24C82178 CN 202210631397.9 2022-06-06 Shandong Simcere Biopharmaceutical Co.,Ltd. Shandong Simcere Biopharmaceutical Co.,Ltd. MULTI-SPECIFIC ANTIBODY TARGETING BCMA, GPRC5D AND T CELLS AND APPLICATION THEREOF ANTICUERPO MULTIESPECIFICO DIRIGIDO A BCMA, GPRC5D Y LINFOCITOS T Y APLICACION DEL MISMO 57 126 AA PAT source 1..126 mol_type protein organism Synthetic construct Construcción sintética EVQLVESGGGLVQPGGSLRLSCSASGFTLDYYMIGWFRQAPGKEREGLSSISPADGSTYYADSVKGRFTISRDSSKNTVYLQMNSLRAEDTAVYYCAAGNEATISWGFGPWEYDYWGQGTMVTVSS 123 AA PAT source 1..123 mol_type protein organism Synthetic construct Construcción sintética EVQLVESGGGLVQPGGSLRLSCAASESISSIHIMAWYRQAPGKQRELVAGIRNDGSTVYVDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCNADQGFGSYSEWERRSRWGQGTTVTVSS 121 AA PAT source 1..121 mol_type protein organism Synthetic construct Construcción sintética EGQMVQSGAEVKKPGSSVKVSCKASGYMFTDHTFHWVRQAPGQGLEWMGYIYPRDQNTKYNEKFKGRVTITADKSTSTAYMELSSLRSEDTAVYYCARAGYYGSSHAMDYWGQGTTVTVSS 107 AA PAT source 1..107 mol_type protein organism Synthetic construct Construcción sintética DIQMTQSPSSLSASVGDRVTITCKASQDVSTAVAWYQQKPGKSPRLLIYSASSRYTGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQLYSTPWTFGGGTKVEIK 121 AA PAT source 1..121 mol_type protein organism Synthetic construct Construcción sintética EVQLVQSGAEVKKPGSSVKVSCKASGYTFTSYGISWVRQAPGQGLEWMGEIYPRSGNTYYNEKFKGRVTLTADKSTSTAYMELSSLRSEDTAVYYCARGRAYGRNYPMDYWGQGTTVTVSS 107 AA PAT source 1..107 mol_type protein organism Synthetic construct Construcción sintética EIVLTQSPATLSLSPGERATLSCRASQSIGTSIHWYQQKPGQSPRLLIKYASESISGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQSNSWPYTFGGGTKVEIK 121 AA PAT source 1..121 mol_type protein organism Synthetic construct Construcción sintética EVQLVQSGAEVKKPGASVKVSCKTSGYIFTNFGITWVRQAPGQRLEWMGENYPRRINTYYNEKFKGRVTITADKSASTAYMELSSLRSEDTAVYYCSRKDIFGLSYALDYWGQGTTVTVSS 107 AA PAT source 1..107 mol_type protein organism Synthetic construct Construcción sintética DIQMTQSPSSLSASVGDRVTITCKASQNVGTNVAWYQHKPGKSPKALIYSASYQYSGVPSRFSGSGSGTDFTLTISSLQPEDVATYICQQYKNYPYTFGGGTKVEIK 123 AA PAT source 1..123 mol_type protein organism Synthetic construct Construcción sintética EVQLVESGGGVVQPGRSLRLSCAASGFTFTDYYMSWVRQAPGKGLEWVAMSRNKAKGHTIEYSSSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDTYESYDGYFDVWGQGTTVTVSS 112 AA PAT source 1..112 mol_type protein organism Synthetic construct Construcción sintética DIVMTQSPDSLAVSLGERATINCKSSQSLFNSRSRKNYLAWYQQKPGQTPKLLIYWASIRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCKQSYYLYTFGQGTKLEIK 231 AA PAT source 1..231 mol_type protein organism Synthetic construct Construcción sintética EPKSSDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG 231 AA PAT source 1..231 mol_type protein organism Synthetic construct Construcción sintética EPKSSDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG 229 AA PAT source 1..229 mol_type protein organism Synthetic construct Construcción sintética ESKYGPPCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK 228 AA PAT source 1..228 mol_type protein organism Synthetic construct Construcción sintética ESKYGPPCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG 228 AA PAT source 1..228 mol_type protein organism Synthetic construct Construcción sintética ESKYGPPCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG 98 AA PAT source 1..98 mol_type protein organism Synthetic construct Construcción sintética ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKV 98 AA PAT source 1..98 mol_type protein organism Synthetic construct Construcción sintética ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRV 451 AA PAT source 1..451 mol_type protein organism Synthetic construct Construcción sintética EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFWMTWVRQAPGKGLEWVANMNQDGSEKYYVDSVKGRFTISRDNAKSSLYLQMNSLRAEDTAVYYCARDREYCISTSCYDDFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK 450 AA PAT source 1..450 mol_type protein organism Synthetic construct Construcción sintética EVQLVESGGGLVQPGRSLRLSCAASGFTFDDYSMHWVRQAPGKGLEWVSGISWNSGSIGYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTALYYCAKYGSGYGKFYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNRFTQKSLSLSLGK 215 AA PAT source 1..215 mol_type protein organism Synthetic construct Construcción sintética DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSYSTPPITFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 445 AA PAT source 1..445 mol_type protein organism Synthetic construct Construcción sintética QVQLVQSGAEVKKPGASVKVSCKASGYSFTGYTMNWVRQAPGQGLEWMGLINPYNSDTNYAQKLQGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARVALRVALDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK 214 AA PAT source 1..214 mol_type protein organism Synthetic construct Construcción sintética DIQMTQSPSSLSASVGDRVTITCKASQNVATHVGWYQQKPGKAPKRLIYSASYRYSGVPSRFSGSGSGTEFTLTISNLQPEDFATYYCQQYNRYPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 452 AA PAT source 1..452 mol_type protein organism Synthetic construct Construcción sintética EVQLVESGGGLVQPGGSLRLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYAASVKGRFTISRDDSKNSLYLQMNSLKTEDTAVYYCARHGNFGNSYVSWFAYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFLLYSKLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK 215 AA PAT source 1..215 mol_type protein organism Synthetic construct Construcción sintética QTVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCALWYSNLWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS 710 AA PAT source 1..710 mol_type protein organism Synthetic construct Construcción sintética EVKLDETGGGLVQPGRPMKLSCVASGFTFSDYWMNWVRQSPEKGLEWVAQIRNKPYNYETYYSDSVKGRFTISRDDSKSSVYLQMNNLRVEDMGIYYCTGSYYGMDYWGQGTSVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVGGGGSGGGGSGGGGSEVQLVESGGGVVQPGRSLRLSCAASGFTFTDYYMSWVRQAPGKGLEWVAMSRNKAKGHTIEYSSSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDTYESYDGYFDVWGQGTTVTVSSGGGGSGGGGSGGGGSDIVMTQSPDSLAVSLGERATINCKSSQSLFNSRSRKNYLAWYQQKPGQTPKLLIYWASIRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCKQSYYLYTFGQGTKLEIKESKYGPPCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK 219 AA PAT source 1..219 mol_type protein organism Synthetic construct Construcción sintética DVVMTQTPLSLPVSLGDQASISCRSSQSLVHSNGNTYLRWYLQKPGQSPKVLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDLGVYFCSQSTHVPWTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 5 AA PAT source 1..5 mol_type protein organism Synthetic construct Construcción sintética YYMIG 17 AA PAT source 1..17 mol_type protein organism Synthetic construct Construcción sintética SISPADGSTYYADSVKG 17 AA PAT source 1..17 mol_type protein organism Synthetic construct Construcción sintética GNEATISWGFGPWEYDY 5 AA PAT source 1..5 mol_type protein organism Synthetic construct Construcción sintética IHIMA 16 AA PAT source 1..16 mol_type protein organism Synthetic construct Construcción sintética GIRNDGSTVYVDSVKG 15 AA PAT source 1..15 mol_type protein organism Synthetic construct Construcción sintética DQGFGSYSEWERRSR 5 AA PAT source 1..5 mol_type protein organism Synthetic construct Construcción sintética DHTFH 17 AA PAT source 1..17 mol_type protein organism Synthetic construct Construcción sintética YIYPRDQNTKYNEKFKG 12 AA PAT source 1..12 mol_type protein organism Synthetic construct Construcción sintética AGYYGSSHAMDY 11 AA PAT source 1..11 mol_type protein organism Synthetic construct Construcción sintética KASQDVSTAVA 7 AA PAT source 1..7 mol_type protein organism Synthetic construct Construcción sintética SASSRYT 9 AA PAT source 1..9 mol_type protein organism Synthetic construct Construcción sintética QQLYSTPWT 5 AA PAT source 1..5 mol_type protein organism Synthetic construct Construcción sintética SYGIS 17 AA PAT source 1..17 mol_type protein organism Synthetic construct Construcción sintética EIYPRSGNTYYNEKFKG 12 AA PAT source 1..12 mol_type protein organism Synthetic construct Construcción sintética GRAYGRNYPMDY 11 AA PAT source 1..11 mol_type protein organism Synthetic construct Construcción sintética RASQSIGTSIH 7 AA PAT source 1..7 mol_type protein organism Synthetic construct Construcción sintética YASESIS 9 AA PAT source 1..9 mol_type protein organism Synthetic construct Construcción sintética QQSNSWPYT 5 AA PAT source 1..5 mol_type protein organism Synthetic construct Construcción sintética NFGIT 17 AA PAT source 1..17 mol_type protein organism Synthetic construct Construcción sintética ENYPRRINTYYNEKFKG 12 AA PAT source 1..12 mol_type protein organism Synthetic construct Construcción sintética KDIFGLSYALDY 11 AA PAT source 1..11 mol_type protein organism Synthetic construct Construcción sintética KASQNVGTNVA 7 AA PAT source 1..7 mol_type protein organism Synthetic construct Construcción sintética SASYQYS 9 AA PAT source 1..9 mol_type protein organism Synthetic construct Construcción sintética QQYKNYPYT 5 AA PAT source 1..5 mol_type protein organism Synthetic construct Construcción sintética DYYMS 19 AA PAT source 1..19 mol_type protein organism Synthetic construct Construcción sintética MSRNKAKGHTIEYSSSVKG 12 AA PAT source 1..12 mol_type protein organism Synthetic construct Construcción sintética DTYESYDGYFDV 17 AA PAT source 1..17 mol_type protein organism Synthetic construct Construcción sintética KSSQSLFNSRSRKNYLA 7 AA PAT source 1..7 mol_type protein organism Synthetic construct Construcción sintética WASIRES 8 AA PAT source 1..8 mol_type protein organism Synthetic construct Construcción sintética KQSYYLYT 19 AA PAT source 1..19 mol_type protein organism Synthetic construct Construcción sintética MGWSWILLFLLSVTAGVHS