US 2943.2600000 ASTRAZENECA AB ASTRAZENECA AB LAMBIASE, Giulia LAMBIASE, Giulia BISPECIFIC ANTI-PSEUDOMONAS ANTIBODIES WITH MODIFIED FC REGIONS AND METHODS OF USE THEREOF ANTICUERPOS ANTI-PSEUDOMONAS BIESPECÍFICOS CON REGIONES FC MODIFICADAS Y MÉTODOS DE USO DE ESTOS 46 5 AA PAT source 1..5 mol_type protein note Anti-PcrV HCDR1 HCDR1 de anti-PcrV organism synthetic construct constructo sintético SYAMN 17 AA PAT source 1..17 mol_type protein note Anti-PcrV HCDR2 HCDR2 de anti-PcrV organism synthetic construct constructo sintético AITMSGITAYYTDDVKG 15 AA PAT source 1..15 mol_type protein note Anti-PcrV HCDR3 HCDR3 de anti-PcrV organism synthetic construct constructo sintético EEFLPGTHYYYGMDV 11 AA PAT source 1..11 mol_type protein note Anti-PcrV LCDR1 LCDR1 de anti-PcrV organism synthetic construct constructo sintético RASQGIRNDLG 7 AA PAT source 1..7 mol_type protein note Anti-PcrV LCDR2 LCDR2 de anti-PcrV organism synthetic construct constructo sintético SASTLQS 9 AA PAT source 1..9 mol_type protein note Anti-PcrV LCDR3 LCDR3 de anti-PcrV organism synthetic construct constructo sintético LQDYNYPWT 5 AA PAT source 1..5 mol_type protein note Anti-Psl HCDR1 HCDR1 de anti-Psl organism synthetic construct constructo sintético PYYWT 16 AA PAT source 1..16 mol_type protein note Anti-Psl HCDR2 HCDR2 de anti-Psl organism synthetic construct constructo sintético YIHSSGYTDYNPSLKS 11 AA PAT source 1..11 mol_type protein note Anti-Psl HCDR3 HCDR3 de anti-Psl organism synthetic construct constructo sintético ADWDRLRALDI 11 AA PAT source 1..11 mol_type protein note Anti-Psl LCDR1 LCDR1 de anti-Psl organism synthetic construct constructo sintético RASQSIRSHLN 7 AA PAT source 1..7 mol_type protein note Anti-Psl LCDR2 LCDR2 de anti-Psl organism synthetic construct constructo sintético GASNLQS 9 AA PAT source 1..9 mol_type protein note Anti-Psl LCDR3 LCDR3 de anti-Psl organism synthetic construct constructo sintético QQSTGAWNW 124 AA PAT source 1..124 mol_type protein note Anti-PcrV VH VH de anti-PcrV organism synthetic construct constructo sintético EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMNWVRQAPGKGLEWVSAITMSGITAYYTDDVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKEEFLPGTHYYYGMDVWGQGTTVTVSS 107 AA PAT source 1..107 mol_type protein note Anti-PcrV VL VL de anti-PcrV organism synthetic construct constructo sintético AIQMTQSPSSLSASVGDRVTITCRASQGIRNDLGWYQQKPGKAPKLLIYSASTLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCLQDYNYPWTFGQGTKVEIK 119 AA PAT source 1..119 mol_type protein note Anti-Psl VH VH de anti-Psl organism synthetic construct constructo sintético QVQLQESGPGLVKPSETLSLTCTVSGGSISPYYWTWIRQPPGKCLELIGYIHSSGYTDYNPSLKSRVTISGDTSKKQFSLKLSSVTAADTAVYYCARADWDRLRALDIWGQGTMVTVSS 107 AA PAT source 1..107 mol_type protein note Anti-Psl VL VL de anti-Psl organism synthetic construct constructo sintético DIQLTQSPSSLSASVGDRVTITCRASQSIRSHLNWYQQKPGKAPKLLIYGASNLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSTGAWNWFGCGTKVEIK 246 AA PAT source 1..246 mol_type protein note Anti-Psl scFv scFv de anti-Psl organism synthetic construct constructo sintético QVQLQESGPGLVKPSETLSLTCTVSGGSISPYYWTWIRQPPGKCLELIGYIHSSGYTDYNPSLKSRVTISGDTSKKQFSLKLSSVTAADTAVYYCARADWDRLRALDIWGQGTMVTVSSGGGGSGGGGSGGGGSGGGGSDIQLTQSPSSLSASVGDRVTITCRASQSIRSHLNWYQQKPGKAPKLLIYGASNLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSTGAWNWFGCGTKVEIK 20 AA PAT source 1..20 mol_type protein note Anti-Psl scFv linker Enlazador de scFv de anti-Psl organism synthetic construct constructo sintético GGGGSGGGGSGGGGSGGGGS 720 AA PAT source 1..720 mol_type protein note MEDI-3902 Heavy Cadena pesada MEDI-3902 organism synthetic construct constructo sintético EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMNWVRQAPGKGLEWVSAITMSGITAYYTDDVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKEEFLPGTHYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCGGGGSGGGGSQVQLQESGPGLVKPSETLSLTCTVSGGSISPYYWTWIRQPPGKCLELIGYIHSSGYTDYNPSLKSRVTISGDTSKKQFSLKLSSVTAADTAVYYCARADWDRLRALDIWGQGTMVTVSSGGGGSGGGGSGGGGSGGGGSDIQLTQSPSSLSASVGDRVTITCRASQSIRSHLNWYQQKPGKAPKLLIYGASNLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSTGAWNWFGCGTKVEIKGGGGSGGGGSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 214 AA PAT source 1..214 mol_type protein note MEDI-3902 and AZD0292 Light Cadena ligera MEDI-3902 y AZD0292 organism synthetic construct constructo sintético AIQMTQSPSSLSASVGDRVTITCRASQGIRNDLGWYQQKPGKAPKLLIYSASTLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCLQDYNYPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 98 AA PAT source 1..98 mol_type protein note CH1 CH1 organism synthetic construct constructo sintético ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRV 5 AA PAT source 1..5 mol_type protein note H1 H1 organism synthetic construct constructo sintético EPKSC 10 AA PAT source 1..10 mol_type protein note H2 H2 organism synthetic construct constructo sintético DKTHTCPPCP 107 AA PAT source 1..107 mol_type protein note CL CL organism synthetic construct constructo sintético RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 217 AA PAT source 1..217 mol_type protein note MEDI3902 CH2-CH3 MEDI3902 CH2-CH3 organism synthetic construct constructo sintético APELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 5 AA PAT source 1..5 mol_type protein note Linker Enlazador organism synthetic construct constructo sintético REGION 1..5 note The entire sequence of amino acids 1-5 can be repeated 0 to 5 times La secuencia completa de aminoácidos 1-5 se puede repetir de 0 a 5 veces GGGGS 4 AA PAT source 1..4 mol_type protein note linker enlazador organism synthetic construct constructo sintético REGION 1..4 note The entire sequence of amino acids 1-4 can be repeated 0 to 5 times La secuencia completa de aminoácidos 1-4 se puede repetir de 0 a 5 veces GGGG 5 AA PAT source 1..5 mol_type protein note L1 L1 organism synthetic construct constructo sintético REGION 1..5 note The entire sequence of amino acids 1-5 can be repeated 2 times La secuencia completa de aminoácidos 1-5 se puede repetir 2 veces GGGGS 5 AA PAT source 1..5 mol_type protein note L2 L2 organism synthetic construct constructo sintético REGION 1..5 note The entire sequence of amino acids 1-5 can be repeated 4 times La secuencia completa de aminoácidos 1-5 se puede repetir 4 veces GGGGS 217 AA PAT source 1..217 mol_type protein note CH2-CH3 (N3Y) CH2-CH3 (N3Y) organism synthetic construct constructo sintético APELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEACSYHLCQKSLSLSPGK 720 AA PAT source 1..720 mol_type protein note AZD0292 Heavy chain AZD0292 Cadena pesada organism synthetic construct constructo sintético EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMNWVRQAPGKGLEWVSAITMSGITAYYTDDVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKEEFLPGTHYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCGGGGSGGGGSQVQLQESGPGLVKPSETLSLTCTVSGGSISPYYWTWIRQPPGKCLELIGYIHSSGYTDYNPSLKSRVTISGDTSKKQFSLKLSSVTAADTAVYYCARADWDRLRALDIWGQGTMVTVSSGGGGSGGGGSGGGGSGGGGSDIQLTQSPSSLSASVGDRVTITCRASQSIRSHLNWYQQKPGKAPKLLIYGASNLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSTGAWNWFGCGTKVEIKGGGGSGGGGSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEACSYHLCQKSLSLSPGK 17 AA PAT source 1..17 mol_type protein note Wild type Fc sub- sequence Subsecuencia Fc silvestre organism synthetic construct constructo sintético MHEALHNHYTQKSLSLS 17 AA PAT source 1..17 mol_type protein note N3Y-containing Fc sub-sequence Subsecuencia Fc que contiene N3Y organism synthetic construct constructo sintético MOD_RES 5..7 note N3Y mutations Mutaciones N3Y MOD_RES 9..10 note N3Y mutations Mutaciones N3Y MHEACSYHLCQKSLSLS 6 AA PAT source 1..6 mol_type protein note WT His435 loop of IgG1, IgG2, IgG4 Bucle His435 silvestre de IgG1, IgG2, IgG4 organism synthetic construct constructo sintético LHNHYT 6 AA PAT source 1..6 mol_type protein note WT His435 loop of IgG3 Bucle His435 silvestre de IgG3 organism synthetic construct constructo sintético LHNRFT 6 AA PAT source 1..6 mol_type protein note Modified His435 loop region variant Variante de región de bucle His435 modificada organism synthetic construct constructo sintético VARIANT 2 note wherein X is histidine or is substituted with arginine, proline, serine, or asparagine en donde X es histidina o está sustituido con arginina, prolina, serina o asparagina VARIANT 5 note wherein X is substituted with leucine, arginine, isoleucine, methionine, or serine en donde X está sustituido con leucina, arginina, isoleucina, metionina o serina CXRHXC 6 AA PAT source 1..6 mol_type protein note Modified His435 loop region variant Variante de región de bucle His435 modificada organism synthetic construct constructo sintético VARIANT 5 note wherein X is substituted with leucine, arginine, isoleucine, lysine, methionine, valine, histidine, serine, or threonine en donde X está sustituido con leucina, arginina, isoleucina, lisina, metionina, valina, histidina, serina o treonina CRRHXC 6 AA PAT source 1..6 mol_type protein note Modified His435 loop region variant Variante de región de bucle His435 modificada organism synthetic construct constructo sintético VARIANT 2 note wherein X is arginine, proline, threonine, lysine, serine, alanine, methionine, or asparagine donde X es arginina, prolina, treonina, lisina, serina, alanina, metionina o asparagina CXRHRC 6 AA PAT source 1..6 mol_type protein note Modified His435 loop region Región de bucle His435 modificada organism synthetic construct constructo sintético CSWHLC 6 AA PAT source 1..6 mol_type protein note Modified His435 loop region Región de bucle His435 modificada organism synthetic construct constructo sintético CSWHLE 000 000 720 AA PAT source 1..720 mol_type protein note Gremubamab YTE variant Variante de Gremubamab YTE organism synthetic construct constructo sintético EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMNWVRQAPGKGLEWVSAITMSGITAYYTDDVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKEEFLPGTHYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCGGGGSGGGGSQVQLQESGPGLVKPSETLSLTCTVSGGSISPYYWTWIRQPPGKCLELIGYIHSSGYTDYNPSLKSRVTISGDTSKKQFSLKLSSVTAADTAVYYCARADWDRLRALDIWGQGTMVTVSSGGGGSGGGGSGGGGSGGGGSDIQLTQSPSSLSASVGDRVTITCRASQSIRSHLNWYQQKPGKAPKLLIYGASNLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSTGAWNWFGCGTKVEIKGGGGSGGGGSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLYITREPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 6 AA PAT source 1..6 mol_type protein note Modified His435 loop region (N3Y) Región de bucle His435 modificada (N3Y) organism synthetic construct constructo sintético CSYHLC 2494 DNA PAT source 1..2494 mol_type other DNA note AZD0292 Heavy chain - cDNA AZD0292 Cadena pesada - ADNc organism synthetic construct constructo sintético tcagatctcaccgtccttgacacgaagcttactgagcacacaggacctgcagggccgccaccatgggctggtcctgcatcatcctgtttctggtggccacagctacaggtgtacactccgaggtgcagctgttggagtctgggggaggcttggtacagcctggggggtccctgagactctcctgtgcagcctctggattcacctttagcagctatgccatgaactgggtccgccaggctccagggaaggggctggagtgggtctcagctattactatgagtggtattaccgcatactacaccgacgacgtgaagggccggttcaccatctccagagacaattccaagaacacgctatatctgcaaatgaacagcctgagggccgaggacacggccgtatattactgtgcgaaggaagaatttttacctggaacgcactactactacggtatggacgtctggggccaagggaccacggtcaccgtctcctcagcgtcgaccaagggcccatccgtcttccccctggcaccctcctccaagagcacctctgggggcacagcggccctgggctgcctggtcaaggactacttccccgaaccggtgacggtgtcctggaactcaggcgctctgaccagcggcgtgcacaccttcccggctgtcctacagtcctcaggactctactccctcagcagcgtggtgaccgtgccctccagcagcttgggcacccagacctacatctgcaacgtgaatcacaagcccagcaacaccaaggtggacaagagagttgagcccaaatcttgtggcggagggggctctggcggagggggatcccaggtgcagctgcaggaatctggccctggcctcgtgaagccctccgagacactgtctctgacctgcaccgtgtccggcggctccatctccccttactactggacctggatcagacagccccctggcaagtgcctggaactgatcggctacatccactcctccggctacaccgactacaaccccagcctgaagtccagagtgaccatctccggcgacacctccaagaagcagttctccctgaagctgtcctccgtgaccgccgctgataccgccgtgtactactgcgccagagccgactgggacagactgagagccctggacatctggggccagggcacaatggtcaccgtgtctagcggaggcggaggatctggtggtggtggatctggcggcggaggaagtggtggcggaggctctgatatccagctgacccagtccccctccagcctgtctgcttctgtgggcgaccgcgtgaccatcacctgtagagcctcccagtccatccggtcccacctgaactggtatcagcagaagcccggcaaggcccccaagctgctgatctacggcgcctccaatctgcagtccggcgtgccctctagattctccggatctggctccggcaccgactttaccctgaccatcagctccctgcagcccgaggacttcgccacctactactgccagcagtctaccggcgcctggaattggttcggctgcggcaccaaggtggaaatcaagggcggaggtggctctggcggagggggatccgacaaaactcacacatgcccaccgtgcccagcacctgaactcctggggggaccgtcagtcttcctcttccccccaaaacccaaggacaccctcatgatctcccggacccctgaggtcacatgcgtggtggtggacgtgagccacgaagaccctgaggtcaagttcaactggtacgtggacggcgtggaggtgcataatgccaagacaaagccgcgggaggagcagtacaacagcacgtaccgtgtggtcagcgtcctcaccgtcctgcaccaggactggctgaatggcaaggagtacaagtgcaaggtctccaacaaagccctcccagcccccatcgagaaaaccatctccaaagccaaagggcagccccgagaaccacaggtctacaccctgcccccatcccgggaggagatgaccaagaaccaggtcagcctgacctgcctggtcaaaggcttctatcccagcgacatcgccgtggagtgggagagcaatgggcagccggagaacaactacaagaccacgcctcccgtgctggactccgacggctccttcttcctctatagcaagctcaccgtggacaagagcaggtggcagcaggggaacgtcttctcatgctccgtgatgcatgaggcttgctcatatcacctctgccagaagagcttaagcctgtctccgggtaaatgagcggccgcgaattcacgtgccagccatctgttgtttgcccctcccccgtgccttccttgaccctggaaggtgccactcccactgtcctttcctaataaaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctggggggtggggtggggcaggacagcaagggggaggattgggaagacaatagcaggcatgatcaattt 981 DNA PAT source 1..981 mol_type other DNA note AZD0292 Light chain - cDNA AZD0292 Cadena ligera - cDNA organism synthetic construct constructo sintético tcagatctcaccgtccttgacacgaagctattcgaactacagttactgagcacacaggacctcgtaccgccatctcaccatggacatgagggtgcccgcccagctgctgggcctgctgctgctgtggctgcccggggccaagtgcgctattcagatgacccagtccccctccagcctgtccgcctctgtgggcgacagagtgaccatcacctgtcgggcctcccagggcatcagaaacgacctgggctggtatcagcagaagcccggcaaggcccccaagctgctgatctactctgcctccaccctgcagtccggcgtgccctccagattttccggctctggctctggcaccgactttaccctgaccatcagctccctgcagcccgaggacttcgccacctactactgtctgcaagactacaactacccctggaccttcggccagggcaccaaggtggaaatcaagcggaccgtggccgctccctccgtgttcatcttcccaccctccgacgagcagctgaagtccggcaccgcctccgtggtctgcctgctgaacaacttctacccccgcgaggccaaggtgcagtggaaggtggacaacgccctgcagtccggcaactcccaggaatccgtcaccgagcaggactccaaggacagcacctactccctgtccagcaccctgaccctgtccaaggccgactacgagaagcacaaggtgtacgcctgcgaagtgacccaccagggcctgtccagccctgtgaccaagtccttcaaccggggcgagtgctgatgaacgtgccagccatctgttgtttgcccctcccccgtgccttccttgaccctggaaggtgccactcccactgtcctttcctaataaaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctggggggtggggtggggcaggacagcaagggggaggattgggaagacaatagcaggca