16266.6000-00000 US 63/495,561 2023-04-12 FUSION PHARMACEUTICALS INC. FUSION PHARMACEUTICALS INC. STEAP2-TARGETED COMPOUNDS AND USE THEREOF COMPUESTOS DIRIGIDOS A LA STEAP2 Y USO DE ESTOS 40 7 AA PAT source 1..7 mol_type protein organism synthetic construct constructo sintético RNSAVWN 18 AA PAT source 1..18 mol_type protein organism synthetic construct constructo sintético RTYYRSKWYNDYAPSVKS 13 AA PAT source 1..13 mol_type protein organism synthetic construct constructo sintético GLRQNQFYYYMDV 125 AA PAT source 1..125 mol_type protein organism synthetic construct constructo sintético QVQLQQSGPGLVKPSQTLSLTCAISGDSVSRNSAVWNWIRQSPSRGLEWLGRTYYRSKWYNDYAPSVKSRITINPDTSKNQFSLQLNSVTPEDTAVYYCARGLRQNQFYYYMDVWGKGTTVTVSS 455 AA PAT source 1..455 mol_type protein organism synthetic construct constructo sintético QVQLQQSGPGLVKPSQTLSLTCAISGDSVSRNSAVWNWIRQSPSRGLEWLGRTYYRSKWYNDYAPSVKSRITINPDTSKNQFSLQLNSVTPEDTAVYYCARGLRQNQFYYYMDVWGKGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPASIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 11 AA PAT source 1..11 mol_type protein organism synthetic construct constructo sintético RASQSVASNLA 7 AA PAT source 1..7 mol_type protein organism synthetic construct constructo sintético GASTRAT 9 AA PAT source 1..9 mol_type protein organism synthetic construct constructo sintético QQYNNWPFT 107 AA PAT source 1..107 mol_type protein organism synthetic construct constructo sintético EIVMTQSPATLSVSPGERATLSCRASQSVASNLAWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYNNWPFTFGPGTKVDIK 214 AA PAT source 1..214 mol_type protein organism synthetic construct constructo sintético EIVMTQSPATLSVSPGERATLSCRASQSVASNLAWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYNNWPFTFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 7 AA PAT source 1..7 mol_type protein organism synthetic construct constructo sintético RNSAVWN 18 AA PAT source 1..18 mol_type protein organism synthetic construct constructo sintético RTYYRSKWYNDYAPSVKS 13 AA PAT source 1..13 mol_type protein organism synthetic construct constructo sintético GLLQNQFYYYMDV 125 AA PAT source 1..125 mol_type protein organism synthetic construct constructo sintético QVQLQQSGPGLVKPSQTLSLTCAISGDSVSRNSAVWNWIRQSPSRGLEWLGRTYYRSKWYNDYAPSVKSRITINPDTSKNQFSLQLNSVTPEDTAVYYCARGLLQNQFYYYMDVWGKGTTVTVSS 455 AA PAT source 1..455 mol_type protein organism synthetic construct constructo sintético QVQLQQSGPGLVKPSQTLSLTCAISGDSVSRNSAVWNWIRQSPSRGLEWLGRTYYRSKWYNDYAPSVKSRITINPDTSKNQFSLQLNSVTPEDTAVYYCARGLLQNQFYYYMDVWGKGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPASIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 11 AA PAT source 1..11 mol_type protein organism synthetic construct constructo sintético RASQSVASNLA 7 AA PAT source 1..7 mol_type protein organism synthetic construct constructo sintético GASTRAT 9 AA PAT source 1..9 mol_type protein organism synthetic construct constructo sintético QQYNNWPFT 107 AA PAT source 1..107 mol_type protein organism synthetic construct constructo sintético EIVMTQSPATLSVSPGERATLSCRASQSVASNLAWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYNNWPFTFGPGTKVDIK 214 AA PAT source 1..214 mol_type protein organism synthetic construct constructo sintético EIVMTQSPATLSVSPGERATLSCRASQSVASNLAWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYNNWPFTFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 7 AA PAT source 1..7 mol_type protein organism synthetic construct constructo sintético RNSAVWN 18 AA PAT source 1..18 mol_type protein organism synthetic construct constructo sintético RTYYRSKWYNDYAVSVKS 13 AA PAT source 1..13 mol_type protein organism synthetic construct constructo sintético GLLQNNFYYYMDV 125 AA PAT source 1..125 mol_type protein organism synthetic construct constructo sintético QVQLQQSGPGLVKPSQTLSLTCAISGDSVSRNSAVWNWIRQSPSRGLEWLGRTYYRSKWYNDYAVSVKSRITINPDTSKNQFSLQVNSVTPEDTAVYYCARGLLQNNFYYYMDVWGKGTTVTVSS 11 AA PAT source 1..11 mol_type protein organism synthetic construct constructo sintético RASQSVNSNLA 7 AA PAT source 1..7 mol_type protein organism synthetic construct constructo sintético GASTRAT 9 AA PAT source 1..9 mol_type protein organism synthetic construct constructo sintético QQYNNWPFT 107 AA PAT source 1..107 mol_type protein organism synthetic construct constructo sintético EIVMTQSPATLSVSPGERATLSCRASQSVNSNLAWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYNNWPFTFGPGTKVDIK 490 AA PAT source 1..490 mol_type protein organism Homo sapiens Homo sapiens MESISMMGSPKSLSETFLPNGINGIKDARKVTVGVIGSGDFAKSLTIRLIRCGYHVVIGSRNPKFASEFFPHVVDVTHHEDALTKTNIIFVAIHREHYTSLWDLRHLLVGKILIDVSNNMRINQYPESNAEYLASLFPDSLIVKGFNVVSAWALQLGPKDASRQVYICSNNIQARQQVIELARQLNFIPIDLGSLSSAREIENLPLRLFTLWRGPVVVAISLATFFFLYSFVRDVIHPYARNQQSDFYKIPIEIVNKTLPIVAITLLSLVYLAGLLAAAYQLYYGTKYRRFPPWLETWLQCRKQLGLLSFFFAMVHVAYSLCLPMRRSERYLFLNMAYQQVHANIENSWNEEEVWRIEMYISFGIMSLGLLSLLAVTSIPSVSNALNWREFSFIQSTLGYVALLISTFHVLIYGWKRAFEEEYYRFYTPPNFVLALVLPSIVILGKIILFLPCISRKLKRIKKGWEKSQFLEEGMGGTIPHVSPERVTVM 498 AA PAT source 1..498 mol_type protein organism synthetic construct constructo sintético MSHQPAVATKMPEEMDKPLISLHLVDSDSSLAKVPDEAPKVGILGSGDFARSLATRLVGSGFKVVVGSRNPKRTARLFPSAAQVTFQEEAVSSPEVIFVAVFREHYSSLCSLSDQLAGKILVDVSNPTEQEHLQHRESNAEYLASLFPTCTVVKAFNVISAWTLQAGPRDGNRQVPICGDQPEAKRAVSEMALAMGFMPVDMGSLASAWEVEAMPLRLLPAWKVPTLLALGLFVCFYAYSFVRDVIHPYARNQQSDFYKIPIEIVNKTLPCVAYVLLSLVYLPGVLAAALQLRRGTKYQRFPDWLDHWLQHRKQIGLLSFFCAALHALYSFCLPLRRSERYLFLNMAYQQVHANIENSWNEEEVWRIEIYLSLGVLALGTLSLLAVTSLPSIANSLNWREFSFVQSSLGFVALVLSTLHTLTYGWKRAFEEEYYRFYTPPNFTLTLLVPCVVILAKALFLLPCISRRLARIRRGWERESTIKFTLPTDHALAEKTSHV 7 AA PAT source 1..7 mol_type protein organism synthetic construct constructo sintético RNSAVWN 18 AA PAT source 1..18 mol_type protein organism synthetic construct constructo sintético RTYYRSKWYNDYAVSVKS 13 AA PAT source 1..13 mol_type protein organism synthetic construct constructo sintético GLLQNQFYYYMDV 125 AA PAT source 1..125 mol_type protein organism synthetic construct constructo sintético QVQLQQSGPGLVKPSQTLSLTCAISGDSVSRNSAVWNWIRQSPSRGLEWLGRTYYRSKWYNDYAVSVKSRITINPDTSKNQFSLQLNSVTPEDTAVYYCARGLLQNQFYYYMDVWGKGTTVTVSS 11 AA PAT source 1..11 mol_type protein organism synthetic construct constructo sintético RASQSVSSNLA 7 AA PAT source 1..7 mol_type protein organism synthetic construct constructo sintético GASTRAT 9 AA PAT source 1..9 mol_type protein organism synthetic construct constructo sintético QQYNNWPFT 107 AA PAT source 1..107 mol_type protein organism synthetic construct constructo sintético EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYNNWPFTFGPGTKVDIK 5 AA PAT source 1..5 mol_type protein organism synthetic construct constructo sintético VARIANT 3 note Any amino acid Cualquier aminoácido LPXTG 5 AA PAT source 1..5 mol_type protein organism synthetic construct constructo sintético VARIANT 4 note Any amino acid Cualquier aminoácido LPTXG