WO MUNO-008/001WO KR 10-2022-0066176 2022-05-30 Hanall Biopharma Co., Ltd. ANTI-FcRn ANTIBODY OR ANTIGEN BINDING FRAGMENT THEREOF WITH IMPROVED STABILITY ANTICUERPO ANTI-FcRn O FRAGMENTO DE UNIÓN A ANTÍGENO DEL MISMO CON ESTABILIDAD MEJORADA 37 11 AA PAT REGION 1..11 note LCDR1 of HL161AN LCDR1 de HL161AN source 1..11 mol_type protein proteína organism synthetic construct constructo sintético GGNNIGSTSVH 7 AA PAT REGION 1..7 note LCDR2 of HL161AN LCDR2 de HL161AN source 1..7 mol_type protein proteína organism synthetic construct constructo sintético DDSDRPS 11 AA PAT REGION 1..11 note LCDR3 of HL161AN LCDR3 de HL161AN source 1..11 mol_type protein proteína organism synthetic construct constructo sintético QVRDSSSDHVI 119 AA PAT REGION 1..119 note VL of HL161AN VL de HL161AN source 1..119 mol_type protein proteína organism synthetic construct constructo sintético SYVLTQPPSVSVAPGQTARITCGGNNIGSTSVHWYQQKPGQAPVLVVHDDSDRPSGIPERFSGSNSGNTATLTISRVEAGDEADYYCQVRDSSSDHVIFGGGTKLTVLGQPKAAPSVTL 5 AA PAT REGION 1..5 note HCDR1 of HL161AN HCDR1 de HL161AN source 1..5 mol_type protein proteína organism synthetic construct constructo sintético SCVMT 17 AA PAT REGION 1..17 note HCDR2 of HL161AN HCDR2 de HL161AN source 1..17 mol_type protein proteína organism synthetic construct constructo sintético VISGSGGSTYYADSVKG 12 AA PAT REGION 1..12 note HCDR3 of HL161AN HCDR3 de HL161AN source 1..12 mol_type protein proteína organism synthetic construct constructo sintético TPWWLRSPFFDY 121 AA PAT REGION 1..121 note VH of HL161AN VH de HL161AN source 1..121 mol_type protein proteína organism synthetic construct constructo sintético EVQLLESGGGLVQPGGSLRLSCAASEFTFGSCVMTWVRQAPGKGLEWVSVISGSGGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKTPWWLRSPFFDYWGQGTLVTVSS 11 AA PAT REGION 1..11 note LCDR1 of HL161ANS LCDR1 de HL161ANS source 1..11 mol_type protein proteína organism synthetic construct constructo sintético GGSNIGSTSVH 119 AA PAT REGION 1..119 note VL of HL161ANS VL of HL161ANS source 1..119 mol_type protein proteína organism synthetic construct constructo sintético SYVLTQPPSVSVAPGQTARITCGGSNIGSTSVHWYQQKPGQAPVLVVHDDSDRPSGIPERFSGSNSGNTATLTISRVEAGDEADYYCQVRDSSSDHVIFGGGTKLTVLGQPKAAPSVTL 5 AA PAT REGION 1..5 note HCDR1 of HL161ANS or HL161ANQ HCDR1 de HL161ANS o HL161ANQ source 1..5 mol_type protein proteína organism synthetic construct constructo sintético SSVMT 121 AA PAT REGION 1..121 note VH of HL161ANS or HL161ANQ VH de HL161ANS o HL161ANQ source 1..121 mol_type protein proteína organism synthetic construct constructo sintético EVQLLESGGGLVQPGGSLRLSCAASEFTFGSSVMTWVRQAPGKGLEWVSVISGSGGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKTPWWLRSPFFDYWGQGTLVTVSS 11 AA PAT REGION 1..11 note LCDR1 of HL161ANQ LCDR1 de HL161ANQ source 1..11 mol_type protein proteína organism synthetic construct constructo sintético GGQNIGSTSVH 119 AA PAT REGION 1..119 note VL of HL161ANQ VL de HL161ANQ source 1..119 mol_type protein proteína organism synthetic construct constructo sintético SYVLTQPPSVSVAPGQTARITCGGQNIGSTSVHWYQQKPGQAPVLVVHDDSDRPSGIPERFSGSNSGNTATLTISRVEAGDEADYYCQVRDSSSDHVIFGGGTKLTVLGQPKAAPSVTL 30 AA PAT REGION 1..30 note FRH1 of HL161AN FRH1 de HL161AN source 1..30 mol_type protein proteína organism synthetic construct constructo sintético EVQLLESGGGLVQPGGSLRLSCAASEFTFG 14 AA PAT REGION 1..14 note FRH2 of HL161AN FRH2 de HL161AN source 1..14 mol_type protein proteína organism synthetic construct constructo sintético WVRQAPGKGLEWVS 32 AA PAT REGION 1..32 note FRH3 of HL161AN FRH3 de HL161AN source 1..32 mol_type protein proteína organism synthetic construct constructo sintético RFTISRDNSKNTLYLQMNSLRAEDTAVYYCAK 11 AA PAT REGION 1..11 note FRH4 of HL161AN FRH4 de HL161AN source 1..11 mol_type protein proteína organism synthetic construct constructo sintético WGQGTLVTVSS 214 AA PAT REGION 1..214 note LC of HL161AN LC de HL161AN source 1..214 mol_type protein proteína organism synthetic construct constructo sintético SYVLTQPPSVSVAPGQTARITCGGNNIGSTSVHWYQQKPGQAPVLVVHDDSDRPSGIPERFSGSNSGNTATLTISRVEAGDEADYYCQVRDSSSDHVIFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS 450 AA PAT REGION 1..450 note HC of HL161AN(IgG1 null) HC de HL161AN(IgG1 null) source 1..450 mol_type protein proteína organism synthetic construct constructo sintético EVQLLESGGGLVQPGGSLRLSCAASEFTFGSCVMTWVRQAPGKGLEWVSVISGSGGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKTPWWLRSPFFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG 214 AA PAT REGION 1..214 note LC of HL161ANS or HL161ANSY or HL161ANSE or HL161ANSYE LC de HL161ANS o HL161ANSY o HL161ANSE o HL161ANSYE source 1..214 mol_type protein proteína organism synthetic construct constructo sintético SYVLTQPPSVSVAPGQTARITCGGSNIGSTSVHWYQQKPGQAPVLVVHDDSDRPSGIPERFSGSNSGNTATLTISRVEAGDEADYYCQVRDSSSDHVIFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS 450 AA PAT REGION 1..450 note HC of HL161ANS or HL161ANQ(IgG1 null) HC de HL161ANS o HL161ANQ(IgG1 null) source 1..450 mol_type protein proteína organism synthetic construct constructo sintético EVQLLESGGGLVQPGGSLRLSCAASEFTFGSSVMTWVRQAPGKGLEWVSVISGSGGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKTPWWLRSPFFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG 447 AA PAT REGION 1..447 note HC of HL161ANS or HL161ANQ(IgG4) HC de HL161ANS o HL161ANQ(IgG4) source 1..447 mol_type protein proteína organism synthetic construct constructo sintético EVQLLESGGGLVQPGGSLRLSCAASEFTFGSSVMTWVRQAPGKGLEWVSVISGSGGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKTPWWLRSPFFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG 214 AA PAT REGION 1..214 note LC of HL161ANQ or HL161ANQY or HL161ANQE or HL161ANQYE LC de HL161ANQ o HL161ANQY o HL161ANQE o HL161ANQYE source 1..214 mol_type protein proteína organism synthetic construct constructo sintético SYVLTQPPSVSVAPGQTARITCGGQNIGSTSVHWYQQKPGQAPVLVVHDDSDRPSGIPERFSGSNSGNTATLTISRVEAGDEADYYCQVRDSSSDHVIFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS 450 AA PAT REGION 1..450 note HC of HL161ANSY or HL161ANQY(IgG1 null) HC de HL161ANSY o HL161ANQY(IgG1 null) source 1..450 mol_type protein proteína organism synthetic construct constructo sintético EVQLLESGGGLVQPGGSLRLSCAASEFTFGSYVMTWVRQAPGKGLEWVSVISGSGGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKTPWWLRSPFFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG 450 AA PAT REGION 1..450 note HC of HL161ANSE or HL161ANQE(IgG1 null) HC de HL161ANSE o HL161ANQE(IgG1 null) source 1..450 mol_type protein proteína organism synthetic construct constructo sintético EVQLLESGGGLVQPGGSLRLSCAASEFTFGSSVMTWVRQAPGKGLEWVSVISGSGGSTYYADSVKGRFTISRDNSKNTLYLEMNSLRAEDTAVYYCAKTPWWLRSPFFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG 450 AA PAT REGION 1..450 note HC of HL161ANSYE or HL161ANQYE(IgG1 null) HC de HL161ANSYE o HL161ANQYE(IgG1 null) source 1..450 mol_type protein proteína organism synthetic construct constructo sintético EVQLLESGGGLVQPGGSLRLSCAASEFTFGSYVMTWVRQAPGKGLEWVSVISGSGGSTYYADSVKGRFTISRDNSKNTLYLEMNSLRAEDTAVYYCAKTPWWLRSPFFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG 642 DNA PAT misc_feature 1..642 note Polynucleotide of HL161AN(IgG1 null) LC Polinucleótido de HL161AN(IgG1 null) LC source 1..642 mol_type other DNA otro ADN organism synthetic construct constructo sintético tcttacgtgctgacccagcccccctccgtgtctgtggctcctggccagaccgccagaatcacctgtggcggcaacaacatcggctccacctccgtgcactggtatcagcagaagcccggccaggcccccgtgctggtggtgcacgacgactccgaccggccttctggcatccctgagcggttctccggctccaactccggcaacaccgccaccctgaccatctccagagtggaagccggcgacgaggccgactactactgccaagtgcgagactcctcctccgaccacgtgatcttcggcggaggcaccaagctgaccgtgctgggccagcctaaggccgctccctccgtgaccctgttccccccatcctccgaggaactgcaggccaacaaggccaccctggtctgcctgatctccgacttctaccctggcgccgtgaccgtggcctggaaggccgacagctctcctgtgaaggccggcgtggaaaccaccaccccctccaagcagtccaacaacaaatacgccgcctcctcctacctgtccctgacccccgagcagtggaagtcccaccggtcctacagctgccaagtgacacacgagggctccaccgtggaaaagaccgtggcccctaccgagtgctcc 1407 DNA PAT misc_feature 1..1407 note Polynucleotide of HL161AN(IgG1 null) HC Polinucleótido de HL161AN(IgG1 null) HC source 1..1407 mol_type other DNA otro ADN organism synthetic construct constructo sintético gaagtgcagctgctggaatccggcggaggcctggtgcagcctggcggctctctgagactgtcctgcgccgcctccgagttcaccttcggcagctgcgtgatgacctgggtccgacaggctcccggcaagggcctggaatgggtgtccgtgatctccggctccggcggctccacctactacgccgactctgtgaagggccggttcaccatctcccgggacaactccaagaacaccctgtacctgcagatgaactccctgcgggccgaggacaccgccgtgtactactgcgccaagaccccctggtggctgcggtcccccttcttcgattactggggccagggcaccctggtgacagtgtcctccgcctccaccaagggcccctccgtgttccctctggccccctccagcaagtccacctctggcggcaccgctgccctgggctgtctggtgaaagactacttccccgagcccgtgaccgtgtcctggaactctggcgccctgacctccggcgtgcacaccttccctgccgtgctgcagtcctccggcctgtactccctgtccagcgtggtgaccgtgccctccagctctctgggcacccagacctacatctgcaacgtgaaccacaagccctccaacaccaaggtggacaagcgggtggaacccaagtcctgcgacaagacccacacctgtcccccctgtcctgcccctgaagctgctggcggccctagcgtgttcctgttccccccaaagcccaaggacaccctgatgatctcccggacccccgaagtgacctgcgtggtggtggacgtgtcccacgaggaccctgaagtgaagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagcccagagaggaacagtacaactccacctaccgggtggtgtccgtgctgaccgtgctgcaccaggactggctgaacggcaaagagtacaagtgcaaggtctccaacaaggccctgcctgcccccatcgaaaagaccatctccaaggccaagggccagccccgcgagccccaggtgtacacactgccccctagccgggaagagatgaccaagaaccaggtgtccctgacatgcctggtgaagggcttctacccctccgacattgccgtggaatgggagtccaacggccagcccgagaacaactacaagaccaccccccctgtgctggactccgacggctcattcttcctgtactccaagctgaccgtggacaagtcccggtggcagcagggcaacgtgttctcctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtccctgagccccggctgagtatacttaattaactgggcctcatgggccttccgctcactgcccgctttccag 645 DNA PAT misc_feature 1..645 note Polynucleotide of HL161ANS(IgG1 null) LC Polinucleótido de HL161ANS(IgG1 null) LC source 1..645 mol_type other DNA otro ADN organism synthetic construct constructo sintético tcttacgtgctgacccagcccccctccgtgtctgtggctcctggccagaccgccagaatcacctgtggcggctcaaacatcggctccacctccgtgcactggtatcagcagaagcccggccaggcccccgtgctggtggtgcacgacgactccgaccggccttctggcatccctgagcggttctccggctccaactccggcaacaccgccaccctgaccatctccagagtggaagccggcgacgaggccgactactactgccaagtgcgagactcctcctccgaccacgtgatcttcggcggaggcaccaagctgaccgtgctgggccagcctaaggccgctccctccgtgaccctgttccccccatcctccgaggaactgcaggccaacaaggccaccctggtctgcctgatctccgacttctaccctggcgccgtgaccgtggcctggaaggccgacagctctcctgtgaaggccggcgtggaaaccaccaccccctccaagcagtccaacaacaaatacgccgcctcctcctacctgtccctgacccccgagcagtggaagtcccaccggtcctacagctgccaagtgacacacgagggctccaccgtggaaaagaccgtggcccctaccgagtgctcctga 1407 DNA PAT misc_feature 1..1407 note Polynucleotide of HL161ANS(IgG1 null) HC Polinucleótido de HL161ANS(IgG1 null) HC source 1..1407 mol_type other DNA otro ADN organism synthetic construct constructo sintético gaagtgcagctgctggaatccggcggaggcctggtgcagcctggcggctctctgagactgtcctgcgccgcctccgagttcaccttcggcagcagcgtgatgacctgggtccgacaggctcccggcaagggcctggaatgggtgtccgtgatctccggctccggcggctccacctactacgccgactctgtgaagggccggttcaccatctcccgggacaactccaagaacaccctgtacctgcagatgaactccctgcgggccgaggacaccgccgtgtactactgcgccaagaccccctggtggctgcggtcccccttcttcgattactggggccagggcaccctggtgacagtgtcctccgcctccaccaagggcccctccgtgttccctctggccccctccagcaagtccacctctggcggcaccgctgccctgggctgcctggtgaaagactacttccccgagcccgtgaccgtgtcctggaactctggcgccctgacctccggcgtgcacaccttccctgccgtgctgcagtcctccggcctgtactccctgtcctccgtggtgaccgtgccctccagctctctgggcacccagacctacatctgcaacgtgaaccacaagccctccaacaccaaggtggacaagcgggtggaacccaagtcctgcgacaagacccacacctgtcccccctgtcctgcccctgaagctgctggcggccctagcgtgttcctgttccccccaaagcccaaggacaccctgatgatctcccggacccccgaagtgacctgcgtggtggtggacgtgtcccacgaggaccctgaagtgaagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagcccagagaggaacagtacaactccacctaccgggtggtgtctgtgctgaccgtgctgcaccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcccccatcgaaaagaccatctccaaggccaagggccagccccgcgagccccaggtgtacacactgccccctagccgggaagagatgaccaagaaccaggtgtccctgacctgtctggtgaaaggcttctacccctccgacattgccgtggaatgggagtccaacggccagcccgagaacaactacaagaccaccccccctgtgctggactccgacggctcattcttcctgtactccaagctgaccgtggacaagtcccggtggcagcagggcaacgtgttctcctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtccctgagccccggctgagtatacttaattaactgggcctcatgggccttccgctcactgcccgctttccag 645 DNA PAT misc_feature 1..645 note Polynucleotide of HL161ANS(IgG4) LC Polinucleótido de HL161ANS(IgG4) LC source 1..645 mol_type other DNA otro ADN organism synthetic construct constructo sintético tcttacgtgctgacccagcccccctccgtgtctgtggctcctggccagaccgccagaatcacctgtggcggctcaaacatcggctccacctccgtgcactggtatcagcagaagcccggccaggcccccgtgctggtggtgcacgacgactccgaccggccttctggcatccctgagcggttctccggctccaactccggcaacaccgccaccctgaccatctccagagtggaagccggcgacgaggccgactactactgccaagtgcgagactcctcctccgaccacgtgatcttcggcggaggcaccaagctgaccgtgctgggccagcctaaggccgctccctccgtgaccctgttccccccatcctccgaggaactgcaggccaacaaggccaccctggtctgcctgatctccgacttctaccctggcgccgtgaccgtggcctggaaggccgacagctctcctgtgaaggccggcgtggaaaccaccaccccctccaagcagtccaacaacaaatacgccgcctcctcctacctgtccctgacccccgagcagtggaagtcccaccggtcctacagctgccaagtgacacacgagggctccaccgtggaaaagaccgtggcccctaccgagtgctcctga 1347 DNA PAT misc_feature 1..1347 note Polynucleotide of HL161ANS(IgG4) HC Polinucleótido de HL161ANS(IgG4) HC source 1..1347 mol_type other DNA otro ADN organism synthetic construct constructo sintético gaagttcagctgttggagtctggcggcggattggttcaacctggcggatctctgagactgtcttgcgccgcctctgagttcaccttcggctcctctgtgatgacctgggtccgacaggctcctggcaaaggactggaatgggtgtccgtgatctctggctctggcggctctacctactacgccgattctgtgaagggcagattcaccatcagccgggacaactccaagaacaccctgtacctgcagatgaactccctgagagccgaggacaccgccgtgtactattgtgctaagaccccttggtggctgcggtcccctttctttgattattggggccagggcaccctggtcaccgtgtcctctgcttctacaaagggcccctctgtgttccctctggctccttgctctagatccacctccgagtctaccgctgctctgggctgtctggtcaaggactactttcctgagcctgtgaccgtgtcttggaactctggtgctctgacctccggcgtgcacacatttccagctgtgctgcagtcctccggcctgtactctctgtcctctgtcgtgaccgtgccttctagctctctgggcaccaagacctacacctgtaacgtggaccacaagccttccaacaccaaggtggacaagcgcgtggaatctaagtacggccctccttgtcctccatgtcctgctccagaattcctcggcggaccctccgtgttcctgtttcctccaaagcctaaggacaccctgatgatctctcggacccctgaagtgacctgcgtggtggtggatgtgtctcaagaggaccccgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagcctagagaggaacagttcaactccacctacagagtggtgtctgtgctgaccgtgctgcaccaggattggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggcctgccttccagcatcgaaaagaccatctccaaggctaagggccagcctcgggaacctcaggtttacaccctgcctccaagccaagaggaaatgaccaagaaccaggtgtccctgacctgcctcgtgaagggcttctacccttccgacattgccgtggaatgggagtctaacggccagccagagaacaactacaagacaacccctcctgtgctggactccgacggctctttcttcctgtattctcgcctgaccgtggacaagtctcggtggcaagagggcaacgtgttctcctgttctgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctctgtccctgggctaatga 645 DNA PAT misc_feature 1..645 note Polynucleotide of HL161ANQ(IgG1 null) LC Polinucleótido de HL161ANQ(IgG1 null) LC source 1..645 mol_type other DNA otro ADN organism synthetic construct constructo sintético tcttacgtgctgacccagcccccctccgtgtctgtggctcctggccagaccgccagaatcacctgtggcggccagaacatcggctccacctccgtgcactggtatcagcagaagcccggccaggcccccgtgctggtggtgcacgacgactccgaccggccttctggcatccctgagcggttctccggctccaactccggcaacaccgccaccctgaccatctccagagtggaagccggcgacgaggccgactactactgccaagtgcgagactcctcctccgaccacgtgatcttcggcggaggcaccaagctgaccgtgctgggccagcctaaggccgctccctccgtgaccctgttccccccatcctccgaggaactgcaggccaacaaggccaccctggtctgcctgatctccgacttctaccctggcgccgtgaccgtggcctggaaggccgacagctctcctgtgaaggccggcgtggaaaccaccaccccctccaagcagtccaacaacaaatacgccgcctcctcctacctgtccctgacccccgagcagtggaagtcccaccggtcctacagctgccaagtgacacacgagggctccaccgtggaaaagaccgtggcccctaccgagtgctcctga 1407 DNA PAT misc_feature 1..1407 note Polynucleotide of HL161ANQ(IgG1 null) HC Polinucleótido de HL161ANQ(IgG1 null) HC source 1..1407 mol_type other DNA otro ADN organism synthetic construct constructo sintético gaagtgcagctgctggaatccggcggaggcctggtgcagcctggcggctctctgagactgtcctgcgccgcctccgagttcaccttcggcagcagcgtgatgacctgggtccgacaggctcccggcaagggcctggaatgggtgtccgtgatctccggctccggcggctccacctactacgccgactctgtgaagggccggttcaccatctcccgggacaactccaagaacaccctgtacctgcagatgaactccctgcgggccgaggacaccgccgtgtactactgcgccaagaccccctggtggctgcggtcccccttcttcgattactggggccagggcaccctggtgacagtgtcctccgcctccaccaagggcccctccgtgttccctctggccccctccagcaagtccacctctggcggcaccgctgccctgggctgcctggtgaaagactacttccccgagcccgtgaccgtgtcctggaactctggcgccctgacctccggcgtgcacaccttccctgccgtgctgcagtcctccggcctgtactccctgtcctccgtggtgaccgtgccctccagctctctgggcacccagacctacatctgcaacgtgaaccacaagccctccaacaccaaggtggacaagcgggtggaacccaagtcctgcgacaagacccacacctgtcccccctgtcctgcccctgaagctgctggcggccctagcgtgttcctgttccccccaaagcccaaggacaccctgatgatctcccggacccccgaagtgacctgcgtggtggtggacgtgtcccacgaggaccctgaagtgaagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagcccagagaggaacagtacaactccacctaccgggtggtgtctgtgctgaccgtgctgcaccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcccccatcgaaaagaccatctccaaggccaagggccagccccgcgagccccaggtgtacacactgccccctagccgggaagagatgaccaagaaccaggtgtccctgacctgtctggtgaaaggcttctacccctccgacattgccgtggaatgggagtccaacggccagcccgagaacaactacaagaccaccccccctgtgctggactccgacggctcattcttcctgtactccaagctgaccgtggacaagtcccggtggcagcagggcaacgtgttctcctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtccctgagccccggctgagtatacttaattaactgggcctcatgggccttccgctcactgcccgctttccag 645 DNA PAT misc_feature 1..645 note Polynucleotide of HL161ANQ(IgG4) LC Polinucleótido de HL161ANQ(IgG4) LC source 1..645 mol_type other DNA otro ADN organism synthetic construct constructo sintético tcttacgtgctgacccagcccccctccgtgtctgtggctcctggccagaccgccagaatcacctgtggcggccagaacatcggctccacctccgtgcactggtatcagcagaagcccggccaggcccccgtgctggtggtgcacgacgactccgaccggccttctggcatccctgagcggttctccggctccaactccggcaacaccgccaccctgaccatctccagagtggaagccggcgacgaggccgactactactgccaagtgcgagactcctcctccgaccacgtgatcttcggcggaggcaccaagctgaccgtgctgggccagcctaaggccgctccctccgtgaccctgttccccccatcctccgaggaactgcaggccaacaaggccaccctggtctgcctgatctccgacttctaccctggcgccgtgaccgtggcctggaaggccgacagctctcctgtgaaggccggcgtggaaaccaccaccccctccaagcagtccaacaacaaatacgccgcctcctcctacctgtccctgacccccgagcagtggaagtcccaccggtcctacagctgccaagtgacacacgagggctccaccgtggaaaagaccgtggcccctaccgagtgctcctga 1347 DNA PAT misc_feature 1..1347 note Polynucleotide of HL161ANQ(IgG4) HC Polinucleótido de HL161ANQ(IgG4) HC source 1..1347 mol_type other DNA otro ADN organism synthetic construct constructo sintético gaagttcagctgttggagtctggcggcggattggttcaacctggcggatctctgagactgtcttgcgccgcctctgagttcaccttcggctcctctgtgatgacctgggtccgacaggctcctggcaaaggactggaatgggtgtccgtgatctctggctctggcggctctacctactacgccgattctgtgaagggcagattcaccatcagccgggacaactccaagaacaccctgtacctgcagatgaactccctgagagccgaggacaccgccgtgtactattgtgctaagaccccttggtggctgcggtcccctttctttgattattggggccagggcaccctggtcaccgtgtcctctgcttctacaaagggcccctctgtgttccctctggctccttgctctagatccacctccgagtctaccgctgctctgggctgtctggtcaaggactactttcctgagcctgtgaccgtgtcttggaactctggtgctctgacctccggcgtgcacacatttccagctgtgctgcagtcctccggcctgtactctctgtcctctgtcgtgaccgtgccttctagctctctgggcaccaagacctacacctgtaacgtggaccacaagccttccaacaccaaggtggacaagcgcgtggaatctaagtacggccctccttgtcctccatgtcctgctccagaattcctcggcggaccctccgtgttcctgtttcctccaaagcctaaggacaccctgatgatctctcggacccctgaagtgacctgcgtggtggtggatgtgtctcaagaggaccccgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagcctagagaggaacagttcaactccacctacagagtggtgtctgtgctgaccgtgctgcaccaggattggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggcctgccttccagcatcgaaaagaccatctccaaggctaagggccagcctcgggaacctcaggtttacaccctgcctccaagccaagaggaaatgaccaagaaccaggtgtccctgacctgcctcgtgaagggcttctacccttccgacattgccgtggaatgggagtctaacggccagccagagaacaactacaagacaacccctcctgtgctggactccgacggctctttcttcctgtattctcgcctgaccgtggacaagtctcggtggcaagagggcaacgtgttctcctgttctgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctctgtccctgggctaatga