WO STEAP2TED-100-WO-PCT US 63/495.547 2023-04-11 MedImmune, LLC MedImmune, LLC Suzanne SITNIKOVA Suzanne SITNIKOVA STEAP2 DIRECTED T-CELL ENGAGERS AND COMPOSITIONS THEREOF ACTIVADORES DE CÉLULAS T DIRIGIDOS A STEAP2 Y COMPOSICIONES DE ESTOS 155 5 AA PAT source 1..5 mol_type protein note STEAP2 30D12 G96P VH CDR1 CDR1 de VH de 30D12 G96P de STEAP2 organism synthetic construct constructo sintético SYGMS 17 AA PAT source 1..17 mol_type protein note STEAP2 30D12 G96P VH CDR2 CDR2 de VH de 30D12 G96P de STEAP2 organism synthetic construct constructo sintético TISSGGSYTFYPDIMKG 13 AA PAT source 1..13 mol_type protein note STEAP2 30D12 G96P VH CDR3 CDR3 de VH de 30D12 G96P de STEAP2 organism synthetic construct constructo sintético RPYGTIYTFSFDA 16 AA PAT source 1..16 mol_type protein note STEAP2 30D12 G96P VL CDR1 CDR1 de VL de 30D12 G96P de STEAP2 organism synthetic construct constructo sintético RSSQSVVHSNANTYLE 7 AA PAT source 1..7 mol_type protein note STEAP2 30D12 G96P VL CDR2 CDR2 de VL de 30D12 G96P de STEAP2 organism synthetic construct constructo sintético KVSNRFS 9 AA PAT source 1..9 mol_type protein note STEAP2 30D12 G96P VL CDR3 CDR3 de VL de 30D12 G96P de STEAP2 organism synthetic construct constructo sintético FQGSHVPYT 122 AA PAT source 1..122 mol_type protein note STEAP2 30D12 G96P VH VH de 30D12 G96P de STEAP2 organism synthetic construct constructo sintético EVQLVESGGGLVKPGGSLRLSCAASGFTFSSYGMSWVRQAPGKRLEWVATISSGGSYTFYPDIMKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARRPYGTIYTFSFDAWGQGTTLTVSS 112 AA PAT source 1..112 mol_type protein note STEAP2 30D12 G96P VL VL de 30D12 G96P de STEAP2 organism synthetic construct constructo sintético DVVMTQSPLSLPVTLGQPASISCRSSQSVVHSNANTYLEWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSHVPYTFGQGTKLEIK 5 AA PAT source 1..5 mol_type protein note STEAP2-2 VH CDR1 CDR1 de VH de STEAP2-2 organism synthetic construct constructo sintético SYGMS 17 AA PAT source 1..17 mol_type protein note STEAP2-2 VH CDR2 CDR2 de VH de STEAP2-2 organism synthetic construct constructo sintético TISSGGSYTFYPDIMKG 13 AA PAT source 1..13 mol_type protein note STEAP2-2 VH CDR3 CDR3 de VH de STEAP2-2 organism synthetic construct constructo sintético RPYGTIYTFSFDS 16 AA PAT source 1..16 mol_type protein note STEAP2-2 VL CDR1 CDR1 de VL de STEAP2-2 organism synthetic construct constructo sintético RSSQSVVHSNGNTYLE 7 AA PAT source 1..7 mol_type protein note STEAP2-2 VL CDR2 CDR2 de VL de STEAP2-2 organism synthetic construct constructo sintético KVSNRFS 9 AA PAT source 1..9 mol_type protein note STEAP2-2 VL CDR3 CDR3 de VL de STEAP2-2 organism synthetic construct constructo sintético FQGSHVPYT 122 AA PAT source 1..122 mol_type protein note STEAP2-2 G96P VH VH de G96P de STEAP2-2 organism synthetic construct constructo sintético EVQLVESGGDLVKPGGSLKLSCAASGFSFSSYGMSWVRQTPDKRLEWVATISSGGSYTFYPDIMKGRFTISRDNAMNTLYLQMSSLKSEDSAMYYCARRPYGTIYTFSFDSWGQGTTLTVSS 112 AA PAT source 1..112 mol_type protein note STEAP2-2 VL VL de STEAP2-2 organism synthetic construct constructo sintético DVLMTQTPLSLPVSLGDQASISCRSSQSVVHSNGNTYLEWYLQKPGQSPKLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDLGVYYCFQGSHVPYTFGGGTKLEIK 5 AA PAT source 1..5 mol_type protein note STEAP2-2 Humanized2 VH CDR1 CDR1 de VH humanizado 2 de STEAP2-2 organism synthetic construct constructo sintético SYGMS 17 AA PAT source 1..17 mol_type protein note STEAP2-2 Humanized2 VH CDR2 CDR2 de VH humanizado 2 de STEAP2-2 organism synthetic construct constructo sintético TISSGGSYTFYPDIMKG 13 AA PAT source 1..13 mol_type protein note STEAP2-2 Humanized2 G96P VH CDR3 CDR3 de VH G96P humanizado 2 de STEAP2-2 organism synthetic construct constructo sintético RPYGTIYTFSFDA 16 AA PAT source 1..16 mol_type protein note STEAP2-2 Humanized2 VL CDR1 CDR1 de VL humanizado 2 de STEAP2-2 organism synthetic construct constructo sintético RSSQSVVHSNANTYLE 7 AA PAT source 1..7 mol_type protein note STEAP2-2 Humanized2 VL CDR2 CDR2 de VL humanizado 2 de STEAP2-2 organism synthetic construct constructo sintético KVSNRFS 9 AA PAT source 1..9 mol_type protein note STEAP2-2 Humanized2 VL CDR3 CDR3 de VL humanizado 2 de STEAP2-2 organism synthetic construct constructo sintético FQGSHVPYT 122 AA PAT source 1..122 mol_type protein note STEAP2-2 G96P VH VH de G96P de STEAP2-2 organism synthetic construct constructo sintético EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYGMSWVRQAPGKRLEWVSTISSGGSYTFYPDIMKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARRPYGTIYTFSFDAWGQGTTLTVSS 112 AA PAT source 1..112 mol_type protein note STEAP2-2 Humanized2 VL VL humanizado 2 de STEAP2-2 organism synthetic construct constructo sintético DVVMTQSPLSLPVTLGQPASISCRSSQSVVHSNANTYLEWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSHVPYTFGQGTKLEIK 219 AA PAT source 1..219 mol_type protein note 30D12-TED3 Light Chain 30D12-TED3 Cadena ligera organism synthetic construct constructo sintético DVVMTQSPLSLPVTLGQPASISCRSSQSVVHSNANTYLEWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSHVPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVECLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 452 AA PAT source 1..452 mol_type protein note 30D12-TED/TED3 hole heavy chain 30D12-TED/TED/TED3 cadena pesada de ojal organism synthetic construct constructo sintético EVQLVESGGGLVKPGGSLRLSCAASGFTFSSYGMSWVRQAPGKRLEWVATISSGGSYTFYPDIMKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARRPYGTIYTFSFDAWGQGTTLTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLKSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPASIEKTISKAKGQPREPQVCTLPPSREEMTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 16 AA PAT source 1..16 mol_type protein note CD3 Vk17 CDR1 CD3 Vk17 CDR1 organism synthetic construct constructo sintético RSSQSLVHNTGNTYLS 7 AA PAT source 1..7 mol_type protein note CD3 Vk17 CDR2 CD3 Vk17 CDR2 organism synthetic construct constructo sintético KVSNRAS 9 AA PAT source 1..9 mol_type protein note CD3 Vk17 CDR3 CD3 Vk17 CDR3 organism synthetic construct constructo sintético GQGTQAPFT 112 AA PAT source 1..112 mol_type protein note Vk17 Vk17 organism synthetic construct constructo sintético DIVMTQSPLSLPVTPGEPASISCRSSQSLVHNTGNTYLSWYLQKPGQSPQSLIYKVSNRASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCGQGTQAPFTFGSGTKVEIK 16 AA PAT source 1..16 mol_type protein note CD3 Vk29 CDR1 CDR1 de CD3 Vk29 organism synthetic construct constructo sintético RSSQSLVHNTGNTYLS 7 AA PAT source 1..7 mol_type protein note CD3 Vk29 CDR2 CD3 Vk29 CDR2 organism synthetic construct constructo sintético KVSNRAS 9 AA PAT source 1..9 mol_type protein note CD3 Vk29 CDR3 CDR3 de CD3 Vk29 organism synthetic construct constructo sintético GQGTQFPFT 112 AA PAT source 1..112 mol_type protein note Vk29 Vk29 organism synthetic construct constructo sintético DIVMTQSPLSLPVTPGEPASISCRSSQSLVHNTGNTYLSWYLQKPGQSPQSLIYKVSNRASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCGQGTQFPFTFGSGTKVEIK 218 AA PAT source 1..218 mol_type protein note TED3 CD3 Light Chain K29 TED3 CD3 Cadena ligera K29 organism synthetic construct constructo sintético DIVMTQSPLSLPVTPGEPASISCRSSQSLVHNTGNTYLSWYLQKPGQSPQSLIYKVSNRASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCGQGTQFPFTFGSGTKVEIKGQPKAAPSVRLFPPCSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTEVS 5 AA PAT source 1..5 mol_type protein note CD3 VH CDR1 SN75 CDR1 SN75 de CD3 VH organism synthetic construct constructo sintético NAWMH 20 AA PAT source 1..20 mol_type protein note CD3 VH CDR2 SN75 CDR2 SN75 de CD3 VH organism synthetic construct constructo sintético QIKDRSQTYATYYAESVKGR 12 AA PAT source 1..12 mol_type protein note CD3 VH CDR3 SN75 CDR3 SN75 de CD3 VH organism synthetic construct constructo sintético RGVYYANAPFDY 121 AA PAT source 1..121 mol_type protein note CD3 VH SN75 SN75 de CD3 VH organism synthetic construct constructo sintético EVQLVESGGALVKPGGSLRLSCAASGFTFSNAWMHWVRQAPGKQLEWVAQIKDRSQTYATYYAESVKGRFTISRDDSKNTLYLQMNSLKTEDTAVYYCRGVYYANAPFDYWGQGTLVTVSS 5 AA PAT source 1..5 mol_type protein note CD3 VH CDR1 SN79 CDR1 SN79 de CD3 VH organism synthetic construct constructo sintético NAWMH 20 AA PAT source 1..20 mol_type protein note CD3 VH CDR2 SN79 CDR2 SN79 de CD3 VH organism synthetic construct constructo sintético QIKDRSQTYATYYAESVKGR 12 AA PAT source 1..12 mol_type protein note CD3 VH CDR3 SN79 CDR3 SN79 de CD3 VH organism synthetic construct constructo sintético RGVYYAVTPFDY 121 AA PAT source 1..121 mol_type protein note CD3 VH SN79 SN79 de CD3 VH organism synthetic construct constructo sintético EVQLVESGGALVKPGGSLRLSCAASGFTFSNAWMHWVRQAPGKQLEWVAQIKDRSQTYATYYAESVKGRFTISRDDSKNTLYLQMNSLKTEDTAVYYCRGVYYAVTPFDYWGQGTLVTVSS 5 AA PAT source 1..5 mol_type protein note CD3 VH CDR1 E75 CDR1 E75 de CD3 VH organism synthetic construct constructo sintético EAWMH 20 AA PAT source 1..20 mol_type protein note CD3 VH CDR2 E75 CDR2 E75 de CD3 VH organism synthetic construct constructo sintético QIKDRSQTYATYYAESVKGR 12 AA PAT source 1..12 mol_type protein note CD3 VH CDR3 E75 CDR3 E75 de CD3 VH organism synthetic construct constructo sintético RGVYYANAPFDY 121 AA PAT source 1..121 mol_type protein note CD3 VH E75 CD3 VH E75 organism synthetic construct constructo sintético EVQLVESGGALVKPGGSLRLSCAASGFTFTEAWMHWVRQAPGKQLEWVAQIKDRSQTYATYYAESVKGRFTISRDDSKNTLYLQMNSLKTEDTAVYYCRGVYYANAPFDYWGQGTLVTVSS 5 AA PAT source 1..5 mol_type protein note CD8 VH CDR1 CDR1 de VH de CD8 organism synthetic construct constructo sintético DFGMN 17 AA PAT source 1..17 mol_type protein note CD8 VH CDR2 CDR2 de VH de CD8 organism synthetic construct constructo sintético LIYYDGSNKFYADSVKG 12 AA PAT source 1..12 mol_type protein note CD8 VH CDR3 CDR3 de VH de CD8 organism synthetic construct constructo sintético PHYDGYYHFFDS 11 AA PAT source 1..11 mol_type protein note CD8 VL CDR1 CDR1 de VL de CD8 organism synthetic construct constructo sintético KGSQDINNYLA 7 AA PAT source 1..7 mol_type protein note CD8 VL CDR2 CDR2 de VL de CD8 organism synthetic construct constructo sintético NTDILHT 8 AA PAT source 1..8 mol_type protein note CD8 VL CDR3 CDR3 de VL de CD8 organism synthetic construct constructo sintético YQYNNGYT 106 AA PAT source 1..106 mol_type protein note CD8 VL VL de CD8 organism synthetic construct constructo sintético DIQMTQSPSSLSASVGDRVTITCKGSQDINNYLAWYQQKPGKAPKLLIYNTDILHTGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCYQYNNGYTFGQGTKVEIK 213 AA PAT source 1..213 mol_type protein note CD8 LC VL SEQ ID NO: 54 + mutant Ck SEQ ID NO: 64 VL de CD8 LC sec. con núm. de ident. 54 + Ck mutante sec. con núm. de ident. 64 organism synthetic construct constructo sintético DIQMTQSPSSLSASVGDRVTITCKGSQDINNYLAWYQQKPGKAPKLLIYNTDILHTGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCYQYNNGYTFGQGTKVEIKRTVAAPSVFIFPPCDEQLKSGTASVKCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEV 121 AA PAT source 1..121 mol_type protein note CD8 VH VH de CD8 organism synthetic construct constructo sintético QVQLVESGGGVVQPGRSLRLSCAASGFTFSDFGMNWVRQAPGKGLEWVALIYYDGSNKFYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKPHYDGYYHFFDSWGQGTLVTVSS 104 AA PAT source 1..104 mol_type protein note CD8 CH1 CH1-portion of SEQ ID NO: 78 w/ S183E CH1 de CD8 CH1-porción de sec. con núm. de ident. 78 c/ S183E organism synthetic construct constructo sintético ASTKGPSVCPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLESVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSVD 686 AA PAT source 1..686 mol_type protein note knob HC SEQ ID NO: 56 CD8 VH + SEQ ID NO: 57 CD8 CH1 + SEQ ID NO: 89 linker + SEQ ID NO: 39 CD3 VH SN75 + SEQ ID NO: 79 IgG1 HC HC botón sec. con núm. de ident.: 56 CD8 VH + sec. con núm. de ident.: 57 CH1 de CD8 + enlazador en la sec. con núm. de ident.: 89 + sec. con núm. de ident.: 39 CD3 VH SN75 + sec. con núm. de ident.: 79 HC de IgG1 organism synthetic construct constructo sintético QVQLVESGGGVVQPGRSLRLSCAASGFTFSDFGMNWVRQAPGKGLEWVALIYYDGSNKFYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKPHYDGYYHFFDSWGQGTLVTVSSASTKGPSVCPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLESVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSVDGGGGSGGGGSEVQLVESGGALVKPGGSLRLSCAASGFTFSNAWMHWVRQAPGKQLEWVAQIKDRSQTYATYYAESVKGRFTISRDDSKNTLYLQMNSLKTEDTAVYYCRGVYYANAPFDYWGQGTLVTVSSASTKGPSVCPLAPSSKSTSGGTADLGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSVDKTHTCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPASIEKTISKAKGQPREPQVYTLPPCREEMTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 106 AA PAT source 1..106 mol_type protein note wt C[lambda] C ts [lambda] organism synthetic construct constructo sintético GQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS 106 AA PAT source 1..106 mol_type protein note V12 C[lambda] (S122C, C212V) V12 C [lambda] (S122C, C212V) organism synthetic construct constructo sintético GQPKAAPSVTLFPPCSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTEVS 106 AA PAT source 1..106 mol_type protein note V12C[lambda] of SEQ ID NO: 60 w/ T117R V12C [lambda] de sec. con núm. de ident. 60 con T117R organism synthetic construct constructo sintético GQPKAAPSVRLFPPCSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTEVS 107 AA PAT source 1..107 mol_type protein note wt Ck Ck ts organism synthetic construct constructo sintético RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 107 AA PAT source 1..107 mol_type protein note wt Ck of SEQ ID NO: 62 w/ V133E Ck ts de sec. con núm. de ident. 62 c/ V133E organism synthetic construct constructo sintético RTVAAPSVFIFPPSDEQLKSGTASVECLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 107 AA PAT source 1..107 mol_type protein note mutant Ck S121C, V133K, C214V Ck mutante S121C, V133K, C214V organism synthetic construct constructo sintético RTVAAPSVFIFPPCDEQLKSGTASVKCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEV 103 AA PAT source 1..103 mol_type protein note IgG1 wt CH1 CH1 ts de IgG1 organism synthetic construct constructo sintético ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSC 103 AA PAT source 1..103 mol_type protein note V12 CH1 (F126C, C220V) CH1 de V12 (F126C, C220V) organism synthetic construct constructo sintético ASTKGPSVCPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSV 103 AA PAT source 1..103 mol_type protein note wt CH1 of SEQ ID NO: 65 w/ S183K CH1 ts de sec. con núm. de ident. 65 con S183K organism synthetic construct constructo sintético ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLKSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSC 104 AA PAT source 1..104 mol_type protein note IgG1 wt CH2 CH2 ts de IgG1 organism synthetic construct constructo sintético LLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTIS 104 AA PAT source 1..104 mol_type protein note wt CH2 of SEQ ID NO: 68 w/ L234F, L235E, and P331S CH2 ts de sec. con núm. de ident. 68 con L234F, L235E y P331S organism synthetic construct constructo sintético FEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPASIEKTIS 107 AA PAT source 1..107 mol_type protein note IgG1wt CH3 CH3 de IgG1 ts organism synthetic construct constructo sintético GQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 330 AA PAT source 1..330 mol_type protein note IgG1 wt constant domain HC HC de dominio constante IgG1 ts organism synthetic construct constructo sintético ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 107 AA PAT source 1..107 mol_type protein note IgG1 CH3 T366S, L368A, Y407V [hole] CH3 de IgG1 T366S, L368A, Y407V [ojal] organism synthetic construct constructo sintético GQPREPQVYTLPPSREEMTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 107 AA PAT source 1..107 mol_type protein note IgG1 CH3 Y349C T366S, L368A, Y407V IgG1 CH3 Y349C T366S, L368A, Y407V organism synthetic construct constructo sintético GQPREPQVCTLPPSREEMTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 107 AA PAT source 1..107 mol_type protein note IgG1 CH3 T366W [knob] CH3 de IgG1 T366W [botón] organism synthetic construct constructo sintético GQPREPQVYTLPPSREEMTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 107 AA PAT source 1..107 mol_type protein note IgG1 CH3 S354C, T366W CH3 de IgG1 S354C, T366W organism synthetic construct constructo sintético GQPREPQVYTLPPCREEMTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 330 AA PAT source 1..330 mol_type protein note IgG1 hole T366S, L368A, Y407V, Y349C Ojal IgG1 T366S, L368A, Y407V, Y349C organism synthetic construct constructo sintético ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVCTLPPSREEMTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 330 AA PAT source 1..330 mol_type protein note IgG1 HC knob CH1, CH2, CH3 T366W, S354C CH1, CH2, CH3 T366W, S354C botón HC de IgG1 organism synthetic construct constructo sintético ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCREEMTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 330 AA PAT source 1..330 mol_type protein note V12 with stabilizing cysteine, interchain cysteine mutations, and knob mutations : T366W, F126C, C220V, S354C V12 con cisteína estabilizadora, mutaciones de cisteína intercatenaria, y mutaciones de botón: T366W, F126C, C220V, S354C organism synthetic construct constructo sintético ASTKGPSVCPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSVDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCREEMTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 330 AA PAT source 1..330 mol_type protein note SEQ ID NO: 78 w/ A141D, L234F, L235E, P331S sec. con núm. de ident. 78 con A141D, L234F, L235E, P331S organism synthetic construct constructo sintético ASTKGPSVCPLAPSSKSTSGGTADLGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSVDKTHTCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPASIEKTISKAKGQPREPQVYTLPPCREEMTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 330 AA PAT source 1..330 mol_type protein note IgG1 hole w/ CH1 F126C, C220V + CH2/CH3 of SEQ ID NO: 76 IgG1 ojal con CH1 F126C, C220V + CH2/CH3 de sec. con núm. de ident. 76 organism synthetic construct constructo sintético ASTKGPSVCPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSVDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVCTLPPSREEMTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 686 AA PAT source 1..686 mol_type protein note STEAP2/CD3 knob HC: SEQ ID NO: 7 VH STEAP2 + SEQ ID NO: 67 wt CH1 w/ S183K + D + SEQ ID NO: 86 linker + SEQ ID NO: 39 CD3 VH SN75 + SEQ ID NO: 82. HC de STEAP2/CD3 botón: sec. con núm. de ident. 7 VH de STEAP2 + sec. con núm. de ident. 67 CH1 ts c/ S183K + D + enlazador en la sec. con núm. de ident. 86 + sec. con núm. de ident. 39 CD3 VH SN75 + sec. con núm. de ident. 82. organism synthetic construct constructo sintético EVQLVESGGGLVKPGGSLRLSCAASGFTFSSYGMSWVRQAPGKRLEWVATISSGGSYTFYPDIMKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARRPYGTIYTFSFDAWGQGTTLTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLKSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDGGGGSGGGGSEVQLVESGGALVKPGGSLRLSCAASGFTFSNAWMHWVRQAPGKQLEWVAQIKDRSQTYATYYAESVKGRFTISRDDSKNTLYLQMNSLKTEDTAVYYCRGVYYANAPFDYWGQGTLVTVSSASTKGPSVCPLAPSSKSTSGGTADLGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSVDKTHTCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVKHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCREEMTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 329 AA PAT source 1..329 mol_type protein note CH1 w/ A141D, CH2, being IgG2 at 233-236, S267K, and wt P at 331; CH3 S354C, T366W. CH1 c/A141D, CH2, es IgG2 en 233-236, S267K, y P ts en 331; CH3 S354C, T366W. organism synthetic construct constructo sintético ASTKGPSVCPLAPSSKSTSGGTADLGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSVDKTHTCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVKHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCREEMTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 131 AA PAT source 1..131 mol_type protein note CD8 VHH VHH de CD8 organism synthetic construct constructo sintético EVQLLESGGGLVQPGGSLRLSCAASGFTFDDYAIGWFRQAPGKEREGVSCIRVSDGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAAGSLYTCVQSIVWPARPYYDMDYWGQGTLVTVSS 6 AA PAT source 1..6 mol_type protein note CD8 VHH CDR1 CDR1 de VHH de CD8 organism synthetic construct constructo sintético DDYAIG 17 AA PAT source 1..17 mol_type protein note CD8 VHH CDR2 CDR2 de VHH de CD8 organism synthetic construct constructo sintético CIRVSDGSTYYADSVKG 22 AA PAT source 1..22 mol_type protein note CD8 VHH CDR3 CDR3 de VHH de CD8 organism synthetic construct constructo sintético GSLYTCVQSIVWPARPYYDMDY 592 AA PAT source 1..592 mol_type protein note hole CD8 VHH STEAP2 HC: SEQ ID NO: 83 CD8 VHH + SEQ ID NO: 89 linker + SEQ ID NO: 7 STEAP2 VH + SEQ ID NO: 88 HC de VHH de CD8 de STEAP2 ojal: sec. con núm. de ident.: 83 VHH de CD8 + enlazador en la sec. con núm. de ident.: 89 + sec. con núm. de ident.: 7 VH de STEAP2 + sec. con núm. de ident.: 88 organism synthetic construct constructo sintético EVQLLESGGGLVQPGGSLRLSCAASGFTFDDYAIGWFRQAPGKEREGVSCIRVSDGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAAGSLYTCVQSIVWPARPYYDMDYWGQGTLVTVSSGGGGSGGGGSEVQLVESGGGLVKPGGSLRLSCAASGFTFSSYGMSWVRQAPGKRLEWVATISSGGSYTFYPDIMKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARRPYGTIYTFSFDAWGQGTTLTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLKSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVKHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVCTLPPSREEMTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 329 AA PAT source 1..329 mol_type protein note IgG1 hole of SEQ ID NO: 76 w/ S183K, CH2 being IgG2 at 233-236, and S267K IgG1 ojal de la sec. con núm. de ident.: 76 c/S183K, CH2 estando IgG2 en 233-236, y S267K organism synthetic construct constructo sintético ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLKSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVKHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVCTLPPSREEMTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 5 AA PAT source 1..5 mol_type protein note linker enlazador organism synthetic construct constructo sintético GGGGS 225 AA PAT source 1..225 mol_type protein note STEAP2 VH + CH1: SEQ ID NO: 7 + SEQ ID NO: 67 VH + CH1 de STEAP2: sec. con núm. de ident.: 7 + sec. con núm. de ident.: 67 organism synthetic construct constructo sintético EVQLVESGGGLVKPGGSLRLSCAASGFTFSSYGMSWVRQAPGKRLEWVATISSGGSYTFYPDIMKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARRPYGTIYTFSFDAWGQGTTLTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLKSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSC 330 AA PAT source 1..330 mol_type protein note STEAP2 hole CH1 SEQ ID NO: 67, CH2 SEQ ID NO: 69, CH3 SEQ ID NO: 73 CH1 de STEAP2 ojal sec. con núm. de ident.: 67, CH2 sec. con núm. de ident.: 69, CH3 sec. con núm. de ident.: 73 organism synthetic construct constructo sintético ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLKSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPASIEKTISKAKGQPREPQVCTLPPSREEMTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 451 AA PAT source 1..451 mol_type protein note knob HC for TED SEQ ID NO: 39 CD3 VH SN75 + SEQ ID NO: 79 IgG1 HC ojal HC para TED sec. con núm. de ident.: 39 CD3 VH SN75 + sec. con núm. de ident.: 79 HC de IgG1 organism synthetic construct constructo sintético EVQLVESGGALVKPGGSLRLSCAASGFTFSNAWMHWVRQAPGKQLEWVAQIKDRSQTYATYYAESVKGRFTISRDDSKNTLYLQMNSLKTEDTAVYYCRGVYYANAPFDYWGQGTLVTVSSASTKGPSVCPLAPSSKSTSGGTADLGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSVDKTHTCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPASIEKTISKAKGQPREPQVYTLPPCREEMTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 451 AA PAT source 1..451 mol_type protein note hole STEAP2 HC for TED2: SEQ ID NO: 7 STEAP2 VH + SEQ ID NO: 88 HC STEAP2 ojal para TED2: Sec. con núm. de ident.: 7 + sec. con núm. de ident.: 88 organism synthetic construct constructo sintético EVQLVESGGGLVKPGGSLRLSCAASGFTFSSYGMSWVRQAPGKRLEWVATISSGGSYTFYPDIMKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARRPYGTIYTFSFDAWGQGTTLTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLKSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVKHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVCTLPPSREEMTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 13 AA PAT source 1..13 mol_type protein note STEAP2-2 Humanized1 VH CDR3 CDR3 de VH humanizado 1 de STEAP2-2 organism synthetic construct constructo sintético RGYGTIYTFSFDA 122 AA PAT source 1..122 mol_type protein note STEAP2-2 Humanized1 VH VH humanizado 1 de STEAP2-2 organism synthetic construct constructo sintético EVQLVESGGGLVKPGGSLRLSCAASGFTFSSYGMSWVRQAPGKRLEWVATISSGGSYTFYPDIMKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARRGYGTIYTFSFDAWGQGTTLTVSS 13 AA PAT source 1..13 mol_type protein note STEAP2-2 VH CDR3 CDR3 de VH de STEAP2-2 organism synthetic construct constructo sintético RGYGTIYTFSFDS 122 AA PAT source 1..122 mol_type protein note STEAP2-2 VH VH de STEAP2-2 organism synthetic construct constructo sintético EVQLVESGGDLVKPGGSLKLSCAASGFSFSSYGMSWVRQTPDKRLEWVATISSGGSYTFYPDIMKGRFTISRDNAMNTLYLQMSSLKSEDSAMYYCARRGYGTIYTFSFDSWGQGTTLTVSS 13 AA PAT source 1..13 mol_type protein note STEAP2-2 Humanized2 VH CDR3 CDR3 de VH humanizado 2 de STEAP2-2 organism synthetic construct constructo sintético RGYGTIYTFSFDA 122 AA PAT source 1..122 mol_type protein note STEAP2-2 Humanized2 VH VH humanizado 2 de STEAP2-2 organism synthetic construct constructo sintético EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYGMSWVRQAPGKRLEWVSTISSGGSYTFYPDIMKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARRGYGTIYTFSFDAWGQGTTLTVSS 11 AA PAT source 1..11 mol_type protein note STEAP2-8 VL CDR1 CDR1 de VL de STEAP2-8 organism synthetic construct constructo sintético RASQSVASNLA 7 AA PAT source 1..7 mol_type protein note STEAP2-8 VL CDR2 CDR2 de VL de STEAP2-8 organism synthetic construct constructo sintético GASTRAT 9 AA PAT source 1..9 mol_type protein note STEAP2-8 VL CDR3 CDR3 de VL de STEAP2-8 organism synthetic construct constructo sintético QQYNNWPFT 7 AA PAT source 1..7 mol_type protein note STEAP2-8 VH CDR1 CDR1 de VH de STEAP2-8 organism synthetic construct constructo sintético RNSAVWN 18 AA PAT source 1..18 mol_type protein note STEAP2-8 VH CDR2 CDR2 de VH de STEAP2-8 organism synthetic construct constructo sintético RTYYRSKWYNDYAPSVKS 13 AA PAT source 1..13 mol_type protein note STEAP2-8 VH CDR3 CDR3 de VH de STEAP2-8 organism synthetic construct constructo sintético GLRQNQFYYYMDV 125 AA PAT source 1..125 mol_type protein note STEAP2-8 VH VH de STEAP2-8 organism synthetic construct constructo sintético QVQLQQSGPGLVKPSQTLSLTCAISGDSVSRNSAVWNWIRQSPSRGLEWLGRTYYRSKWYNDYAPSVKSRITINPDTSKNQFSLQLNSVTPEDTAVYYCARGLRQNQFYYYMDVWGKGTTVTVSS 107 AA PAT source 1..107 mol_type protein note STEAP2-8 VL VL de STEAP2-8 organism synthetic construct constructo sintético EIVMTQSPATLSVSPGERATLSCRASQSVASNLAWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYNNWPFTFGPGTKVDIK 11 AA PAT source 1..11 mol_type protein note STEAP2 40A3 VL CDR1 CDR1 de VL 40A3 de STEAP2 organism synthetic construct constructo sintético RASQSVNSNLA 7 AA PAT source 1..7 mol_type protein note STEAP2 40A3 VL CDR2 CDR2 de VL 40A3 de STEAP2 organism synthetic construct constructo sintético GASTRAT 9 AA PAT source 1..9 mol_type protein note STEAP2 40A3 VL CDR3 CDR3 de VL 40A3 de STEAP2 organism synthetic construct constructo sintético QQYNNWPFT 7 AA PAT source 1..7 mol_type protein note STEAP2 40A3 VH CDR1 CDR1 de VH 40A3 de STEAP2 organism synthetic construct constructo sintético RNSAVWN 18 AA PAT source 1..18 mol_type protein note STEAP2 40A3 VH CDR2 CDR2 de VH 40A3 de STEAP2 organism synthetic construct constructo sintético RTYYRSKWYNDYAVSVKS 13 AA PAT source 1..13 mol_type protein note STEAP2 40A3 VH CDR3 CDR3 de VH 40A3 de STEAP2 organism synthetic construct constructo sintético GLLQNNFYYYMDV 125 AA PAT source 1..125 mol_type protein note STEAP2 40A3 VH VH 40A3 de STEAP2 organism synthetic construct constructo sintético QVQLQQSGPGLVKPSQTLSLTCAISGDSVSRNSAVWNWIRQSPSRGLEWLGRTYYRSKWYNDYAVSVKSRITINPDTSKNQFSLQVNSVTPEDTAVYYCARGLLQNNFYYYMDVWGKGTTVTVSS 107 AA PAT source 1..107 mol_type protein note STEAP2 40A3 VL VL 40A3 de STEAP2 organism synthetic construct constructo sintético EIVMTQSPATLSVSPGERATLSCRASQSVNSNLAWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYNNWPFTFGPGTKVDIK 219 AA PAT source 1..219 mol_type protein note STEAP2 LC: SEQ ID NO: 16 + SEQ ID NO: 63 [wt Ck w/ V133E] STEAP2 LC: Sec. con núm. de ident.: 16 + sec. con núm. de ident.: 63 [Cκ ts c/V133E] organism synthetic construct constructo sintético DVLMTQTPLSLPVSLGDQASISCRSSQSVVHSNGNTYLEWYLQKPGQSPKLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDLGVYYCFQGSHVPYTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVECLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 219 AA PAT source 1..219 mol_type protein note STEAP2 LC: SEQ ID NO: 24 + SEQ ID NO: 63 [wt Ck w/ V133E] STEAP2 LC: Sec. con núm. de ident.: 24 + sec. con núm. de ident.: 63 [Cκ ts c/V133E] organism synthetic construct constructo sintético DVVMTQSPLSLPVTLGQPASISCRSSQSVVHSNANTYLEWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSHVPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVECLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 214 AA PAT source 1..214 mol_type protein note STEAP2 LC: SEQ ID NO: 107 + SEQ ID NO: 63 [wt Ck] w/ V133E] STEAP2 LC: Sec. con núm. de ident.: 107 + sec. con núm. de ident.: 63 [Cκ ts] c/V133E] organism synthetic construct constructo sintético EIVMTQSPATLSVSPGERATLSCRASQSVASNLAWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYNNWPFTFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVECLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 214 AA PAT source 1..214 mol_type protein note STEAP2 LC: SEQ ID NO: 115 + SEQ ID NO: 63 [wt Ck w/ V133E] STEAP2 LC: Sec. con núm. de ident.: 115 + sec. con núm. de ident.: 63 [Cκ ts c/V133E] organism synthetic construct constructo sintético EIVMTQSPATLSVSPGERATLSCRASQSVNSNLAWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYNNWPFTFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVECLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 452 AA PAT source 1..452 mol_type protein note STEAP2 HC hole: STEAP2 VH SEQ ID NO: 15 + SEQ ID NO: 67 wt CH1 w/ S183K + SEQ ID NO: 69 + SEQ ID NO: 73 HC de STEAP2 ojal: VH de STEAP2 sec. con núm. de ident.: 15 + sec. con núm. de ident.: 67 CH1 ts c/S183K + sec. con núm. de ident.: 69 + sec. con núm. de ident.: 73 organism synthetic construct constructo sintético EVQLVESGGDLVKPGGSLKLSCAASGFSFSSYGMSWVRQTPDKRLEWVATISSGGSYTFYPDIMKGRFTISRDNAMNTLYLQMSSLKSEDSAMYYCARRPYGTIYTFSFDSWGQGTTLTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLKSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPASIEKTISKAKGQPREPQVCTLPPSREEMTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 452 AA PAT source 1..452 mol_type protein note STEAP2 HC hole: STEAP2 VH SEQ ID NO: 23 + SEQ ID NO: 67 wt CH1 w/ S183K + SEQ ID NO: 69 + SEQ ID NO: 73 HC de STEAP2 ojal: VH de STEAP2 sec. con núm. de ident.: 23 + sec. con núm. de ident.: 67 CH1 ts C/S183K + sec. con núm. de ident.: 69 + sec. con núm. de ident.: 73 organism synthetic construct constructo sintético EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYGMSWVRQAPGKRLEWVSTISSGGSYTFYPDIMKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARRPYGTIYTFSFDAWGQGTTLTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLKSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPASIEKTISKAKGQPREPQVCTLPPSREEMTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 452 AA PAT source 1..452 mol_type protein note STEAP2 HC hole: STEAP2 VH SEQ ID NO: 95 + SEQ ID NO: 67 wt CH1 w/ S183K + SEQ ID NO: 69 + SEQ ID NO: 73 HC de STEAP2 ojal: VH de STEAP2 sec. con núm. de ident.: 95 + sec. con núm. de ident.: 67 CH1 ts C/S183K + sec. con núm. de ident.: 69 + sec. con núm. de ident.: 73 organism synthetic construct constructo sintético EVQLVESGGGLVKPGGSLRLSCAASGFTFSSYGMSWVRQAPGKRLEWVATISSGGSYTFYPDIMKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARRGYGTIYTFSFDAWGQGTTLTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLKSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPASIEKTISKAKGQPREPQVCTLPPSREEMTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 452 AA PAT source 1..452 mol_type protein note STEAP2 HC hole: STEAP2 VH SEQ ID NO: 97 + SEQ ID NO: 67 + SEQ ID NO: 69 + SEQ ID NO: 73 HC de STEAP2 ojal: VH de STEAP2 sec. con núm. de ident.: 97 + sec. con núm. de ident.: 67 + sec. con núm. de ident.: 69 + sec. con núm. de ident.: 73 organism synthetic construct constructo sintético EVQLVESGGDLVKPGGSLKLSCAASGFSFSSYGMSWVRQTPDKRLEWVATISSGGSYTFYPDIMKGRFTISRDNAMNTLYLQMSSLKSEDSAMYYCARRGYGTIYTFSFDSWGQGTTLTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLKSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPASIEKTISKAKGQPREPQVCTLPPSREEMTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 452 AA PAT source 1..452 mol_type protein note STEAP2 HC hole: STEAP2 VH SEQ ID NO: 99 + SEQ ID NO: 67 + SEQ ID NO: 69 + SEQ ID NO: 73 HC de STEAP2 ojal: VH de STEAP2 sec. con núm. de ident.: 99 + sec. con núm. de ident.: 67 + sec. con núm. de ident.: 69 + sec. con núm. de ident.: 73 organism synthetic construct constructo sintético EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYGMSWVRQAPGKRLEWVSTISSGGSYTFYPDIMKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARRGYGTIYTFSFDAWGQGTTLTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLKSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPASIEKTISKAKGQPREPQVCTLPPSREEMTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 455 AA PAT source 1..455 mol_type protein note STEAP2 HC hole: STEAP2 VH SEQ ID NO: 106 + SEQ ID NO: 67 + SEQ ID NO: 69 + SEQ ID NO: 73 HC de STEAP2 ojal: VH de STEAP2 sec. con núm. de ident.: 106 + sec. con núm. de ident.: 67 + sec. con núm. de ident.: 69 + sec. con núm. de ident.: 73 organism synthetic construct constructo sintético QVQLQQSGPGLVKPSQTLSLTCAISGDSVSRNSAVWNWIRQSPSRGLEWLGRTYYRSKWYNDYAPSVKSRITINPDTSKNQFSLQLNSVTPEDTAVYYCARGLRQNQFYYYMDVWGKGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLKSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPASIEKTISKAKGQPREPQVCTLPPSREEMTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 455 AA PAT source 1..455 mol_type protein note STEAP2 HC hole: STEAP2 VH SEQ ID NO: 114 + SEQ ID NO: 67 + SEQ ID NO: 69 + SEQ ID NO: 73 HC de STEAP2 ojal: VH de STEAP2 sec. con núm. de ident.: 114 + sec. con núm. de ident.: 67 + sec. con núm. de ident.: 69 + sec. con núm. de ident.: 73 organism synthetic construct constructo sintético QVQLQQSGPGLVKPSQTLSLTCAISGDSVSRNSAVWNWIRQSPSRGLEWLGRTYYRSKWYNDYAVSVKSRITINPDTSKNQFSLQVNSVTPEDTAVYYCARGLLQNNFYYYMDVWGKGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLKSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPASIEKTISKAKGQPREPQVCTLPPSREEMTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 7 AA PAT source 1..7 mol_type protein note STEAP2-3 VH CDR1 CDR1 de VH de STEAP2-3 organism synthetic construct constructo sintético RNSAVWN 18 AA PAT source 1..18 mol_type protein note STEAP2-3 VH CDR2 CDR2 de VH de STEAP2-3 organism synthetic construct constructo sintético RTYYRSKWYNDYAVSVKS 13 AA PAT source 1..13 mol_type protein note STEAP2-3 VH CDR3 CDR3 de VH de STEAP2-3 organism synthetic construct constructo sintético GLLQNQFYYYMDV 11 AA PAT source 1..11 mol_type protein note STEAP2-3 VL CDR1(40A3GL-LO7) CDR1 de VL de STEAP2-3 (40A3GL-LO7) organism synthetic construct constructo sintético RASQSVSSNLA 7 AA PAT source 1..7 mol_type protein note STEAP2-3 VL CDR2 CDR2 de VL de STEAP2-3 organism synthetic construct constructo sintético GASTRAT 9 AA PAT source 1..9 mol_type protein note STEAP2-3 VL CDR3 CDR3 de VL de STEAP2-3 organism synthetic construct constructo sintético QQYNNWPFT 125 AA PAT source 1..125 mol_type protein note STEAP2-3 VH VH de STEAP2-3 organism synthetic construct constructo sintético QVQLQQSGPGLVKPSQTLSLTCAISGDSVSRNSAVWNWIRQSPSRGLEWLGRTYYRSKWYNDYAVSVKSRITINPDTSKNQFSLQLNSVTPEDTAVYYCARGLLQNQFYYYMDVWGKGTTVTVSS 107 AA PAT source 1..107 mol_type protein note STEAP2-3 VL VL de STEAP2-3 organism synthetic construct constructo sintético EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYNNWPFTFGPGTKVDIK 7 AA PAT source 1..7 mol_type protein note 40A3GL-LO11 VH CDR 1 CDR 1 de VH de 40A3GL-LO11 organism synthetic construct constructo sintético RNSAVWN 18 AA PAT source 1..18 mol_type protein note 40A3GL-LO11 VH CDR 2 CDR 2 de VH de 40A3GL-LO11 organism synthetic construct constructo sintético RTYYRSKWYNDYAPSVKS 13 AA PAT source 1..13 mol_type protein note 40A3GL-LO11 VH CDR 3 CDR 3 de VH de 40A3GL-LO11 organism synthetic construct constructo sintético GLLQNQFYYYMDV 11 AA PAT source 1..11 mol_type protein note 40A3GL-LO11 VL CDR 1 CDR 1 de VL de 40A3GL-LO11 organism synthetic construct constructo sintético RASQSVASNLA 7 AA PAT source 1..7 mol_type protein note 40A3GL-LO11 VL CDR 2 CDR 2 de VL de 40A3GL-LO11 organism synthetic construct constructo sintético GASTRAT 9 AA PAT source 1..9 mol_type protein note 40A3GL-LO11 VL CDR 3 CDR 3 de VL de 40A3GL-LO11 organism synthetic construct constructo sintético QQYNNWPFT 125 AA PAT source 1..125 mol_type protein note 40A3GL-LO11 VH VH de 40A3GL-LO11 organism synthetic construct constructo sintético QVQLQQSGPGLVKPSQTLSLTCAISGDSVSRNSAVWNWIRQSPSRGLEWLGRTYYRSKWYNDYAPSVKSRITINPDTSKNQFSLQLNSVTPEDTAVYYCARGLLQNQFYYYMDVWGKGTTVTVSS 107 AA PAT source 1..107 mol_type protein note 40A3GL-LO11 VL VL de 40A3GL-LO11 organism synthetic construct constructo sintético EIVMTQSPATLSVSPGERATLSCRASQSVASNLAWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYNNWPFTFGPGTKVDIK 7 AA PAT source 1..7 mol_type protein note STEAP2 40A3 LO12 VH CDR1 CDR1 de VH de 40A3 LO12 de STEAP2 organism synthetic construct constructo sintético RNSAVWN 18 AA PAT source 1..18 mol_type protein note STEAP2 40A3 LO12 VH CDR2 CDR2 de VH de 40A3 LO12 de STEAP2 organism synthetic construct constructo sintético RTYYRSKWYNDYAVSVKS 13 AA PAT source 1..13 mol_type protein note STEAP2 40A3 LO12 VH CDR3 CDR3 de VH de 40A3 LO12 de STEAP2 organism synthetic construct constructo sintético GLRQNQFYYYMDV 11 AA PAT source 1..11 mol_type protein note STEAP240A3 LO12 VL CDR1 CDR1 de VL de 40A3 LO12 de STEAP2 organism synthetic construct constructo sintético RASQSVASNLA 7 AA PAT source 1..7 mol_type protein note STEAP2a40A3 LO12 VL CDR2 CDR2 de VL de LO12 de STEAP2a40A3 organism synthetic construct constructo sintético GASTRAT 9 AA PAT source 1..9 mol_type protein note STEAP2a 40A3 LO12 VL CDR3 CDR3 de VL de 40A3 LO12 de STEAP2a organism synthetic construct constructo sintético QQYNNWPFT 125 AA PAT source 1..125 mol_type protein note STEAP2 VH 40A3 LO12 VH de 40A3 LO12 de STEAP2 organism synthetic construct constructo sintético QVQLQQSGPGLVKPSQTLSLTCAISGDSVSRNSAVWNWIRQSPSRGLEWLGRTYYRSKWYNDYAVSVKSRITINPDTSKNQFSLQLNSVTPEDTAVYYCARGLRQNQFYYYMDVWGKGTTVTVSS 107 AA PAT source 1..107 mol_type protein note STEAP2 VL 40A3 LO12 VL de 40A3 LO12 de STEAP2 organism synthetic construct constructo sintético EIVMTQSPATLSVSPGERATLSCRASQSVASNLAWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYNNWPFTFGPGTKVDIK 689 AA PAT source 1..689 mol_type protein note TED4 LO12 Knob Heavy Chain Cadena pesada TED4 LO12 botón organism synthetic construct constructo sintético QVQLQQSGPGLVKPSQTLSLTCAISGDSVSRNSAVWNWIRQSPSRGLEWLGRTYYRSKWYNDYAVSVKSRITINPDTSKNQFSLQLNSVTPEDTAVYYCARGLRQNQFYYYMDVWGKGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLKSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDGGGGSGGGGSEVQLVESGGALVKPGGSLRLSCAASGFTFTEAWMHWVRQAPGKQLEWVAQIKDRSQTYATYYAESVKGRFTISRDDSKNTLYLQMNSLKTEDTAVYYCRGVYYANAPFDYWGQGTLVTVSSASTKGPSVCPLAPSSKSTSGGTADLGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSVDKTHTCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVKHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCREEMTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 214 AA PAT source 1..214 mol_type protein note TED4 LO12 Kappa Chain Cadena Kappa TED4 LO12 organism synthetic construct constructo sintético EIVMTQSPATLSVSPGERATLSCRASQSVASNLAWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYNNWPFTFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVECLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 595 AA PAT source 1..595 mol_type protein note TED4 LO12 hole Heavy Chain Cadena pesada TED4 LO12 ojal organism synthetic construct constructo sintético EVQLLESGGGLVQPGGSLRLSCAASGFTFDDYAIGWFRQAPGKEREGVSCIRVSDGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAAGSLYTCVQSIVWPARPYYDMDYWGQGTLVTVSSGGGGSGGGGSQVQLQQSGPGLVKPSQTLSLTCAISGDSVSRNSAVWNWIRQSPSRGLEWLGRTYYRSKWYNDYAVSVKSRITINPDTSKNQFSLQLNSVTPEDTAVYYCARGLRQNQFYYYMDVWGKGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLKSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVKHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVCTLPPSREEMTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 218 AA PAT source 1..218 mol_type protein note TED4 LO12 Lambda Chain Cadena Lambda TED4 LO12 organism synthetic construct constructo sintético DIVMTQSPLSLPVTPGEPASISCRSSQSLVHNTGNTYLSWYLQKPGQSPQSLIYKVSNRASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCGQGTQAPFTFGSGTKVEIKGQPKAAPSVRLFPPCSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTEVS 13 AA PAT source 1..13 mol_type protein note IgG1 Hinge Bisagra IgG1 organism synthetic construct constructo sintético DKTHTCPPCPAPE