SEQUENCE LISTING <110> Sania TX Ltd <120> Method <130> SANI.3WO <140> PCT/IB2024/054426 <141> 2024-05-07 <150> 2306914.9 <151> 2023-05-10 <160> 16 <170> PatentIn version 3.5 <210> 1 <211> 2619 <212> DNA <213> Homo sapiens <400> 1 atggggctca aggcgcgcag ggcggcgggg gcggctggcg gcggcggcga cgggggcggc 60 ggaggcggcg gggcggctaa cccagccgga ggggacgcgg cggcggccgg cgacgaggag 120 cggaaagtgg ggctggcgcc cggcgacgtg gagcaagtca ccttggcgct cggggccgga 180 gccgacaaag acgggaccct gctgctggag ggcggcggcc gcgacgaggg gcagcggagg 240 accccgcagg gcatcgggct cctggccaag accccgctga gccgcccagt caagagaaac 300 aacgccaagt accggcgcat ccaaactttg atctacgacg ccctggagag accgcggggc 360 tgggcgctgc tttaccacgc gttggtgttc ctgattgtcc tggggtgctt gattctggct 420 gtcctgacca cattcaagga gtatgagact gtctcgggag actggcttct gttactggag 480 acatttgcta ttttcatctt tggagccgag tttgctttga ggatctgggc tgctggatgt 540 tgctgccgat acaaaggctg gcggggccga ctgaagtttg ccaggaagcc cctgtgcatg 600 ttggacatct ttgtgctgat tgcctctgtg ccagtggttg ctgtgggaaa ccaaggcaat 660 gttctggcca cctccctgcg aagcctgcgc ttcctgcaga tcctgcgcat gctgcggatg 720 gaccggagag gtggcacctg gaagcttctg ggctcagcca tctgtgccca cagcaaagaa 780 ctcatcacgg cctggtacat cggtttcctg acactcatcc tttcttcatt tcttgtctac 840 ctggttgaga aagacgtccc agaggtggat gcacaaggag aggagatgaa agaggagttt 900 gagacctatg cagatgccct gtggtggggc ctgatcacac tggccaccat tggctatgga 960 gacaagacac ccaaaacgtg ggaaggccgt ctgattgccg ccaccttttc cttaattggc 1020 gtctcctttt ttgcccttcc agcgggcatc ctggggtccg ggctggccct caaggtgcag 1080 gagcaacacc gtcagaagca ctttgagaaa aggaggaagc cagctgctga gctcattcag 1140 gctgcctgga ggtattatgc taccaacccc aacaggattg acctggtggc gacatggaga 1200 ttttatgaat cagtcgtctc ttttcctttc ttcaggaaag aacagctgga ggcagcatcc 1260 agccaaaagc tgggtctctt ggatcgggtt cgcctttcta atcctcgtgg tagcaatact 1320 aaaggaaagc tatttacccc tctgaatgta gatgccatag aagaaagtcc ttctaaagaa 1380 ccaaagcctg ttggcttaaa caataaagag cgtttccgca cggccttccg catgaaagcc 1440 tacgctttct ggcagagttc tgaagatgcc gggacaggtg accccatggc ggaagacagg 1500 ggctatggga atgacttccc catcgaagac atgatcccca ccctgaaggc cgccatccga 1560 gccgtcagaa ttctacaatt ccgtctctat aaaaaaaaat tcaaggagac tttgaggcct 1620 tacgatgtga aggatgtgat tgagcagtat tctgccgggc atctcgacat gctttccagg 1680 ataaagtacc ttcagacgag aatagatatg attttcaccc ctggacctcc ctccacgcca 1740 aaacacaaga agtctcagaa agggtcagca ttcaccttcc catcccagca atctcccagg 1800 aatgaaccat atgtagccag accatccaca tcagaaatcg aagaccaaag catgatgggg 1860 aagtttgtaa aagttgaaag acaggttcag gacatgggga agaagctgga cttcctcgtg 1920 gatatgcaca tgcaacacat ggaacggttg caggtgcagg tcacggagta ttacccaacc 1980 aagggcacct cctcgccagc tgaagcagag aagaaggagg acaacaggta ttccgatttg 2040 aaaaccatca tctgcaacta ttctgagaca ggccccccgg aaccacccta cagcttccac 2100 caggtgacca ttgacaaagt cagcccctat gggttttttg cacatgaccc tgtgaacctg 2160 ccccgagggg gacccagttc tggaaaggtt caggcaactc ctccttcctc agcaacaacg 2220 tatgtggaga ggcccacggt cctgcctatc ttgactcttc tcgactcccg agtgagctgc 2280 cactcccagg ctgacctgca gggcccctac tcggaccgaa tctccccccg gcagagacgt 2340 agcatcacgc gagacagtga cacacctctg tccctgatgt cggtcaacca cgaggagctg 2400 gagaggtctc caagtggctt cagcatctcc caggacagag atgattatgt gttcggcccc 2460 aatggggggt cgagctggat gagggagaag cggtacctcg ccgagggtga gacggacaca 2520 gacacggacc ccttcacgcc cagcggctcc atgcctctgt cgtccacagg ggatgggatt 2580 tctgattcag tatggacccc ttccaataag cccatttaa 2619 <210> 2 <211> 2619 <212> DNA <213> Homo sapiens <400> 2 atggggctca aggcgcgcag ggcggcgggg gcggctggcg gcggcggcga cgggggcggc 60 ggaggcggcg gggcggctaa cccagccgga ggggacgcgg cggcggccgg cgacgaggag 120 cggaaagtgg ggctggcgcc cggcgacgtg gagcaagtca ccttggcgct cggggccgga 180 gccgacaaag acgggaccct gctgctggag ggcggcggcc gcgacgaggg gcagcggagg 240 accccgcagg gcatcgggct cctggccaag accccgctga gccgcccagt caagagaaac 300 aacgccaagt accggcgcat ccaaactttg atctacgacg ccctggagag accgcggggc 360 tgggcgctgc tttaccacgc gttggtgttc ctgattgtcc tggggtgctt gattctggct 420 gtcctgacca cattcaagga gtatgagact gtctcgggag actggcttct gttactggag 480 acatttgcta ttttcatctt tggagccgag tttgctttga ggatctgggc tgctggatgt 540 tgctgccgat acaaaggctg gcggggccga ctgaagtttg ccaggaagcc cctgtgcatg 600 ttggacatct ttgtgctgat tgcctctgtg ccagtggttg ctgtgggaaa ccaaggcaat 660 gttctggcca cctccctgcg aagcctgcgc ttcctgcaga tcctgcgcat gctgcggatg 720 gaccggagag gtggcacctg gaagcttctg ggctcagcca tctgtgccca cagcaaagaa 780 ctcatcacgg cctggtacat cggtttcctg acactcatcc tttcttcatt tcttgtctac 840 ctggttgaga aagacgtccc agaggtggat gcacaaggag aggagatgaa agaggagttt 900 gagacctatg cagatgccct gtggtggggc ctgatcacac tgaccaccat tggctatgga 960 gacaagacac ccaaaacgtg ggaaggccgt ctgattgccg ccaccttttc cttaattggc 1020 gtctcctttt ttgcccttcc agcgggcatc ctggggtccg ggctggccct caaggtgcag 1080 gagcaacacc gtcagaagca ctttgagaaa aggaggaagc cagctgctga gctcattcag 1140 gctgcctgga ggtattatgc taccaacccc aacaggattg acctggtggc gacatggaga 1200 ttttatgaat cagtcgtctc ttttcctttc ttcaggaaag aacagctgga ggcagcatcc 1260 agccaaaagc tgggtctctt ggatcgggtt cgcctttcta atcctcgtgg tagcaatact 1320 aaaggaaagc tatttacccc tctgaatgta gatgccatag aagaaagtcc ttctaaagaa 1380 ccaaagcctg ttggcttaaa caataaagag cgtttccgca cggccttccg catgaaagcc 1440 tacgctttct ggcagagttc tgaagatgcc gggacaggtg accccatggc ggaagacagg 1500 ggctatggga atgacttccc catcgaagac atgatcccca ccctgaaggc cgccatccga 1560 gccgtcagaa ttctacaatt ccgtctctat aaaaaaaaat tcaaggagac tttgaggcct 1620 tacgatgtga aggatgtgat tgagcagtat tctgccgggc atctcgacat gctttccagg 1680 ataaagtacc ttcagacgag aatagatatg attttcaccc ctggacctcc ctccacgcca 1740 aaacacaaga agtctcagaa agggtcagca ttcaccttcc catcccagca atctcccagg 1800 aatgaaccat atgtagccag accatccaca tcagaaatcg aagaccaaag catgatgggg 1860 aagtttgtaa aagttgaaag acaggttcag gacatgggga agaagctgga cttcctcgtg 1920 gatatgcaca tgcaacacat ggaacggttg caggtgcagg tcacggagta ttacccaacc 1980 aagggcacct cctcgccagc tgaagcagag aagaaggagg acaacaggta ttccgatttg 2040 aaaaccatca tctgcaacta ttctgagaca ggccccccgg aaccacccta cagcttccac 2100 caggtgacca ttgacaaagt cagcccctat gggttttttg cacatgaccc tgtgaacctg 2160 ccccgagggg gacccagttc tggaaaggtt caggcaactc ctccttcctc agcaacaacg 2220 tatgtggaga ggcccacggt cctgcctatc ttgactcttc tcgactcccg agtgagctgc 2280 cactcccagg ctgacctgca gggcccctac tcggaccgaa tctccccccg gcagagacgt 2340 agcatcacgc gagacagtga cacacctctg tccctgatgt cggtcaacca cgaggagctg 2400 gagaggtctc caagtggctt cagcatctcc caggacagag atgattatgt gttcggcccc 2460 aatggggggt cgagctggat gagggagaag cggtacctcg ccgagggtga gacggacaca 2520 gacacggacc ccttcacgcc cagcggctcc atgcctctgt cgtccacagg ggatgggatt 2580 tctgattcag tatggacccc ttccaataag cccatttaa 2619 <210> 3 <211> 2619 <212> DNA <213> Homo sapiens <400> 3 atggggctca aggcgcgcag ggcggcgggg gcggctggcg gcggcggcga cgggggcggc 60 ggaggcggcg gggcggctaa cccagccgga ggggacgcgg cggcggccgg cgacgaggag 120 cggaaagtgg ggctggcgcc cggcgacgtg gagcaagtca ccttggcgct cggggccgga 180 gccgacaaag acgggaccct gctgctggag ggcggcggcc gcgacgaggg gcagcggagg 240 accccgcagg gcatcgggct cctggccaag accccgctga gccgcccagt caagagaaac 300 aacgccaagt accggcgcat ccaaactttg atctacgacg ccctggagag accgcggggc 360 tgggcgctgc tttaccacgc gttggtgttc ctgattgtcc tggggtgctt gattctggct 420 gtcctgacca cattcaagga gtatgagact gtctcgggag actggcttct gttactggag 480 acatttgcta ttttcatctt tggagccgag tttgctttga ggatctgggc tgctggatgt 540 tgctgccgat acaaaggctg gcggggccga ctgaagtttg ccaggaagcc cctgtgcatg 600 ttggacatct ttgtgctgat tgcctctgtg ccagtggttg ctgtgggaaa ccaaggcaat 660 gttctggcca cctccctgcg aagcctgcgc ttcctgcaga tcctgcgcat gctgcggatg 720 gaccggagag gtggcacctg gaagcttctg ggctcagcca tctgtgccca cagcaaagaa 780 ctcatcacgg cctggtacat cggtttcctg acactcatcc tttcttcatt tcttgtctac 840 ctggttgaga aagacgtccc agaggtggat gcacaaggag aggagatgaa agaggagttt 900 gagacctatg cagatgccct gtggtggggc ctgatcacac tgtccaccat tggctatgga 960 gacaagacac ccaaaacgtg ggaaggccgt ctgattgccg ccaccttttc cttaattggc 1020 gtctcctttt ttgcccttcc agcgggcatc ctggggtccg ggctggccct caaggtgcag 1080 gagcaacacc gtcagaagca ctttgagaaa aggaggaagc cagctgctga gctcattcag 1140 gctgcctgga ggtattatgc taccaacccc aacaggattg acctggtggc gacatggaga 1200 ttttatgaat cagtcgtctc ttttcctttc ttcaggaaag aacagctgga ggcagcatcc 1260 agccaaaagc tgggtctctt ggatcgggtt cgcctttcta atcctcgtgg tagcaatact 1320 aaaggaaagc tatttacccc tctgaatgta gatgccatag aagaaagtcc ttctaaagaa 1380 ccaaagcctg ttggcttaaa caataaagag cgtttccgca cggccttccg catgaaagcc 1440 tacgctttct ggcagagttc tgaagatgcc gggacaggtg accccatggc ggaagacagg 1500 ggctatggga atgacttccc catcgaagac atgatcccca ccctgaaggc cgccatccga 1560 gccgtcagaa ttctacaatt ccgtctctat aaaaaaaaat tcaaggagac tttgaggcct 1620 tacgatgtga aggatgtgat tgagcagtat tctgccgggc atctcgacat gctttccagg 1680 ataaagtacc ttcagacgag aatagatatg attttcaccc ctggacctcc ctccacgcca 1740 aaacacaaga agtctcagaa agggtcagca ttcaccttcc catcccagca atctcccagg 1800 aatgaaccat atgtagccag accatccaca tcagaaatcg aagaccaaag catgatgggg 1860 aagtttgtaa aagttgaaag acaggttcag gacatgggga agaagctgga cttcctcgtg 1920 gatatgcaca tgcaacacat ggaacggttg caggtgcagg tcacggagta ttacccaacc 1980 aagggcacct cctcgccagc tgaagcagag aagaaggagg acaacaggta ttccgatttg 2040 aaaaccatca tctgcaacta ttctgagaca ggccccccgg aaccacccta cagcttccac 2100 caggtgacca ttgacaaagt cagcccctat gggttttttg cacatgaccc tgtgaacctg 2160 ccccgagggg gacccagttc tggaaaggtt caggcaactc ctccttcctc agcaacaacg 2220 tatgtggaga ggcccacggt cctgcctatc ttgactcttc tcgactcccg agtgagctgc 2280 cactcccagg ctgacctgca gggcccctac tcggaccgaa tctccccccg gcagagacgt 2340 agcatcacgc gagacagtga cacacctctg tccctgatgt cggtcaacca cgaggagctg 2400 gagaggtctc caagtggctt cagcatctcc caggacagag atgattatgt gttcggcccc 2460 aatggggggt cgagctggat gagggagaag cggtacctcg ccgagggtga gacggacaca 2520 gacacggacc ccttcacgcc cagcggctcc atgcctctgt cgtccacagg ggatgggatt 2580 tctgattcag tatggacccc ttccaataag cccatttaa 2619 <210> 4 <211> 2619 <212> DNA <213> Homo sapiens <400> 4 atggggctca aggcgcgcag ggcggcgggg gcggctggcg gcggcggcga cgggggcggc 60 ggaggcggcg gggcggctaa cccagccgga ggggacgcgg cggcggccgg cgacgaggag 120 cggaaagtgg ggctggcgcc cggcgacgtg gagcaagtca ccttggcgct cggggccgga 180 gccgacaaag acgggaccct gctgctggag ggcggcggcc gcgacgaggg gcagcggagg 240 accccgcagg gcatcgggct cctggccaag accccgctga gccgcccagt caagagaaac 300 aacgccaagt accggcgcat ccaaactttg atctacgacg ccctggagag accgcggggc 360 tgggcgctgc tttaccacgc gttggtgttc ctgattgtcc tggggtgctt gattctggct 420 gtcctgacca cattcaagga gtatgagact gtctcgggag actggcttct gttactggag 480 acatttgcta ttttcatctt tggagccgag tttgctttga ggatctgggc tgctggatgt 540 tgctgccgat acaaaggctg gcggggccga ctgaagtttg ccaggaagcc cctgtgcatg 600 ttggacatct ttgtgctgat tgcctctgtg ccagtggttg ctgtgggaaa ccaaggcaat 660 gttctggcca cctccctgcg aagcctgcgc ttcctgcaga tcctgcgcat gctgcggatg 720 gaccggagag gtggcacctg gaagcttctg ggctcagcca tctgtgccca cagcaaagaa 780 ctcatcacgg cctggtacat cggtttcctg acactcatcc tttcttcatt tcttgtctac 840 ctggttgaga aagacgtccc agaggtggat gcacaaggag aggagatgaa agaggagttt 900 gagacctatg cagatgccct gtggtggggc ctgatcacac tggtcaccat tggctatgga 960 gacaagacac ccaaaacgtg ggaaggccgt ctgattgccg ccaccttttc cttaattggc 1020 gtctcctttt ttgcccttcc agcgggcatc ctggggtccg ggctggccct caaggtgcag 1080 gagcaacacc gtcagaagca ctttgagaaa aggaggaagc cagctgctga gctcattcag 1140 gctgcctgga ggtattatgc taccaacccc aacaggattg acctggtggc gacatggaga 1200 ttttatgaat cagtcgtctc ttttcctttc ttcaggaaag aacagctgga ggcagcatcc 1260 agccaaaagc tgggtctctt ggatcgggtt cgcctttcta atcctcgtgg tagcaatact 1320 aaaggaaagc tatttacccc tctgaatgta gatgccatag aagaaagtcc ttctaaagaa 1380 ccaaagcctg ttggcttaaa caataaagag cgtttccgca cggccttccg catgaaagcc 1440 tacgctttct ggcagagttc tgaagatgcc gggacaggtg accccatggc ggaagacagg 1500 ggctatggga atgacttccc catcgaagac atgatcccca ccctgaaggc cgccatccga 1560 gccgtcagaa ttctacaatt ccgtctctat aaaaaaaaat tcaaggagac tttgaggcct 1620 tacgatgtga aggatgtgat tgagcagtat tctgccgggc atctcgacat gctttccagg 1680 ataaagtacc ttcagacgag aatagatatg attttcaccc ctggacctcc ctccacgcca 1740 aaacacaaga agtctcagaa agggtcagca ttcaccttcc catcccagca atctcccagg 1800 aatgaaccat atgtagccag accatccaca tcagaaatcg aagaccaaag catgatgggg 1860 aagtttgtaa aagttgaaag acaggttcag gacatgggga agaagctgga cttcctcgtg 1920 gatatgcaca tgcaacacat ggaacggttg caggtgcagg tcacggagta ttacccaacc 1980 aagggcacct cctcgccagc tgaagcagag aagaaggagg acaacaggta ttccgatttg 2040 aaaaccatca tctgcaacta ttctgagaca ggccccccgg aaccacccta cagcttccac 2100 caggtgacca ttgacaaagt cagcccctat gggttttttg cacatgaccc tgtgaacctg 2160 ccccgagggg gacccagttc tggaaaggtt caggcaactc ctccttcctc agcaacaacg 2220 tatgtggaga ggcccacggt cctgcctatc ttgactcttc tcgactcccg agtgagctgc 2280 cactcccagg ctgacctgca gggcccctac tcggaccgaa tctccccccg gcagagacgt 2340 agcatcacgc gagacagtga cacacctctg tccctgatgt cggtcaacca cgaggagctg 2400 gagaggtctc caagtggctt cagcatctcc caggacagag atgattatgt gttcggcccc 2460 aatggggggt cgagctggat gagggagaag cggtacctcg ccgagggtga gacggacaca 2520 gacacggacc ccttcacgcc cagcggctcc atgcctctgt cgtccacagg ggatgggatt 2580 tctgattcag tatggacccc ttccaataag cccatttaa 2619 <210> 5 <211> 2619 <212> DNA <213> Homo sapiens <400> 5 atggggctca aggcgcgcag ggcggcgggg gcggctggcg gcggcggcga cgggggcggc 60 ggaggcggcg gggcggctaa cccagccgga ggggacgcgg cggcggccgg cgacgaggag 120 cggaaagtgg ggctggcgcc cggcgacgtg gagcaagtca ccttggcgct cggggccgga 180 gccgacaaag acgggaccct gctgctggag ggcggcggcc gcgacgaggg gcagcggagg 240 accccgcagg gcatcgggct cctggccaag accccgctga gccgcccagt caagagaaac 300 aacgccaagt accggcgcat ccaaactttg atctacgacg ccctggagag accgcggggc 360 tgggcgctgc tttaccacgc gttggtgttc ctgattgtcc tggggtgctt gattctggct 420 gtcctgacca cattcaagga gtatgagact gtctcgggag actggcttct gttactggag 480 acatttgcta ttttcatctt tggagccgag tttgctttga ggatctgggc tgctggatgt 540 tgctgccgat acaaaggctg gcggggccga ctgaagtttg ccaggaagcc cctgtgcatg 600 ttggacatct ttgtgctgat tgcctctgtg ccagtggttg ctgtgggaaa ccaaggcaat 660 gttctggcca cctccctgcg aagcctgcgc ttcctgcaga tcctgcgcat gctgcggatg 720 gaccggagag gtggcacctg gaagcttctg ggctcagcca tctgtgccca cagcaaagaa 780 ctcatcacgg cctggtacat cggtttcctg acactcatcc tttcttcatt tcttgtctac 840 ctggttgaga aagacgtccc agaggtggat gcacaaggag aggagatgaa agaggagttt 900 gagacctatg cagatgccct gtggtggggc ctgatcacac tgtgcaccat tggctatgga 960 gacaagacac ccaaaacgtg ggaaggccgt ctgattgccg ccaccttttc cttaattggc 1020 gtctcctttt ttgcccttcc agcgggcatc ctggggtccg ggctggccct caaggtgcag 1080 gagcaacacc gtcagaagca ctttgagaaa aggaggaagc cagctgctga gctcattcag 1140 gctgcctgga ggtattatgc taccaacccc aacaggattg acctggtggc gacatggaga 1200 ttttatgaat cagtcgtctc ttttcctttc ttcaggaaag aacagctgga ggcagcatcc 1260 agccaaaagc tgggtctctt ggatcgggtt cgcctttcta atcctcgtgg tagcaatact 1320 aaaggaaagc tatttacccc tctgaatgta gatgccatag aagaaagtcc ttctaaagaa 1380 ccaaagcctg ttggcttaaa caataaagag cgtttccgca cggccttccg catgaaagcc 1440 tacgctttct ggcagagttc tgaagatgcc gggacaggtg accccatggc ggaagacagg 1500 ggctatggga atgacttccc catcgaagac atgatcccca ccctgaaggc cgccatccga 1560 gccgtcagaa ttctacaatt ccgtctctat aaaaaaaaat tcaaggagac tttgaggcct 1620 tacgatgtga aggatgtgat tgagcagtat tctgccgggc atctcgacat gctttccagg 1680 ataaagtacc ttcagacgag aatagatatg attttcaccc ctggacctcc ctccacgcca 1740 aaacacaaga agtctcagaa agggtcagca ttcaccttcc catcccagca atctcccagg 1800 aatgaaccat atgtagccag accatccaca tcagaaatcg aagaccaaag catgatgggg 1860 aagtttgtaa aagttgaaag acaggttcag gacatgggga agaagctgga cttcctcgtg 1920 gatatgcaca tgcaacacat ggaacggttg caggtgcagg tcacggagta ttacccaacc 1980 aagggcacct cctcgccagc tgaagcagag aagaaggagg acaacaggta ttccgatttg 2040 aaaaccatca tctgcaacta ttctgagaca ggccccccgg aaccacccta cagcttccac 2100 caggtgacca ttgacaaagt cagcccctat gggttttttg cacatgaccc tgtgaacctg 2160 ccccgagggg gacccagttc tggaaaggtt caggcaactc ctccttcctc agcaacaacg 2220 tatgtggaga ggcccacggt cctgcctatc ttgactcttc tcgactcccg agtgagctgc 2280 cactcccagg ctgacctgca gggcccctac tcggaccgaa tctccccccg gcagagacgt 2340 agcatcacgc gagacagtga cacacctctg tccctgatgt cggtcaacca cgaggagctg 2400 gagaggtctc caagtggctt cagcatctcc caggacagag atgattatgt gttcggcccc 2460 aatggggggt cgagctggat gagggagaag cggtacctcg ccgagggtga gacggacaca 2520 gacacggacc ccttcacgcc cagcggctcc atgcctctgt cgtccacagg ggatgggatt 2580 tctgattcag tatggacccc ttccaataag cccatttaa 2619 <210> 6 <211> 2619 <212> DNA <213> Homo sapiens <400> 6 atggggctca aggcgcgcag ggcggcgggg gcggctggcg gcggcggcga cgggggcggc 60 ggaggcggcg gggcggctaa cccagccgga ggggacgcgg cggcggccgg cgacgaggag 120 cggaaagtgg ggctggcgcc cggcgacgtg gagcaagtca ccttggcgct cggggccgga 180 gccgacaaag acgggaccct gctgctggag ggcggcggcc gcgacgaggg gcagcggagg 240 accccgcagg gcatcgggct cctggccaag accccgctga gccgcccagt caagagaaac 300 aacgccaagt accggcgcat ccaaactttg atctacgacg ccctggagag accgcggggc 360 tgggcgctgc tttaccacgc gttggtgttc ctgattgtcc tggggtgctt gattctggct 420 gtcctgacca cattcaagga gtatgagact gtctcgggag actggcttct gttactggag 480 acatttgcta ttttcatctt tggagccgag tttgctttga ggatctgggc tgctggatgt 540 tgctgccgat acaaaggctg gcggggccga ctgaagtttg ccaggaagcc cctgtgcatg 600 ttggacatct ttgtgctgat tgcctctgtg ccagtggttg ctgtgggaaa ccaaggcaat 660 gttctggcca cctccctgcg aagcctgcgc ttcctgcaga tcctgcgcat gctgcggatg 720 gaccggagag gtggcacctg gaagcttctg ggctcagcca tctgtgccca cagcaaagaa 780 ctcatcacgg cctggtacat cggtttcctg acactcatcc tttcttcatt tcttgtctac 840 ctggttgaga aagacgtccc agaggtggat gcacaaggag aggagatgaa agaggagttt 900 gagacctatg cagatgccct gtggtggggc ctgatcacac tgaacaccat tggctatgga 960 gacaagacac ccaaaacgtg ggaaggccgt ctgattgccg ccaccttttc cttaattggc 1020 gtctcctttt ttgcccttcc agcgggcatc ctggggtccg ggctggccct caaggtgcag 1080 gagcaacacc gtcagaagca ctttgagaaa aggaggaagc cagctgctga gctcattcag 1140 gctgcctgga ggtattatgc taccaacccc aacaggattg acctggtggc gacatggaga 1200 ttttatgaat cagtcgtctc ttttcctttc ttcaggaaag aacagctgga ggcagcatcc 1260 agccaaaagc tgggtctctt ggatcgggtt cgcctttcta atcctcgtgg tagcaatact 1320 aaaggaaagc tatttacccc tctgaatgta gatgccatag aagaaagtcc ttctaaagaa 1380 ccaaagcctg ttggcttaaa caataaagag cgtttccgca cggccttccg catgaaagcc 1440 tacgctttct ggcagagttc tgaagatgcc gggacaggtg accccatggc ggaagacagg 1500 ggctatggga atgacttccc catcgaagac atgatcccca ccctgaaggc cgccatccga 1560 gccgtcagaa ttctacaatt ccgtctctat aaaaaaaaat tcaaggagac tttgaggcct 1620 tacgatgtga aggatgtgat tgagcagtat tctgccgggc atctcgacat gctttccagg 1680 ataaagtacc ttcagacgag aatagatatg attttcaccc ctggacctcc ctccacgcca 1740 aaacacaaga agtctcagaa agggtcagca ttcaccttcc catcccagca atctcccagg 1800 aatgaaccat atgtagccag accatccaca tcagaaatcg aagaccaaag catgatgggg 1860 aagtttgtaa aagttgaaag acaggttcag gacatgggga agaagctgga cttcctcgtg 1920 gatatgcaca tgcaacacat ggaacggttg caggtgcagg tcacggagta ttacccaacc 1980 aagggcacct cctcgccagc tgaagcagag aagaaggagg acaacaggta ttccgatttg 2040 aaaaccatca tctgcaacta ttctgagaca ggccccccgg aaccacccta cagcttccac 2100 caggtgacca ttgacaaagt cagcccctat gggttttttg cacatgaccc tgtgaacctg 2160 ccccgagggg gacccagttc tggaaaggtt caggcaactc ctccttcctc agcaacaacg 2220 tatgtggaga ggcccacggt cctgcctatc ttgactcttc tcgactcccg agtgagctgc 2280 cactcccagg ctgacctgca gggcccctac tcggaccgaa tctccccccg gcagagacgt 2340 agcatcacgc gagacagtga cacacctctg tccctgatgt cggtcaacca cgaggagctg 2400 gagaggtctc caagtggctt cagcatctcc caggacagag atgattatgt gttcggcccc 2460 aatggggggt cgagctggat gagggagaag cggtacctcg ccgagggtga gacggacaca 2520 gacacggacc ccttcacgcc cagcggctcc atgcctctgt cgtccacagg ggatgggatt 2580 tctgattcag tatggacccc ttccaataag cccatttaa 2619 <210> 7 <211> 2619 <212> DNA <213> Homo sapiens <400> 7 atggggctca aggcgcgcag ggcggcgggg gcggctggcg gcggcggcga cgggggcggc 60 ggaggcggcg gggcggctaa cccagccgga ggggacgcgg cggcggccgg cgacgaggag 120 cggaaagtgg ggctggcgcc cggcgacgtg gagcaagtca ccttggcgct cggggccgga 180 gccgacaaag acgggaccct gctgctggag ggcggcggcc gcgacgaggg gcagcggagg 240 accccgcagg gcatcgggct cctggccaag accccgctga gccgcccagt caagagaaac 300 aacgccaagt accggcgcat ccaaactttg atctacgacg ccctggagag accgcggggc 360 tgggcgctgc tttaccacgc gttggtgttc ctgattgtcc tggggtgctt gattctggct 420 gtcctgacca cattcaagga gtatgagact gtctcgggag actggcttct gttactggag 480 acatttgcta ttttcatctt tggagccgag tttgctttga ggatctgggc tgctggatgt 540 tgctgccgat acaaaggctg gcggggccga ctgaagtttg ccaggaagcc cctgtgcatg 600 ttggacatct ttgtgctgat tgcctctgtg ccagtggttg ctgtgggaaa ccaaggcaat 660 gttctggcca cctccctgcg aagcctgcgc ttcctgcaga tcctgcgcat gctgcggatg 720 gaccggagag gtggcacctg gaagcttctg ggctcagcca tctgtgccca cagcaaagaa 780 ctcatcacgg cctggtacat cggtttcctg acactcatcc tttcttcatt tcttgtctac 840 ctggttgaga aagacgtccc agaggtggat gcacaaggag aggagatgaa agaggagttt 900 gagacctatg cagatgccct gtggtggggc ctgatcacac tgcagaccat tggctatgga 960 gacaagacac ccaaaacgtg ggaaggccgt ctgattgccg ccaccttttc cttaattggc 1020 gtctcctttt ttgcccttcc agcgggcatc ctggggtccg ggctggccct caaggtgcag 1080 gagcaacacc gtcagaagca ctttgagaaa aggaggaagc cagctgctga gctcattcag 1140 gctgcctgga ggtattatgc taccaacccc aacaggattg acctggtggc gacatggaga 1200 ttttatgaat cagtcgtctc ttttcctttc ttcaggaaag aacagctgga ggcagcatcc 1260 agccaaaagc tgggtctctt ggatcgggtt cgcctttcta atcctcgtgg tagcaatact 1320 aaaggaaagc tatttacccc tctgaatgta gatgccatag aagaaagtcc ttctaaagaa 1380 ccaaagcctg ttggcttaaa caataaagag cgtttccgca cggccttccg catgaaagcc 1440 tacgctttct ggcagagttc tgaagatgcc gggacaggtg accccatggc ggaagacagg 1500 ggctatggga atgacttccc catcgaagac atgatcccca ccctgaaggc cgccatccga 1560 gccgtcagaa ttctacaatt ccgtctctat aaaaaaaaat tcaaggagac tttgaggcct 1620 tacgatgtga aggatgtgat tgagcagtat tctgccgggc atctcgacat gctttccagg 1680 ataaagtacc ttcagacgag aatagatatg attttcaccc ctggacctcc ctccacgcca 1740 aaacacaaga agtctcagaa agggtcagca ttcaccttcc catcccagca atctcccagg 1800 aatgaaccat atgtagccag accatccaca tcagaaatcg aagaccaaag catgatgggg 1860 aagtttgtaa aagttgaaag acaggttcag gacatgggga agaagctgga cttcctcgtg 1920 gatatgcaca tgcaacacat ggaacggttg caggtgcagg tcacggagta ttacccaacc 1980 aagggcacct cctcgccagc tgaagcagag aagaaggagg acaacaggta ttccgatttg 2040 aaaaccatca tctgcaacta ttctgagaca ggccccccgg aaccacccta cagcttccac 2100 caggtgacca ttgacaaagt cagcccctat gggttttttg cacatgaccc tgtgaacctg 2160 ccccgagggg gacccagttc tggaaaggtt caggcaactc ctccttcctc agcaacaacg 2220 tatgtggaga ggcccacggt cctgcctatc ttgactcttc tcgactcccg agtgagctgc 2280 cactcccagg ctgacctgca gggcccctac tcggaccgaa tctccccccg gcagagacgt 2340 agcatcacgc gagacagtga cacacctctg tccctgatgt cggtcaacca cgaggagctg 2400 gagaggtctc caagtggctt cagcatctcc caggacagag atgattatgt gttcggcccc 2460 aatggggggt cgagctggat gagggagaag cggtacctcg ccgagggtga gacggacaca 2520 gacacggacc ccttcacgcc cagcggctcc atgcctctgt cgtccacagg ggatgggatt 2580 tctgattcag tatggacccc ttccaataag cccatttaa 2619 <210> 8 <211> 2619 <212> DNA <213> Homo sapiens <400> 8 atggggctca aggcgcgcag ggcggcgggg gcggctggcg gcggcggcga cgggggcggc 60 ggaggcggcg gggcggctaa cccagccgga ggggacgcgg cggcggccgg cgacgaggag 120 cggaaagtgg ggctggcgcc cggcgacgtg gagcaagtca ccttggcgct cggggccgga 180 gccgacaaag acgggaccct gctgctggag ggcggcggcc gcgacgaggg gcagcggagg 240 accccgcagg gcatcgggct cctggccaag accccgctga gccgcccagt caagagaaac 300 aacgccaagt accggcgcat ccaaactttg atctacgacg ccctggagag accgcggggc 360 tgggcgctgc tttaccacgc gttggtgttc ctgattgtcc tggggtgctt gattctggct 420 gtcctgacca cattcaagga gtatgagact gtctcgggag actggcttct gttactggag 480 acatttgcta ttttcatctt tggagccgag tttgctttga ggatctgggc tgctggatgt 540 tgctgccgat acaaaggctg gcggggccga ctgaagtttg ccaggaagcc cctgtgcatg 600 ttggacatct ttgtgctgat tgcctctgtg ccagtggttg ctgtgggaaa ccaaggcaat 660 gttctggcca cctccctgcg aagcctgcgc ttcctgcaga tcctgcgcat gctgcggatg 720 gaccggagag gtggcacctg gaagcttctg ggctcagcca tctgtgccca cagcaaagaa 780 ctcatcacgg cctggtacat cggtttcctg acactcatcc tttcttcatt tcttgtctac 840 ctggttgaga aagacgtccc agaggtggat gcacaaggag aggagatgaa agaggagttt 900 gagacctatg cagatgccct gtggtggggc ctgatcacac tgtacaccat tggctatgga 960 gacaagacac ccaaaacgtg ggaaggccgt ctgattgccg ccaccttttc cttaattggc 1020 gtctcctttt ttgcccttcc agcgggcatc ctggggtccg ggctggccct caaggtgcag 1080 gagcaacacc gtcagaagca ctttgagaaa aggaggaagc cagctgctga gctcattcag 1140 gctgcctgga ggtattatgc taccaacccc aacaggattg acctggtggc gacatggaga 1200 ttttatgaat cagtcgtctc ttttcctttc ttcaggaaag aacagctgga ggcagcatcc 1260 agccaaaagc tgggtctctt ggatcgggtt cgcctttcta atcctcgtgg tagcaatact 1320 aaaggaaagc tatttacccc tctgaatgta gatgccatag aagaaagtcc ttctaaagaa 1380 ccaaagcctg ttggcttaaa caataaagag cgtttccgca cggccttccg catgaaagcc 1440 tacgctttct ggcagagttc tgaagatgcc gggacaggtg accccatggc ggaagacagg 1500 ggctatggga atgacttccc catcgaagac atgatcccca ccctgaaggc cgccatccga 1560 gccgtcagaa ttctacaatt ccgtctctat aaaaaaaaat tcaaggagac tttgaggcct 1620 tacgatgtga aggatgtgat tgagcagtat tctgccgggc atctcgacat gctttccagg 1680 ataaagtacc ttcagacgag aatagatatg attttcaccc ctggacctcc ctccacgcca 1740 aaacacaaga agtctcagaa agggtcagca ttcaccttcc catcccagca atctcccagg 1800 aatgaaccat atgtagccag accatccaca tcagaaatcg aagaccaaag catgatgggg 1860 aagtttgtaa aagttgaaag acaggttcag gacatgggga agaagctgga cttcctcgtg 1920 gatatgcaca tgcaacacat ggaacggttg caggtgcagg tcacggagta ttacccaacc 1980 aagggcacct cctcgccagc tgaagcagag aagaaggagg acaacaggta ttccgatttg 2040 aaaaccatca tctgcaacta ttctgagaca ggccccccgg aaccacccta cagcttccac 2100 caggtgacca ttgacaaagt cagcccctat gggttttttg cacatgaccc tgtgaacctg 2160 ccccgagggg gacccagttc tggaaaggtt caggcaactc ctccttcctc agcaacaacg 2220 tatgtggaga ggcccacggt cctgcctatc ttgactcttc tcgactcccg agtgagctgc 2280 cactcccagg ctgacctgca gggcccctac tcggaccgaa tctccccccg gcagagacgt 2340 agcatcacgc gagacagtga cacacctctg tccctgatgt cggtcaacca cgaggagctg 2400 gagaggtctc caagtggctt cagcatctcc caggacagag atgattatgt gttcggcccc 2460 aatggggggt cgagctggat gagggagaag cggtacctcg ccgagggtga gacggacaca 2520 gacacggacc ccttcacgcc cagcggctcc atgcctctgt cgtccacagg ggatgggatt 2580 tctgattcag tatggacccc ttccaataag cccatttaa 2619 <210> 9 <211> 872 <212> PRT <213> Homo sapiens <400> 9 Met Gly Leu Lys Ala Arg Arg Ala Ala Gly Ala Ala Gly Gly Gly Gly 1 5 10 15 Asp Gly Gly Gly Gly Gly Gly Gly Ala Ala Asn Pro Ala Gly Gly Asp 20 25 30 Ala Ala Ala Ala Gly Asp Glu Glu Arg Lys Val Gly Leu Ala Pro Gly 35 40 45 Asp Val Glu Gln Val Thr Leu Ala Leu Gly Ala Gly Ala Asp Lys Asp 50 55 60 Gly Thr Leu Leu Leu Glu Gly Gly Gly Arg Asp Glu Gly Gln Arg Arg 65 70 75 80 Thr Pro Gln Gly Ile Gly Leu Leu Ala Lys Thr Pro Leu Ser Arg Pro 85 90 95 Val Lys Arg Asn Asn Ala Lys Tyr Arg Arg Ile Gln Thr Leu Ile Tyr 100 105 110 Asp Ala Leu Glu Arg Pro Arg Gly Trp Ala Leu Leu Tyr His Ala Leu 115 120 125 Val Phe Leu Ile Val Leu Gly Cys Leu Ile Leu Ala Val Leu Thr Thr 130 135 140 Phe Lys Glu Tyr Glu Thr Val Ser Gly Asp Trp Leu Leu Leu Leu Glu 145 150 155 160 Thr Phe Ala Ile Phe Ile Phe Gly Ala Glu Phe Ala Leu Arg Ile Trp 165 170 175 Ala Ala Gly Cys Cys Cys Arg Tyr Lys Gly Trp Arg Gly Arg Leu Lys 180 185 190 Phe Ala Arg Lys Pro Leu Cys Met Leu Asp Ile Phe Val Leu Ile Ala 195 200 205 Ser Val Pro Val Val Ala Val Gly Asn Gln Gly Asn Val Leu Ala Thr 210 215 220 Ser Leu Arg Ser Leu Arg Phe Leu Gln Ile Leu Arg Met Leu Arg Met 225 230 235 240 Asp Arg Arg Gly Gly Thr Trp Lys Leu Leu Gly Ser Ala Ile Cys Ala 245 250 255 His Ser Lys Glu Leu Ile Thr Ala Trp Tyr Ile Gly Phe Leu Thr Leu 260 265 270 Ile Leu Ser Ser Phe Leu Val Tyr Leu Val Glu Lys Asp Val Pro Glu 275 280 285 Val Asp Ala Gln Gly Glu Glu Met Lys Glu Glu Phe Glu Thr Tyr Ala 290 295 300 Asp Ala Leu Trp Trp Gly Leu Ile Thr Leu Ala Thr Ile Gly Tyr Gly 305 310 315 320 Asp Lys Thr Pro Lys Thr Trp Glu Gly Arg Leu Ile Ala Ala Thr Phe 325 330 335 Ser Leu Ile Gly Val Ser Phe Phe Ala Leu Pro Ala Gly Ile Leu Gly 340 345 350 Ser Gly Leu Ala Leu Lys Val Gln Glu Gln His Arg Gln Lys His Phe 355 360 365 Glu Lys Arg Arg Lys Pro Ala Ala Glu Leu Ile Gln Ala Ala Trp Arg 370 375 380 Tyr Tyr Ala Thr Asn Pro Asn Arg Ile Asp Leu Val Ala Thr Trp Arg 385 390 395 400 Phe Tyr Glu Ser Val Val Ser Phe Pro Phe Phe Arg Lys Glu Gln Leu 405 410 415 Glu Ala Ala Ser Ser Gln Lys Leu Gly Leu Leu Asp Arg Val Arg Leu 420 425 430 Ser Asn Pro Arg Gly Ser Asn Thr Lys Gly Lys Leu Phe Thr Pro Leu 435 440 445 Asn Val Asp Ala Ile Glu Glu Ser Pro Ser Lys Glu Pro Lys Pro Val 450 455 460 Gly Leu Asn Asn Lys Glu Arg Phe Arg Thr Ala Phe Arg Met Lys Ala 465 470 475 480 Tyr Ala Phe Trp Gln Ser Ser Glu Asp Ala Gly Thr Gly Asp Pro Met 485 490 495 Ala Glu Asp Arg Gly Tyr Gly Asn Asp Phe Pro Ile Glu Asp Met Ile 500 505 510 Pro Thr Leu Lys Ala Ala Ile Arg Ala Val Arg Ile Leu Gln Phe Arg 515 520 525 Leu Tyr Lys Lys Lys Phe Lys Glu Thr Leu Arg Pro Tyr Asp Val Lys 530 535 540 Asp Val Ile Glu Gln Tyr Ser Ala Gly His Leu Asp Met Leu Ser Arg 545 550 555 560 Ile Lys Tyr Leu Gln Thr Arg Ile Asp Met Ile Phe Thr Pro Gly Pro 565 570 575 Pro Ser Thr Pro Lys His Lys Lys Ser Gln Lys Gly Ser Ala Phe Thr 580 585 590 Phe Pro Ser Gln Gln Ser Pro Arg Asn Glu Pro Tyr Val Ala Arg Pro 595 600 605 Ser Thr Ser Glu Ile Glu Asp Gln Ser Met Met Gly Lys Phe Val Lys 610 615 620 Val Glu Arg Gln Val Gln Asp Met Gly Lys Lys Leu Asp Phe Leu Val 625 630 635 640 Asp Met His Met Gln His Met Glu Arg Leu Gln Val Gln Val Thr Glu 645 650 655 Tyr Tyr Pro Thr Lys Gly Thr Ser Ser Pro Ala Glu Ala Glu Lys Lys 660 665 670 Glu Asp Asn Arg Tyr Ser Asp Leu Lys Thr Ile Ile Cys Asn Tyr Ser 675 680 685 Glu Thr Gly Pro Pro Glu Pro Pro Tyr Ser Phe His Gln Val Thr Ile 690 695 700 Asp Lys Val Ser Pro Tyr Gly Phe Phe Ala His Asp Pro Val Asn Leu 705 710 715 720 Pro Arg Gly Gly Pro Ser Ser Gly Lys Val Gln Ala Thr Pro Pro Ser 725 730 735 Ser Ala Thr Thr Tyr Val Glu Arg Pro Thr Val Leu Pro Ile Leu Thr 740 745 750 Leu Leu Asp Ser Arg Val Ser Cys His Ser Gln Ala Asp Leu Gln Gly 755 760 765 Pro Tyr Ser Asp Arg Ile Ser Pro Arg Gln Arg Arg Ser Ile Thr Arg 770 775 780 Asp Ser Asp Thr Pro Leu Ser Leu Met Ser Val Asn His Glu Glu Leu 785 790 795 800 Glu Arg Ser Pro Ser Gly Phe Ser Ile Ser Gln Asp Arg Asp Asp Tyr 805 810 815 Val Phe Gly Pro Asn Gly Gly Ser Ser Trp Met Arg Glu Lys Arg Tyr 820 825 830 Leu Ala Glu Gly Glu Thr Asp Thr Asp Thr Asp Pro Phe Thr Pro Ser 835 840 845 Gly Ser Met Pro Leu Ser Ser Thr Gly Asp Gly Ile Ser Asp Ser Val 850 855 860 Trp Thr Pro Ser Asn Lys Pro Ile 865 870 <210> 10 <211> 872 <212> PRT <213> Homo sapiens <400> 10 Met Gly Leu Lys Ala Arg Arg Ala Ala Gly Ala Ala Gly Gly Gly Gly 1 5 10 15 Asp Gly Gly Gly Gly Gly Gly Gly Ala Ala Asn Pro Ala Gly Gly Asp 20 25 30 Ala Ala Ala Ala Gly Asp Glu Glu Arg Lys Val Gly Leu Ala Pro Gly 35 40 45 Asp Val Glu Gln Val Thr Leu Ala Leu Gly Ala Gly Ala Asp Lys Asp 50 55 60 Gly Thr Leu Leu Leu Glu Gly Gly Gly Arg Asp Glu Gly Gln Arg Arg 65 70 75 80 Thr Pro Gln Gly Ile Gly Leu Leu Ala Lys Thr Pro Leu Ser Arg Pro 85 90 95 Val Lys Arg Asn Asn Ala Lys Tyr Arg Arg Ile Gln Thr Leu Ile Tyr 100 105 110 Asp Ala Leu Glu Arg Pro Arg Gly Trp Ala Leu Leu Tyr His Ala Leu 115 120 125 Val Phe Leu Ile Val Leu Gly Cys Leu Ile Leu Ala Val Leu Thr Thr 130 135 140 Phe Lys Glu Tyr Glu Thr Val Ser Gly Asp Trp Leu Leu Leu Leu Glu 145 150 155 160 Thr Phe Ala Ile Phe Ile Phe Gly Ala Glu Phe Ala Leu Arg Ile Trp 165 170 175 Ala Ala Gly Cys Cys Cys Arg Tyr Lys Gly Trp Arg Gly Arg Leu Lys 180 185 190 Phe Ala Arg Lys Pro Leu Cys Met Leu Asp Ile Phe Val Leu Ile Ala 195 200 205 Ser Val Pro Val Val Ala Val Gly Asn Gln Gly Asn Val Leu Ala Thr 210 215 220 Ser Leu Arg Ser Leu Arg Phe Leu Gln Ile Leu Arg Met Leu Arg Met 225 230 235 240 Asp Arg Arg Gly Gly Thr Trp Lys Leu Leu Gly Ser Ala Ile Cys Ala 245 250 255 His Ser Lys Glu Leu Ile Thr Ala Trp Tyr Ile Gly Phe Leu Thr Leu 260 265 270 Ile Leu Ser Ser Phe Leu Val Tyr Leu Val Glu Lys Asp Val Pro Glu 275 280 285 Val Asp Ala Gln Gly Glu Glu Met Lys Glu Glu Phe Glu Thr Tyr Ala 290 295 300 Asp Ala Leu Trp Trp Gly Leu Ile Thr Leu Thr Thr Ile Gly Tyr Gly 305 310 315 320 Asp Lys Thr Pro Lys Thr Trp Glu Gly Arg Leu Ile Ala Ala Thr Phe 325 330 335 Ser Leu Ile Gly Val Ser Phe Phe Ala Leu Pro Ala Gly Ile Leu Gly 340 345 350 Ser Gly Leu Ala Leu Lys Val Gln Glu Gln His Arg Gln Lys His Phe 355 360 365 Glu Lys Arg Arg Lys Pro Ala Ala Glu Leu Ile Gln Ala Ala Trp Arg 370 375 380 Tyr Tyr Ala Thr Asn Pro Asn Arg Ile Asp Leu Val Ala Thr Trp Arg 385 390 395 400 Phe Tyr Glu Ser Val Val Ser Phe Pro Phe Phe Arg Lys Glu Gln Leu 405 410 415 Glu Ala Ala Ser Ser Gln Lys Leu Gly Leu Leu Asp Arg Val Arg Leu 420 425 430 Ser Asn Pro Arg Gly Ser Asn Thr Lys Gly Lys Leu Phe Thr Pro Leu 435 440 445 Asn Val Asp Ala Ile Glu Glu Ser Pro Ser Lys Glu Pro Lys Pro Val 450 455 460 Gly Leu Asn Asn Lys Glu Arg Phe Arg Thr Ala Phe Arg Met Lys Ala 465 470 475 480 Tyr Ala Phe Trp Gln Ser Ser Glu Asp Ala Gly Thr Gly Asp Pro Met 485 490 495 Ala Glu Asp Arg Gly Tyr Gly Asn Asp Phe Pro Ile Glu Asp Met Ile 500 505 510 Pro Thr Leu Lys Ala Ala Ile Arg Ala Val Arg Ile Leu Gln Phe Arg 515 520 525 Leu Tyr Lys Lys Lys Phe Lys Glu Thr Leu Arg Pro Tyr Asp Val Lys 530 535 540 Asp Val Ile Glu Gln Tyr Ser Ala Gly His Leu Asp Met Leu Ser Arg 545 550 555 560 Ile Lys Tyr Leu Gln Thr Arg Ile Asp Met Ile Phe Thr Pro Gly Pro 565 570 575 Pro Ser Thr Pro Lys His Lys Lys Ser Gln Lys Gly Ser Ala Phe Thr 580 585 590 Phe Pro Ser Gln Gln Ser Pro Arg Asn Glu Pro Tyr Val Ala Arg Pro 595 600 605 Ser Thr Ser Glu Ile Glu Asp Gln Ser Met Met Gly Lys Phe Val Lys 610 615 620 Val Glu Arg Gln Val Gln Asp Met Gly Lys Lys Leu Asp Phe Leu Val 625 630 635 640 Asp Met His Met Gln His Met Glu Arg Leu Gln Val Gln Val Thr Glu 645 650 655 Tyr Tyr Pro Thr Lys Gly Thr Ser Ser Pro Ala Glu Ala Glu Lys Lys 660 665 670 Glu Asp Asn Arg Tyr Ser Asp Leu Lys Thr Ile Ile Cys Asn Tyr Ser 675 680 685 Glu Thr Gly Pro Pro Glu Pro Pro Tyr Ser Phe His Gln Val Thr Ile 690 695 700 Asp Lys Val Ser Pro Tyr Gly Phe Phe Ala His Asp Pro Val Asn Leu 705 710 715 720 Pro Arg Gly Gly Pro Ser Ser Gly Lys Val Gln Ala Thr Pro Pro Ser 725 730 735 Ser Ala Thr Thr Tyr Val Glu Arg Pro Thr Val Leu Pro Ile Leu Thr 740 745 750 Leu Leu Asp Ser Arg Val Ser Cys His Ser Gln Ala Asp Leu Gln Gly 755 760 765 Pro Tyr Ser Asp Arg Ile Ser Pro Arg Gln Arg Arg Ser Ile Thr Arg 770 775 780 Asp Ser Asp Thr Pro Leu Ser Leu Met Ser Val Asn His Glu Glu Leu 785 790 795 800 Glu Arg Ser Pro Ser Gly Phe Ser Ile Ser Gln Asp Arg Asp Asp Tyr 805 810 815 Val Phe Gly Pro Asn Gly Gly Ser Ser Trp Met Arg Glu Lys Arg Tyr 820 825 830 Leu Ala Glu Gly Glu Thr Asp Thr Asp Thr Asp Pro Phe Thr Pro Ser 835 840 845 Gly Ser Met Pro Leu Ser Ser Thr Gly Asp Gly Ile Ser Asp Ser Val 850 855 860 Trp Thr Pro Ser Asn Lys Pro Ile 865 870 <210> 11 <211> 872 <212> PRT <213> Homo sapiens <400> 11 Met Gly Leu Lys Ala Arg Arg Ala Ala Gly Ala Ala Gly Gly Gly Gly 1 5 10 15 Asp Gly Gly Gly Gly Gly Gly Gly Ala Ala Asn Pro Ala Gly Gly Asp 20 25 30 Ala Ala Ala Ala Gly Asp Glu Glu Arg Lys Val Gly Leu Ala Pro Gly 35 40 45 Asp Val Glu Gln Val Thr Leu Ala Leu Gly Ala Gly Ala Asp Lys Asp 50 55 60 Gly Thr Leu Leu Leu Glu Gly Gly Gly Arg Asp Glu Gly Gln Arg Arg 65 70 75 80 Thr Pro Gln Gly Ile Gly Leu Leu Ala Lys Thr Pro Leu Ser Arg Pro 85 90 95 Val Lys Arg Asn Asn Ala Lys Tyr Arg Arg Ile Gln Thr Leu Ile Tyr 100 105 110 Asp Ala Leu Glu Arg Pro Arg Gly Trp Ala Leu Leu Tyr His Ala Leu 115 120 125 Val Phe Leu Ile Val Leu Gly Cys Leu Ile Leu Ala Val Leu Thr Thr 130 135 140 Phe Lys Glu Tyr Glu Thr Val Ser Gly Asp Trp Leu Leu Leu Leu Glu 145 150 155 160 Thr Phe Ala Ile Phe Ile Phe Gly Ala Glu Phe Ala Leu Arg Ile Trp 165 170 175 Ala Ala Gly Cys Cys Cys Arg Tyr Lys Gly Trp Arg Gly Arg Leu Lys 180 185 190 Phe Ala Arg Lys Pro Leu Cys Met Leu Asp Ile Phe Val Leu Ile Ala 195 200 205 Ser Val Pro Val Val Ala Val Gly Asn Gln Gly Asn Val Leu Ala Thr 210 215 220 Ser Leu Arg Ser Leu Arg Phe Leu Gln Ile Leu Arg Met Leu Arg Met 225 230 235 240 Asp Arg Arg Gly Gly Thr Trp Lys Leu Leu Gly Ser Ala Ile Cys Ala 245 250 255 His Ser Lys Glu Leu Ile Thr Ala Trp Tyr Ile Gly Phe Leu Thr Leu 260 265 270 Ile Leu Ser Ser Phe Leu Val Tyr Leu Val Glu Lys Asp Val Pro Glu 275 280 285 Val Asp Ala Gln Gly Glu Glu Met Lys Glu Glu Phe Glu Thr Tyr Ala 290 295 300 Asp Ala Leu Trp Trp Gly Leu Ile Thr Leu Ser Thr Ile Gly Tyr Gly 305 310 315 320 Asp Lys Thr Pro Lys Thr Trp Glu Gly Arg Leu Ile Ala Ala Thr Phe 325 330 335 Ser Leu Ile Gly Val Ser Phe Phe Ala Leu Pro Ala Gly Ile Leu Gly 340 345 350 Ser Gly Leu Ala Leu Lys Val Gln Glu Gln His Arg Gln Lys His Phe 355 360 365 Glu Lys Arg Arg Lys Pro Ala Ala Glu Leu Ile Gln Ala Ala Trp Arg 370 375 380 Tyr Tyr Ala Thr Asn Pro Asn Arg Ile Asp Leu Val Ala Thr Trp Arg 385 390 395 400 Phe Tyr Glu Ser Val Val Ser Phe Pro Phe Phe Arg Lys Glu Gln Leu 405 410 415 Glu Ala Ala Ser Ser Gln Lys Leu Gly Leu Leu Asp Arg Val Arg Leu 420 425 430 Ser Asn Pro Arg Gly Ser Asn Thr Lys Gly Lys Leu Phe Thr Pro Leu 435 440 445 Asn Val Asp Ala Ile Glu Glu Ser Pro Ser Lys Glu Pro Lys Pro Val 450 455 460 Gly Leu Asn Asn Lys Glu Arg Phe Arg Thr Ala Phe Arg Met Lys Ala 465 470 475 480 Tyr Ala Phe Trp Gln Ser Ser Glu Asp Ala Gly Thr Gly Asp Pro Met 485 490 495 Ala Glu Asp Arg Gly Tyr Gly Asn Asp Phe Pro Ile Glu Asp Met Ile 500 505 510 Pro Thr Leu Lys Ala Ala Ile Arg Ala Val Arg Ile Leu Gln Phe Arg 515 520 525 Leu Tyr Lys Lys Lys Phe Lys Glu Thr Leu Arg Pro Tyr Asp Val Lys 530 535 540 Asp Val Ile Glu Gln Tyr Ser Ala Gly His Leu Asp Met Leu Ser Arg 545 550 555 560 Ile Lys Tyr Leu Gln Thr Arg Ile Asp Met Ile Phe Thr Pro Gly Pro 565 570 575 Pro Ser Thr Pro Lys His Lys Lys Ser Gln Lys Gly Ser Ala Phe Thr 580 585 590 Phe Pro Ser Gln Gln Ser Pro Arg Asn Glu Pro Tyr Val Ala Arg Pro 595 600 605 Ser Thr Ser Glu Ile Glu Asp Gln Ser Met Met Gly Lys Phe Val Lys 610 615 620 Val Glu Arg Gln Val Gln Asp Met Gly Lys Lys Leu Asp Phe Leu Val 625 630 635 640 Asp Met His Met Gln His Met Glu Arg Leu Gln Val Gln Val Thr Glu 645 650 655 Tyr Tyr Pro Thr Lys Gly Thr Ser Ser Pro Ala Glu Ala Glu Lys Lys 660 665 670 Glu Asp Asn Arg Tyr Ser Asp Leu Lys Thr Ile Ile Cys Asn Tyr Ser 675 680 685 Glu Thr Gly Pro Pro Glu Pro Pro Tyr Ser Phe His Gln Val Thr Ile 690 695 700 Asp Lys Val Ser Pro Tyr Gly Phe Phe Ala His Asp Pro Val Asn Leu 705 710 715 720 Pro Arg Gly Gly Pro Ser Ser Gly Lys Val Gln Ala Thr Pro Pro Ser 725 730 735 Ser Ala Thr Thr Tyr Val Glu Arg Pro Thr Val Leu Pro Ile Leu Thr 740 745 750 Leu Leu Asp Ser Arg Val Ser Cys His Ser Gln Ala Asp Leu Gln Gly 755 760 765 Pro Tyr Ser Asp Arg Ile Ser Pro Arg Gln Arg Arg Ser Ile Thr Arg 770 775 780 Asp Ser Asp Thr Pro Leu Ser Leu Met Ser Val Asn His Glu Glu Leu 785 790 795 800 Glu Arg Ser Pro Ser Gly Phe Ser Ile Ser Gln Asp Arg Asp Asp Tyr 805 810 815 Val Phe Gly Pro Asn Gly Gly Ser Ser Trp Met Arg Glu Lys Arg Tyr 820 825 830 Leu Ala Glu Gly Glu Thr Asp Thr Asp Thr Asp Pro Phe Thr Pro Ser 835 840 845 Gly Ser Met Pro Leu Ser Ser Thr Gly Asp Gly Ile Ser Asp Ser Val 850 855 860 Trp Thr Pro Ser Asn Lys Pro Ile 865 870 <210> 12 <211> 872 <212> PRT <213> Homo sapiens <400> 12 Met Gly Leu Lys Ala Arg Arg Ala Ala Gly Ala Ala Gly Gly Gly Gly 1 5 10 15 Asp Gly Gly Gly Gly Gly Gly Gly Ala Ala Asn Pro Ala Gly Gly Asp 20 25 30 Ala Ala Ala Ala Gly Asp Glu Glu Arg Lys Val Gly Leu Ala Pro Gly 35 40 45 Asp Val Glu Gln Val Thr Leu Ala Leu Gly Ala Gly Ala Asp Lys Asp 50 55 60 Gly Thr Leu Leu Leu Glu Gly Gly Gly Arg Asp Glu Gly Gln Arg Arg 65 70 75 80 Thr Pro Gln Gly Ile Gly Leu Leu Ala Lys Thr Pro Leu Ser Arg Pro 85 90 95 Val Lys Arg Asn Asn Ala Lys Tyr Arg Arg Ile Gln Thr Leu Ile Tyr 100 105 110 Asp Ala Leu Glu Arg Pro Arg Gly Trp Ala Leu Leu Tyr His Ala Leu 115 120 125 Val Phe Leu Ile Val Leu Gly Cys Leu Ile Leu Ala Val Leu Thr Thr 130 135 140 Phe Lys Glu Tyr Glu Thr Val Ser Gly Asp Trp Leu Leu Leu Leu Glu 145 150 155 160 Thr Phe Ala Ile Phe Ile Phe Gly Ala Glu Phe Ala Leu Arg Ile Trp 165 170 175 Ala Ala Gly Cys Cys Cys Arg Tyr Lys Gly Trp Arg Gly Arg Leu Lys 180 185 190 Phe Ala Arg Lys Pro Leu Cys Met Leu Asp Ile Phe Val Leu Ile Ala 195 200 205 Ser Val Pro Val Val Ala Val Gly Asn Gln Gly Asn Val Leu Ala Thr 210 215 220 Ser Leu Arg Ser Leu Arg Phe Leu Gln Ile Leu Arg Met Leu Arg Met 225 230 235 240 Asp Arg Arg Gly Gly Thr Trp Lys Leu Leu Gly Ser Ala Ile Cys Ala 245 250 255 His Ser Lys Glu Leu Ile Thr Ala Trp Tyr Ile Gly Phe Leu Thr Leu 260 265 270 Ile Leu Ser Ser Phe Leu Val Tyr Leu Val Glu Lys Asp Val Pro Glu 275 280 285 Val Asp Ala Gln Gly Glu Glu Met Lys Glu Glu Phe Glu Thr Tyr Ala 290 295 300 Asp Ala Leu Trp Trp Gly Leu Ile Thr Leu Val Thr Ile Gly Tyr Gly 305 310 315 320 Asp Lys Thr Pro Lys Thr Trp Glu Gly Arg Leu Ile Ala Ala Thr Phe 325 330 335 Ser Leu Ile Gly Val Ser Phe Phe Ala Leu Pro Ala Gly Ile Leu Gly 340 345 350 Ser Gly Leu Ala Leu Lys Val Gln Glu Gln His Arg Gln Lys His Phe 355 360 365 Glu Lys Arg Arg Lys Pro Ala Ala Glu Leu Ile Gln Ala Ala Trp Arg 370 375 380 Tyr Tyr Ala Thr Asn Pro Asn Arg Ile Asp Leu Val Ala Thr Trp Arg 385 390 395 400 Phe Tyr Glu Ser Val Val Ser Phe Pro Phe Phe Arg Lys Glu Gln Leu 405 410 415 Glu Ala Ala Ser Ser Gln Lys Leu Gly Leu Leu Asp Arg Val Arg Leu 420 425 430 Ser Asn Pro Arg Gly Ser Asn Thr Lys Gly Lys Leu Phe Thr Pro Leu 435 440 445 Asn Val Asp Ala Ile Glu Glu Ser Pro Ser Lys Glu Pro Lys Pro Val 450 455 460 Gly Leu Asn Asn Lys Glu Arg Phe Arg Thr Ala Phe Arg Met Lys Ala 465 470 475 480 Tyr Ala Phe Trp Gln Ser Ser Glu Asp Ala Gly Thr Gly Asp Pro Met 485 490 495 Ala Glu Asp Arg Gly Tyr Gly Asn Asp Phe Pro Ile Glu Asp Met Ile 500 505 510 Pro Thr Leu Lys Ala Ala Ile Arg Ala Val Arg Ile Leu Gln Phe Arg 515 520 525 Leu Tyr Lys Lys Lys Phe Lys Glu Thr Leu Arg Pro Tyr Asp Val Lys 530 535 540 Asp Val Ile Glu Gln Tyr Ser Ala Gly His Leu Asp Met Leu Ser Arg 545 550 555 560 Ile Lys Tyr Leu Gln Thr Arg Ile Asp Met Ile Phe Thr Pro Gly Pro 565 570 575 Pro Ser Thr Pro Lys His Lys Lys Ser Gln Lys Gly Ser Ala Phe Thr 580 585 590 Phe Pro Ser Gln Gln Ser Pro Arg Asn Glu Pro Tyr Val Ala Arg Pro 595 600 605 Ser Thr Ser Glu Ile Glu Asp Gln Ser Met Met Gly Lys Phe Val Lys 610 615 620 Val Glu Arg Gln Val Gln Asp Met Gly Lys Lys Leu Asp Phe Leu Val 625 630 635 640 Asp Met His Met Gln His Met Glu Arg Leu Gln Val Gln Val Thr Glu 645 650 655 Tyr Tyr Pro Thr Lys Gly Thr Ser Ser Pro Ala Glu Ala Glu Lys Lys 660 665 670 Glu Asp Asn Arg Tyr Ser Asp Leu Lys Thr Ile Ile Cys Asn Tyr Ser 675 680 685 Glu Thr Gly Pro Pro Glu Pro Pro Tyr Ser Phe His Gln Val Thr Ile 690 695 700 Asp Lys Val Ser Pro Tyr Gly Phe Phe Ala His Asp Pro Val Asn Leu 705 710 715 720 Pro Arg Gly Gly Pro Ser Ser Gly Lys Val Gln Ala Thr Pro Pro Ser 725 730 735 Ser Ala Thr Thr Tyr Val Glu Arg Pro Thr Val Leu Pro Ile Leu Thr 740 745 750 Leu Leu Asp Ser Arg Val Ser Cys His Ser Gln Ala Asp Leu Gln Gly 755 760 765 Pro Tyr Ser Asp Arg Ile Ser Pro Arg Gln Arg Arg Ser Ile Thr Arg 770 775 780 Asp Ser Asp Thr Pro Leu Ser Leu Met Ser Val Asn His Glu Glu Leu 785 790 795 800 Glu Arg Ser Pro Ser Gly Phe Ser Ile Ser Gln Asp Arg Asp Asp Tyr 805 810 815 Val Phe Gly Pro Asn Gly Gly Ser Ser Trp Met Arg Glu Lys Arg Tyr 820 825 830 Leu Ala Glu Gly Glu Thr Asp Thr Asp Thr Asp Pro Phe Thr Pro Ser 835 840 845 Gly Ser Met Pro Leu Ser Ser Thr Gly Asp Gly Ile Ser Asp Ser Val 850 855 860 Trp Thr Pro Ser Asn Lys Pro Ile 865 870 <210> 13 <211> 872 <212> PRT <213> Homo sapiens <400> 13 Met Gly Leu Lys Ala Arg Arg Ala Ala Gly Ala Ala Gly Gly Gly Gly 1 5 10 15 Asp Gly Gly Gly Gly Gly Gly Gly Ala Ala Asn Pro Ala Gly Gly Asp 20 25 30 Ala Ala Ala Ala Gly Asp Glu Glu Arg Lys Val Gly Leu Ala Pro Gly 35 40 45 Asp Val Glu Gln Val Thr Leu Ala Leu Gly Ala Gly Ala Asp Lys Asp 50 55 60 Gly Thr Leu Leu Leu Glu Gly Gly Gly Arg Asp Glu Gly Gln Arg Arg 65 70 75 80 Thr Pro Gln Gly Ile Gly Leu Leu Ala Lys Thr Pro Leu Ser Arg Pro 85 90 95 Val Lys Arg Asn Asn Ala Lys Tyr Arg Arg Ile Gln Thr Leu Ile Tyr 100 105 110 Asp Ala Leu Glu Arg Pro Arg Gly Trp Ala Leu Leu Tyr His Ala Leu 115 120 125 Val Phe Leu Ile Val Leu Gly Cys Leu Ile Leu Ala Val Leu Thr Thr 130 135 140 Phe Lys Glu Tyr Glu Thr Val Ser Gly Asp Trp Leu Leu Leu Leu Glu 145 150 155 160 Thr Phe Ala Ile Phe Ile Phe Gly Ala Glu Phe Ala Leu Arg Ile Trp 165 170 175 Ala Ala Gly Cys Cys Cys Arg Tyr Lys Gly Trp Arg Gly Arg Leu Lys 180 185 190 Phe Ala Arg Lys Pro Leu Cys Met Leu Asp Ile Phe Val Leu Ile Ala 195 200 205 Ser Val Pro Val Val Ala Val Gly Asn Gln Gly Asn Val Leu Ala Thr 210 215 220 Ser Leu Arg Ser Leu Arg Phe Leu Gln Ile Leu Arg Met Leu Arg Met 225 230 235 240 Asp Arg Arg Gly Gly Thr Trp Lys Leu Leu Gly Ser Ala Ile Cys Ala 245 250 255 His Ser Lys Glu Leu Ile Thr Ala Trp Tyr Ile Gly Phe Leu Thr Leu 260 265 270 Ile Leu Ser Ser Phe Leu Val Tyr Leu Val Glu Lys Asp Val Pro Glu 275 280 285 Val Asp Ala Gln Gly Glu Glu Met Lys Glu Glu Phe Glu Thr Tyr Ala 290 295 300 Asp Ala Leu Trp Trp Gly Leu Ile Thr Leu Cys Thr Ile Gly Tyr Gly 305 310 315 320 Asp Lys Thr Pro Lys Thr Trp Glu Gly Arg Leu Ile Ala Ala Thr Phe 325 330 335 Ser Leu Ile Gly Val Ser Phe Phe Ala Leu Pro Ala Gly Ile Leu Gly 340 345 350 Ser Gly Leu Ala Leu Lys Val Gln Glu Gln His Arg Gln Lys His Phe 355 360 365 Glu Lys Arg Arg Lys Pro Ala Ala Glu Leu Ile Gln Ala Ala Trp Arg 370 375 380 Tyr Tyr Ala Thr Asn Pro Asn Arg Ile Asp Leu Val Ala Thr Trp Arg 385 390 395 400 Phe Tyr Glu Ser Val Val Ser Phe Pro Phe Phe Arg Lys Glu Gln Leu 405 410 415 Glu Ala Ala Ser Ser Gln Lys Leu Gly Leu Leu Asp Arg Val Arg Leu 420 425 430 Ser Asn Pro Arg Gly Ser Asn Thr Lys Gly Lys Leu Phe Thr Pro Leu 435 440 445 Asn Val Asp Ala Ile Glu Glu Ser Pro Ser Lys Glu Pro Lys Pro Val 450 455 460 Gly Leu Asn Asn Lys Glu Arg Phe Arg Thr Ala Phe Arg Met Lys Ala 465 470 475 480 Tyr Ala Phe Trp Gln Ser Ser Glu Asp Ala Gly Thr Gly Asp Pro Met 485 490 495 Ala Glu Asp Arg Gly Tyr Gly Asn Asp Phe Pro Ile Glu Asp Met Ile 500 505 510 Pro Thr Leu Lys Ala Ala Ile Arg Ala Val Arg Ile Leu Gln Phe Arg 515 520 525 Leu Tyr Lys Lys Lys Phe Lys Glu Thr Leu Arg Pro Tyr Asp Val Lys 530 535 540 Asp Val Ile Glu Gln Tyr Ser Ala Gly His Leu Asp Met Leu Ser Arg 545 550 555 560 Ile Lys Tyr Leu Gln Thr Arg Ile Asp Met Ile Phe Thr Pro Gly Pro 565 570 575 Pro Ser Thr Pro Lys His Lys Lys Ser Gln Lys Gly Ser Ala Phe Thr 580 585 590 Phe Pro Ser Gln Gln Ser Pro Arg Asn Glu Pro Tyr Val Ala Arg Pro 595 600 605 Ser Thr Ser Glu Ile Glu Asp Gln Ser Met Met Gly Lys Phe Val Lys 610 615 620 Val Glu Arg Gln Val Gln Asp Met Gly Lys Lys Leu Asp Phe Leu Val 625 630 635 640 Asp Met His Met Gln His Met Glu Arg Leu Gln Val Gln Val Thr Glu 645 650 655 Tyr Tyr Pro Thr Lys Gly Thr Ser Ser Pro Ala Glu Ala Glu Lys Lys 660 665 670 Glu Asp Asn Arg Tyr Ser Asp Leu Lys Thr Ile Ile Cys Asn Tyr Ser 675 680 685 Glu Thr Gly Pro Pro Glu Pro Pro Tyr Ser Phe His Gln Val Thr Ile 690 695 700 Asp Lys Val Ser Pro Tyr Gly Phe Phe Ala His Asp Pro Val Asn Leu 705 710 715 720 Pro Arg Gly Gly Pro Ser Ser Gly Lys Val Gln Ala Thr Pro Pro Ser 725 730 735 Ser Ala Thr Thr Tyr Val Glu Arg Pro Thr Val Leu Pro Ile Leu Thr 740 745 750 Leu Leu Asp Ser Arg Val Ser Cys His Ser Gln Ala Asp Leu Gln Gly 755 760 765 Pro Tyr Ser Asp Arg Ile Ser Pro Arg Gln Arg Arg Ser Ile Thr Arg 770 775 780 Asp Ser Asp Thr Pro Leu Ser Leu Met Ser Val Asn His Glu Glu Leu 785 790 795 800 Glu Arg Ser Pro Ser Gly Phe Ser Ile Ser Gln Asp Arg Asp Asp Tyr 805 810 815 Val Phe Gly Pro Asn Gly Gly Ser Ser Trp Met Arg Glu Lys Arg Tyr 820 825 830 Leu Ala Glu Gly Glu Thr Asp Thr Asp Thr Asp Pro Phe Thr Pro Ser 835 840 845 Gly Ser Met Pro Leu Ser Ser Thr Gly Asp Gly Ile Ser Asp Ser Val 850 855 860 Trp Thr Pro Ser Asn Lys Pro Ile 865 870 <210> 14 <211> 872 <212> PRT <213> Homo sapiens <400> 14 Met Gly Leu Lys Ala Arg Arg Ala Ala Gly Ala Ala Gly Gly Gly Gly 1 5 10 15 Asp Gly Gly Gly Gly Gly Gly Gly Ala Ala Asn Pro Ala Gly Gly Asp 20 25 30 Ala Ala Ala Ala Gly Asp Glu Glu Arg Lys Val Gly Leu Ala Pro Gly 35 40 45 Asp Val Glu Gln Val Thr Leu Ala Leu Gly Ala Gly Ala Asp Lys Asp 50 55 60 Gly Thr Leu Leu Leu Glu Gly Gly Gly Arg Asp Glu Gly Gln Arg Arg 65 70 75 80 Thr Pro Gln Gly Ile Gly Leu Leu Ala Lys Thr Pro Leu Ser Arg Pro 85 90 95 Val Lys Arg Asn Asn Ala Lys Tyr Arg Arg Ile Gln Thr Leu Ile Tyr 100 105 110 Asp Ala Leu Glu Arg Pro Arg Gly Trp Ala Leu Leu Tyr His Ala Leu 115 120 125 Val Phe Leu Ile Val Leu Gly Cys Leu Ile Leu Ala Val Leu Thr Thr 130 135 140 Phe Lys Glu Tyr Glu Thr Val Ser Gly Asp Trp Leu Leu Leu Leu Glu 145 150 155 160 Thr Phe Ala Ile Phe Ile Phe Gly Ala Glu Phe Ala Leu Arg Ile Trp 165 170 175 Ala Ala Gly Cys Cys Cys Arg Tyr Lys Gly Trp Arg Gly Arg Leu Lys 180 185 190 Phe Ala Arg Lys Pro Leu Cys Met Leu Asp Ile Phe Val Leu Ile Ala 195 200 205 Ser Val Pro Val Val Ala Val Gly Asn Gln Gly Asn Val Leu Ala Thr 210 215 220 Ser Leu Arg Ser Leu Arg Phe Leu Gln Ile Leu Arg Met Leu Arg Met 225 230 235 240 Asp Arg Arg Gly Gly Thr Trp Lys Leu Leu Gly Ser Ala Ile Cys Ala 245 250 255 His Ser Lys Glu Leu Ile Thr Ala Trp Tyr Ile Gly Phe Leu Thr Leu 260 265 270 Ile Leu Ser Ser Phe Leu Val Tyr Leu Val Glu Lys Asp Val Pro Glu 275 280 285 Val Asp Ala Gln Gly Glu Glu Met Lys Glu Glu Phe Glu Thr Tyr Ala 290 295 300 Asp Ala Leu Trp Trp Gly Leu Ile Thr Leu Asn Thr Ile Gly Tyr Gly 305 310 315 320 Asp Lys Thr Pro Lys Thr Trp Glu Gly Arg Leu Ile Ala Ala Thr Phe 325 330 335 Ser Leu Ile Gly Val Ser Phe Phe Ala Leu Pro Ala Gly Ile Leu Gly 340 345 350 Ser Gly Leu Ala Leu Lys Val Gln Glu Gln His Arg Gln Lys His Phe 355 360 365 Glu Lys Arg Arg Lys Pro Ala Ala Glu Leu Ile Gln Ala Ala Trp Arg 370 375 380 Tyr Tyr Ala Thr Asn Pro Asn Arg Ile Asp Leu Val Ala Thr Trp Arg 385 390 395 400 Phe Tyr Glu Ser Val Val Ser Phe Pro Phe Phe Arg Lys Glu Gln Leu 405 410 415 Glu Ala Ala Ser Ser Gln Lys Leu Gly Leu Leu Asp Arg Val Arg Leu 420 425 430 Ser Asn Pro Arg Gly Ser Asn Thr Lys Gly Lys Leu Phe Thr Pro Leu 435 440 445 Asn Val Asp Ala Ile Glu Glu Ser Pro Ser Lys Glu Pro Lys Pro Val 450 455 460 Gly Leu Asn Asn Lys Glu Arg Phe Arg Thr Ala Phe Arg Met Lys Ala 465 470 475 480 Tyr Ala Phe Trp Gln Ser Ser Glu Asp Ala Gly Thr Gly Asp Pro Met 485 490 495 Ala Glu Asp Arg Gly Tyr Gly Asn Asp Phe Pro Ile Glu Asp Met Ile 500 505 510 Pro Thr Leu Lys Ala Ala Ile Arg Ala Val Arg Ile Leu Gln Phe Arg 515 520 525 Leu Tyr Lys Lys Lys Phe Lys Glu Thr Leu Arg Pro Tyr Asp Val Lys 530 535 540 Asp Val Ile Glu Gln Tyr Ser Ala Gly His Leu Asp Met Leu Ser Arg 545 550 555 560 Ile Lys Tyr Leu Gln Thr Arg Ile Asp Met Ile Phe Thr Pro Gly Pro 565 570 575 Pro Ser Thr Pro Lys His Lys Lys Ser Gln Lys Gly Ser Ala Phe Thr 580 585 590 Phe Pro Ser Gln Gln Ser Pro Arg Asn Glu Pro Tyr Val Ala Arg Pro 595 600 605 Ser Thr Ser Glu Ile Glu Asp Gln Ser Met Met Gly Lys Phe Val Lys 610 615 620 Val Glu Arg Gln Val Gln Asp Met Gly Lys Lys Leu Asp Phe Leu Val 625 630 635 640 Asp Met His Met Gln His Met Glu Arg Leu Gln Val Gln Val Thr Glu 645 650 655 Tyr Tyr Pro Thr Lys Gly Thr Ser Ser Pro Ala Glu Ala Glu Lys Lys 660 665 670 Glu Asp Asn Arg Tyr Ser Asp Leu Lys Thr Ile Ile Cys Asn Tyr Ser 675 680 685 Glu Thr Gly Pro Pro Glu Pro Pro Tyr Ser Phe His Gln Val Thr Ile 690 695 700 Asp Lys Val Ser Pro Tyr Gly Phe Phe Ala His Asp Pro Val Asn Leu 705 710 715 720 Pro Arg Gly Gly Pro Ser Ser Gly Lys Val Gln Ala Thr Pro Pro Ser 725 730 735 Ser Ala Thr Thr Tyr Val Glu Arg Pro Thr Val Leu Pro Ile Leu Thr 740 745 750 Leu Leu Asp Ser Arg Val Ser Cys His Ser Gln Ala Asp Leu Gln Gly 755 760 765 Pro Tyr Ser Asp Arg Ile Ser Pro Arg Gln Arg Arg Ser Ile Thr Arg 770 775 780 Asp Ser Asp Thr Pro Leu Ser Leu Met Ser Val Asn His Glu Glu Leu 785 790 795 800 Glu Arg Ser Pro Ser Gly Phe Ser Ile Ser Gln Asp Arg Asp Asp Tyr 805 810 815 Val Phe Gly Pro Asn Gly Gly Ser Ser Trp Met Arg Glu Lys Arg Tyr 820 825 830 Leu Ala Glu Gly Glu Thr Asp Thr Asp Thr Asp Pro Phe Thr Pro Ser 835 840 845 Gly Ser Met Pro Leu Ser Ser Thr Gly Asp Gly Ile Ser Asp Ser Val 850 855 860 Trp Thr Pro Ser Asn Lys Pro Ile 865 870 <210> 15 <211> 872 <212> PRT <213> Homo sapiens <400> 15 Met Gly Leu Lys Ala Arg Arg Ala Ala Gly Ala Ala Gly Gly Gly Gly 1 5 10 15 Asp Gly Gly Gly Gly Gly Gly Gly Ala Ala Asn Pro Ala Gly Gly Asp 20 25 30 Ala Ala Ala Ala Gly Asp Glu Glu Arg Lys Val Gly Leu Ala Pro Gly 35 40 45 Asp Val Glu Gln Val Thr Leu Ala Leu Gly Ala Gly Ala Asp Lys Asp 50 55 60 Gly Thr Leu Leu Leu Glu Gly Gly Gly Arg Asp Glu Gly Gln Arg Arg 65 70 75 80 Thr Pro Gln Gly Ile Gly Leu Leu Ala Lys Thr Pro Leu Ser Arg Pro 85 90 95 Val Lys Arg Asn Asn Ala Lys Tyr Arg Arg Ile Gln Thr Leu Ile Tyr 100 105 110 Asp Ala Leu Glu Arg Pro Arg Gly Trp Ala Leu Leu Tyr His Ala Leu 115 120 125 Val Phe Leu Ile Val Leu Gly Cys Leu Ile Leu Ala Val Leu Thr Thr 130 135 140 Phe Lys Glu Tyr Glu Thr Val Ser Gly Asp Trp Leu Leu Leu Leu Glu 145 150 155 160 Thr Phe Ala Ile Phe Ile Phe Gly Ala Glu Phe Ala Leu Arg Ile Trp 165 170 175 Ala Ala Gly Cys Cys Cys Arg Tyr Lys Gly Trp Arg Gly Arg Leu Lys 180 185 190 Phe Ala Arg Lys Pro Leu Cys Met Leu Asp Ile Phe Val Leu Ile Ala 195 200 205 Ser Val Pro Val Val Ala Val Gly Asn Gln Gly Asn Val Leu Ala Thr 210 215 220 Ser Leu Arg Ser Leu Arg Phe Leu Gln Ile Leu Arg Met Leu Arg Met 225 230 235 240 Asp Arg Arg Gly Gly Thr Trp Lys Leu Leu Gly Ser Ala Ile Cys Ala 245 250 255 His Ser Lys Glu Leu Ile Thr Ala Trp Tyr Ile Gly Phe Leu Thr Leu 260 265 270 Ile Leu Ser Ser Phe Leu Val Tyr Leu Val Glu Lys Asp Val Pro Glu 275 280 285 Val Asp Ala Gln Gly Glu Glu Met Lys Glu Glu Phe Glu Thr Tyr Ala 290 295 300 Asp Ala Leu Trp Trp Gly Leu Ile Thr Leu Gln Thr Ile Gly Tyr Gly 305 310 315 320 Asp Lys Thr Pro Lys Thr Trp Glu Gly Arg Leu Ile Ala Ala Thr Phe 325 330 335 Ser Leu Ile Gly Val Ser Phe Phe Ala Leu Pro Ala Gly Ile Leu Gly 340 345 350 Ser Gly Leu Ala Leu Lys Val Gln Glu Gln His Arg Gln Lys His Phe 355 360 365 Glu Lys Arg Arg Lys Pro Ala Ala Glu Leu Ile Gln Ala Ala Trp Arg 370 375 380 Tyr Tyr Ala Thr Asn Pro Asn Arg Ile Asp Leu Val Ala Thr Trp Arg 385 390 395 400 Phe Tyr Glu Ser Val Val Ser Phe Pro Phe Phe Arg Lys Glu Gln Leu 405 410 415 Glu Ala Ala Ser Ser Gln Lys Leu Gly Leu Leu Asp Arg Val Arg Leu 420 425 430 Ser Asn Pro Arg Gly Ser Asn Thr Lys Gly Lys Leu Phe Thr Pro Leu 435 440 445 Asn Val Asp Ala Ile Glu Glu Ser Pro Ser Lys Glu Pro Lys Pro Val 450 455 460 Gly Leu Asn Asn Lys Glu Arg Phe Arg Thr Ala Phe Arg Met Lys Ala 465 470 475 480 Tyr Ala Phe Trp Gln Ser Ser Glu Asp Ala Gly Thr Gly Asp Pro Met 485 490 495 Ala Glu Asp Arg Gly Tyr Gly Asn Asp Phe Pro Ile Glu Asp Met Ile 500 505 510 Pro Thr Leu Lys Ala Ala Ile Arg Ala Val Arg Ile Leu Gln Phe Arg 515 520 525 Leu Tyr Lys Lys Lys Phe Lys Glu Thr Leu Arg Pro Tyr Asp Val Lys 530 535 540 Asp Val Ile Glu Gln Tyr Ser Ala Gly His Leu Asp Met Leu Ser Arg 545 550 555 560 Ile Lys Tyr Leu Gln Thr Arg Ile Asp Met Ile Phe Thr Pro Gly Pro 565 570 575 Pro Ser Thr Pro Lys His Lys Lys Ser Gln Lys Gly Ser Ala Phe Thr 580 585 590 Phe Pro Ser Gln Gln Ser Pro Arg Asn Glu Pro Tyr Val Ala Arg Pro 595 600 605 Ser Thr Ser Glu Ile Glu Asp Gln Ser Met Met Gly Lys Phe Val Lys 610 615 620 Val Glu Arg Gln Val Gln Asp Met Gly Lys Lys Leu Asp Phe Leu Val 625 630 635 640 Asp Met His Met Gln His Met Glu Arg Leu Gln Val Gln Val Thr Glu 645 650 655 Tyr Tyr Pro Thr Lys Gly Thr Ser Ser Pro Ala Glu Ala Glu Lys Lys 660 665 670 Glu Asp Asn Arg Tyr Ser Asp Leu Lys Thr Ile Ile Cys Asn Tyr Ser 675 680 685 Glu Thr Gly Pro Pro Glu Pro Pro Tyr Ser Phe His Gln Val Thr Ile 690 695 700 Asp Lys Val Ser Pro Tyr Gly Phe Phe Ala His Asp Pro Val Asn Leu 705 710 715 720 Pro Arg Gly Gly Pro Ser Ser Gly Lys Val Gln Ala Thr Pro Pro Ser 725 730 735 Ser Ala Thr Thr Tyr Val Glu Arg Pro Thr Val Leu Pro Ile Leu Thr 740 745 750 Leu Leu Asp Ser Arg Val Ser Cys His Ser Gln Ala Asp Leu Gln Gly 755 760 765 Pro Tyr Ser Asp Arg Ile Ser Pro Arg Gln Arg Arg Ser Ile Thr Arg 770 775 780 Asp Ser Asp Thr Pro Leu Ser Leu Met Ser Val Asn His Glu Glu Leu 785 790 795 800 Glu Arg Ser Pro Ser Gly Phe Ser Ile Ser Gln Asp Arg Asp Asp Tyr 805 810 815 Val Phe Gly Pro Asn Gly Gly Ser Ser Trp Met Arg Glu Lys Arg Tyr 820 825 830 Leu Ala Glu Gly Glu Thr Asp Thr Asp Thr Asp Pro Phe Thr Pro Ser 835 840 845 Gly Ser Met Pro Leu Ser Ser Thr Gly Asp Gly Ile Ser Asp Ser Val 850 855 860 Trp Thr Pro Ser Asn Lys Pro Ile 865 870 <210> 16 <211> 872 <212> PRT <213> Homo sapiens <400> 16 Met Gly Leu Lys Ala Arg Arg Ala Ala Gly Ala Ala Gly Gly Gly Gly 1 5 10 15 Asp Gly Gly Gly Gly Gly Gly Gly Ala Ala Asn Pro Ala Gly Gly Asp 20 25 30 Ala Ala Ala Ala Gly Asp Glu Glu Arg Lys Val Gly Leu Ala Pro Gly 35 40 45 Asp Val Glu Gln Val Thr Leu Ala Leu Gly Ala Gly Ala Asp Lys Asp 50 55 60 Gly Thr Leu Leu Leu Glu Gly Gly Gly Arg Asp Glu Gly Gln Arg Arg 65 70 75 80 Thr Pro Gln Gly Ile Gly Leu Leu Ala Lys Thr Pro Leu Ser Arg Pro 85 90 95 Val Lys Arg Asn Asn Ala Lys Tyr Arg Arg Ile Gln Thr Leu Ile Tyr 100 105 110 Asp Ala Leu Glu Arg Pro Arg Gly Trp Ala Leu Leu Tyr His Ala Leu 115 120 125 Val Phe Leu Ile Val Leu Gly Cys Leu Ile Leu Ala Val Leu Thr Thr 130 135 140 Phe Lys Glu Tyr Glu Thr Val Ser Gly Asp Trp Leu Leu Leu Leu Glu 145 150 155 160 Thr Phe Ala Ile Phe Ile Phe Gly Ala Glu Phe Ala Leu Arg Ile Trp 165 170 175 Ala Ala Gly Cys Cys Cys Arg Tyr Lys Gly Trp Arg Gly Arg Leu Lys 180 185 190 Phe Ala Arg Lys Pro Leu Cys Met Leu Asp Ile Phe Val Leu Ile Ala 195 200 205 Ser Val Pro Val Val Ala Val Gly Asn Gln Gly Asn Val Leu Ala Thr 210 215 220 Ser Leu Arg Ser Leu Arg Phe Leu Gln Ile Leu Arg Met Leu Arg Met 225 230 235 240 Asp Arg Arg Gly Gly Thr Trp Lys Leu Leu Gly Ser Ala Ile Cys Ala 245 250 255 His Ser Lys Glu Leu Ile Thr Ala Trp Tyr Ile Gly Phe Leu Thr Leu 260 265 270 Ile Leu Ser Ser Phe Leu Val Tyr Leu Val Glu Lys Asp Val Pro Glu 275 280 285 Val Asp Ala Gln Gly Glu Glu Met Lys Glu Glu Phe Glu Thr Tyr Ala 290 295 300 Asp Ala Leu Trp Trp Gly Leu Ile Thr Leu Tyr Thr Ile Gly Tyr Gly 305 310 315 320 Asp Lys Thr Pro Lys Thr Trp Glu Gly Arg Leu Ile Ala Ala Thr Phe 325 330 335 Ser Leu Ile Gly Val Ser Phe Phe Ala Leu Pro Ala Gly Ile Leu Gly 340 345 350 Ser Gly Leu Ala Leu Lys Val Gln Glu Gln His Arg Gln Lys His Phe 355 360 365 Glu Lys Arg Arg Lys Pro Ala Ala Glu Leu Ile Gln Ala Ala Trp Arg 370 375 380 Tyr Tyr Ala Thr Asn Pro Asn Arg Ile Asp Leu Val Ala Thr Trp Arg 385 390 395 400 Phe Tyr Glu Ser Val Val Ser Phe Pro Phe Phe Arg Lys Glu Gln Leu 405 410 415 Glu Ala Ala Ser Ser Gln Lys Leu Gly Leu Leu Asp Arg Val Arg Leu 420 425 430 Ser Asn Pro Arg Gly Ser Asn Thr Lys Gly Lys Leu Phe Thr Pro Leu 435 440 445 Asn Val Asp Ala Ile Glu Glu Ser Pro Ser Lys Glu Pro Lys Pro Val 450 455 460 Gly Leu Asn Asn Lys Glu Arg Phe Arg Thr Ala Phe Arg Met Lys Ala 465 470 475 480 Tyr Ala Phe Trp Gln Ser Ser Glu Asp Ala Gly Thr Gly Asp Pro Met 485 490 495 Ala Glu Asp Arg Gly Tyr Gly Asn Asp Phe Pro Ile Glu Asp Met Ile 500 505 510 Pro Thr Leu Lys Ala Ala Ile Arg Ala Val Arg Ile Leu Gln Phe Arg 515 520 525 Leu Tyr Lys Lys Lys Phe Lys Glu Thr Leu Arg Pro Tyr Asp Val Lys 530 535 540 Asp Val Ile Glu Gln Tyr Ser Ala Gly His Leu Asp Met Leu Ser Arg 545 550 555 560 Ile Lys Tyr Leu Gln Thr Arg Ile Asp Met Ile Phe Thr Pro Gly Pro 565 570 575 Pro Ser Thr Pro Lys His Lys Lys Ser Gln Lys Gly Ser Ala Phe Thr 580 585 590 Phe Pro Ser Gln Gln Ser Pro Arg Asn Glu Pro Tyr Val Ala Arg Pro 595 600 605 Ser Thr Ser Glu Ile Glu Asp Gln Ser Met Met Gly Lys Phe Val Lys 610 615 620 Val Glu Arg Gln Val Gln Asp Met Gly Lys Lys Leu Asp Phe Leu Val 625 630 635 640 Asp Met His Met Gln His Met Glu Arg Leu Gln Val Gln Val Thr Glu 645 650 655 Tyr Tyr Pro Thr Lys Gly Thr Ser Ser Pro Ala Glu Ala Glu Lys Lys 660 665 670 Glu Asp Asn Arg Tyr Ser Asp Leu Lys Thr Ile Ile Cys Asn Tyr Ser 675 680 685 Glu Thr Gly Pro Pro Glu Pro Pro Tyr Ser Phe His Gln Val Thr Ile 690 695 700 Asp Lys Val Ser Pro Tyr Gly Phe Phe Ala His Asp Pro Val Asn Leu 705 710 715 720 Pro Arg Gly Gly Pro Ser Ser Gly Lys Val Gln Ala Thr Pro Pro Ser 725 730 735 Ser Ala Thr Thr Tyr Val Glu Arg Pro Thr Val Leu Pro Ile Leu Thr 740 745 750 Leu Leu Asp Ser Arg Val Ser Cys His Ser Gln Ala Asp Leu Gln Gly 755 760 765 Pro Tyr Ser Asp Arg Ile Ser Pro Arg Gln Arg Arg Ser Ile Thr Arg 770 775 780 Asp Ser Asp Thr Pro Leu Ser Leu Met Ser Val Asn His Glu Glu Leu 785 790 795 800 Glu Arg Ser Pro Ser Gly Phe Ser Ile Ser Gln Asp Arg Asp Asp Tyr 805 810 815 Val Phe Gly Pro Asn Gly Gly Ser Ser Trp Met Arg Glu Lys Arg Tyr 820 825 830 Leu Ala Glu Gly Glu Thr Asp Thr Asp Thr Asp Pro Phe Thr Pro Ser 835 840 845 Gly Ser Met Pro Leu Ser Ser Thr Gly Asp Gly Ile Ser Asp Ser Val 850 855 860 Trp Thr Pro Ser Asn Lys Pro Ile 865 870