118003-11720 US 63/514,392 2023-07-19 REGENERON PHARMACEUTICALS, INC CHALOTHORN, Dan ANTI-FACTOR XII/XIIa ANTIBODIES AND USES THEREOF ANTICUERPOS ANTI-FACTOR XII/XIIa Y SUS USOS 40 369 DNA PAT misc_feature 1..369 note Synthetic Sintético source 1..369 mol_type other DNA organism synthetic construct Construcción sintética gaggtgcagctggtggagtctgggggaggcttggtacagcctggggggtccctgagactctcctgtgcagcctctggattcacctttagcagctatgccatgcactgggtccgccaggctccagggaaggggctggagtgggtctcaggtattggtggtagtggtggtaacacatactacgcagactccgtgaagggccgcttcaccatctccagagacaattccaagaactcgctgtatttgcaaatgaacagcctgagagccgaggacacggccgtttattactgtgcgagcttcataccagctgccataagagggggcgactggatcgacccctggggccagggaaccctggtcaccgtctcctca 123 AA PAT REGION 1..123 note Synthetic Sintético source 1..123 mol_type protein organism synthetic construct Construcción sintética EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYAMHWVRQAPGKGLEWVSGIGGSGGNTYYADSVKGRFTISRDNSKNSLYLQMNSLRAEDTAVYYCASFIPAAIRGGDWIDPWGQGTLVTVSS 24 DNA PAT misc_feature 1..24 note Synthetic Sintético source 1..24 mol_type other DNA organism synthetic construct Construcción sintética ggattcacctttagcagctatgcc 8 AA PAT REGION 1..8 note Synthetic Sintético source 1..8 mol_type protein organism synthetic construct Construcción sintética GFTFSSYA 24 DNA PAT misc_feature 1..24 note Synthetic Sintético source 1..24 mol_type other DNA organism synthetic construct Construcción sintética attggtggtagtggtggtaacaca 8 AA PAT REGION 1..8 note Synthetic Sintético source 1..8 mol_type protein organism synthetic construct Construcción sintética IGGSGGNT 48 DNA PAT misc_feature 1..48 note Synthetic Sintético source 1..48 mol_type other DNA organism synthetic construct Construcción sintética gcgagcttcataccagctgccataagagggggcgactggatcgacccc 16 AA PAT REGION 1..16 note Synthetic Sintético source 1..16 mol_type protein organism synthetic construct Construcción sintética ASFIPAAIRGGDWIDP 321 DNA PAT misc_feature 1..321 note Synthetic Sintético source 1..321 mol_type other DNA organism synthetic construct Construcción sintética gacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcaccatcacttgccgggcgagtcagggcataagaaattatttagcctggtatcaacagaaaccagggaagattcctaagctcctgatctatgctgcatccactttgcaatcaggggtcccatctcggttcagtggcagtggatctgggacagatttcactctcaccatcagcagcctgcagcctgaagatattgcaacttattactgtcaatactataacagtgccccgctcactttcggcggagggaccaaggtggagatcaaa 107 AA PAT REGION 1..107 note Synthetic Sintético source 1..107 mol_type protein organism synthetic construct Construcción sintética DIQMTQSPSSLSASVGDRVTITCRASQGIRNYLAWYQQKPGKIPKLLIYAASTLQSGVPSRFSGSGSGTDFTLTISSLQPEDIATYYCQYYNSAPLTFGGGTKVEIK 18 DNA PAT misc_feature 1..18 note Synthetic Sintético source 1..18 mol_type other DNA organism synthetic construct Construcción sintética cagggcataagaaattat 6 AA PAT REGION 1..6 note Synthetic Sintético source 1..6 mol_type protein organism synthetic construct Construcción sintética QGIRNY 000 000 27 DNA PAT misc_feature 1..27 note Synthetic Sintético source 1..27 mol_type other DNA organism synthetic construct Construcción sintética caatactataacagtgccccgctcact 9 AA PAT REGION 1..9 note Synthetic Sintético source 1..9 mol_type protein organism synthetic construct Construcción sintética QYYNSAPLT 1353 DNA PAT misc_feature 1..1353 note Synthetic Sintético source 1..1353 mol_type other DNA organism synthetic construct Construcción sintética gaggtgcagctggtggagtctgggggaggcttggtacagcctggggggtccctgagactctcctgtgcagcctctggattcacctttagcagctatgccatgcactgggtccgccaggctccagggaaggggctggagtgggtctcaggtattggtggtagtggtggtaacacatactacgcagactccgtgaagggccgcttcaccatctccagagacaattccaagaactcgctgtatttgcaaatgaacagcctgagagccgaggacacggccgtttattactgtgcgagcttcataccagctgccataagagggggcgactggatcgacccctggggccagggaaccctggtcaccgtctcctcagcctccaccaagggcccatcggtcttccccctggcgccctgctccaggagcacctccgagagcacagccgccctgggctgcctggtcaaggactacttccccgaaccggtgacggtgtcgtggaactcaggcgccctgaccagcggcgtgcacaccttcccggctgtcctacagtcctcaggactctactccctcagcagcgtggtgaccgtgccctccagcagcttgggcacgaagacctacacctgcaacgtagatcacaagcccagcaacaccaaggtggacaagagagttgagtccaaatatggtcccccatgcccaccctgcccagcacctgagttcctggggggaccatcagtcttcctgttccccccaaaacccaaggacactctcatgatctcccggacccctgaggtcacgtgcgtggtggtggacgtgagccaggaagaccccgaggtccagttcaactggtacgtggatggcgtggaggtgcataatgccaagacaaagccgcgggaggagcagttcaacagcacgtaccgtgtggtcagcgtcctcaccgtcctgcaccaggactggctgaacggcaaggagtacaagtgcaaggtctccaacaaaggcctcccgtcctccatcgagaaaaccatctccaaagccaaagggcagccccgagagccacaggtgtacaccctgcccccatcccaggaggagatgaccaagaaccaggtcagcctgacctgcctggtcaaaggcttctaccccagcgacatcgccgtggagtgggagagcaatgggcagccggagaacaactacaagaccacgcctcccgtgctggactccgacggctccttcttcctctacagcaggctcaccgtggacaagagcaggtggcaggaggggaatgtcttctcatgctccgtgatgcatgaggctctgcacaaccactacacacagaagtccctctccctgtctctgggtaaatga 450 AA PAT REGION 1..450 note Synthetic Sintético source 1..450 mol_type protein organism synthetic construct Construcción sintética EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYAMHWVRQAPGKGLEWVSGIGGSGGNTYYADSVKGRFTISRDNSKNSLYLQMNSLRAEDTAVYYCASFIPAAIRGGDWIDPWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK 645 DNA PAT misc_feature 1..645 note Synthetic Sintético source 1..645 mol_type other DNA organism synthetic construct Construcción sintética gacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcaccatcacttgccgggcgagtcagggcataagaaattatttagcctggtatcaacagaaaccagggaagattcctaagctcctgatctatgctgcatccactttgcaatcaggggtcccatctcggttcagtggcagtggatctgggacagatttcactctcaccatcagcagcctgcagcctgaagatattgcaacttattactgtcaatactataacagtgccccgctcactttcggcggagggaccaaggtggagatcaaacgaactgtggctgcaccatctgtcttcatcttcccgccatctgatgagcagttgaaatctggaactgcctctgttgtgtgcctgctgaataacttctatcccagagaggccaaagtacagtggaaggtggataacgccctccaatcgggtaactcccaggagagtgtcacagagcaggacagcaaggacagcacctacagcctcagcagcaccctgacgctgagcaaagcagactacgagaaacacaaagtctacgcctgcgaagtcacccatcagggcctgagctcgcccgtcacaaagagcttcaacaggggagagtgttag 214 AA PAT REGION 1..214 note Synthetic Sintético source 1..214 mol_type protein organism synthetic construct Construcción sintética DIQMTQSPSSLSASVGDRVTITCRASQGIRNYLAWYQQKPGKIPKLLIYAASTLQSGVPSRFSGSGSGTDFTLTISSLQPEDIATYYCQYYNSAPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 369 DNA PAT misc_feature 1..369 note Synthetic Sintético source 1..369 mol_type other DNA organism synthetic construct Construcción sintética caggtacagctgcagcagtcaggtccaggactggtgaagccctcgcagaccctctcactcacctgtgccatctccggggacagtgtctctagcaacagtgctgcttggaactggatcaggcagtccccatcgagaggccttgagtggctgggaaagacatactacaggtccaagtggtataatgattatacaaaatctgtgaaaagtcgaataaccatcaacccagacacatccaagaaccacttctccctgcaactgaactctatgactcccgaggacacggctgtgtattactgtgcaagagaggttagtgggaggtacaactggttcgactcctggggccagggaaccctggtcaccgtctcctca 123 AA PAT REGION 1..123 note Synthetic Sintético source 1..123 mol_type protein organism synthetic construct Construcción sintética QVQLQQSGPGLVKPSQTLSLTCAISGDSVSSNSAAWNWIRQSPSRGLEWLGKTYYRSKWYNDYTKSVKSRITINPDTSKNHFSLQLNSMTPEDTAVYYCAREVSGRYNWFDSWGQGTLVTVSS 30 DNA PAT misc_feature 1..30 note Synthetic Sintético source 1..30 mol_type other DNA organism synthetic construct Construcción sintética ggggacagtgtctctagcaacagtgctgct 10 AA PAT REGION 1..10 note Synthetic Sintético source 1..10 mol_type protein organism synthetic construct Construcción sintética GDSVSSNSAA 27 DNA PAT misc_feature 1..27 note Synthetic Sintético source 1..27 mol_type other DNA organism synthetic construct Construcción sintética acatactacaggtccaagtggtataat 9 AA PAT REGION 1..9 note Synthetic Sintético source 1..9 mol_type protein organism synthetic construct Construcción sintética TYYRSKWYN 39 DNA PAT misc_feature 1..39 note Synthetic Sintético source 1..39 mol_type other DNA organism synthetic construct Construcción sintética gcaagagaggttagtgggaggtacaactggttcgactcc 13 AA PAT REGION 1..13 note Synthetic Sintético source 1..13 mol_type protein organism synthetic construct Construcción sintética AREVSGRYNWFDS 318 DNA PAT misc_feature 1..318 note Synthetic Sintético source 1..318 mol_type other DNA organism synthetic construct Construcción sintética gacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcaccatcacttgccgggcaagtcagaccattaacagttacttaaattggtatcagcagaaaccagggaaagcccctaagctcctgatctatgctgcatccagtttgcgaagtggggtcccatcaaggttcagtggcagtggatctgggacagatttcactctcaccatcagcagtctgcaacctgaagattttgcaacttactactgtcaacagaattacagaaccttcactttcggcggagggaccaaggtggagatcaaa 106 AA PAT REGION 1..106 note Synthetic Sintético source 1..106 mol_type protein organism synthetic construct Construcción sintética DIQMTQSPSSLSASVGDRVTITCRASQTINSYLNWYQQKPGKAPKLLIYAASSLRSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQNYRTFTFGGGTKVEIK 18 DNA PAT misc_feature 1..18 note Synthetic Sintético source 1..18 mol_type other DNA organism synthetic construct Construcción sintética cagaccattaacagttac 6 AA PAT REGION 1..6 note Synthetic Sintético source 1..6 mol_type protein organism synthetic construct Construcción sintética QTINSY 24 DNA PAT misc_feature 1..24 note Synthetic Sintético source 1..24 mol_type other DNA organism synthetic construct Construcción sintética caacagaattacagaaccttcact 8 AA PAT REGION 1..8 note Synthetic Sintético source 1..8 mol_type protein organism synthetic construct Construcción sintética QQNYRTFT 1353 DNA PAT misc_feature 1..1353 note Synthetic Sintético source 1..1353 mol_type other DNA organism synthetic construct Construcción sintética caggtacagctgcagcagtcaggtccaggactggtgaagccctcgcagaccctctcactcacctgtgccatctccggggacagtgtctctagcaacagtgctgcttggaactggatcaggcagtccccatcgagaggccttgagtggctgggaaagacatactacaggtccaagtggtataatgattatacaaaatctgtgaaaagtcgaataaccatcaacccagacacatccaagaaccacttctccctgcaactgaactctatgactcccgaggacacggctgtgtattactgtgcaagagaggttagtgggaggtacaactggttcgactcctggggccagggaaccctggtcaccgtctcctcagcctccaccaagggcccatcggtcttccccctggcgccctgctccaggagcacctccgagagcacagccgccctgggctgcctggtcaaggactacttccccgaaccggtgacggtgtcgtggaactcaggcgccctgaccagcggcgtgcacaccttcccggctgtcctacagtcctcaggactctactccctcagcagcgtggtgaccgtgccctccagcagcttgggcacgaagacctacacctgcaacgtagatcacaagcccagcaacaccaaggtggacaagagagttgagtccaaatatggtcccccatgcccaccctgcccagcacctgagttcctggggggaccatcagtcttcctgttccccccaaaacccaaggacactctcatgatctcccggacccctgaggtcacgtgcgtggtggtggacgtgagccaggaagaccccgaggtccagttcaactggtacgtggatggcgtggaggtgcataatgccaagacaaagccgcgggaggagcagttcaacagcacgtaccgtgtggtcagcgtcctcaccgtcctgcaccaggactggctgaacggcaaggagtacaagtgcaaggtctccaacaaaggcctcccgtcctccatcgagaaaaccatctccaaagccaaagggcagccccgagagccacaggtgtacaccctgcccccatcccaggaggagatgaccaagaaccaggtcagcctgacctgcctggtcaaaggcttctaccccagcgacatcgccgtggagtgggagagcaatgggcagccggagaacaactacaagaccacgcctcccgtgctggactccgacggctccttcttcctctacagcaggctcaccgtggacaagagcaggtggcaggaggggaatgtcttctcatgctccgtgatgcatgaggctctgcacaaccactacacacagaagtccctctccctgtctctgggtaaatga 450 AA PAT REGION 1..450 note Synthetic Sintético source 1..450 mol_type protein organism synthetic construct Construcción sintética QVQLQQSGPGLVKPSQTLSLTCAISGDSVSSNSAAWNWIRQSPSRGLEWLGKTYYRSKWYNDYTKSVKSRITINPDTSKNHFSLQLNSMTPEDTAVYYCAREVSGRYNWFDSWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK 642 DNA PAT misc_feature 1..642 note Synthetic Sintético source 1..642 mol_type other DNA organism synthetic construct Construcción sintética gacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcaccatcacttgccgggcaagtcagaccattaacagttacttaaattggtatcagcagaaaccagggaaagcccctaagctcctgatctatgctgcatccagtttgcgaagtggggtcccatcaaggttcagtggcagtggatctgggacagatttcactctcaccatcagcagtctgcaacctgaagattttgcaacttactactgtcaacagaattacagaaccttcactttcggcggagggaccaaggtggagatcaaacgaactgtggctgcaccatctgtcttcatcttcccgccatctgatgagcagttgaaatctggaactgcctctgttgtgtgcctgctgaataacttctatcccagagaggccaaagtacagtggaaggtggataacgccctccaatcgggtaactcccaggagagtgtcacagagcaggacagcaaggacagcacctacagcctcagcagcaccctgacgctgagcaaagcagactacgagaaacacaaagtctacgcctgcgaagtcacccatcagggcctgagctcgcccgtcacaaagagcttcaacaggggagagtgttag 213 AA PAT REGION 1..213 note Synthetic Sintético source 1..213 mol_type protein organism synthetic construct Construcción sintética DIQMTQSPSSLSASVGDRVTITCRASQTINSYLNWYQQKPGKAPKLLIYAASSLRSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQNYRTFTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 1353 DNA PAT source 1..1353 mol_type other DNA organism synthetic construct Construcción sintética gaggtgcagctggtggagtctgggggaggcttggtacagcctggggggtccctgagactctcctgtgcagcctctggattcacctttagcagctatgccatgcactgggtccgccaggctccagggaaggggctggagtgggtctcaggtattggtggtagtggtggtaacacatactacgcagactccgtgaagggccgcttcaccatctccagagacaattccaagaactcgctgtatttgcaaatgaacagcctgagagccgaggacacggccgtttattactgtgcgagcttcataccagctgccataagagggggcgactggatcgacccctggggccagggaaccctggtcaccgtctcctcagcctccaccaagggcccatcggtcttccccctggcgccctgctccaggagcacctccgagagcacagccgccctgggctgcctggtcaaggactacttccccgaaccggtgacggtgtcgtggaactcaggcgccctgaccagcggcgtgcacaccttcccggctgtcctacagtcctcaggactctactccctcagcagcgtggtgaccgtgccctccagcagcttgggcacgaagacctacacctgcaacgtagatcacaagcccagcaacaccaaggtggacaagagagttgagtccaaatatggtcccccatgcccaccctgcccagcacctgagttcctggggggaccatcagtcttcctgttccccccaaaacccaaggacactctctacatcacccgggagcctgaggtcacgtgcgtggtggtggacgtgagccaggaagaccccgaggtccagttcaactggtacgtggatggcgtggaggtgcataatgccaagacaaagccgcgggaggagcagttcaacagcacgtaccgtgtggtcagcgtcctcaccgtcctgcaccaggactggctgaacggcaaggagtacaagtgcaaggtctccaacaaaggcctcccgtcctccatcgagaaaaccatctccaaagccaaagggcagccccgagagccacaggtgtacaccctgcccccatcccaggaggagatgaccaagaaccaggtcagcctgacctgcctggtcaaaggcttctaccccagcgacatcgccgtggagtgggagagcaatgggcagccggagaacaactacaagaccacgcctcccgtgctggactccgacggctccttcttcctctacagcaggctcaccgtggacaagagcaggtggcaggaggggaatgtcttctcatgctccgtgatgcatgaggctctgcacaaccactacacacagaagtccctctccctgtctctgggtaaatga 450 AA PAT source 1..450 mol_type protein organism synthetic construct Construcción sintética EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYAMHWVRQAPGKGLEWVSGIGGSGGNTYYADSVKGRFTISRDNSKNSLYLQMNSLRAEDTAVYYCASFIPAAIRGGDWIDPWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLYITREPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK