EP PCT/EP2024/055725 2024-03-05 CPX74792PC EP 23160259 2023-03-06 Ascendis Pharma A/S Drug Compounds COMPUESTOS FARMACOLÓGICOS 58 31 AA PAT source 1..31 mol_type protein organism Homo sapiens Homo sapiens HAEGTFTSDVSSYLEGQAAKEFIAWLVKGRG 31 AA PAT source 1..31 mol_type protein organism synthetic construct constructo sintético SITE 2 note Aib Aib HXEGTFTSDVSSYLEGQAAKEFIAWLVRGRG 31 AA PAT source 1..31 mol_type protein organism synthetic construct constructo sintético SITE 2 note Aib Aib MOD_RES 31 note C-terminus is amidated El extremo C terminal está amidado HXEGTFTSDVSSYLEGQAAKEFIAWLVRGRG 39 AA PAT source 1..39 mol_type protein organism synthetic construct constructo sintético HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS 39 AA PAT source 1..39 mol_type protein organism synthetic construct constructo sintético MOD_RES 39 note C-terminus is amidated El extremo C terminal está amidado HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS 44 AA PAT source 1..44 mol_type protein organism synthetic construct constructo sintético MOD_RES 44 note C-terminus is amidated El extremo C terminal está amidado HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPSKKKKKK 44 AA PAT source 1..44 mol_type protein organism synthetic construct constructo sintético HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPSKKKKKK 39 AA PAT source 1..39 mol_type protein organism synthetic construct constructo sintético SITE 2 note D-Ala D-Ala SITE 14 note Nle Nle HAEGTFTSDLSKQXEEEAVRLFIEWLKQGGPSSGAPPPC 39 AA PAT source 1..39 mol_type protein organism synthetic construct constructo sintético SITE 2 note D-alanine D-alanina SITE 14 note Nle Nle MOD_RES 39 note C-terminus is amidated El extremo C terminal está amidado HAEGTFTSDLSKQXEEEAVRLFIEWLKQGGPSSGAPPPC 39 AA PAT source 1..39 mol_type protein organism synthetic construct constructo sintético SITE 2 note D-alanine D-alanina SITE 14 note Nle Nle SITE 39 note sulfur of cysteine is PEGylated el azufre de la cisteína está PEGilado HAEGTFTSDLSKQXEEEAVRLFIEWLKQGGPSSGAPPPC 39 AA PAT source 1..39 mol_type protein organism synthetic construct constructo sintético SITE 2 note D-alanine D-alanina SITE 14 note Nle Nle SITE 39 note sulfur of cysteine is PEGylated el azufre de la cisteína está PEGilado MOD_RES 39 note C-terminus is amidated El extremo C terminal está amidado HAEGTFTSDLSKQXEEEAVRLFIEWLKQGGPSSGAPPPC 31 AA PAT source 1..31 mol_type protein organism synthetic construct constructo sintético HAEGTFTSDVSSYLEGQAAKEFIAWLVRGRG 31 AA PAT source 1..31 mol_type protein organism synthetic construct constructo sintético MOD_RES 31 note C-terminus is amidated El extremo C terminal está amidado HAEGTFTSDVSSYLEGQAAKEFIAWLVRGRG 31 AA PAT source 1..31 mol_type protein organism synthetic construct constructo sintético HVEGTFTSDVSSYLEEQAAREFIKWLVRGRG 31 AA PAT source 1..31 mol_type protein organism synthetic construct constructo sintético MOD_RES 31 note C-terminus is amidated El extremo C terminal está amidado HVEGTFTSDVSSYLEEQAAREFIKWLVRGRG 31 AA PAT source 1..31 mol_type protein organism synthetic construct constructo sintético HGEGTFTSDVSSYLEGQAAKEFIAWLVRGRG 31 AA PAT source 1..31 mol_type protein organism synthetic construct constructo sintético MOD_RES 31 note C-terminus is amidated El extremo C terminal está amidado HGEGTFTSDVSSYLEGQAAKEFIAWLVRGRG 32 AA PAT source 1..32 mol_type protein organism synthetic construct constructo sintético SITE 2 note Aib Aib HXEGTFTSDVSSYLEGQAAKEFIAWLVRGRGL 32 AA PAT source 1..32 mol_type protein organism synthetic construct constructo sintético SITE 2 note Aib Aib MOD_RES 32 note C-terminus is amidated El extremo C terminal está amidado HXEGTFTSDVSSYLEGQAAKEFIAWLVRGRGL 39 AA PAT source 1..39 mol_type protein organism synthetic construct constructo sintético SITE 2 note Aib Aib SITE 13 note Aib Aib MOD_RES 39 note C-terminus is amidated El extremo C terminal está amidado YXEGTFTSDYSIXLDKIAQKAFVQWLIAGGPSSGAPPPS 39 AA PAT source 1..39 mol_type protein organism synthetic construct constructo sintético SITE 2 note Aib Aib SITE 13 note Aib Aib YXEGTFTSDYSIXLDKIAQKAFVQWLIAGGPSSGAPPPS 30 AA PAT source 1..30 mol_type protein organism synthetic construct constructo sintético HSQGTFTSDKSEYLDSERARDFVAWLEAGG 30 AA PAT source 1..30 mol_type protein organism synthetic construct constructo sintético MOD_RES 30 note C-terminus is amidated El extremo C terminal está amidado HSQGTFTSDKSEYLDSERARDFVAWLEAGG 29 AA PAT source 1..29 mol_type protein organism synthetic construct constructo sintético SITE 2 note 1-amino-cyclobutanecarboxylic acid (Ac4c) Ácido 1-amino-ciclobutanocarboxílico (Ac4c) MOD_RES 29 note C-terminus is amidated El extremo C terminal está amidado HXQGTFTSDYSKYLDERAAKDFIKWLESA 29 AA PAT source 1..29 mol_type protein organism synthetic construct constructo sintético SITE 2 note 1-amino-cyclobutanecarboxylic acid (Ac4c) Ácido 1-amino-ciclobutanocarboxílico (Ac4c) HXQGTFTSDYSKYLDERAAKDFIKWLESA 29 AA PAT source 1..29 mol_type protein organism synthetic construct constructo sintético SITE 2 note Aib Aib SITE 16 note E at position 16 and K at position 20 are connected via a lactam bridge E en la posición 16 y K en la posición 20 están conectadas mediante un puente de lactama SITE 20 note E at position 16 and K at position 20 are connected via a lactam bridge E en la posición 16 y K en la posición 20 están conectadas mediante un puente de lactama HXQGTFTSDYSKYLDEKAAKEFIQWLLQT 29 AA PAT source 1..29 mol_type protein organism synthetic construct constructo sintético SITE 2 note Aib Aib SITE 16 note E at position20 and K at position 20 are connected via a lactam bridge E en la posición20 y K en la posición 20 están conectadas mediante un puente de lactama SITE 20 note E at position20 and K at position 20 are connected via a lactam bridge E en la posición20 y K en la posición 20 están conectadas mediante un puente de lactama MOD_RES 29 note C-terminus is amidated El extremo C terminal está amidado HXQGTFTSDYSKYLDEKAAKEFIQWLLQT 34 AA PAT source 1..34 mol_type protein organism synthetic construct constructo sintético SITE 2 note Aib Aib MOD_RES 34 note C-terminus is amidated El extremo C terminal está amidado HXQGTFTSDYSKYLDEKKAKEFVEWLLEGGPSSG 34 AA PAT source 1..34 mol_type protein organism synthetic construct constructo sintético SITE 2 note Aib Aib HXQGTFTSDYSKYLDEKKAKEFVEWLLEGGPSSG 33 AA PAT source 1..33 mol_type protein organism synthetic construct constructo sintético SITE 2 note Aib Aib HXEGSFTSELATILDKQAARDFIAWLIQHKITD 33 AA PAT source 1..33 mol_type protein organism synthetic construct constructo sintético SITE 2 note Aib Aib MOD_RES 33 note C-terminus is amidated El extremo C terminal está amidado HXEGSFTSELATILDKQAARDFIAWLIQHKITD 39 AA PAT source 1..39 mol_type protein organism synthetic construct constructo sintético SITE 2 note Aib Aib SITE 13 note alpha-methyl-leucine (alphaMeL) alfa-metil-leucina (alfaMeL) SITE 20 note Aib Aib MOD_RES 39 note C-terminus is amidated El extremo C terminal está amidado YXQGTFTSDYSIXLDKKAQXAFIEYLLEGGPSSGAPPPS 39 AA PAT source 1..39 mol_type protein organism synthetic construct constructo sintético SITE 2 note Aib Aib SITE 13 note alpha-methyl-leucine (alphaMeL) alfa-metil-leucina (alfaMeL) SITE 20 note Aib Aib YXQGTFTSDYSIXLDKKAQXAFIEYLLEGGPSSGAPPPS 18 AA PAT source 1..18 mol_type protein organism synthetic construct constructo sintético WWEQDRDWDFDVFGGGTP 11 AA PAT source 1..11 mol_type protein organism synthetic construct constructo sintético DISULFID 3..9 note cysteines at position 3 and 9 are connected via a disulfide bridge Las cisteínas en la posición 3 y 9 están conectadas mediante un puente disulfuro DICLPRWGCLW 18 AA PAT source 1..18 mol_type protein organism synthetic construct constructo sintético DISULFID 7..13 note cysteines at position 7 and 13 are connected via a disulfide bridge Las cisteínas en la posición 7 y 13 están conectadas mediante un puente disulfuro RLIEDICLPRWGCLWEDD 46 AA PAT source 1..46 mol_type protein organism synthetic construct constructo sintético LAEAKVLANRELDKYGVSDFYKRLINKAKTVEGVEALKLHILAALP 46 AA PAT source 1..46 mol_type protein organism synthetic construct constructo sintético IAEAKEAANAELDSYGVSDFYKRLIDKAKTVEGVEALKDAILAALP 8 AA PAT source 1..8 mol_type protein organism synthetic construct constructo sintético SITE 1 note fluorescein-(AEEA), wherein AEEA is 2-(2-(2-aminoethoxy)acetyl fluoresceína-(AEEA), en donde AEEA es 2-(2-(2-aminoetoxi)acetilo SITE 5 note K(palmitate) K(palmitato) XEYEXEYE 31 AA PAT source 1..31 mol_type protein organism synthetic construct constructo sintético SITE 2 note Aib Aib LIPID 20 note ([2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)16-CO2H ([2-(2-amino-etoxi)-etoxi]-acetil)2-(gamma-Glu)-CO-(CH2)16-CO2H HXEGTFTSDVSSYLEGQAAKEFIAWLVRGRG 31 AA PAT source 1..31 mol_type protein organism synthetic construct constructo sintético LIPID 20 note palmitoyl-Gln-OH palmitoil-Gln-OH HAEGTFTSDVSSYLEGQAAKEFIAWLVRGRG 31 AA PAT source 1..31 mol_type protein organism synthetic construct constructo sintético LIPID 24 note ([2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)16-CO2H ([2-(2-amino-etoxi)-etoxi]-acetil)2-(gamma-Glu)-CO-(CH2)16-CO2H HVEGTFTSDVSSYLEEQAAREFIKWLVRGRG 31 AA PAT source 1..31 mol_type protein organism synthetic construct constructo sintético LIPID 20 note ([2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)20-CO2H ([2-(2-amino-etoxi)-etoxi]-acetil)2-(gamma-Glu)-CO-(CH2)20-CO2H HGEGTFTSDVSSYLEGQAAKEFIAWLVRGRG 32 AA PAT source 1..32 mol_type protein organism synthetic construct constructo sintético SITE 2 note Aib Aib LIPID 20 note AEEA-Aib-gammaGlu-ODDA AEEA-Aib-gammaGlu-ODDA HXEGTFTSDVSSYLEGQAAKEFIAWLVRGRGL 39 AA PAT source 1..39 mol_type protein organism synthetic construct constructo sintético SITE 2 note Aib Aib SITE 13 note Aib Aib LIPID 20 note ([2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gammaGlu)1-CO-(CH2)18-CO2H ([2-(2-amino-etoxi)-etoxi]-acetil)2-(gammaGlu)1-CO-(CH2)18-CO2H MOD_RES 39 note C-terminus is amidated El extremo C terminal está amidado YXEGTFTSDYSIXLDKIAQKAFVQWLIAGGPSSGAPPPS 30 AA PAT source 1..30 mol_type protein organism synthetic construct constructo sintético LIPID 10 note gamma-Glu-palmitoyl gamma-Glu-palmitoilo HSQGTFTSDKSEYLDSERARDFVAWLEAGG 29 AA PAT source 1..29 mol_type protein organism synthetic construct constructo sintético SITE 2 note 1-amino-cyclobutanecarboxylic acid (Ac4c) Ácido 1-amino-ciclobutanocarboxílico (Ac4c) LIPID 24 note [l7-carboxy-heptadecanoyl]-isoGlu-GSGSGG [l7-carboxi-heptadecanoil]-isoGlu-GSGSGG MOD_RES 29 note C-terminus is amidated El extremo C terminal está amidado HXQGTFTSDYSKYLDERAAKDFIKWLESA 29 AA PAT source 1..29 mol_type protein organism synthetic construct constructo sintético SITE 2 note Aib Aib SITE 16 note E at position 16 and the K at position 20 are connected via a lactam bridge E en la posición 16 y la K en la posición 20 están conectadas mediante un puente de lactama SITE 20 note E at position 16 and the K at position 20 are connected via a lactam bridge E en la posición 16 y la K en la posición 20 están conectadas mediante un puente de lactama LIPID 17 note glucuronic acid C-18 ácido glucurónico C-18 MOD_RES 29 note C-terminus is amidated El extremo C terminal está amidado HXQGTFTSDYSKYLDEKAAKEFIQWLLQT 34 AA PAT source 1..34 mol_type protein organism synthetic construct constructo sintético SITE 2 note Aib Aib LIPID 20 note ([2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)18-CO2H ([2-(2-amino-etoxi)-etoxi]-acetil)2-(gamma-Glu)-CO-(CH2)18-CO2H MOD_RES 34 note C-terminus is amidated El extremo C terminal está amidado HXQGTFTSDYSKYLDEKKAKEFVEWLLEGGPSSG 33 AA PAT source 1..33 mol_type protein organism synthetic construct constructo sintético SITE 2 note Aib Aib LIPID 16 note [17-carboxy-heptadecanoyl]-isoGlu [17-carboxi-heptadecanoil]-isoGlu HXEGSFTSELATILDKQAARDFIAWLIQHKITD 39 AA PAT source 1..39 mol_type protein organism synthetic construct constructo sintético SITE 2 note Aib Aib SITE 13 note alpha-methyl-leucine (alphaMeL) alfa-metil-leucina (alfaMeL) SITE 20 note Aib Aib LIPID 17 note (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gammaGlu)-CO-(CH2)18-CO2H (2-[2-(2-amino-etoxi)-etoxi]-acetil)-(gammaGlu)-CO-(CH2)18-CO2H MOD_RES 39 note C-terminus is amidated El extremo C terminal está amidado YXQGTFTSDYSIXLDKKAQXAFIEYLLEGGPSSGAPPPS 35 AA PAT source 1..35 mol_type protein organism synthetic construct constructo sintético MOD_RES 1 note D-Lysine, wherein the side chain is acylated with COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer, wherein MINIPEG is COCH2OCH2CH2OCH2CH2NH D-Lisina, en donde la cadena lateral está acilada con COC16H32CO2H mediante un separador gamma Glu-(MINIPEG)2-gamma Glu, en donde MINIPEG es COCH2OCH2CH2OCH2CH2NH SITE 2 note n-methyl glycine (sarcosine) n-metil glicina (sarcosina) MOD_RES 35 note side chain of lysine is acylated with COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer, wherein MINIPEG is COCH2OCH2CH2OCH2CH2NH la cadena lateral de lisina está acilada con COC16H32CO2H mediante un separador gamma Glu-(MINIPEG)2-gamma Glu, en donde MINIPEG es COCH2OCH2CH2OCH2CH2NH KXSVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHK 35 AA PAT source 1..35 mol_type protein organism synthetic construct constructo sintético MOD_RES 1 note D-Lysine, wherein the side chain is acylated with COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer, wherein (miniPEG)2 is COCH2OCH2CH2OCH2CH2NH D-Lisina, en donde la cadena lateral está acilada con COC16H32CO2H mediante un separador gamma Glu-(MINIPEG)2-gamma Glu, en donde (miniPEG)2 es COCH2OCH2CH2OCH2CH2NH SITE 2 note n-methyl glycine (sarcosine) n-metil glicina (sarcosina) MOD_RES 35 note side chain of lysine is acylated with COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer, wherein (miniPEG)2 is COCH2OCH2CH2OCH2CH2NH la cadena lateral de lisina está acilada con COC16H32CO2H mediante un separador gamma Glu-(MINIPEG)2-gamma Glu, en donde (miniPEG)2 es COCH2OCH2CH2OCH2CH2NH KXSVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHK 40 AA PAT source 1..40 mol_type protein organism synthetic construct constructo sintético SITE 2 note AiB AiB HXEGTFTSDVSSYLEEEAAKEFIAWLVRGGPSSGAPPPSK 31 AA PAT source 1..31 mol_type protein organism synthetic construct constructo sintético SITE 2 note Aib Aib HXEGTFTSDVSSYLEEQAAKEFIAWLVRGGG 71 AA PAT source 1..71 mol_type protein organism synthetic construct constructo sintético SITE 2 note Aib Aib HXEGTFTSDVSSYLEEQAAKEFIAWLVRGGGGAQPGAQPGAQPGAQPGAQPGAQPGAQPGAQPGAQPGQKP 39 AA PAT source 1..39 mol_type protein organism synthetic construct constructo sintético SITE 13 note AiB AiB SITE 2 note 2 2 note Aib Aib YXEGTFTSDYSIXLDKIAQKAFVQWLIAGGPSSGAPPPS 191 AA PAT source 1..191 mol_type protein organism Homo sapiens Homo sapiens FPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQTSLCFSESIPTPSNREETQQKSNLELLRISLLLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF