WO PCT/IB2023/000335 2023-06-08 58651-825(generic) US 63/351,077 2022-06-10 HORIZON THERAPEUTICS IRELAND DAC IGF1R ANTIBODIES ANTICUERPOS IGF1R 57 118 AA PAT source 1..118 mol_type protein organism constructo sintético QVELVESGGGVVQPGRSQRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAIIWFDGSSTYYADSVRGRFTISRDNSKNTLYLQMNSLRAEDTAVYFCARELGRRYFDLWGRGTLVSVSS 108 AA PAT source 1..108 mol_type protein organism constructo sintético EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASKRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSKWPPWTFGQGTKVESK 118 AA PAT source 1..118 mol_type protein organism constructo sintético QVELVESGGGVVQPGRSQRLSCAASGFTFSSTGMHWVRQAPGKGLEWVAYIWFDGSSTYYADSVRGRFTISRDNSKNTLYLQMNSLRAEDTAVYFCARELNRRYFDLWGRGTLVSVSS 108 AA PAT source 1..108 mol_type protein organism constructo sintético EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASKRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSKYPPWTFGQGTKVESK 118 AA PAT source 1..118 mol_type protein organism constructo sintético QVELVESGGGVVQPGRSQRLSCAASGFTFSSHGMHWVRQAPGKGLEWVAIIAGDASTTYYADSVRGRFTISRDNSKNTLYLQMNSLRAEDTAVYFCARELGRRYFDLWGRGTLVSVSS 108 AA PAT source 1..108 mol_type protein organism constructo sintético EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASKRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSKYPPWTFGQGTKVESK 118 AA PAT source 1..118 mol_type protein organism constructo sintético QVELVESGGGVVQPGRSQRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAIIWFDGSSTYYADSVRGRFTISRDNSKNTLYLQMNSLRAEDTAVYFCARELGRRYFDLWGRGTLVSVSS 108 AA PAT source 1..108 mol_type protein organism constructo sintético EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASKRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSKYPPWTFGQGTKVESK 118 AA PAT source 1..118 mol_type protein organism constructo sintético QVELVESGGGVVQPGRSQRLSCAASGFTFSSYGMHWVRQAPGKGLEWVATIWFDGSSTYYADSVRGRFTISRDNSKNTLYLQMNSLRAEDTAVYFCARELGRRYFDLWGRGTLVSVSS 108 AA PAT source 1..108 mol_type protein organism constructo sintético EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASKRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSKYPPWTFGQGTKVESK 118 AA PAT source 1..118 mol_type protein organism constructo sintético QVELVESGGGVVQPGRSQRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAIINFDGSSTYYADSVRGRFTISRDNSKNTLYLQMNSLRAEDTAVYFCARELGRRYFDLWGRGTLVSVSS 108 AA PAT source 1..108 mol_type protein organism constructo sintético EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASKRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSKYPPWTFGQGTKVESK 118 AA PAT source 1..118 mol_type protein organism constructo sintético QVELVESGGGVVQPGRSQRLSCAASGFTFSSAGMHWVRQAPGKGLEWVAIIWADGSSTYYADSVRGRFTISRDNSKNTLYLQMNSLRAEDTAVYFCARELGRRYFDLWGRGTLVSVSS 108 AA PAT source 1..108 mol_type protein organism constructo sintético EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASKRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSKYPPWTFGQGTKVESK 118 AA PAT source 1..118 mol_type protein organism constructo sintético QVELVESGGGVVQPGRSQRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAYIWFDGSSTYYADSVRGRFTISRDNSKNTLYLQMNSLRAEDTAVYFCARELGRRYFDLWGRGTLVSVSS 108 AA PAT source 1..108 mol_type protein organism constructo sintético EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASKRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSKYPPWTFGQGTKVESK 118 AA PAT source 1..118 mol_type protein organism constructo sintético QVELVESGGGVVQPGRSQRLSCAASGFTFSSHGMHWVRQAPGKGLEWVAYIWFDGSSTYYADSVRGRFTISRDNSKNTLYLQMNSLRAEDTAVYFCARELGRRYFDLWGRGTLVSVSS 108 AA PAT source 1..108 mol_type protein organism constructo sintético EIVLTQSPATLSLSPGERATLSCRASQSVSSALAWYQQKPGQAPRLLIYDASKRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSKYPPWTFGQGTKVESK 118 AA PAT source 1..118 mol_type protein organism constructo sintético QVELVESGGGVVQPGRSQRLSCAASGFTFSSHGMHWVRQAPGKGLEWVATIWFDGSSTYYADSVRGRFTISRDNSKNTLYLQMNSLRAEDTAVYFCARELGRRYFDLWGRGTLVSVSS 108 AA PAT source 1..108 mol_type protein organism constructo sintético EIVLTQSPATLSLSPGERATLSCRASQSVSSTLAWYQQKPGQAPRLLIYDASKRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSKYPPWTFGQGTKVESK 118 AA PAT source 1..118 mol_type protein organism constructo sintético QVELVESGGGVVQPGRSQRLSCAASGFTFSSYGMHWVRQAPGKGLEWVATIWHDGSSTYYADSVRGRFTISRDNSKNTLYLQMNSLRAEDTAVYFCARELGRRYFDLWGRGTLVSVSS 108 AA PAT source 1..108 mol_type protein organism constructo sintético EIVLTQSPATLSLSPGERATLSCRASQSVSSALAWYQQKPGQAPRLLIYDASKRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRGKYPPWTFGQGTKVESK 000 000 000 000 000 000 000 5 AA PAT source 1..5 mol_type protein organism constructo sintético SHGMH 5 AA PAT source 1..5 mol_type protein organism constructo sintético STGMH 5 AA PAT source 1..5 mol_type protein organism constructo sintético SAGMH 5 AA PAT source 1..5 mol_type protein organism constructo sintético SYGMH 17 AA PAT source 1..17 mol_type protein organism constructo sintético IIAGDASTTYYADSVRG 17 AA PAT source 1..17 mol_type protein organism constructo sintético YIWFDGSSTYYADSVRG 17 AA PAT source 1..17 mol_type protein organism constructo sintético IIWADGSSTYYADSVRG 17 AA PAT source 1..17 mol_type protein organism constructo sintético IINFDGSSTYYADSVRG 17 AA PAT source 1..17 mol_type protein organism constructo sintético IIWFDGSSTYYADSVRG 17 AA PAT source 1..17 mol_type protein organism constructo sintético TIWHDGSSTYYADSVRG 17 AA PAT source 1..17 mol_type protein organism constructo sintético TIWFDGSSTYYADSVRG 9 AA PAT source 1..9 mol_type protein organism constructo sintético ELGRRYFDL 9 AA PAT source 1..9 mol_type protein organism constructo sintético ELNRRYFDL 11 AA PAT source 1..11 mol_type protein organism constructo sintético RASQSVSSALA 11 AA PAT source 1..11 mol_type protein organism constructo sintético RASQSVSSTLA 11 AA PAT source 1..11 mol_type protein organism constructo sintético RASQSVSSYLA 7 AA PAT source 1..7 mol_type protein organism constructo sintético DASKRAT 10 AA PAT source 1..10 mol_type protein organism constructo sintético QQRGKYPPWT 10 AA PAT source 1..10 mol_type protein organism constructo sintético QQRSKYPPWT 10 AA PAT source 1..10 mol_type protein organism constructo sintético QQRSKWPPWT 000 448 AA PAT source 1..448 mol_type protein organism constructo sintético QVELVESGGGVVQPGRSQRLSCAASGFTFSSHGMHWVRQAPGKGLEWVAYIWFDGSSTYYADSVRGRFTISRDNSKNTLYLQMNSLRAEDTAVYFCARELGRRYFDLWGRGTLVSVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLYITREPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 215 AA PAT source 1..215 mol_type protein organism constructo sintético EIVLTQSPATLSLSPGERATLSCRASQSVSSALAWYQQKPGQAPRLLIYDASKRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSKYPPWTFGQGTKVESKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 5 AA PAT source 1..5 mol_type protein organism constructo sintético VARIANT 2 note H, Y, A o T SXGMH 17 AA PAT source 1..17 mol_type protein organism constructo sintético VARIANT 1 note I, T o Y VARIANT 3 note W, N o A VARIANT 4 note F, H, A o G VARIANT 6 note G o A VARIANT 8 note S o T XIXXDXSXTYYADSVRG 9 AA PAT source 1..9 mol_type protein organism constructo sintético VARIANT 3 note G o N ELXRRYFDL 11 AA PAT source 1..11 mol_type protein organism constructo sintético VARIANT 9 note Y, A o T RASQSVSSXLA 10 AA PAT source 1..10 mol_type protein organism constructo sintético VARIANT 4 note S o G VARIANT 6 note Y o W QQRXKXPPWT