotide sequence of anti-Ly6E antibody clone 3A3.v2.D92S organism synthetic construct atgggatggtcatgtatcatcctttttctagtagcaactgcaaccggtgtacattcagacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcaccatcacttgcaaggcgagtcagaacgttggctccaatgtagattggtatcagcagaaaccagggaaagcccctaagctcctgatctacaaggcatccaatcggtacacaggggtcccatcaaggttcagtggaagtggatctgggacagattttactttcaccatcagcagcctgcagcctgaagatattgcaacatattactgtatgcagtcttctactaagtacacttttggccagggtaccaaggtggagatcaaacgaactgtggctgcaccatctgtcttcatcttcccgccatctgatgagcagttgaaatctggaactgcttctgttgtgtgcctgctgaataacttctatcccagagaggccaaagtacagtggaaggtggataacgccctccaatcgggtaactcccaggagagtgtcacagagcaggacagcaaggacagcacctacagcctcagcagcaccctgacgctgagcaaagcagactacgagaaacacaaagtctacgcctgcgaagtcacccatcagggcctgagctcgcccgtcacaaagagcttcaacaggggagagtgttaagaaacagctatgacatgattacgaattaa 106 AA PAT source 1..106 mol_type protein note Humanized variable light chain amino acid sequence of anti-Ly6E antibody clone 3A3.v2.D92E organism synthetic construct DIQMTQSPSSLSASVGDRVTITCKASQNVGSNVDWYQQKPGKAPKLLIYKASNRYTGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCMQSETKYTFGQGTKVEIK 123 AA PAT source 1..123 mol_type protein note Humanized variable heavy chain amino acid sequence of anti-Ly6E antibody clone 3A3 organism synthetic construct EVQLVESGGGLVQPGGSLKLSCAASGFTFSTVAMHWVRQASGKGLEWVGRIRTKPVNYETYYADSVKGRFTISRDDSKSTVYLQMNSLKTEDTAVYYCSAPNYYDGTYSFAYWGQGTLVTVSS 452 AA PAT source 1..452 mol_type protein note Humanized heavy chain amino acid sequence of anti-Ly6E antibody clone 3A3, without C-term lysine (K) organism synthetic construct EVQLVESGGGLVQPGGSLKLSCAASGFTFSTVAMHWVRQASGKGLEWVGRIRTKPVNYETYYADSVKGRFTISRDDSKSTVYLQMNSLKTEDTAVYYCSAPNYYDGTYSFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG 452 AA PAT source 1..452 mol_type protein note Chimeric heavy chain amino acid sequence of anti-Ly6E antibody clone 3A3, without C-term lysine (K) organism synthetic construct AVQLVEFGGGLVQPKESLKISCAASGFTFSTVAMHWVRQAPGKGLEWIARIRTKPVNYETYYADSVKGRFTISRDDSKSMVYLQMDNLKTEDAAMYYCSAPNYYDGTYSFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG