IOTS-103-WO US 63/495127 2023-04-10 MedImmune LLC MedImmune LLC Optimized CD3 Antigen Binding Domains Dominios de unión al antígeno CD3 optimizado 120 112 AA PAT source 1..112 mol_type protein organism synthetic construct constructo sintético DIVMTQTPLSLSVTPGQPASISCKSSQSLVHNNANTYLSWYLQKPGQSPQSLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCGQGTQYPFTFGSGTKVEIK 16 AA PAT source 1..16 mol_type protein organism synthetic construct constructo sintético KSSQSLVHNNANTYLS 7 AA PAT source 1..7 mol_type protein organism synthetic construct constructo sintético KVSNRFS 9 AA PAT source 1..9 mol_type protein organism synthetic construct constructo sintético GQGTQYPFT 121 AA PAT source 1..121 mol_type protein organism synthetic construct constructo sintético QVQLVESGGGVVQPGRSLRLSCAASGFTFTKAWMHWVRQAPGKQLEWVAQIKDKSNSYATYYADSVKGRFTISRDDSKNTLYLQMNSLRAEDTAVYYCRGVYYALSPFDYWGQGTLVTVSS 5 AA PAT source 1..5 mol_type protein organism synthetic construct constructo sintético KAWMH 19 AA PAT source 1..19 mol_type protein organism synthetic construct constructo sintético QIKDKSNSYATYYADSVKG 12 AA PAT source 1..12 mol_type protein organism synthetic construct constructo sintético RGVYYALSPFDY 112 AA PAT source 1..112 mol_type protein organism synthetic construct constructo sintético DIVMTQSPLSLPVTPGEPASISCRSSQSLVHNQANTYLSWYLQKPGQSPQSLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCGQGTQYPFTFGSGTKVEIK 16 AA PAT source 1..16 mol_type protein organism synthetic construct constructo sintético RSSQSLVHNQANTYLS 7 AA PAT source 1..7 mol_type protein organism synthetic construct constructo sintético KVSNRFS 9 AA PAT source 1..9 mol_type protein organism synthetic construct constructo sintético GQGTQYPFT 112 AA PAT source 1..112 mol_type protein organism synthetic construct constructo sintético DIVMTQSPLSLPVTPGEPASISCRSSQSLVHNTGNTYLSWYLQKPGQSPQSLIYKVSNRASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCGQGTQYPFTFGSGTKVEIK 16 AA PAT source 1..16 mol_type protein organism synthetic construct constructo sintético RSSQSLVHNTGNTYLS 7 AA PAT source 1..7 mol_type protein organism synthetic construct constructo sintético KVSNRAS 9 AA PAT source 1..9 mol_type protein organism synthetic construct constructo sintético GQGTQYPFT 112 AA PAT source 1..112 mol_type protein organism synthetic construct constructo sintético DIVMTQSPLSLPVTPGEPASISCRSSQSLVHNQANTYLSWYLQKPGQSPQSLIYKVSNRYSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCGQGTQYPFTFGSGTKVEIK 16 AA PAT source 1..16 mol_type protein organism synthetic construct constructo sintético RSSQSLVHNQANTYLS 7 AA PAT source 1..7 mol_type protein organism synthetic construct constructo sintético KVSNRYS 9 AA PAT source 1..9 mol_type protein organism synthetic construct constructo sintético GQGTQYPFT 121 AA PAT source 1..121 mol_type protein organism synthetic construct constructo sintético EVQLVESGGALVKPGGSLRLSCAASGFTFTKAWMHWVRQAPGKQLEWVAQIKDKSNSYATYYAESVKGRFTISRDDSKNTLYLQMNSLKTEDTAVYYCRGVYYALSPFDYWGQGTLVTVSS 5 AA PAT source 1..5 mol_type protein organism synthetic construct constructo sintético KAWMH 20 AA PAT source 1..20 mol_type protein organism synthetic construct constructo sintético QIKDKSNSYATYYAESVKGR 12 AA PAT source 1..12 mol_type protein organism synthetic construct constructo sintético RGVYYALSPFDY 121 AA PAT source 1..121 mol_type protein organism synthetic construct constructo sintético EVQLVESGGALVKPGGSLRLSCAASGFTFTKAYMHWVRQAPGKQLEWVAQIKDKSNSYATYYAESVKGRFTISRDDSKNTLYLQMNSLKTEDTAVYYCRGVYYALSPFDYWGQGTLVTVSS 5 AA PAT source 1..5 mol_type protein organism synthetic construct constructo sintético KAYMH 20 AA PAT source 1..20 mol_type protein organism synthetic construct constructo sintético QIKDKSNSYATYYAESVKGR 12 AA PAT source 1..12 mol_type protein organism synthetic construct constructo sintético RGVYYALSPFDY 121 AA PAT source 1..121 mol_type protein organism synthetic construct constructo sintético EVQLVESGGALVKPGGSLRLSCAASGFTFSNAWMHWVRQAPGKQLEWVAQIKDKSNSYATYYAESVKGRFTISRDDSKNTLYLQMNSLKTEDTAVYYCRGVYYALSPFDYWGQGTLVTVSS 5 AA PAT source 1..5 mol_type protein organism synthetic construct constructo sintético NAWMH 20 AA PAT source 1..20 mol_type protein organism synthetic construct constructo sintético QIKDKSNSYATYYAESVKGR 12 AA PAT source 1..12 mol_type protein organism synthetic construct constructo sintético RGVYYALSPFDY 121 AA PAT source 1..121 mol_type protein organism synthetic construct constructo sintético EVQLVESGGALVKPGGSLRLSCAASGFTFTKAWMSWVRQAPGKQLEWVAQIKDKSNSYATYYAESVKGRFTISRDDSKNTLYLQMNSLKTEDTAVYYCRGVYYALSPFDYWGQGTLVTVSS 5 AA PAT source 1..5 mol_type protein organism synthetic construct constructo sintético KAWMS 20 AA PAT source 1..20 mol_type protein organism synthetic construct constructo sintético QIKDKSNSYATYYAESVKGR 12 AA PAT source 1..12 mol_type protein organism synthetic construct constructo sintético RGVYYALSPFDY 121 AA PAT source 1..121 mol_type protein organism synthetic construct constructo sintético EVQLVESGGALVKPGGSLRLSCAASGFTFTKAYMHWVRQAPGKQLEWVAQIKDRSQSYATYYAESVKGRFTISRDDSKNTLYLQMNSLKTEDTAVYYCRGVYYALSPFDYWGQGTLVTVSS 5 AA PAT source 1..5 mol_type protein organism synthetic construct constructo sintético KAYMH 20 AA PAT source 1..20 mol_type protein organism synthetic construct constructo sintético QIKDRSQSYATYYAESVKGR 12 AA PAT source 1..12 mol_type protein organism synthetic construct constructo sintético RGVYYALSPFDY 121 AA PAT source 1..121 mol_type protein organism synthetic construct constructo sintético EVQLVESGGALVKPGGSLRLSCAASGFTFSNAYMHWVRQAPGKQLEWVAQIKDRSQSYATYYAESVKGRFTISRDDSKNTLYLQMNSLKTEDTAVYYCRGVYYALSPFDYWGQGTLVTVSS 5 AA PAT source 1..5 mol_type protein organism synthetic construct constructo sintético NAYMH 20 AA PAT source 1..20 mol_type protein organism synthetic construct constructo sintético QIKDRSQSYATYYAESVKGR 12 AA PAT source 1..12 mol_type protein organism synthetic construct constructo sintético RGVYYALSPFDY 112 AA PAT source 1..112 mol_type protein organism synthetic construct constructo sintético DIVMTQSPLSLPVTPGEPASISCRSSQSLVHNTGNTYLSWYLQKPGQSPQSLIYKVSNRASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCGQGTQAPFTFGSGTKVEIK 16 AA PAT source 1..16 mol_type protein organism synthetic construct constructo sintético RSSQSLVHNTGNTYLS 7 AA PAT source 1..7 mol_type protein organism synthetic construct constructo sintético KVSNRAS 9 AA PAT source 1..9 mol_type protein organism synthetic construct constructo sintético GQGTQAPFT 121 AA PAT source 1..121 mol_type protein organism synthetic construct constructo sintético EVQLVESGGALVKPGGSLRLSCAASGFTFSNAWMHWVRQAPGKQLEWVAQIKDRSQTYATYYAESVKGRFTISRDDSKNTLYLQMNSLKTEDTAVYYCRGVYYALAPFDYWGQGTLVTVSS 5 AA PAT source 1..5 mol_type protein organism synthetic construct constructo sintético NAWMH 20 AA PAT source 1..20 mol_type protein organism synthetic construct constructo sintético QIKDRSQTYATYYAESVKGR 12 AA PAT source 1..12 mol_type protein organism synthetic construct constructo sintético RGVYYALAPFDY 121 AA PAT source 1..121 mol_type protein organism synthetic construct constructo sintético EVQLVESGGALVKPGGSLRLSCAASGFTFTKAYMHWVRQAPGKQLEWVAQIKDRSQSYATYYAESVKGRFTISRDDSKNTLYLQMNSLKTEDTAVYYCRGVYYALAPFDYWGQGTLVTVSS 5 AA PAT source 1..5 mol_type protein organism synthetic construct constructo sintético KAYMH 8 AA PAT source 1..8 mol_type protein organism synthetic construct constructo sintético QIKDRSQS 12 AA PAT source 1..12 mol_type protein organism synthetic construct constructo sintético RGVYYALAPFDY 112 AA PAT source 1..112 mol_type protein organism synthetic construct constructo sintético DIVMTQSPLSLPVTPGEPASISCRSSQSLVHNTGNTYLSWYLQKPGQSPQSLIYKVSNRASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCGQGTQAPFSFGSGTKVEIK 16 AA PAT source 1..16 mol_type protein organism synthetic construct constructo sintético RSSQSLVHNTGNTYLS 7 AA PAT source 1..7 mol_type protein organism synthetic construct constructo sintético KVSNRAS 9 AA PAT source 1..9 mol_type protein organism synthetic construct constructo sintético GQGTQAPFS 112 AA PAT source 1..112 mol_type protein organism synthetic construct constructo sintético DIVMTQSPLSLPVTPGEPASISCRSSQSLVHNTGNTYLSWYLQKPGQSPQSLIYKVSNRASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCGQGTQFPFTFGSGTKVEIK 16 AA PAT source 1..16 mol_type protein organism synthetic construct constructo sintético RSSQSLVHNTGNTYLS 7 AA PAT source 1..7 mol_type protein organism synthetic construct constructo sintético KVSNRAS 9 AA PAT source 1..9 mol_type protein organism synthetic construct constructo sintético GQGTQFPFT 121 AA PAT source 1..121 mol_type protein organism synthetic construct constructo sintético EVQLVESGGALVKPGGSLRLSCAASGFTFTRAWMHWVRQAPGKQLEWVAQIKDRSQTYATYYAESVKGRFTISRDDSKNTLYLQMNSLKTEDTAVYYCRGVYYANAPFDYWGQGTLVTVSS 5 AA PAT source 1..5 mol_type protein organism synthetic construct constructo sintético RAWMH 20 AA PAT source 1..20 mol_type protein organism synthetic construct constructo sintético QIKDRSQTYATYYAESVKGR 12 AA PAT source 1..12 mol_type protein organism synthetic construct constructo sintético RGVYYANAPFDY 121 AA PAT source 1..121 mol_type protein organism synthetic construct constructo sintético EVQLVESGGALVKPGGSLRLSCAASGFTFTRAWMHWVRQAPGKQLEWVAQIKDRSQTYATYYAESVKGRFTISRDDSKNTLYLQMNSLKTEDTAVYYCRGVYYAVTPFDYWGQGTLVTVSS 5 AA PAT source 1..5 mol_type protein organism synthetic construct constructo sintético RAWMH 20 AA PAT source 1..20 mol_type protein organism synthetic construct constructo sintético QIKDRSQTYATYYAESVKGR 12 AA PAT source 1..12 mol_type protein organism synthetic construct constructo sintético RGVYYAVTPFDY 121 AA PAT source 1..121 mol_type protein organism synthetic construct constructo sintético EVQLVESGGALVKPGGSLRLSCAASGFTFTRAWMHWVRQAPGKQLEWVAQIKDRSQTYATYYAESVKGRFTISRDDSKNTLYLQMNSLKTEDTAVYYCRGVYYANTPFDYWGQGTLVTVSS 5 AA PAT source 1..5 mol_type protein organism synthetic construct constructo sintético RAWMH 20 AA PAT source 1..20 mol_type protein organism synthetic construct constructo sintético QIKDRSQTYATYYAESVKGR 12 AA PAT source 1..12 mol_type protein organism synthetic construct constructo sintético RGVYYANTPFDY 121 AA PAT source 1..121 mol_type protein organism synthetic construct constructo sintético EVQLVESGGALVKPGGSLRLSCAASGFTFSNAWMHWVRQAPGKQLEWVAQIKDRSQTYATYYAESVKGRFTISRDDSKNTLYLQMNSLKTEDTAVYYCRGVYYANAPFDYWGQGTLVTVSS 5 AA PAT source 1..5 mol_type protein organism synthetic construct constructo sintético NAWMH 20 AA PAT source 1..20 mol_type protein organism synthetic construct constructo sintético QIKDRSQTYATYYAESVKGR 12 AA PAT source 1..12 mol_type protein organism synthetic construct constructo sintético RGVYYANAPFDY 121 AA PAT source 1..121 mol_type protein organism synthetic construct constructo sintético EVQLVESGGALVKPGGSLRLSCAASGFTFSNAWMHWVRQAPGKQLEWVAQIKDRSQTYATYYAESVKGRFTISRDDSKNTLYLQMNSLKTEDTAVYYCRGVYYAVTPFDYWGQGTLVTVSS 5 AA PAT source 1..5 mol_type protein organism synthetic construct constructo sintético NAWMH 20 AA PAT source 1..20 mol_type protein organism synthetic construct constructo sintético QIKDRSQTYATYYAESVKGR 12 AA PAT source 1..12 mol_type protein organism synthetic construct constructo sintético RGVYYAVTPFDY 121 AA PAT source 1..121 mol_type protein organism synthetic construct constructo sintético EVQLVESGGALVKPGGSLRLSCAASGFTFSNAWMHWVRQAPGKQLEWVAQIKDRSQTYATYYAESVKGRFTISRDDSKNTLYLQMNSLKTEDTAVYYCRGVYYANTPFDYWGQGTLVTVSS 5 AA PAT source 1..5 mol_type protein organism synthetic construct constructo sintético NAWMH 20 AA PAT source 1..20 mol_type protein organism synthetic construct constructo sintético QIKDRSQTYATYYAESVKGR 12 AA PAT source 1..12 mol_type protein organism synthetic construct constructo sintético RGVYYANTPFDY 121 AA PAT source 1..121 mol_type protein organism synthetic construct constructo sintético EVQLVESGGALVKPGGSLRLSCAASGFTFTEAWMHWVRQAPGKQLEWVAQIKDRSQTYATYYAESVKGRFTISRDDSKNTLYLQMNSLKTEDTAVYYCRGVYYANAPFDYWGQGTLVTVSS 5 AA PAT source 1..5 mol_type protein organism synthetic construct constructo sintético EAWMH 20 AA PAT source 1..20 mol_type protein organism synthetic construct constructo sintético QIKDRSQTYATYYAESVKGR 12 AA PAT source 1..12 mol_type protein organism synthetic construct constructo sintético RGVYYANAPFDY 121 AA PAT source 1..121 mol_type protein organism synthetic construct constructo sintético EVQLVESGGALVKPGGSLRLSCAASGFTFTEAWMHWVRQAPGKQLEWVAQIKDRSQTYATYYAESVKGRFTISRDDSKNTLYLQMNSLKTEDTAVYYCRGVYYAVTPFDYWGQGTLVTVSS 5 AA PAT source 1..5 mol_type protein organism synthetic construct constructo sintético EAWMH 20 AA PAT source 1..20 mol_type protein organism synthetic construct constructo sintético QIKDRSQTYATYYAESVKGR 12 AA PAT source 1..12 mol_type protein organism synthetic construct constructo sintético RGVYYAVTPFDY 121 AA PAT source 1..121 mol_type protein organism synthetic construct constructo sintético EVQLVESGGALVKPGGSLRLSCAASGFTFTEAWMHWVRQAPGKQLEWVAQIKDRSQTYATYYAESVKGRFTISRDDSKNTLYLQMNSLKTEDTAVYYCRGVYYANTPFDYWGQGTLVTVSS 5 AA PAT source 1..5 mol_type protein organism synthetic construct constructo sintético EAWMH 20 AA PAT source 1..20 mol_type protein organism synthetic construct constructo sintético QIKDRSQTYATYYAESVKGR 12 AA PAT source 1..12 mol_type protein organism synthetic construct constructo sintético RGVYYANTPFDY 103 AA PAT source 1..103 mol_type protein organism Homo sapiens Homo sapiens ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSC 104 AA PAT source 1..104 mol_type protein organism Homo sapiens Homo sapiens LLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTIS 107 AA PAT source 1..107 mol_type protein organism Homo sapiens Homo sapiens GQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 330 AA PAT source 1..330 mol_type protein organism Homo sapiens Homo sapiens ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 106 AA PAT source 1..106 mol_type protein organism Homo sapiens Homo sapiens GQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS 107 AA PAT source 1..107 mol_type protein organism Homo sapiens Homo sapiens RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 106 AA PAT source 1..106 mol_type protein organism synthetic construct constructo sintético GQPKAAPSVTLFPPCSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTEVS 103 AA PAT source 1..103 mol_type protein organism synthetic construct constructo sintético ASTKGPSVCPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSV 6 AA PAT source 1..6 mol_type protein organism synthetic construct constructo sintético DDYAIG 17 AA PAT source 1..17 mol_type protein organism synthetic construct constructo sintético CIRVSDGSTYYADSVKG 22 AA PAT source 1..22 mol_type protein organism synthetic construct constructo sintético GSLYTCVQSIVWPARPYYDMDY 131 AA PAT source 1..131 mol_type protein organism synthetic construct constructo sintético EVQLLESGGGLVQPGGSLRLSCAASGFTFDDYAIGWFRQAPGKEREGVSCIRVSDGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAAGSLYTCVQSIVWPARPYYDMDYWGQGTLVTVSS 5 AA PAT source 1..5 mol_type protein organism synthetic construct constructo sintético GGGGS 6 AA PAT source 1..6 mol_type protein organism synthetic construct constructo sintético SGGGGS 10 AA PAT source 1..10 mol_type protein organism synthetic construct constructo sintético GGGGSGGGGS 6 AA PAT source 1..6 mol_type protein organism synthetic construct constructo sintético TDYAIG 6 AA PAT source 1..6 mol_type protein organism synthetic construct constructo sintético SDYAIG 131 AA PAT source 1..131 mol_type protein organism synthetic construct constructo sintético EVQLLESGGGLVQPGGSLRLSCAASGFTFTDYAIGWFRQAPGKEREGVSCIRVSDGSTYYADSVKGRFTISRDSSKNTLYLQMNSLRAEDTAVYYCAAGSLYTCVQSIVWPARPYYDMDYWGQGTLVTVSS 131 AA PAT source 1..131 mol_type protein organism synthetic construct constructo sintético EVQLLESGGGLVQPGGSLRLSCAASGFTFTDYAIGWFRQAPGKEREGVSCIRVSDGSTYYADSVKGRFTISRDNAKNTLYLQMNSLRAEDTAVYYCAAGSLYTCVQSIVWPARPYYDMDYWGQGTLVTVSS 131 AA PAT source 1..131 mol_type protein organism synthetic construct constructo sintético EVQLLESGGGLVQPGGSLRLSCAASGFTFSDYAIGWFRQAPGKEREGVSCIRVSDGSTYYADSVKGRFTISRDTSKNTLYLQMNSLRAEDTAVYYCAAGSLYTCVQSIVWPARPYYDMDYWGQGTLVTVSS