WO 138881-0836 WO PCT/CN2023/082099 2023-03-17 BEIGENE SWITZERLAND GMBH QU, Liang ANTI-B7H3 ANTIBODIES AND METHODS OF USE ANTICUERPOS ANTI–B7H3 Y MÉTODOS DE USO 122 1605 DNA PAT source 1..1605 mol_type genomic DNA note Human B7H3-full length B7H3 humana-longitud completa organism Homo sapiens Homo sapiens atgctgcgtcggcggggcagccctggcatgggtgtgcatgtgggtgcagccctgggagcactgtggttctgcctcacaggagccctggaggtccaggtccctgaagacccagtggtggcactggtgggcaccgatgccaccctgtgctgctccttctcccctgagcctggcttcagcctggcacagctcaacctcatctggcagctgacagataccaaacagctggtgcacagctttgctgagggccaggaccagggcagcgcctatgccaaccgcacggccctcttcccggacctgctggcacagggcaacgcatccctgaggctgcagcgcgtgcgtgtggcggacgagggcagcttcacctgcttcgtgagcatccgggatttcggcagcgctgccgtcagcctgcaggtggccgctccctactcgaagcccagcatgaccctggagcccaacaaggacctgcggccaggggacacggtgaccatcacgtgctccagctaccagggctaccctgaggctgaggtgttctggcaggatgggcagggtgtgcccctgactggcaacgtgaccacgtcgcagatggccaacgagcagggcttgtttgatgtgcacagcatcctgcgggtggtgctgggtgcaaatggcacctacagctgcctggtgcgcaaccccgtgctgcagcaggatgcgcacagctctgtcaccatcacaccccagagaagccccacaggagccgtggaggtccaggtccctgaggacccggtggtggccctagtgggcaccgatgccaccctgcgctgctccttctcccccgagcctggcttcagcctggcacagctcaacctcatctggcagctgacagacaccaaacagctggtgcacagtttcaccgaaggccgggaccagggcagcgcctatgccaaccgcacggccctcttcccggacctgctggcacaaggcaatgcatccctgaggctgcagcgcgtgcgtgtggcggacgagggcagcttcacctgcttcgtgagcatccgggatttcggcagcgctgccgtcagcctgcaggtggccgctccctactcgaagcccagcatgaccctggagcccaacaaggacctgcggccaggggacacggtgaccatcacgtgctccagctaccggggctaccctgaggctgaggtgttctggcaggatgggcagggtgtgcccctgactggcaacgtgaccacgtcgcagatggccaacgagcagggcttgtttgatgtgcacagcgtcctgcgggtggtgctgggtgcgaatggcacctacagctgcctggtgcgcaaccccgtgctgcagcaggatgcgcacggctctgtcaccatcacagggcagcctatgacattccccccagaggccctgtgggtgaccgtggggctgtctgtctgtctcattgcactgctggtggccctggctttcgtgtgctggagaaagatcaaacagagctgtgaggaggagaatgcaggagctgaggaccaggatggggagggagaaggctccaagacagccctgcagcctctgaaacactctgacagcaaagaagatgatggacaagaaatagcctga 534 AA PAT source 1..534 mol_type protein note Human B7H3-full length B7H3 humana-longitud completa organism Homo sapiens Homo sapiens MLRRRGSPGMGVHVGAALGALWFCLTGALEVQVPEDPVVALVGTDATLCCSFSPEPGFSLAQLNLIWQLTDTKQLVHSFAEGQDQGSAYANRTALFPDLLAQGNASLRLQRVRVADEGSFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVTITCSSYQGYPEAEVFWQDGQGVPLTGNVTTSQMANEQGLFDVHSILRVVLGANGTYSCLVRNPVLQQDAHSSVTITPQRSPTGAVEVQVPEDPVVALVGTDATLRCSFSPEPGFSLAQLNLIWQLTDTKQLVHSFTEGRDQGSAYANRTALFPDLLAQGNASLRLQRVRVADEGSFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVTITCSSYRGYPEAEVFWQDGQGVPLTGNVTTSQMANEQGLFDVHSVLRVVLGANGTYSCLVRNPVLQQDAHGSVTITGQPMTFPPEALWVTVGLSVCLIALLVALAFVCWRKIKQSCEEENAGAEDQDGEGEGSKTALQPLKHSDSKEDDGQEIA 702 DNA PAT source 1..702 mol_type genomic DNA note huIgG1 Fc Fc de huIgG1 organism Homo sapiens Homo sapiens gctagcgagcccaaatcttgtgacaaaactcacacatgcccaccgtgcccagcacctgaactcctggggggaccgtcagtcttcctcttccccccaaaacccaaggacaccctcatgatctcccggacccctgaggtcacatgcgtggtggtggacgtgagccacgaagaccctgaggtcaagttcaactggtacgtggacggcgtggaggtgcataatgccaagacaaagccgcgggaggagcagtacaacagcacgtaccgtgtggtcagcgtcctcaccgtcctgcaccaggactggctgaatggcaaggagtacaagtgcaaggtctccaacaaagccctcccagcccccatcgagaaaaccatctccaaagccaaagggcagccccgagaaccacaggtgtacaccctgcccccatcccgggatgagctgaccaagaaccaggtcagcctgacctgcctggtcaaaggcttctatcccagcgacatcgccgtggagtgggagagcaatgggcagccggagaacaactacaagaccacgcctcccgtgctggactccgacggctccttcttcctctacagcaagctcaccgtggacaagagcaggtggcagcaggggaacgtcttctcatgctccgtgatgcatgaggctctgcacaaccactacacgcagaagagcctctccctgtctccgggtaaa 234 AA PAT source 1..234 mol_type protein note huIgG1 Fc Fc de huIgG1 organism Homo sapiens Homo sapiens ASEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 705 DNA PAT source 1..705 mol_type other DNA note mIgG2a Fc Fc de mIgG2a organism Mus sp. Mus sp. gctagcgagcccagagggcccacaatcaagccctgtcctccatgcaaatgcccagcacctaacctcttgggtggaccatccgtcttcatcttccctccaaagatcaaggatgtactcatgatctccctgagccccatggtcacatgtgtggtggtggatgtgagcgaggatgacccagatgtccagatcagctggttcgtgaacaacgtggaagtactcacagctcagacacaaacccatagagaggattacaacagtactctccgggtggtcagtgccctccccatccagcaccaggactggatgagtggcaaggagttcaaatgcaaggtcaacaacaaagccctcccagcgcccatcgagagaaccatctcaaaacccaaagggtcagtaagagctccacaggtatatgtcttgcctccaccagaagaagagatgactaagaaacaggtcactctgacctgcatggtcacagacttcatgcctgaagacatttacgtggagtggaccaacaacgggaaaacagagctaaactacaagaacactgaaccagtcctggactctgatggttcttacttcatgtacagcaagctgagagtggaaaagaagaactgggtggaaagaaatagctactcctgctcagtggtccacgagggtctgcacaatcaccacacgactaagagcttctcccggactccgggtaaa 235 AA PAT source 1..235 mol_type protein note mIgG2a Fc Fc de mIgG2a organism Mus sp. Mus sp. ASEPRGPTIKPCPPCKCPAPNLLGGPSVFIFPPKIKDVLMISLSPMVTCVVVDVSEDDPDVQISWFVNNVEVLTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKALPAPIERTISKPKGSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTPGK 5 AA PAT source 1..5 mol_type protein note HCDR1 (Kabat) HCDR1 (Kabat) organism synthetic construct construcción sintética TYFMG 17 AA PAT source 1..17 mol_type protein note HCDR2 (Kabat) HCDR2 (Kabat) organism synthetic construct construcción sintética VINWSGGTSYYKDSVKG 14 AA PAT source 1..14 mol_type protein note HCDR3 (Chothia) HCDR3 (Chothia) note HCDR3 (Kabat) HCDR3 (Kabat) organism synthetic construct construcción sintética KGSGTYDREGEYDY 123 AA PAT source 1..123 mol_type protein note VHH AA AA de VHH organism synthetic construct construcción sintética EVQLVESGGGLVQTGDSLRLSCAASPRTFQTYFMGWFRQAPGKEREFVSVINWSGGTSYYKDSVKGRFTISRDNAKNTVYLQMNNLKPEDTAVYYCAAKGSGTYDREGEYDYWGQGTQVTVSS 369 DNA PAT source 1..369 mol_type other DNA note VHH DNA ADN de VHH organism synthetic construct construcción sintética gaggtgcagctggtggagtctgggggaggattggtgcagactggggactctctgagactctcctgtgcagcctctccacgcaccttccagacctatttcatgggctggttccgccaggctccagggaaggagcgtgagtttgtatcagttattaactggagtggcggtacctcatactataaagattccgtgaagggccgattcaccatctccagagacaacgccaagaataccgtgtatctacaaatgaacaacctgaaacctgaggacacggccgtttattactgtgcagctaaggggtccggtacttacgaccgagagggggaatatgactactggggccaggggacccaggtcaccgtctcctca 5 AA PAT source 1..5 mol_type protein note HCDR1 (Kabat) HCDR1 (Kabat) organism synthetic construct construcción sintética DYHMS 17 AA PAT source 1..17 mol_type protein note HCDR2 (Kabat) HCDR2 (Kabat) organism synthetic construct construcción sintética GILNTGLSPTYAATVTG 11 AA PAT source 1..11 mol_type protein note HCDR3 (Chothia) HCDR3 (Chothia) note HCDR3 (Kabat) HCDR3 (Kabat) organism synthetic construct construcción sintética GYYRATPSQAN 120 AA PAT source 1..120 mol_type protein note VHH AA AA de VHH organism synthetic construct construcción sintética EVQLLESGGGLVQPGGSLRLSCAASGFTFSDYHMSWVRQAPGKGLEWVSGILNTGLSPTYAATVTGRFTISRDNAKNTLYLSMNSLKPEDTAVYYCAQGYYRATPSQANRGQGTQVTVSS 360 DNA PAT source 1..360 mol_type other DNA note VHH DNA ADN de VHH organism synthetic construct construcción sintética gaggtgcagctgctggagtctgggggaggcttggtgcagcctggggggtctctgagactctcctgtgcagcctctggattcaccttcagtgattatcacatgagctgggtccgccaggctccaggaaaggggctcgagtgggtctcaggtattcttaatacaggtcttagtccaacttatgcagccaccgtgacgggccgattcaccatctccagagacaacgccaagaatacgctgtatctctcaatgaacagcctgaaacctgaggacacggccgtgtattattgtgcccagggatactatcgagctaccccctcccaagccaacaggggccaggggacccaggtcaccgtctcctca 696 DNA PAT source 1..696 mol_type other DNA note DNA ADN organism synthetic construct construcción sintética gaacctaaatcatcagataagactcatacatgccctccttgccctgcacctgaacttcttggaggaccttcagtgttcctatttccaccgaaacctaaagatacacttatgatctcaagaacacctgaagtgacatgcgtggtggtggatgtgtcacacgaagatcctgaagtgaaatttaactggtacgtggatggagtggaagtgcacaacgcaaagaccaagcctagagaagaacaatacaactcaacatacagagtggtgtcagtgcttacagtgcttcaccaagattggcttaacggaaaggagtataaatgcaaagtgtcaaacaaagcacttcctgcacctatcgagaagaccatttcaaaagcaaaaggacaacctagagaacctcaagtgtacacacttcctccttcaagagaagaaatgacaaagaatcaggtgtcgctgacttgtctcgtcaaaggattctatccatcagatatcgcagtggaatgggaatcaaacggacaacctgagaataattacaagactacgcctcctgtgcttgattcagatggatcattcttcctatattcaaagctgacggtggataaatcaagatggcaacaaggaaacgtgttctcctgttcagtgatgcacgaagcacttcacaaccactacacacagaagtccttatcgttgtctcccggaaag 232 AA PAT source 1..232 mol_type protein note AA AA organism synthetic construct construcción sintética EPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 369 DNA PAT source 1..369 mol_type other DNA note VHH DNA ADN de VHH organism synthetic construct construcción sintética gaagtgcaactggtggagtccggcggcgggctggtccaaaccggggacagcctgagactgagctgcgccgcctcccctagaacctttcagacctacttcatgggctggttcagacaagcccccggcaaggagagagagttcgtgagcgtgatcaactggagcggcggcacaagctactacaaggacagcgtgaagggcagattcaccatcagcagagacaacgccaagaacacagtgtacctgcagatgaacaacctgaagcccgaggacaccgccgtgtactactgcgccgccaagggcagcggcacctacgacagagagggcgagtacgactactggggccaaggcacccaagtgaccgtgagcagc 123 AA PAT source 1..123 mol_type protein note VHH AA AA de VHH organism synthetic construct construcción sintética EVQLVESGGGLVQPGGSLRLSCAASPRTFQTYFMGWFRQAPGKEREFVSVINWSGGTSYYKDSVKGRFTISRDNSKNTVYLQMNSLRAEDTAVYYCAAKGSGTYDREGEYDYWGQGTLVTVSS 369 DNA PAT source 1..369 mol_type other DNA note VHH DNA ADN de VHH organism synthetic construct construcción sintética gaggtgcaactcgtggagagcggcgggggcctggtccaacccgggggcagcctgagactgagctgcgccgctagccctagaacctttcagacctacttcatgggctggttcagacaagcccccggcaaggagagagagttcgtgagcgtgatcaactggagcggcggcacaagctactacaaggacagcgtgaagggcagattcaccatcagcagagacaacagcaagaacaccgtgtacctgcagatgaacagcctgagagccgaggacaccgccgtgtactactgcgccgccaagggcagcggcacctacgacagagagggcgagtacgactactggggccaaggcaccctggtgaccgtgagcagc 123 AA PAT source 1..123 mol_type protein note VHH AA AA de VHH organism synthetic construct construcción sintética EVQLVESGGGLVQPGGSLRLSCAASGRTFQTYFMGWFRQAPGKEREFVSVINWSGGTSYYKDSVKGRFTISRDNSKNTVYLQMNSLRAEDTAVYYCAAKGSGTYDREGEYDYWGQGTLVTVSS 369 DNA PAT source 1..369 mol_type other DNA note VHH DNA ADN de VHH organism synthetic construct construcción sintética gaggtgcaactcgtggagagcggcgggggcctggtccaacccgggggcagcctgagactgagctgcgccgctagcggcagaacctttcagacctacttcatgggctggttcagacaagcccccggcaaggagagagagttcgtgagcgtgatcaactggagcggcggcacaagctactacaaggacagcgtgaagggcagattcaccatcagcagagacaacagcaagaacaccgtgtacctgcagatgaacagcctgagagccgaggacaccgccgtgtactactgcgccgccaagggcagcggcacctacgacagagagggcgagtacgactactggggccaaggcaccctggtgaccgtgagcagc 123 AA PAT source 1..123 mol_type protein note VHH AA AA de VHH organism synthetic construct construcción sintética EVQLVESGGGLVQPGGSLRLSCAASPFTFQTYFMGWFRQAPGKEREFVSVINWSGGTSYYKDSVKGRFTISRDNSKNTVYLQMNSLRAEDTAVYYCAAKGSGTYDREGEYDYWGQGTLVTVSS 369 DNA PAT source 1..369 mol_type other DNA note VHH DNA ADN de VHH organism synthetic construct construcción sintética gaggtgcaactcgtggagagcggcgggggcctggtccaacccgggggcagcctgagactgagctgcgccgctagccctttcacctttcagacctacttcatgggctggttcagacaagcccccggcaaggagagagagttcgtgagcgtgatcaactggagcggcggcacaagctactacaaggacagcgtgaagggcagattcaccatcagcagagacaacagcaagaacaccgtgtacctgcagatgaacagcctgagagccgaggacaccgccgtgtactactgcgccgccaagggcagcggcacctacgacagagagggcgagtacgactactggggccaaggcaccctggtgaccgtgagcagc 123 AA PAT source 1..123 mol_type protein note VHH AA AA de VHH organism synthetic construct construcción sintética EVQLVESGGGLVQPGGSLRLSCAASPRTFSTYFMGWFRQAPGKEREFVSVINWSGGTSYYKDSVKGRFTISRDNSKNTVYLQMNSLRAEDTAVYYCAAKGSGTYDREGEYDYWGQGTLVTVSS 369 DNA PAT source 1..369 mol_type other DNA note VHH DNA ADN de VHH organism synthetic construct construcción sintética gaggtgcaactcgtggagagcggcgggggcctggtccaacccgggggcagcctgagactgagctgcgccgctagccctagaacctttagcacctacttcatgggctggttcagacaagcccccggcaaggagagagagttcgtgagcgtgatcaactggagcggcggcacaagctactacaaggacagcgtgaagggcagattcaccatcagcagagacaacagcaagaacaccgtgtacctgcagatgaacagcctgagagccgaggacaccgccgtgtactactgcgccgccaagggcagcggcacctacgacagagagggcgagtacgactactggggccaaggcaccctggtgaccgtgagcagc 123 AA PAT source 1..123 mol_type protein note VHH AA AA de VHH organism synthetic construct construcción sintética EVQLVESGGGLVQPGGSLRLSCAASPRTFQTYFMGWVRQAPGKEREFVSVINWSGGTSYYKDSVKGRFTISRDNSKNTVYLQMNSLRAEDTAVYYCAAKGSGTYDREGEYDYWGQGTLVTVSS 369 DNA PAT source 1..369 mol_type other DNA note VHH DNA ADN de VHH organism synthetic construct construcción sintética gaggtgcaactcgtggagagcggcgggggcctggtccaacccgggggcagcctgagactgagctgcgccgctagccctagaacctttcagacctacttcatgggctgggtgagacaagcccccggcaaggagagagagttcgtgagcgtgatcaactggagcggcggcacaagctactacaaggacagcgtgaagggcagattcaccatcagcagagacaacagcaagaacaccgtgtacctgcagatgaacagcctgagagccgaggacaccgccgtgtactactgcgccgccaagggcagcggcacctacgacagagagggcgagtacgactactggggccaaggcaccctggtgaccgtgagcagc 123 AA PAT source 1..123 mol_type protein note VHH AA AA de VHH organism synthetic construct construcción sintética EVQLVESGGGLVQPGGSLRLSCAASPRTFQTYFMGWFRQAPGKGREFVSVINWSGGTSYYKDSVKGRFTISRDNSKNTVYLQMNSLRAEDTAVYYCAAKGSGTYDREGEYDYWGQGTLVTVSS 369 DNA PAT source 1..369 mol_type other DNA note VHH DNA ADN de VHH organism synthetic construct construcción sintética gaggtgcaactcgtggagagcggcgggggcctggtccaacccgggggcagcctgagactgagctgcgccgctagccctagaacctttcagacctacttcatgggctggttcagacaagcccccggcaagggcagagagttcgtgagcgtgatcaactggagcggcggcacaagctactacaaggacagcgtgaagggcagattcaccatcagcagagacaacagcaagaacaccgtgtacctgcagatgaacagcctgagagccgaggacaccgccgtgtactactgcgccgccaagggcagcggcacctacgacagagagggcgagtacgactactggggccaaggcaccctggtgaccgtgagcagc 123 AA PAT source 1..123 mol_type protein note VHH AA AA de VHH organism synthetic construct construcción sintética EVQLVESGGGLVQPGGSLRLSCAASPRTFQTYFMGWFRQAPGKELEFVSVINWSGGTSYYKDSVKGRFTISRDNSKNTVYLQMNSLRAEDTAVYYCAAKGSGTYDREGEYDYWGQGTLVTVSS 369 DNA PAT source 1..369 mol_type other DNA note VHH DNA ADN de VHH organism synthetic construct construcción sintética gaggtgcaactcgtggagagcggcgggggcctggtccaacccgggggcagcctgagactgagctgcgccgctagccctagaacctttcagacctacttcatgggctggttcagacaagcccccggcaaggagctggagttcgtgagcgtgatcaactggagcggcggcacaagctactacaaggacagcgtgaagggcagattcaccatcagcagagacaacagcaagaacaccgtgtacctgcagatgaacagcctgagagccgaggacaccgccgtgtactactgcgccgccaagggcagcggcacctacgacagagagggcgagtacgactactggggccaaggcaccctggtgaccgtgagcagc 123 AA PAT source 1..123 mol_type protein note VHH AA AA de VHH organism synthetic construct construcción sintética EVQLVESGGGLVQPGGSLRLSCAASPRTFQTYFMGWFRQAPGKEREWVSVINWSGGTSYYKDSVKGRFTISRDNSKNTVYLQMNSLRAEDTAVYYCAAKGSGTYDREGEYDYWGQGTLVTVSS 369 DNA PAT source 1..369 mol_type other DNA note VHH DNA ADN de VHH organism synthetic construct construcción sintética gaggtgcaactcgtggagagcggcgggggcctggtccaacccgggggcagcctgagactgagctgcgccgctagccctagaacctttcagacctacttcatgggctggttcagacaagcccccggcaaggagagagagtgggtgagcgtgatcaactggagcggcggcacaagctactacaaggacagcgtgaagggcagattcaccatcagcagagacaacagcaagaacaccgtgtacctgcagatgaacagcctgagagccgaggacaccgccgtgtactactgcgccgccaagggcagcggcacctacgacagagagggcgagtacgactactggggccaaggcaccctggtgaccgtgagcagc 123 AA PAT source 1..123 mol_type protein note VHH AA AA de VHH organism synthetic construct construcción sintética EVQLVESGGGLVQPGGSLRLSCAASPRTFQTYFMGWFRQAPGKEREFVSVINWSGGTSYYKDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAAKGSGTYDREGEYDYWGQGTLVTVSS 369 DNA PAT source 1..369 mol_type other DNA note VHH DNA ADN de VHH organism synthetic construct construcción sintética gaggtgcaactcgtggagagcggcgggggcctggtccaacccgggggcagcctgagactgagctgcgccgctagccctagaacctttcagacctacttcatgggctggttcagacaagcccccggcaaggagagagagttcgtgagcgtgatcaactggagcggcggcacaagctactacaaggacagcgtgaagggcagattcaccatcagcagagacaacagcaagaacaccctgtacctgcagatgaacagcctgagagccgaggacaccgccgtgtactactgcgccgccaagggcagcggcacctacgacagagagggcgagtacgactactggggccaaggcaccctggtgaccgtgagcagc 123 AA PAT source 1..123 mol_type protein note VHH AA AA de VHH organism synthetic construct construcción sintética EVQLVESGGGLVQPGGSLRLSCAASPRTFQTYFMGWFRQAPGKEREFVSVINWSGGTSYYKDSVKGRFTISRDNSKNTVYLQMNSLRAEDTAVYYCAKKGSGTYDREGEYDYWGQGTLVTVSS 369 DNA PAT source 1..369 mol_type other DNA note VHH DNA ADN de VHH organism synthetic construct construcción sintética gaggtgcaactcgtggagagcggcgggggcctggtccaacccgggggcagcctgagactgagctgcgccgctagccctagaacctttcagacctacttcatgggctggttcagacaagcccccggcaaggagagagagttcgtgagcgtgatcaactggagcggcggcacaagctactacaaggacagcgtgaagggcagattcaccatcagcagagacaacagcaagaacaccgtgtacctgcagatgaacagcctgagagccgaggacaccgccgtgtactactgcgccaagaagggcagcggcacctacgacagagagggcgagtacgactactggggccaaggcaccctggtgaccgtgagcagc 123 AA PAT source 1..123 mol_type protein note VHH AA AA de VHH organism synthetic construct construcción sintética EVQLVESGGGLVQPGGSLRLSCAASPRTFQTYFMGWFRQAPGKGLEWVSVINWSGGTSYYKDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAAKGSGTYDREGEYDYWGQGTLVTVSS 369 DNA PAT source 1..369 mol_type other DNA note VHH DNA ADN de VHH organism synthetic construct construcción sintética gaggtgcaactcgtggagagcggcgggggcctggtccaacccgggggcagcctgagactgagctgcgccgctagccctagaacctttcagacctacttcatgggctggttcagacaagcccccggcaagggcctggagtgggtgagcgtgatcaactggagcggcggcacaagctactacaaggacagcgtgaagggcagattcaccatcagcagagacaacagcaagaacaccctgtacctgcagatgaacagcctgagagccgaggacaccgccgtgtactactgcgccgccaagggcagcggcacctacgacagagagggcgagtacgactactggggccaaggcaccctggtgaccgtgagcagc 123 AA PAT source 1..123 mol_type protein note VHH AA AA de VHH organism synthetic construct construcción sintética EVQLVESGGGLVQPGGSLRLSCAASPRTFQTYFMGWFRQAPGKELEWVSVINWSGGTSYYKDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAAKGSGTYDREGEYDYWGQGTLVTVSS 369 DNA PAT source 1..369 mol_type other DNA note VHH DNA ADN de VHH organism synthetic construct construcción sintética gaggtgcaactcgtggagagcggcgggggcctggtccaacccgggggcagcctgagactgagctgcgccgctagccctagaacctttcagacctacttcatgggctggttcagacaagcccccggcaaggagctggagtgggtgagcgtgatcaactggagcggcggcacaagctactacaaggacagcgtgaagggcagattcaccatcagcagagacaacagcaagaacaccctgtacctgcagatgaacagcctgagagccgaggacaccgccgtgtactactgcgccgccaagggcagcggcacctacgacagagagggcgagtacgactactggggccaaggcaccctggtgaccgtgagcagc 123 AA PAT source 1..123 mol_type protein note VHH AA AA de VHH organism synthetic construct construcción sintética EVQLVESGGGLVQPGGSLRLSCAASPFTFQTYFMGWFRQAPGKELEWVSVINWSGGTSYYKDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAAKGSGTYDREGEYDYWGQGTLVTVSS 369 DNA PAT source 1..369 mol_type other DNA note VHH DNA ADN de VHH organism synthetic construct construcción sintética gaggtgcaactcgtggagagcggcgggggcctggtccaacccgggggcagcctgagactgagctgcgccgctagccctttcacctttcagacctacttcatgggctggttcagacaagcccccggcaaggagctggagtgggtgagcgtgatcaactggagcggcggcacaagctactacaaggacagcgtgaagggcagattcaccatcagcagagacaacagcaagaacaccctgtacctgcagatgaacagcctgagagccgaggacaccgccgtgtactactgcgccgccaagggcagcggcacctacgacagagagggcgagtacgactactggggccaaggcaccctggtgaccgtgagcagc 123 AA PAT source 1..123 mol_type protein note VHH AA AA de VHH organism synthetic construct construcción sintética EVQLVESGGGLVQPGGSLRLSCAASPRTFSTYFMGWFRQAPGKELEWVSVINWSGGTSYYKDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAAKGSGTYDREGEYDYWGQGTLVTVSS 369 DNA PAT source 1..369 mol_type other DNA note VHH DNA ADN de VHH organism synthetic construct construcción sintética gaggtgcaactcgtggagagcggcgggggcctggtccaacccgggggcagcctgagactgagctgcgccgctagccctagaacctttagcacctacttcatgggctggttcagacaagcccccggcaaggagctggagtgggtgagcgtgatcaactggagcggcggcacaagctactacaaggacagcgtgaagggcagattcaccatcagcagagacaacagcaagaacaccctgtacctgcagatgaacagcctgagagccgaggacaccgccgtgtactactgcgccgccaagggcagcggcacctacgacagagagggcgagtacgactactggggccaaggcaccctggtgaccgtgagcagc 123 AA PAT source 1..123 mol_type protein note VHH AA AA de VHH organism synthetic construct construcción sintética EVQLVESGGGLVQPGGSLRLSCAASPFTFSTYFMGWFRQAPGKELEWVSVINWSGGTSYYKDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAAKGSGTYDREGEYDYWGQGTLVTVSS 369 DNA PAT source 1..369 mol_type other DNA note VHH DNA ADN de VHH organism synthetic construct construcción sintética gaggtgcaactcgtggagagcggcgggggcctggtccaacccgggggcagcctgagactgagctgcgccgctagccctttcacctttagcacctacttcatgggctggttcagacaagcccccggcaaggagctggagtgggtgagcgtgatcaactggagcggcggcacaagctactacaaggacagcgtgaagggcagattcaccatcagcagagacaacagcaagaacaccctgtacctgcagatgaacagcctgagagccgaggacaccgccgtgtactactgcgccgccaagggcagcggcacctacgacagagagggcgagtacgactactggggccaaggcaccctggtgaccgtgagcagc 123 AA PAT source 1..123 mol_type protein note VHH AA AA de VHH organism synthetic construct construcción sintética EVQLVESGGGLVQPGGSLRLSCAASPRTFQTYFMGWFRQAPGKGREWVSVINWSGGTSYYKDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAAKGSGTYDREGEYDYWGQGTLVTVSS 369 DNA PAT source 1..369 mol_type other DNA note VHH DNA ADN de VHH organism synthetic construct construcción sintética gaggtgcaactcgtggagagcggcgggggcctggtccaacccgggggcagcctgagactgagctgcgccgctagccctagaacctttcagacctacttcatgggctggttcagacaagcccccggcaagggcagagagtgggtgagcgtgatcaactggagcggcggcacaagctactacaaggacagcgtgaagggcagattcaccatcagcagagacaacagcaagaacaccctgtacctgcagatgaacagcctgagagccgaggacaccgccgtgtactactgcgccgccaagggcagcggcacctacgacagagagggcgagtacgactactggggccaaggcaccctggtgaccgtgagcagc 120 AA PAT source 1..120 mol_type protein note VHH AA AA de VHH organism synthetic construct construcción sintética EVQLLESGGGLVQPGGSLRLSCAASGFTFSDYHMSWVRQAPGKGLEWVSGILNTGLSPTYAATVTGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAQGYYRATPSQANRGQGTLVTVSS 360 DNA PAT source 1..360 mol_type other DNA note VHH DNA ADN de VHH organism synthetic construct construcción sintética gaagtgcagctgctggaatccgggggggggctcgtgcagcccgggggcagcctgagactgagctgcgccgctagcggcttcaccttcagcgactaccacatgagctgggtgagacaagcccccggcaagggcctggagtgggtgagcggcatcctgaacaccggcctgagccccacctacgccgccaccgtgaccggcagattcaccatcagcagagacaacagcaagaacaccctgtacctgcagatgaacagcctgagagccgaggacaccgccgtgtactactgcgcccaaggctactacagagccacccctagccaagccaacagaggccaaggcaccctggtgaccgtgagcagc 120 AA PAT source 1..120 mol_type protein note VHH AA AA de VHH organism synthetic construct construcción sintética EVQLLESGGGLVQPGGSLRLSCAASGFTFSDYHMSWVRQAPGKGLEWVSGILNTGLSPTYAATVTGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKGYYRATPSQANRGQGTLVTVSS 360 DNA PAT source 1..360 mol_type other DNA note VHH DNA ADN de VHH organism synthetic construct construcción sintética gaagtgcagctgctggaatccgggggggggctcgtgcagcccgggggcagcctgagactgagctgcgccgctagcggcttcaccttcagcgactaccacatgagctgggtgagacaagcccccggcaagggcctggagtgggtgagcggcatcctgaacaccggcctgagccccacctacgccgccaccgtgaccggcagattcaccatcagcagagacaacagcaagaacaccctgtacctgcagatgaacagcctgagagccgaggacaccgccgtgtactactgcgccaagggctactacagagccacccctagccaagccaacagaggccaaggcaccctggtgaccgtgagcagc 120 AA PAT source 1..120 mol_type protein note VHH AA AA de VHH organism synthetic construct construcción sintética EVQLLESGGGLVQPGGSLRLSCAASGFTFSDYHMSWVRQAPGKGLEWVSGILNTGLSPTYAATVTGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAQGYYRATPSQANWGQGTLVTVSS 360 DNA PAT source 1..360 mol_type other DNA note VHH DNA ADN de VHH organism synthetic construct construcción sintética gaagtgcagctgctggaatccgggggggggctcgtgcagcccgggggcagcctgagactgagctgcgccgctagcggcttcaccttcagcgactaccacatgagctgggtgagacaagcccccggcaagggcctggagtgggtgagcggcatcctgaacaccggcctgagccccacctacgccgccaccgtgaccggcagattcaccatcagcagagacaacagcaagaacaccctgtacctgcagatgaacagcctgagagccgaggacaccgccgtgtactactgcgcccaaggctactacagagccacccctagccaagccaactggggccaaggcaccctggtgaccgtgagcagc 438 AA PAT source 1..438 mol_type protein note AA AA organism synthetic construct construcción sintética LEVQVPEDPVVALVGTDATLCCSFSPEPGFSLAQLNLIWQLTDTKQLVHSFAEGQDQGSAYANRTALFPDLLAQGNASLRLQRVRVADEGSFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVTITCSSYQGYPEAEVFWQDGQGVPLTGNVTTSQMANEQGLFDVHSILRVVLGANGTYSCLVRNPVLQQDAHSSVTITPQRSPTGAVEVQVPEDPVVALVGTDATLRCSFSPEPGFSLAQLNLIWQLTDTKQLVHSFTEGRDQGSAYANRTALFPDLLAQGNASLRLQRVRVADEGSFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVTITCSSYRGYPEAEVFWQDGQGVPLTGNVTTSQMANEQGLFDVHSVLRVVLGANGTYSCLVRNPVLQQDAHGSVTITGQPMTFPPEA 8 AA PAT source 1..8 mol_type protein note HCDR1 IMGT IMGT de HCDR1 organism synthetic construct construcción sintética PRTFQTYF 8 AA PAT source 1..8 mol_type protein note HCDR2 IMGT IMGT de HCDR2 organism synthetic construct construcción sintética INWSGGTS 16 AA PAT source 1..16 mol_type protein note HCDR3 IMGT IMGT de HCDR3 organism synthetic construct construcción sintética AAKGSGTYDREGEYDY 7 AA PAT source 1..7 mol_type protein note HCDR1 Chothia HCDR1 Chothia organism synthetic construct construcción sintética PRTFQTY 6 AA PAT source 1..6 mol_type protein note HCDR2 (Chothia) HCDR2 (Chothia) organism synthetic construct construcción sintética NWSGGT 8 AA PAT source 1..8 mol_type protein note HCDR1 IMGT IMGT de HCDR1 organism synthetic construct construcción sintética GRTFQTYF 7 AA PAT source 1..7 mol_type protein note HCDR1 (Chothia) HCDR1 (Chothia) organism synthetic construct construcción sintética GRTFQTY 8 AA PAT source 1..8 mol_type protein note HCDR1 (IMGT)q HCDR1 (IMGT)q organism synthetic construct construcción sintética PFTFQTYF 7 AA PAT source 1..7 mol_type protein note HCDR1 (Chothia) HCDR1 (Chothia) organism synthetic construct construcción sintética PFTFQTY 8 AA PAT source 1..8 mol_type protein note HCDR1 (IMGT) HCDR1 (IMGT) organism synthetic construct construcción sintética PRTFSTYF 7 AA PAT source 1..7 mol_type protein note HCDR1 (Chothia) HCDR1 (Chothia) organism synthetic construct construcción sintética PRTFSTY 16 AA PAT source 1..16 mol_type protein note HCDR3 (IMGT) HCDR3 (IMGT) organism synthetic construct construcción sintética AKKGSGTYDREGEYDY 8 AA PAT source 1..8 mol_type protein note HCDR1 (IMGT) HCDR1 (IMGT) organism synthetic construct construcción sintética PFTFSTYF 7 AA PAT source 1..7 mol_type protein note PFTFSTY PFTFSTY organism synthetic construct construcción sintética PFTFSTY 8 AA PAT source 1..8 mol_type protein note HCDR1 (IMGT) HCDR1 (IMGT) organism synthetic construct construcción sintética GFTFSDYH 8 AA PAT source 1..8 mol_type protein note HCDR2 (IMGT) HCDR2 (IMGT) organism synthetic construct construcción sintética ILNTGLSP 13 AA PAT source 1..13 mol_type protein note HCDR3 (IMGT) HCDR3 (IMGT) organism synthetic construct construcción sintética AQGYYRATPSQAN 7 AA PAT source 1..7 mol_type protein note HCDR1 (Chothia) HCDR1 (Chothia) organism synthetic construct construcción sintética GFTFSDY 6 AA PAT source 1..6 mol_type protein note HCDR2 (Chothia) HCDR2 (Chothia) organism synthetic construct construcción sintética LNTGLS 13 AA PAT source 1..13 mol_type protein note HCDR3 (IMGT) HCDR3 (IMGT) organism synthetic construct construcción sintética AKGYYRATPSQAN 000 000 000 000 000 4 AA PAT source 1..4 mol_type protein note linker enlazador organism synthetic construct construcción sintética GGGS 4 AA PAT source 1..4 mol_type protein note Linker Enlazador organism synthetic construct construcción sintética SGGG 5 AA PAT source 1..5 mol_type protein note linker enlazador organism synthetic construct construcción sintética GGGGS 7 AA PAT source 1..7 mol_type protein note linker enlazador organism synthetic construct construcción sintética GGGGSGS 7 AA PAT source 1..7 mol_type protein note linker enlazador organism synthetic construct construcción sintética GGGGSGS 8 AA PAT source 1..8 mol_type protein note linker enlazador organism synthetic construct construcción sintética GGGGSGGS 10 AA PAT source 1..10 mol_type protein note linker enlazador organism synthetic construct construcción sintética GGGGSGGGGS 15 AA PAT source 1..15 mol_type protein note linker enlazador organism synthetic construct construcción sintética GGGGSGGGGSGGGGS 16 AA PAT source 1..16 mol_type protein note linker enlazador organism synthetic construct construcción sintética AKTTPKLEEGEFSEAR 17 AA PAT source 1..17 mol_type protein note linker enlazador organism synthetic construct construcción sintética AKTTPKLEEGEFSEARV 9 AA PAT source 1..9 mol_type protein note linker enlazador organism synthetic construct construcción sintética AKTTPKLGG 10 AA PAT source 1..10 mol_type protein note linker enlazador organism synthetic construct construcción sintética SAKTTPKLGG 17 AA PAT source 1..17 mol_type protein note linker enlazador organism synthetic construct construcción sintética AKTTPKLEEGEFSEARV 6 AA PAT source 1..6 mol_type protein note linker enlazador organism synthetic construct construcción sintética SAKTTP 10 AA PAT source 1..10 mol_type protein note SAKTTPKLGG SAKTTPKLGG organism synthetic construct construcción sintética SAKTTPKLGG 6 AA PAT source 1..6 mol_type protein note RADAAP RADAAP organism synthetic construct construcción sintética RADAAP 9 AA PAT source 1..9 mol_type protein note RADAAPTVS RADAAPTVS organism synthetic construct construcción sintética RADAAPTVS 12 AA PAT source 1..12 mol_type protein note RADAAAAGGPGS RADAAAAGGPGS organism synthetic construct construcción sintética RADAAAAGGPGS 27 AA PAT source 1..27 mol_type protein note Linker Enlazador organism synthetic construct construcción sintética RADAAAAGGGGSGGGGSGGGGSGGGGS 6 AA PAT source 1..6 mol_type protein note SAKTTP SAKTTP organism synthetic construct construcción sintética SAKTTP 10 AA PAT source 1..10 mol_type protein note linker enlazador organism synthetic construct construcción sintética SAKTTPKLGG 18 AA PAT source 1..18 mol_type protein note linker enlazador organism synthetic construct construcción sintética SAKTTPKLEEGEFSEARV 5 AA PAT source 1..5 mol_type protein note linker enlazador organism synthetic construct construcción sintética ADAAP 12 AA PAT source 1..12 mol_type protein note linker enlazador organism synthetic construct construcción sintética ADAAPTVSIFPP 5 AA PAT source 1..5 mol_type protein note linker enlazador organism synthetic construct construcción sintética TVAAP 12 AA PAT source 1..12 mol_type protein note TVAAPSVFIFPP TVAAPSVFIFPP organism synthetic construct construcción sintética TVAAPSVFIFPP 6 AA PAT source 1..6 mol_type protein note QPKAAP QPKAAP organism synthetic construct construcción sintética QPKAAP 13 AA PAT source 1..13 mol_type protein note QPKAAPSVTLFPP QPKAAPSVTLFPP organism synthetic construct construcción sintética QPKAAPSVTLFPP 6 AA PAT source 1..6 mol_type protein note linker enlazador organism synthetic construct construcción sintética AKTTPP 13 AA PAT source 1..13 mol_type protein note AKTTPPSVTPLAP AKTTPPSVTPLAP organism synthetic construct construcción sintética AKTTPPSVTPLAP 6 AA PAT source 1..6 mol_type protein note linker enlazador organism synthetic construct construcción sintética AKTTAP 13 AA PAT source 1..13 mol_type protein note linker enlazador organism synthetic construct construcción sintética AKTTAPSVYPLAP 6 AA PAT source 1..6 mol_type protein note ASTKGP ASTKGP organism synthetic construct construcción sintética ASTKGP 13 AA PAT source 1..13 mol_type protein note linker enlazador organism synthetic construct construcción sintética ASTKGPSVFPLAP 15 AA PAT source 1..15 mol_type protein note GENKVEYAPALMALS GENKVEYAPALMALS organism synthetic construct construcción sintética GENKVEYAPALMALS 15 AA PAT source 1..15 mol_type protein note linker enlazador organism synthetic construct construcción sintética GPAKELTPLKEAKVS 15 AA PAT source 1..15 mol_type protein note linker enlazador organism synthetic construct construcción sintética GHEAAAVMQVQYPAS 20 AA PAT source 1..20 mol_type protein note linker enlazador organism synthetic construct construcción sintética GGGGSGGGGSGGGGSGGGGS 360 DNA PAT source 1..360 mol_type other DNA note VHH DNA ADN de VHH organism synthetic construct construcción sintética gaggtgcaactgctggagtccggcgggggcctggtgcagcccggcgggagcctgagactgagctgcgccgctagcggcttcaccttcagcgactaccacatgagctgggtgagacaagcccccggcaagggcctggagtgggtgagcggcatcctgaacaccggcctgagccccacctacgccgccaccgtgaccggcagattcaccatcagcagagataacgccaaaaacaccctgtacctgagcatgaacagcctgaagcccgaggacaccgccgtgtactactgcgcccaaggctactacagagccacccctagccaagccaacagaggccaaggcacccaagtgaccgtgagcagc