WO PCT/US2024/027617 2024-05-03 P12724WO00/BAS US 63/463,649 2023-05-03 VIDA PHARMACAL INC. MODIFIED CHIMERIC ANTIGENS IBMP 8.1 AND 8.3 FOR THE DETECTION AND DIAGNOSIS OF TRYPANOSOMA CRUZI 14 141 AA PAT source 1..141 mol_type protein organism Trypanosoma cruzi MGSSHHHHHHGSEEGSRGDSSMPASASEEGSRGDSSMPAKAAIAPAKAAAAPAKAAAAPAAEPKSAEPKPAEPKSGDKPSPFGQAAAGDKPSPFGQAGDKPSPFGQAAAGDKPSPFGQAGDKPSPFGQAAAGDKPSPFGQA 119 AA PAT source 1..119 mol_type protein organism Trypanosoma cruzi MGSSHHHHHHGSEEGSRGDSSMPASASEEGSRGDSSMPAKAAIAPAKAAAAPAKAAAAPAAEPKSAEPKPAEPKSGDKPSPFGQAAAGDKPSPFGQAGDKPSPFGQAAAGDKPSPFGQA 183 AA PAT source 1..183 mol_type protein organism Trypanosoma cruzi MGSSHHHHHHGPKPAEPKPAEPKPAEPKPAEPKPAEPKPAEPKPAEPKPAEPKPAEKVAEAEKQKAAEATKVAEAEKQRAAEATKVAEAEKQKAAEATPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPSPFGQAAAGDKPSPFGQAAAGDKPSPFGQAAAGDKP 205 AA PAT source 1..205 mol_type protein organism Trypanosoma cruzi MGSSHHHHHHGPKPAEPKPAEPKPAEPKPAEPKPAEPKPAEPKPAEPKPAEPKPAEKVAEAEKQKAAEATKVAEAEKQRAAEATKVAEGDKPSPFGQAAAGDKPSPFGQAAEKQKAAEATPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPSPFGQAAAGDKPSPFGQAAAGDKPSPFGQAAAGDKP 227 AA PAT source 1..227 mol_type protein organism Trypanosoma cruzi MGSSHHHHHHGPKPAEPKPAEPKPAEPKPAEPKPAEPKPAEPKPAEPKPAEPKPAEKVAEAEKQKAAEATKVAEAEKQRAAEATKVAEGDKPSPFGQAAAGDKPSPFGQAGDKPSPFGQAAAGDKPSPFGQAAEKQKAAEATPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPSPFGQAAAGDKPSPFGQAAAGDKPSPFGQAAAGDKP 237 AA PAT source 1..237 mol_type protein organism Trypanosoma cruzi MGSSHHHHHHGPKPAEPKPAEPKPAEPKPAEPKPAEPKPAEPKPAEPKPAEPKPAEKVAEAEKQKAAEATKVAEAEKQRAAEATKVAEGDKPSPFGQAGDKPSPFGQAAAGDKPSPFGQAGDKPSPFGQAAAGDKPSPFGQAAEKQKAAEATPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPSPFGQAAAGDKPSPFGQAAAGDKPSPFGQAAAGDKP 22 AA PAT source 1..22 mol_type protein organism Trypanosoma cruzi GDKPSPFGQAAAGDKPSPFGQA 264 AA PAT source 1..264 mol_type protein organism Trypanosoma cruzi MGSSHHHHHHGDSTAHGTPSTPADSSAHSTPSTPAKFAELLEQQKNAQFPGKEPKSAEPKPAEPKSEKQKAAEATKVAEAEKQRAAEATKVAEASSMPASASEEGSRGDSSMPAGDKPSPFGQAAAGDKPSPFGQAAMEQERRQLLEKDPRRNAKEIAALEESMNARAQELAREKKLADRAFLDQKPERVPLADVPLDDDSDFVAKAAIAPAKAAAAPAKAAAAPAALPQEEQEDVGPRHVDPDHFRSTTQDAYRPVDPSAYKR 97 AA PAT source 1..97 mol_type protein organism Trypanosoma cruzi MGSSHHHHHHGSEEGSRGDSSMPASASEEGSRGDSSMPAKAAIAPAKAAAAPAKAAAAPAAEPKSAEPKPAEPKSGDKPSPFGQAAAGDKPSPFGQA 161 AA PAT source 1..161 mol_type protein organism Trypanosoma cruzi MGSSHHHHHHGPKPAEPKPAEPKPAEPKPAEPKPAEPKPAEPKPAEPKPAEPKPAEKVAEAEKQKAAEATKVAEAEKQRAAEATKVAEAEKQKAAEATPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPSPFGQAAAAAGDKP 879 AA PAT source 1..879 mol_type protein organism Trypanosoma cruzi MGRTVVGASRMFWLTHFVPLLLALCPSEPAHALAPGSSRVELFKRQNSTVPFEENGEVRQRVVHSFRLPALVNVDGVMVAIADARYDTSNDNSLIDTVVKYSVDDGETWETQIAIKNSRASSVSRVVDPTVIVKGNKIYVLVGSYNSSTSYWTSHGDARDWDILLAVGEVTKSIVDGKTTANITWGSPVSLKEFFPAYMEGMHTNQFLGGAGVAIVASNGNLVYPVQVTNKRKQVFSKIFYSEDDGKTWKFGKGRSDFGCSEPVALEWEGKLIINTRVDYRRRLVYESSDTEKPWVEAVGTLSRCWGPSPKSDQPGSQSSFTAVTIEGMRVMLFTHPLNFKGWWLRDRLNLWLTDNQRIYNVGQLSIGDENSAYSSVLYKDDKLYCLHEINSNEVYSLVFARLVGELRIIKSVLQSWKKWDSHLSSICTPADPAASSSERVCGPAVTTVGLAGFLSHSANKTKWKDAYRCVDASTANAERVSNGLKFAGVGGGALWPVSQQGQNQRYRFANHAFTLVASVTIHEAPSVASPLLGASLDSSGGKKLLGLSYDEKHQWQPIYGSTPVTPTGSWETGKRYHVVLTMANRNGSVYVDGELLKGSGQTVVPDRTPDISHFYVGGYGRSDMPTISHVTVNNVLLYNRQLNAEEIKTLFLSQDLIGTEAHMDSSSDSSAHGTPSTPVDSTAHGTPSTPADSSAHSTPSTPADSSAHSTPSTPVDSSAHSTPSTPADSSAHSTPSTPADSSAHSTPSTPVDSTAHGTPSTPADSSAHSTPSTPVDSSAHSTPSTPADSSAHSTPSTPVDSSAHSTPSTPADSSAHGTPSTPVDSSAHSTPSTPADSSANGTVLILPDGAALSTFSGGGLLLCACALLLHVFFTAVFF 62 AA PAT SITE 20 note misc_feature - Xaa can be any naturally occurring amino acid SITE 31 note misc_feature - Xaa can be any naturally occurring amino acid SITE 44 note misc_feature - Xaa can be any naturally occurring amino acid source 1..62 mol_type protein organism Trypanosoma cruzi MTTCRLLCALLALALCCCLXACTTANGGSTXSTPPSGTENKPAXGEAPSQPGASSGEAEASS 68 AA PAT source 1..68 mol_type protein organism Trypanosoma cruzi MEQERRQLLEKDPRRNAKEIAALEESMNARAQELAREKKLADRAFLDQKPERVPLADVPLDDDSDFVA 227 AA PAT source 1..227 mol_type protein organism Trypanosoma cruzi PPPFGQAAAGDKPSPFGQAAAGDKPPPFGQAAAGDKPSPFGQAAAGDKPPPFGQAAAGDKPSPFGQAAAGGKPPPFGQAAAGDKPSPFGQAAAGDKPPPFGQAAAGDKPSPFGQAAAGDKPPPFGQAAAGDKPPPFGQAAEGDKPPPFGQAAAGDKPAPFGQAAEGDKPPPFGQAAAADKPSLFGQAAAGDKLSLFGQAAAGDKPPPFGQAAEGDKPPPFGQAAAGD