LISTADO DE SECUENCIAS <110> NOVARTIS AG <120> NUEVOS COMPUESTOS BICÍCLICOS Y SUS USOS <130> PAT059226 <140> <141> <150> PCT/CN2022/124865 <151> 2022-10-12 <150> EP22208192.9 <151> 2022-11-17 <150> US63/494033 <151> 2023-04-04 <150> PCT/CN2023/108913 <151> 2023-07-24 <160> 12 <170> PatentIn version 3.5 <210> 1 <211> 9674 <212> ADN <213> Secuencia Artificial <220> <223> Descripción de la Secuencia Artificial: Polinucleótido sintético <400> 1 aaccatctcg caaataaata agtattttac tgttttcgta acagttttgt aataaaaaaa 60 cctataaata ttccggatta ttcataccgt cccaccatcg ggcgccatgg cttctcacca 120 ccatcaccat caccatcatc atcacgctca gcacgacgag gctgtggaca acaagttcaa 180 caaggagcag cagaacgctt tctacgagat cctgcacctc cctaacctga acgaggagca 240 gcgtaacgct ttcatccagt ccctgaagga cgacccttct cagtctgcta acctgctggc 300 tgaggctaag aagctgaacg acgctcaggc tcctaaggtg gacaacaagt tcaacaagga 360 gcagcagaac gctttctacg agatcctgca cctccctaac ctgaacgagg agcagcgtaa 420 cgctttcatc cagtccctga aggacgaccc ttctcagtct gctaacctgc tggctgaggc 480 taagaagctg aacgacgctc aggctcctaa ggtggacgct aacggtggcg gcggttccgg 540 cggtggtggc tctctcgagg ttctgttcca gggtccgaat gaaggcgagg aagatgatga 600 caaagacttc ctgtggccag ctccaaacga agaacaggtg acttgtctca agatgtactt 660 cggtcatagc agcttcaaac cagtgcagtg gaaagttatc cacagcgttc ttgaagaacg 720 tcgtgataat gtggctgtga tggctactgg ctatggtaag agcctgtgtt tccagtaccc 780 gccagtttac gttggtaaga tcggtctggt gattagcccg ctgatctctc tgatggaaga 840 ccaggtgctg caacttaaga tgagcaacat cccggcttgt ttcctgggtt ctgcacaaag 900 cgagaacgtg ctcaccgata tcaagctggg taagtaccgt atcgtgtacg tgacgccaga 960 atactgtagc ggcaacatgg gtcttctgca acagctcgaa gctgatattg gcatcaccct 1020 cattgcagtg gacgaagctc actgtatcag cgagtggggt catgatttcc gcgactcttt 1080 ccgtaaactg ggttctctga agactgcact tccgatggtt ccaattgtgg cactgaccgc 1140 aactgcttct agctctattc gtgaagacat cgttcgttgc ctgaacctcc gtaacccaca 1200 aattacctgc accggctttg accgtccgaa cctgtacctg gaggttcgtc gtaagaccgg 1260 taatatcctt caggacctgc aaccattcct ggttaagacc agcagccact gggagttcga 1320 aggtccgact atcatctact gcccaagccg taagatgacc cagcaggtta ctggtgaact 1380 gcgtaaactg aacctgagct gtggcactta ccacgcaggc atgtctttct ctacccgtaa 1440 agacatccat catcgtttcg tgcgtgatga aatccagtgc gttatcgcta ccattgcatt 1500 cggcatgggt atcaacaaag ctgacatccg tcaagtgatt cactacggtg caccgaaaga 1560 catggaaagc tactaccagg aaatcggccg tgcaggtcgt gatggtctgc aaagctcttg 1620 tcatgtgctg tgggcaccag cagatattaa cctgaaccgt cacctgctga ctgaaattcg 1680 taacgagaaa ttccgtctgt acaaactgaa gatgatggcg aagatggaga aatacctgca 1740 tagctcccgt tgtcgtcgtc aaatcattct gagccatttc gaggataaac aggtgcagaa 1800 agcttctctg ggtatcatgg gcactgagaa gtgctgcgat aactgtcgta gccgtcttga 1860 tcactgctac agcatggacg atagcgaaga cacttcttgg gatttcggtc cacaagcatt 1920 caaactgctg agcgcagttg atatcctggg tgagaaattc ggcatcggcc tcccaatcct 1980 gtttctgcgc ggttctaact ctcagcgtct tgctgatcaa taccgtcgtc actctctgtt 2040 cggcactggt aaagaccaga ccgaatcttg gtggaaagca ttcagccgtc aacttatcac 2100 cgaaggcttt ctggtggaag tgtctcgtta caacaagttc atgaagatct gcgcactgac 2160 taagaaaggt cgtaactggc tgcacaaggc aaataccgag tctcagtctc ttatccttca 2220 ggctaacgaa gaactgtgcc cgaagaagct tctgctgcca tcttctaaga ccgtgagctc 2280 tggtactaaa gagcattgct acaaccaggt gccggttgaa ctgtctaccg agaagaagtc 2340 caacctggag aagctgtact cctacaaacc gtgcgacaag atctcctccg gttctaatat 2400 cagcaagaag tccatcatgg tgcagtctcc ggagaaagct tacagcagct ctcagccagt 2460 tatctctgca caggaacagg aaactcagat tgtgctgtac ggtaaactgg tggaagcacg 2520 tcagaaacac gctaacaaga tggacgtgcc gccagcaatt cttgcaacca acaagattct 2580 ggtggacatg gctaagatgc gcccaactac tgttgagaac gtgaaacgta tcgacggtgt 2640 tagcgaaggt aaagctgcaa tgctggcacc actgcttgaa gttatcaagc atttctgcca 2700 gaccaactct gttcagaccg acctgttctc ttctaccaaa ccataatggt accgaattcg 2760 cggccgcaga gctcgctctg gtgccacgcg gtagttccgc ttggagccac ccgcagttcg 2820 aaaagtaagt gattaacctc aggttataca tatattttga atttaattaa ttatacatat 2880 attttatatt atttttgtct tttattatcg aggggccgtt gttggtgtgg ggttttgcat 2940 agaaataaca atgggagttg gcgacgttgc tgcgccaaca ccacctccct tccctccttt 3000 catcatgtat ctgtagataa aataaaatat taaacctaaa aacaagaccg cgcctatcaa 3060 caaaatgata ggcattaact tgccgctgac gctgtcacta acgttggacg atttgccgac 3120 taaaccttca tcgcccagta accaatctag gtagctgagc gcatgcaagc tgatccgggt 3180 tattagtaca tttattaagc gctagattct gtgcgttgtt gatttacaga caattgttgt 3240 acgtatttta ataattcatt aaatttataa tctttagggt ggtatgttag agcgaaaatc 3300 aaatgatttt cagcgtcttt atatctgaat ttaaatatta aatcctcaat agatttgtaa 3360 aataggtttc gattagtttc aaacaagggt tgtttttccg aaccgatggc tggactatct 3420 aatggatttt cgctcaacgc cacaaaactt gccaaatctt gtagcagcaa tctagctttg 3480 tcgatattcg tttgtgtttt gttttgtaat aaaggttcga cgtcgttcaa aatattatgc 3540 gcttttgtat ttctttcatc actgtcgtta gtgtacaatt gactcgacgt aaacacgtta 3600 aatagagctt ggacatattt aacatcgggc gtgttagctt tattaggccg attatcgtcg 3660 tcgtcccaac cctcgtcgtt agaagttgct tccgaagacg attttgccat agccacacga 3720 cgcctattaa ttgtgtcggc taacacgtcc gcgatcaaat ttgtagttga gctttttgga 3780 attatttctg attgcgggcg tttttgggcg ggtttcaatc taactgtgcc cgattttaat 3840 tcagacaaca cgttagaaag cgatggtgca ggcggtggta acatttcaga cggcaaatct 3900 actaatggcg gcggtggtgg agctgatgat aaatctacca tcggtggagg cgcaggcggg 3960 gctggcggcg gaggcggagg cggaggtggt ggcggtgatg cagacggcgg tttaggctca 4020 aatgtctctt taggcaacac agtcggcacc tcaactattg tactggtttc gggcgccgtt 4080 tttggtttga ccggtctaag acgagtgcga tttttttcgt ttctaatagc ttccaacaat 4140 tgttgtctgt cgtctaaagg tgcagcgggt tgaggttccg tcggcattgg tggagcgggc 4200 ggcaattcag acatcgatgg tggtggtggt ggtggaggcg ctggaatgtt aggcacggga 4260 gaaggtggtg gcggcggtgc cgccggtata atttgttctg gtttagtttg ttcgcgcacg 4320 attgtgggca ccggcgcagg cgccgctggc tgcacaacgg aaggtcgtct gcttcgaggc 4380 agcgcttggg gtggtggcaa ttcaatatta taattggaat acaaatcgta aaaatctgct 4440 ataagcattg taatttcgct atcgtttacc gtgccgatat ttaacaaccg ctcaatgtaa 4500 gcaattgtat tgtaaagaga ttgtctcaag ctcggatcga tcccgcacgc cgataacaag 4560 ccttttcatt tttactacag cattgtagtg gcgagacact tcgctgtcgt cgaggtttaa 4620 acgcttcctc gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag 4680 ctcactcaaa ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca 4740 tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt 4800 tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc 4860 gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct 4920 ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg 4980 tggcgctttc tcatagctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca 5040 agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact 5100 atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta 5160 acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta 5220 actacggcta cactagaagg acagtatttg gtatctgcgc tctgctgaag ccagttacct 5280 tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt 5340 tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga 5400 tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca 5460 tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat 5520 caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg 5580 cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt 5640 agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag 5700 acccacgctc accggctcca gatttatcag caataaacca gccagccgga agggccgagc 5760 gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag 5820 ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca 5880 tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa 5940 ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga 6000 tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata 6060 attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca 6120 agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg 6180 ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg 6240 ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg 6300 cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag 6360 gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac 6420 tcttcctttt tcaatattat tgaagcattt atcagggtta ttgtctcatg agcggataca 6480 tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag 6540 tgccacctga cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg gttacgcgca 6600 gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc ttcccttcct 6660 ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcgggggctc cctttagggt 6720 tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt gatggttcac 6780 gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag tccacgttct 6840 ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg gtctattctt 6900 ttgatttata agggattttg ccgatttcgg cctattggtt aaaaaatgag ctgatttaac 6960 aaaaatttaa cgcgaatttt aacaaaatat taacgtttac aatttcccat tcgccattca 7020 ggctgcgcaa ctgttgggaa gggcgatcgg tgcgggcctc ttcgctatta cgccaggaac 7080 ggctccgccc actattaatg aaattaaaaa ttccaatttt aaaaaacgca gcaagagaaa 7140 catttgtatg aaagaatgcg tagaaggaaa gaaaaatgtc gtcgacatgc tgaacaacaa 7200 gattaatatg cctccgtgta taaaaaaaat attgaacgat ttgaaagaaa acaatgtacc 7260 gcgcggcggt atgtacagga agaggtttat actaaactgt tacattgcaa acgtggtttc 7320 gtgtgccaag tgtgaaaacc gatgtttaat caaggctctg acgcatttct acaaccacga 7380 ctccaagtgt gtgggtgaag tcatgcatct tttaatcaaa tcccaagatg tgtataaacc 7440 accaaactgc caaaaaatga aaactgtcga caagctctgt ccgtttgctg gcaactgcaa 7500 gggtctcaat cctatttgta attattgaat aataaaacaa ttataaatgc taaatttgtt 7560 ttttattaac gatacaaacc aaacgcaaca agaacatttg tagtattatc tataattgaa 7620 aacgcgtagt tataatcgct gaggtaatat ttaaaatcat tttcaaatga ttcacagtta 7680 atttgcgaca atataatttt attttcacat aaactagacg ccttgtcgtc ttcttcttcg 7740 tattccttct ctttttcatt tttctcttca taaaaattaa catagttatt atcgtatcca 7800 tatatgtatc tatcgtatag agtaaatttt ttgttgtcat aaatatatat gtctttttta 7860 atggggtgta tagtaccgct gcgcatagtt tttctgtaat ttacaacagt gctattttct 7920 ggtagttctt cggagtgtgt tgctttaatt attaaattta tataatcaat gaatttggga 7980 tcgtcggttt tgtacaatat gttgccggca tagtacgcag cttcttctag ttcaattaca 8040 ccatttttta gcagcaccgg attaacataa ctttccaaaa tgttgtacga accgttaaac 8100 aaaaacagtt cacctccctt ttctatacta ttgtctgcga gcagttgttt gttgttaaaa 8160 ataacagcca ttgtaataag acgcacaaac taatatcaca aactggaaat gtctatcaat 8220 atatagttgc tgatcagatc tacccgtagt ggctatggca gggcttgccg ccccgacgtt 8280 ggctgcgagc cctgggcctt cacccgaact tgggggttgg ggtggggaaa aggaagaaac 8340 gcgggcgtat tggtcccaat ggggtctcgg tggggtatcg acagagtgcc agccctggga 8400 ccgaaccccg cgtttatgaa caaacgaccc aacacccgtg cgttttattc tgtcttttta 8460 ttgccgtcat agcgcgggtt ccttccggta ttgtctcctt ccgtgtttca gttagcctcc 8520 cccatctccc ggtaccgcat gctatgcatc ggccgcttta cttgtacagc tcgtccatgc 8580 cgagagtgat cccggcggcg gtcacgaact ccagcaggac catgtgatcg cgcttctcgt 8640 tggggtcttt gctcagggcg gactgggtgc tcaggtagtg gttgtcgggc agcagcacgg 8700 ggccgtcgcc gatgggggtg ttctgctggt agtggtcggc gagctgcacg ctgccgtcct 8760 cgatgttgtg gcggatcttg aagttcacct tgatgccgtt cttctgcttg tcggccatga 8820 tatagacgtt gtggctgttg tagttgtact ccagcttgtg ccccaggatg ttgccgtcct 8880 ccttgaagtc gatgcccttc agctcgatgc ggttcaccag ggtgtcgccc tcgaacttca 8940 cctcggcgcg ggtcttgtag ttgccgtcgt ccttgaagaa gatggtgcgc tcctggacgt 9000 agccttcggg catggcggac ttgaagaagt cgtgctgctt catgtggtcg gggtagcggc 9060 tgaagcactg cacgccgtag gtcagggtgg tcacgagggt gggccagggc acgggcagct 9120 tgccggtggt gcagatgaac ttcagggtca gcttgccgta ggtggcatcg ccctcgccct 9180 cgccggacac gctgaacttg tggccgttta cgtcgccgtc cagctcgacc aggatgggca 9240 ccaccccggt gaacagctcc tcgcccttgc tcaccatcgt cgagatcccg ggcgtttaaa 9300 ttgtgtaatt tatgtagctg taatttttac cttattaata ttttttacgc tttgcattcg 9360 acgactgaac tcccaaatat atgtttaact cgtcttggtc gtttgaattt ttgttgctgt 9420 gtttcctaat attttccatc accttaaata tgttattgta atcctcaatg ttgaacttgc 9480 aattggacac ggcatagttt tccatagtcg tgtaaaacat ggtattggct gcattgtaat 9540 acatccgact gagcgggtac ggatctatgt gtttgagcag cctgttcaaa aactctgcat 9600 cgtcgcaaaa cggaatttgg tacccgggcg tatactccgg aatattaata gatcatggag 9660 ataattaaaa tgat 9674 <210> 2 <211> 45 <212> ADN <213> Secuencia Artificial <220> <223> Descripción de la Secuencia Artificial: oligonucleótido sintético <400> 2 tttttttttt tttttttttt ttccaagtaa aacgacggcc agtgc 45 <210> 3 <211> 445 <212> PRT <213> Secuencia Artificial <220> <223> Descripción de la Secuencia Artificial: Polipéptido sintético <400> 3 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 20 25 30 Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Val Ile Tyr Ala Asp Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Ala Tyr Gly Asn Tyr Trp Tyr Ile Asp Val Trp Gly Gln Gly Thr 100 105 110 Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 115 120 125 Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 130 135 140 Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 145 150 155 160 Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 165 170 175 Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 180 185 190 Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 195 200 205 Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 210 215 220 Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Gly Pro Ser Val Phe Leu 225 230 235 240 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 245 250 255 Val Thr Cys Val Val Val Ala Val Ser Gln Glu Asp Pro Glu Val Gln 260 265 270 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 275 280 285 Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 290 295 300 Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 305 310 315 320 Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 325 330 335 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 340 345 350 Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 355 360 365 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 370 375 380 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 385 390 395 400 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 405 410 415 Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 420 425 430 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 435 440 445 <210> 4 <211> 214 <212> PRT <213> Secuencia Artificial <220> <223> Descripción de la Secuencia Artificial: Polipéptido sintético <400> 4 Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Glu Ser Val Ser Asn Asp 20 25 30 Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Asn Tyr Ala Phe His Arg Phe Thr Gly Val Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 65 70 75 80 Glu Asp Val Ala Val Tyr Tyr Cys His Gln Ala Tyr Ser Ser Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 100 105 110 Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 115 120 125 Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 130 135 140 Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 145 150 155 160 Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 165 170 175 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 180 185 190 Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 195 200 205 Phe Asn Arg Gly Glu Cys 210 <210> 5 <211> 118 <212> PRT <213> Secuencia Artificial <220> <223> Descripción de la Secuencia Artificial: Polipéptido sintético <400> 5 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 20 25 30 Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Val Ile Tyr Ala Asp Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Ala Tyr Gly Asn Tyr Trp Tyr Ile Asp Val Trp Gly Gln Gly Thr 100 105 110 Thr Val Thr Val Ser Ser 115 <210> 6 <211> 107 <212> PRT <213> Secuencia Artificial <220> <223> Descripción de la Secuencia Artificial: Polipéptido sintético <400> 6 Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Glu Ser Val Ser Asn Asp 20 25 30 Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Asn Tyr Ala Phe His Arg Phe Thr Gly Val Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 65 70 75 80 Glu Asp Val Ala Val Tyr Tyr Cys His Gln Ala Tyr Ser Ser Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 7 <211> 10 <212> PRT <213> Secuencia Artificial <220> <223> Descripción de la Secuencia Artificial: péptido sintético <400> 7 Gly Phe Ser Leu Thr Ser Tyr Gly Val His 1 5 10 <210> 8 <211> 16 <212> PRT <213> Secuencia Artificial <220> <223> Descripción de la Secuencia Artificial: péptido sintético <400> 8 Val Ile Tyr Ala Asp Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 9 <211> 12 <212> PRT <213> Secuencia Artificial <220> <223> Descripción de la Secuencia Artificial: péptido sintético <400> 9 Ala Arg Ala Tyr Gly Asn Tyr Trp Tyr Ile Asp Val 1 5 10 <210> 10 <211> 11 <212> PRT <213> Secuencia Artificial <220> <223> Descripción de la Secuencia Artificial: péptido sintético <400> 10 Lys Ser Ser Glu Ser Val Ser Asn Asp Val Ala 1 5 10 <210> 11 <211> 7 <212> PRT <213> Secuencia Artificial <220> <223> Descripción de la Secuencia Artificial: péptido sintético <400> 11 Tyr Ala Phe His Arg Phe Thr 1 5 <210> 12 <211> 9 <212> PRT <213> Secuencia Artificial <220> <223> Descripción de la Secuencia Artificial: péptido sintético <400> 12 His Gln Ala Tyr Ser Ser Pro Tyr Thr 1 5