EP 342-126 PCT2 US 63/387,403 2022-12-14 Astellas Pharma Europe BV TERAPIA DE COMBINACIÓN QUE INVOLUCRA AGENTES DE UNIÓN BIESPECÍFICOS QUE SE UNEN A CLDN18.2 Y CD3 E INHIBIDORES DE PUNTO DE CONTROL INMUNITARIO 29 261 AA PAT source 1..261 mol_type protein organism Homo sapiens MAVTACQGLGFVVSLIGIAGIIAATCMDQWSTQDLYNNPVTAVFNYQGLWRSCVRESSGFTECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAGGLTLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKIYDGGARTEDEVQSYPSKHDYV 20 AA PAT REGION 1..20 note Peptide linker source 1..20 mol_type protein organism synthetic construct GKPGSGKPGSGKPGSGKPGS 9 AA PAT REGION 1..9 note Peptide linker source 1..9 mol_type protein organism synthetic construct KTHTCPPCP 19 AA PAT REGION 1..19 note Peptide linker source 1..19 mol_type protein organism synthetic construct GGGGSGGGGSKTHTCPPCP 10 AA PAT REGION 1..10 note Peptide linker source 1..10 mol_type protein organism synthetic construct GGGGSGGGGS 15 AA PAT REGION 1..15 note Peptide linker source 1..15 mol_type protein organism synthetic construct EPKSCDKTHTCPPCP 329 AA PAT REGION 1..329 note Immunoglobulin-derived sequence source 1..329 mol_type protein organism synthetic construct ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSDTKVDKKVEPKSCDKTHTCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVKHEDPEVKFNWYVDGVEVHNAKTKPREEEYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCDVSGFYPSDIAVEWESDGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWEQGDVFSCSVMHEALHNHYTQKSLSLSPGK 216 AA PAT REGION 1..216 note Immunoglobulin-derived sequence source 1..216 mol_type protein organism synthetic construct APPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVKHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREQMTKNQVKLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 107 AA PAT REGION 1..107 note Immunoglobulin-derived sequence source 1..107 mol_type protein organism synthetic construct RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 5 AA PAT REGION 1..5 note CDR sequence source 1..5 mol_type protein organism synthetic construct SYWIN 17 AA PAT REGION 1..17 note CDR sequence source 1..17 mol_type protein organism synthetic construct NIYPSDSYTNYNQKFQG 9 AA PAT REGION 1..9 note CDR sequence source 1..9 mol_type protein organism synthetic construct SWRGNSFDY 17 AA PAT REGION 1..17 note CDR sequence source 1..17 mol_type protein organism synthetic construct KSSQSLLNSGNQKNYLT 7 AA PAT REGION 1..7 note CDR sequence source 1..7 mol_type protein organism synthetic construct WASTRES 9 AA PAT REGION 1..9 note CDR sequence source 1..9 mol_type protein organism synthetic construct QNDYSYPFT 118 AA PAT REGION 1..118 note Immunoglobulin-derived sequence source 1..118 mol_type protein organism synthetic construct EVQLVQSGAEVKKPGESLRISCKASGYTFTSYWINWVRQMPGKGLEWMGNIYPSDSYTNYNQKFQGHVTISVDKSISTAYLQWSSLKASDTAMYYCTRSWRGNSFDYWGQGTLVTVSS 113 AA PAT REGION 1..113 note Immunoglobulin-derived sequence source 1..113 mol_type protein organism synthetic construct DIVMTQSPDSLAVSLGERATINCKSSQSLLNSGNQKNYLTWYQQKPGQPPKLLIYWASTRESGVPDRFTGSGSGTDFTLTISSLQAEDVAVYYCQNDYSYPFTFGSGTKLEIK 5 AA PAT REGION 1..5 note CDR sequence source 1..5 mol_type protein organism synthetic construct TYAMN 14 AA PAT REGION 1..14 note CDR sequence source 1..14 mol_type protein organism synthetic construct HGNFGDSYVSWFAY 14 AA PAT REGION 1..14 note CDR sequence source 1..14 mol_type protein organism synthetic construct GSSTGAVTTSNYAN 7 AA PAT REGION 1..7 note CDR sequence source 1..7 mol_type protein organism synthetic construct GTNKRAP 9 AA PAT REGION 1..9 note CDR sequence source 1..9 mol_type protein organism synthetic construct ALWYSNHWV 19 AA PAT REGION 1..19 note CDR sequence source 1..19 mol_type protein organism synthetic construct RIRSKANNYATYYADSVKG 109 AA PAT REGION 1..109 note Immunoglobulin-derived sequence source 1..109 mol_type protein organism synthetic construct QAVVTQEPSLTVSPGGTVTLTCGSSTGAVTTSNYANWVQQKPGKSPRGLIGGTNKRAPGVPARFSGSLLGGKAALTISGAQPEDEADYYCALWYSNHWVFGGGTKLTVL 125 AA PAT REGION 1..125 note Immunoglobulin-derived sequence source 1..125 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGFTFSTYAMNWVRQAPGKGLEWVGRIRSKANNYATYYADSVKGRFTISRDDSKNTLYLQMNSLRAEDTAVYYCVRHGNFGDSYVSWFAYWGQGTLVTVSS 254 AA PAT REGION 1..254 note Immunoglobulin-derived sequence source 1..254 mol_type protein organism synthetic construct QAVVTQEPSLTVSPGGTVTLTCGSSTGAVTTSNYANWVQQKPGKSPRGLIGGTNKRAPGVPARFSGSLLGGKAALTISGAQPEDEADYYCALWYSNHWVFGGGTKLTVLGKPGSGKPGSGKPGSGKPGSEVQLVESGGGLVQPGGSLRLSCAASGFTFSTYAMNWVRQAPGKGLEWVGRIRSKANNYATYYADSVKGRFTISRDDSKNTLYLQMNSLRAEDTAVYYCVRHGNFGDSYVSWFAYWGQGTLVTVSS 447 AA PAT REGION 1..447 note Immunoglobulin-derived sequence source 1..447 mol_type protein organism synthetic construct EVQLVQSGAEVKKPGESLRISCKASGYTFTSYWINWVRQMPGKGLEWMGNIYPSDSYTNYNQKFQGHVTISVDKSISTAYLQWSSLKASDTAMYYCTRSWRGNSFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSDTKVDKKVEPKSCDKTHTCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVKHEDPEVKFNWYVDGVEVHNAKTKPREEEYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCDVSGFYPSDIAVEWESDGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWEQGDVFSCSVMHEALHNHYTQKSLSLSPGK 720 AA PAT REGION 1..720 note Immunoglobulin-derived sequence source 1..720 mol_type protein organism synthetic construct EVQLVQSGAEVKKPGESLRISCKASGYTFTSYWINWVRQMPGKGLEWMGNIYPSDSYTNYNQKFQGHVTISVDKSISTAYLQWSSLKASDTAMYYCTRSWRGNSFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCGGGGSGGGGSQAVVTQEPSLTVSPGGTVTLTCGSSTGAVTTSNYANWVQQKPGKSPRGLIGGTNKRAPGVPARFSGSLLGGKAALTISGAQPEDEADYYCALWYSNHWVFGGGTKLTVLGKPGSGKPGSGKPGSGKPGSEVQLVESGGGLVQPGGSLRLSCAASGFTFSTYAMNWVRQAPGKGLEWVGRIRSKANNYATYYADSVKGRFTISRDDSKNTLYLQMNSLRAEDTAVYYCVRHGNFGDSYVSWFAYWGQGTLVTVSSGGGGSGGGGSKTHTCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVKHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREQMTKNQVKLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 220 AA PAT REGION 1..220 note Immunoglobulin-derived sequence source 1..220 mol_type protein organism synthetic construct DIVMTQSPDSLAVSLGERATINCKSSQSLLNSGNQKNYLTWYQQKPGQPPKLLIYWASTRESGVPDRFTGSGSGTDFTLTISSLQAEDVAVYYCQNDYSYPFTFGSGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC