WO STEAP2ADC-100-WO-PCT US 63/495.545 2023-04-11 MedImmune, LLC MedImmune, LLC Darlene MONLISH Darlene MONLISH STEAP2 ANTIBODY DRUG CONJUGATES AND USES THEREOF CONJUGADOS ANTICUERPO-FÁRMACO DE STEAP2 Y USOS DE ESTOS 60 7 AA PAT source 1..7 mol_type protein note 40A3GL-LO14 VH CDR 1 CDR 1 de VH de 40A3GL-LO14 organism synthetic construct constructo sintético RNSAVWN 18 AA PAT source 1..18 mol_type protein note 40A3GL-LO14 VH CDR 2 CDR 2 de VH de 40A3GL-LO14 organism synthetic construct constructo sintético RTYYRSKWYNDYAPSVKS 13 AA PAT source 1..13 mol_type protein note 40A3GL-LO14 VH CDR 3 CDR 3 de VH de 40A3GL-LO14 organism synthetic construct constructo sintético GLRQNQFYYYMDV 11 AA PAT source 1..11 mol_type protein note 40A3GL-LO14 VL CDR 1 CDR 1 de VL de 40A3GL-LO14 organism synthetic construct constructo sintético RASQSVASNLA 7 AA PAT source 1..7 mol_type protein note 40A3GL-LO14 VL CDR 2 CDR 2 de VL de 40A3GL-LO14 organism synthetic construct constructo sintético GASTRAT 9 AA PAT source 1..9 mol_type protein note 40A3GL-LO14 VL CDR 3 CDR 3 de VL de 40A3GL-LO14 organism synthetic construct constructo sintético QQYNNWPFT 7 AA PAT source 1..7 mol_type protein note 40A3GL-LO11 VH CDR 1 CDR 1 de VH de 40A3GL-LO11 organism synthetic construct constructo sintético RNSAVWN 18 AA PAT source 1..18 mol_type protein note 40A3GL-LO11 VH CDR 2 CDR 2 de VH de 40A3GL-LO11 organism synthetic construct constructo sintético RTYYRSKWYNDYAPSVKS 13 AA PAT source 1..13 mol_type protein note 40A3GL-LO11 VH CDR 3 CDR 3 de VH de 40A3GL-LO11 organism synthetic construct constructo sintético GLLQNQFYYYMDV 11 AA PAT source 1..11 mol_type protein note 40A3GL-LO11 VL CDR 1 CDR 1 de VL de 40A3GL-LO11 organism synthetic construct constructo sintético RASQSVASNLA 7 AA PAT source 1..7 mol_type protein note 40A3GL-LO11 VL CDR 2 CDR 2 de VL de 40A3GL-LO11 organism synthetic construct constructo sintético GASTRAT 9 AA PAT source 1..9 mol_type protein note 40A3GL-LO11 VL CDR 3 CDR 3 de VL de 40A3GL-LO11 organism synthetic construct constructo sintético QQYNNWPFT 7 AA PAT source 1..7 mol_type protein note STEAP2 VH CDR1 CDR1 de VH de STEAP2 organism synthetic construct constructo sintético RNSAVWN 18 AA PAT source 1..18 mol_type protein note STEAP2 VH CDR2 CDR2 de VH de STEAP2 organism synthetic construct constructo sintético RTYYRSKWYNDYAVSVKS 13 AA PAT source 1..13 mol_type protein note STEAP2 VH CDR3 CDR3 de VH de STEAP2 organism synthetic construct constructo sintético GLLQNNFYYYMDV 11 AA PAT source 1..11 mol_type protein note STEAP2 VL CDR1 (40A3) CDR1 de VL de STEAP2 (40A3) organism synthetic construct constructo sintético RASQSVNSNLA 7 AA PAT source 1..7 mol_type protein note STEAP2 VL CDR2 CDR2 de VL de STEAP2 organism synthetic construct constructo sintético GASTRAT 9 AA PAT source 1..9 mol_type protein note STEAP2 VL CDR3 CDR3 de VL de STEAP2 organism synthetic construct constructo sintético QQYNNWPFT 7 AA PAT source 1..7 mol_type protein note STEAP2-3 VH CDR1 CDR1 de VH de STEAP2-3 organism synthetic construct constructo sintético RNSAVWN 18 AA PAT source 1..18 mol_type protein note STEAP2-3 VH CDR2 CDR2 de VH de STEAP2-3 organism synthetic construct constructo sintético RTYYRSKWYNDYAVSVKS 13 AA PAT source 1..13 mol_type protein note STEAP2-3 VH CDR3 CDR3 de VH de STEAP2-3 organism synthetic construct constructo sintético GLLQNQFYYYMDV 11 AA PAT source 1..11 mol_type protein note STEAP2-3 VL CDR1(40A3GL-LO7) CDR1 de VL de STEAP2-3 (40A3GL-LO7) organism synthetic construct constructo sintético RASQSVSSNLA 7 AA PAT source 1..7 mol_type protein note STEAP2-3 VL CDR2 CDR2 de VL de STEAP2-3 organism synthetic construct constructo sintético GASTRAT 9 AA PAT source 1..9 mol_type protein note STEAP2-3 VL CDR3 CDR3 de VL de STEAP2-3 organism synthetic construct constructo sintético QQYNNWPFT 5 AA PAT source 1..5 mol_type protein note Humanized STEAP2-2 VH CDR1 CDR1 de VH de STEAP2-2 humanizado organism synthetic construct constructo sintético SYGMS 17 AA PAT source 1..17 mol_type protein note Humanized STEAP2-2 VH CDR2 CDR2 de VH de STEAP2-2 humanizado organism synthetic construct constructo sintético TISSGGSYTFYPDIMKG 13 AA PAT source 1..13 mol_type protein note Humanized STEAP2-2 VH CDR3 CDR3 de VH de STEAP2-2 humanizado organism synthetic construct constructo sintético RGYGTIYTFSFDA 16 AA PAT source 1..16 mol_type protein note Humanized STEAP2-2 VL CDR1 CDR1 de VL de STEAP2-2 humanizado organism synthetic construct constructo sintético RSSQSVVHSNANTYLE 7 AA PAT source 1..7 mol_type protein note Humanized STEAP2-2 VL CDR2 CDR2 de VL de STEAP2-2 humanizado organism synthetic construct constructo sintético KVSNRFS 9 AA PAT source 1..9 mol_type protein note Humanized STEAP2-2 VL CDR3 CDR3 de VL de STEAP2-2 humanizado organism synthetic construct constructo sintético FQGSHVPYT 125 AA PAT source 1..125 mol_type protein note 40A3GL-LO14 VH VH de 40A3GL-LO14 organism synthetic construct constructo sintético QVQLQQSGPGLVKPSQTLSLTCAISGDSVSRNSAVWNWIRQSPSRGLEWLGRTYYRSKWYNDYAPSVKSRITINPDTSKNQFSLQLNSVTPEDTAVYYCARGLRQNQFYYYMDVWGKGTTVTVSS 107 AA PAT source 1..107 mol_type protein note 40A3GL-LO14 VL VL de 40A3GL-LO14 organism synthetic construct constructo sintético EIVMTQSPATLSVSPGERATLSCRASQSVASNLAWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYNNWPFTFGPGTKVDIK 125 AA PAT source 1..125 mol_type protein note 40A3GL-LO11 VH VH de 40A3GL-LO11 organism synthetic construct constructo sintético QVQLQQSGPGLVKPSQTLSLTCAISGDSVSRNSAVWNWIRQSPSRGLEWLGRTYYRSKWYNDYAPSVKSRITINPDTSKNQFSLQLNSVTPEDTAVYYCARGLLQNQFYYYMDVWGKGTTVTVSS 107 AA PAT source 1..107 mol_type protein note 40A3GL-LO11 VL VL de 40A3GL-LO11 organism synthetic construct constructo sintético EIVMTQSPATLSVSPGERATLSCRASQSVASNLAWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYNNWPFTFGPGTKVDIK 125 AA PAT source 1..125 mol_type protein note STEAP2 VH VH de STEAP2 organism synthetic construct constructo sintético QVQLQQSGPGLVKPSQTLSLTCAISGDSVSRNSAVWNWIRQSPSRGLEWLGRTYYRSKWYNDYAVSVKSRITINPDTSKNQFSLQVNSVTPEDTAVYYCARGLLQNNFYYYMDVWGKGTTVTVSS 107 AA PAT source 1..107 mol_type protein note STEAP2 VL VL de STEAP2 organism synthetic construct constructo sintético EIVMTQSPATLSVSPGERATLSCRASQSVNSNLAWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYNNWPFTFGPGTKVDIK 125 AA PAT source 1..125 mol_type protein note STEAP2-3 VH VH de STEAP2-3 organism synthetic construct constructo sintético QVQLQQSGPGLVKPSQTLSLTCAISGDSVSRNSAVWNWIRQSPSRGLEWLGRTYYRSKWYNDYAVSVKSRITINPDTSKNQFSLQLNSVTPEDTAVYYCARGLLQNQFYYYMDVWGKGTTVTVSS 107 AA PAT source 1..107 mol_type protein note STEAP2-3 VL VL de STEAP2-3 organism synthetic construct constructo sintético EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYNNWPFTFGPGTKVDIK 122 AA PAT source 1..122 mol_type protein note Humanized STEAP2-2 VH VH de STEAP2-2 humanizado organism synthetic construct constructo sintético EVQLVESGGGLVKPGGSLRLSCAASGFTFSSYGMSWVRQAPGKRLEWVATISSGGSYTFYPDIMKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARRGYGTIYTFSFDAWGQGTTLTVSS 112 AA PAT source 1..112 mol_type protein note Humanized STEAP2-2 VL VL de STEAP2-2 humanizado organism synthetic construct constructo sintético DVVMTQSPLSLPVTLGQPASISCRSSQSVVHSNANTYLEWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSHVPYTFGQGTKLEIK 455 AA PAT source 1..455 mol_type protein note 40A3GL-LO14 Heavy chain (L234F/L235E/P331S) Cadena pesada 40A3GL-LO14 (L234F/L235E/P331S) organism synthetic construct constructo sintético QVQLQQSGPGLVKPSQTLSLTCAISGDSVSRNSAVWNWIRQSPSRGLEWLGRTYYRSKWYNDYAPSVKSRITINPDTSKNQFSLQLNSVTPEDTAVYYCARGLRQNQFYYYMDVWGKGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPASIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 214 AA PAT source 1..214 mol_type protein note 40A3GL-LO14 Light chain Cadena ligera 40A3GL-LO14 organism synthetic construct constructo sintético EIVMTQSPATLSVSPGERATLSCRASQSVASNLAWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYNNWPFTFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 455 AA PAT source 1..455 mol_type protein note 40A3GL-LO11 Heavy chain (L234F/L235E/P331S) Cadena pesada 40A3GL-LO11 (L234F/L235E/P331S) organism synthetic construct constructo sintético QVQLQQSGPGLVKPSQTLSLTCAISGDSVSRNSAVWNWIRQSPSRGLEWLGRTYYRSKWYNDYAPSVKSRITINPDTSKNQFSLQLNSVTPEDTAVYYCARGLLQNQFYYYMDVWGKGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPASIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 214 AA PAT source 1..214 mol_type protein note 40A3GL-LO11 Light chain Cadena ligera 40A3GL-LO11 organism synthetic construct constructo sintético EIVMTQSPATLSVSPGERATLSCRASQSVASNLAWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYNNWPFTFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 120 AA PAT source 1..120 mol_type protein note STEAP2-4 VH VH de STEAP2-4 organism synthetic construct constructo sintético EVQLVESGGGLVQPGGSLRLSCAASGFTFSSFAMTWVRQAPGKGLEWVSVITYSGGRTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYFCAKDRIAAVGPFDYWGQGTLVTVSS 107 AA PAT source 1..107 mol_type protein note STEAP2-4 VL VL de STEAP2-4 organism synthetic construct constructo sintético DIQLTQSPSFLSASVGDRVTITCRASQGISVYLAWYQQEPGKAPKLLIYAASTLQSGVPSRFSGSGSGTEFTLTISSLQPEDFATYYCQQLNSYPRTFGQGTKVEIK 116 AA PAT source 1..116 mol_type protein note STEAP2-5 VH VH de STEAP2-5 organism synthetic construct constructo sintético QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYGISWVRQAPGQGLEWMGWISGYTGNTNYAQKLQGRVTMTADTSTSTAYMELRSLRSDDTAVYYCARGGSYFDYWGQGTLVTVSS 108 AA PAT source 1..108 mol_type protein note STEAP2-5 VL VL de STEAP2-5 organism synthetic construct constructo sintético DIQMTQSPSTLSASVGDRVTITCRASQSISRWLAWYQQKPGKAPKLLIYKASSLESGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQFNSFSPITFGQGTRLEIK 117 AA PAT source 1..117 mol_type protein note STEAP2-6 VH VH de STEAP2-6 organism synthetic construct constructo sintético QVQLQQPGAELVKPGASVKLSCKASGYTFTSYWMEWVKQRPGQGLEWIGMIHPNSGITNYNERFKNKATLTVDKSSSTAYMQLSSLTSEDSAVYYCARDHYYILAYWGQGTLVTVSA 112 AA PAT source 1..112 mol_type protein note STEAP2-6 VL VL de STEAP2-6 organism synthetic construct constructo sintético DVLMTQTPLSLPVSLGDQASISCRSSQSVVHSNGNTYLEWYLQKPGQSPKLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDLGVYYCFQGSHVPYTFGGGTKLEIK 120 AA PAT source 1..120 mol_type protein note STEAP2-7 VH VH de STEAP2-7 organism synthetic construct constructo sintético QVQLQQPGADLVKPGASVKMSCKASGHTFTNYWVTWVKQRPGQGLEWIGNFYPGSGIIKYNENFRSKATLTVDISSSTAYMQLSSLTSEDSAVYYCARSKLGDSFYFDYWGQGTTLTVSS 112 AA PAT source 1..112 mol_type protein note STEAP2-7 VL VL de STEAP2-7 organism synthetic construct constructo sintético DVVMTQTPLSLPVSLGNQASISCRSSQSLVHSNGNTYLHWYLQKPGQSPKLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDLGVYFCSQSTHVPLTFGAGTKLEIK 330 AA PAT source 1..330 mol_type protein note Wild type Constant Region Región constante silvestre organism synthetic construct constructo sintético ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 330 AA PAT source 1..330 mol_type protein note Triple Mutation (TM)Variant IgG1 Constant Region ((L234F/L235E/P331S) Región constante (L234F/L235E/P331S) variante IgG1 de triple mutación (TM) organism synthetic construct constructo sintético ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPASIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 455 AA PAT source 1..455 mol_type protein note 40A3GL-LO14 VH with Wild Type IgG1 Fc VH de 40A3GL-LO14 con IgG1 Fc silvestre organism synthetic construct constructo sintético QVQLQQSGPGLVKPSQTLSLTCAISGDSVSRNSAVWNWIRQSPSRGLEWLGRTYYRSKWYNDYAPSVKSRITINPDTSKNQFSLQLNSVTPEDTAVYYCARGLRQNQFYYYMDVWGKGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 6821 DNA PAT source 1..6821 mol_type other DNA note STEAP2 Nucleotide Sequence Secuencia de nucleótidos STEAP2 organism synthetic construct constructo sintético agtcagcgttcctcgggccctcggcgccacgagctgtccgggcacgcagcccctagcggcgcgtcgctgccaagccggcctccgcgcgcctccctccttccttctcccctggctgttcgcgatccagcttgggtaggcggggaagcagctggagtgcgaccgccgcggcagccaccctgcaaccgccagtcggagagctaagggcaagtcctgaggttgggcccaggagaaagaaggcaaggagacattgtcccaggatattcttggtgatcttggaagtgtccgtatcatggaatcaatctctatgatgggaagccctaagagccttagtgaaacttttttacctaatggcataaatggtatcaaagatgcaaggaaggtcactgtaggtgtgattggaagtggagattttgccaaatccttgaccattcgacttattagatgcggctatcatgtggtcataggaagtagaaatcctaagtttgcttctgaattttttcctcatgtggtagatgtcactcatcatgaagatgctctcacaaaaacaaatataatatttgttgctatacacagagaacattatacctccctgtgggacctgagacatctgcttgtgggtaaaatcctgattgatgtgagcaataacatgaggataaaccagtacccagaatccaatgctgaatatttggcttcattattcccagattctttgattgtcaaaggatttaatgttgtctcagcttgggcacttcagttaggacctaaggatgccagccggcaggtttatatatgcagcaacaatattcaagcgcgacaacaggttattgaacttgcccgccagttgaatttcattcccattgacttgggatccttatcatcagccagagagattgaaaatttacccctacgactctttactctctggagagggccagtggtggtagctataagcttggccacattttttttcctttattcctttgtcagagatgtgattcatccatatgctagaaaccaacagagtgacttttacaaaattcctatagagattgtgaataaaaccttacctatagttgccattactttgctctccctagtatacctcgcaggtcttctggcagctgcttatcaactttattacggcaccaagtataggagatttccaccttggttggaaacctggttacagtgtagaaaacagcttggattactaagttttttcttcgctatggtccatgttgcctacagcctctgcttaccgatgagaaggtcagagagatatttgtttctcaacatggcttatcagcaggttcatgcaaatattgaaaactcttggaatgaggaagaagtttggagaattgaaatgtatatctcctttggcataatgagccttggcttactttccctcctggcagtcacttctatcccttcagtgagcaatgctttaaactggagagaattcagttttattcagtctacacttggatatgtcgctctgctcataagtactttccatgttttaatttatggatggaaacgagcttttgaggaagagtactacagattttatacaccaccaaactttgttcttgctcttgttttgccctcaattgtaattctgggtaagattattttattccttccatgtataagccgaaagctaaaacgaattaaaaaaggctgggaaaagagccaatttctggaagaaggtatgggaggaacaattcctcatgtctccccggagagggtcacagtaatgtgatgacaaatggtgttcacagctgccatataaagttctactcatgccattatttttatgacttctacgttcagttacaagtatgctgtcaaattatcgtgggttgaaacttgttaaatgagatttcaactgacttagtgatagagttttcttcaagttaattttcacaaatgtcatgtttgccaatatgaatttttctagtcaacatattattgtaatttaggtatgttttgttttgttttgcacaactgtaaccctgttgttactttatatttcataatcaggcaaaaatacttacagttaataatatagatataatgttaaaaacaatttgcaaaccagcagaattttaagcttttaaaataattcaatggatatacatttttttctgaagattaagattttaattattcaacttaaaaagtagaaatgcattattatacatttttttaagaaaggacacgttatgttagcatctaggtaaggctgcatgatagcattcctatatttctctcataaaataggatttgaaggatgaaattaattgtatgaagcaatgtgattatatgaagagacacaaattaaaaagacaaattaaacctgaaattatatttaaaatatatttgagacatgaaatacatactgataatacatacctcatgaaagattttattctttattgtgttacagagcagtttcattttcatattaatatactgatcaggaagaggattcagtaacatttggcttccaaaactgctatctctaatacggtaccaatcctaggaactgtatactagttcctacttagaacaaaagtatcaagtttgcacacaagtaatctgccagctgacctttgtcgcaccttaaccagtcaccacttgctatggtataggattatactgatgttctttgagggattctgatgtgctaggcatggttctaagtactttacttgtattatcccatttaatacttagaacaaccccgtgagataagtagttattatcctcattttacacatgagggaccgaaggatagaaaagttatttttcaaaggtcttgcagttaataaatggcagagtgagcattcaagtccaggtagtcatattccagaggccacggttttaaccactaggctctagagctcccgccgcgcccctatgcattatgttcacaatgccaatctagatgcttcctcttttgtataaagtcactgacattctttagagtgggttgggtgcatccaaaaatgtataaaaatattattataataaacttattactgcttgtagggtaattcacagttacttaccctattcttgcttggaacatgagcctggagacccatggcagtccatatgcctccctatgcagtgaagggccctagcagtgttaacaaattgctgagatcccacggagtctttcaaaaatctctgtagagttagtcttctccttttctcttcctgagaagttctcctgcctgcataaccattcattagggagtactttacaagcatgaaggatattagggtaagtggctaattataaatctactctagagacatataatcatacagattattcataaaatttttcagtgctgtccttccacatttaattgcattttgctcaaactgtagaatgccctacattccccccaccccaatttgctatttccttattaaaatagaaaattataggcaagatacaattatatgcgttcctcttcctgaaattataacatttctaaacttacccacgtaggtactactgaatccaactgccaacaataaaaagacttttatttagtagaggctacctttcccaccagtgactctttttctacaactgccttgtcagtttggtaattcacttatgattttctaatgttctcttggtgaattttattatcttgtaccctctttttttttttttttttttttaaagacagagtcttgctctgtcacccaggctggagtgcagtggcacgatctcggctcactgcaagctctgcctcccgggttcacgccattctcctgcctcagcctcccgagtagctgggactacaggtgcccgccaccatgcccggctgatttctttttgtatttttagtagagacggagtttcaccgtgttagccaggatggtctcgatctcctgacctcgtgatccgcccgccttggcctccaaagtgctgggattacaggtgtgagctaccgcgcccggcctattatcttgtactttctaactgagccctctattttctttattttaataatatttctccccacttgagaatcacttgttagttcttggtaggaattcagttgggcaatgataacttttatgggcaaaaacattctattatagtgaactaatgaaaataacagcgtattttcaatattttcttattccttaaattccactcttttaacactatgcttaaccacttaatgtgatgaaatattcctaaaagttaaatgactattaaagcatatattgttgcatgtatatattaagtagccgatactctaaataaaaataccactgttacagataaatggggcctttaaaaatatgaaaaacaaacttgtgaaaatgtataaaagatgcatctgttgtttcaaatggcactatcttcttttcagtactacaaaaacagaataattttgaagttttagaataaatgtaatatatttactataattctaaatgtttaaatgcttttctaaaaatgcaaaactatgatgtttagttgctttattttacctctatgtgattatttttcttaattgttattttttataatcattatttttctgaaccattcttctggcctcagaagtaggactgaattctactattgctaggtgtgagaaagtggtggtgagaaccttagagcagtggagatttgctacctggtctgtgttttgagaagtgccccttagaaagttaaaagaatgtagaaaagatactcagtcttaatcctatgcaaaaaaaaaaatcaagtaattgttttcctatgaggaaaataaccatgagctgtatcatgctacttagcttttatgtaaatatttcttatgtctcctctattaagagtatttaaaatcatatttaaatatgaatctattcatgctaacattatttttcaaaacatacatggaaatttagcccagattgtctacatataaggtttttatttgaattgtaaaatatttaaaagtatgaataaaatatatttataggtatttatcagagatgattattttgtgctacatacaggttggctaatgagctctagtgttaaactacctgattaatttcttataaagcagcataaccttggcttgattaaggaattctactttcaaaaattaatctgataatagtaacaaggtatattatactttcattacaatcaaattatagaaattacttgtgtaaaagggcttcaagaatatatccaatttttaaatattttaatatatctcctatctgataacttaattcttctaaattaccacttgccattaagctatttcataataaattctgtacagtttccccccaaaaaagagatttatttatgaaatatttaaagtttctaatgtggtattttaaataaagtatcataaatgtaataagtaaatatttatttaggaatactgtgaacactgaactaattattcctgtgtcagtctatgaaatccctgttttgaaatacgtaaacagcctaaaatgtgttgaaattattttgtaaatccatgacttaaaacaagatacatacatagtataacacacctcacagtgttaagatttatattgtgaaatgagacaccctaccttcaattgttcatcagtgggtaaaacaaattctgatgtacattcaggacaaatgattagccctaaatgaaactgtaataatttcagtggaaactcaatctgtttttacctttaaacagtgaattttacatgaatgaatgggttcttcactttttttttagtatgagaaaattatacagtgcttaattttcagagattctttccatatgttactaaaaaatgttttgttcagcctaacatactgagttttttttaactttctaaattattgaatttccatcatgcattcatccaaaattaaggcagactgtttggattcttccagtggccagatgagctaaattaaatcacaaaagcagatgcttttgtatgatctccaaattgccaactttaaggaaatattctcttgaaattgtctttaaagatcttttgcagctttgcagatacccagactgagctggaactggaatttgtcttcctattgactctacttctttaaaagcggctgcccattacattcctcagctgtccttgcagttaggtgtacatgtgactgagtgttggccagtgagatgaagtctcctcaaaggaaggcagcatgtgtcctttttcatcccttcatcttgctgctgggattgtggatataacaggagccctggcagctgtctccagaggatcaaagccacacccaaagagtaaggcagattagagaccagaaagaccttgactacttccctacttccactgctttttcctgcatttaagccattgtaaatctgggtgtgttacatgaagtgaaaattaattctttctgcccttcagttctttatcctgataccatttaacactgtctgaattaactagactgcaataattctttcttttgaaagcttttaaaggataatgtgcaattcacattaaaattgattttccattgtcaattagttatactcattttcctgccttgatctttcattagatattttgtatctgcttggaatatattatcttctttttaactgtgtaattggtaattactaaaactctgtaatctccaaaatattgctatcaaattacacaccatgttttctatcattctcatagatctgccttataaacatttaaataaaaagtactatttaatgatttaacttctgttttgaaatgttgtatacacgtggatttttttctcattaaataataattctagtatttga 490 AA PAT source 1..490 mol_type protein note STEAP2 Sequence Secuencia STEAP2 organism synthetic construct constructo sintético MESISMMGSPKSLSETFLPNGINGIKDARKVTVGVIGSGDFAKSLTIRLIRCGYHVVIGSRNPKFASEFFPHVVDVTHHEDALTKTNIIFVAIHREHYTSLWDLRHLLVGKILIDVSNNMRINQYPESNAEYLASLFPDSLIVKGFNVVSAWALQLGPKDASRQVYICSNNIQARQQVIELARQLNFIPIDLGSLSSAREIENLPLRLFTLWRGPVVVAISLATFFFLYSFVRDVIHPYARNQQSDFYKIPIEIVNKTLPIVAITLLSLVYLAGLLAAAYQLYYGTKYRRFPPWLETWLQCRKQLGLLSFFFAMVHVAYSLCLPMRRSERYLFLNMAYQQVHANIENSWNEEEVWRIEMYISFGIMSLGLLSLLAVTSIPSVSNALNWREFSFIQSTLGYVALLISTFHVLIYGWKRAFEEEYYRFYTPPNFVLALVLPSIVILGKIILFLPCISRKLKRIKKGWEKSQFLEEGMGGTIPHVSPERVTVM 107 AA PAT source 1..107 mol_type protein note Kappa Light Chain Constant Region Región constante de la cadena ligera Kappa organism synthetic construct constructo sintético RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 227 AA PAT source 1..227 mol_type protein note FC comprising a L234F/L235E/P331S triple mutation (TM) FC que comprende una mutación triple L234F/L235E/P331S (TM) organism synthetic construct constructo sintético DKTHTCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPASIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 227 AA PAT source 1..227 mol_type protein note Wild Type Fc of IgG1 Fc silvestre de IgG1 organism synthetic construct constructo sintético DKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK