WO 24-0221-WO US 63/588.282 2023-10-05 Capstan Therapeutics, Inc. Capstan Therapeutics, Inc. CONSTRAINED IONIZABLE CATIONIC LIPIDS AND LIPID NANOPARTICLES LÍPIDOS CATIÓNICOS IONIZABLES RESTRINGIDOS Y NANOPARTÍCULAS LIPÍDICAS 6 450 AA PAT source 1..450 mol_type protein organism synthetic construct constructo sintético QVQLVQSGAEVKKPGASVKVSCKASRYTFTDYNLHWVRQAPGQGLEWMGFIYPYNGGTGYAQKFQGRVTMTVDTSTSTAYMELSSLRSEDTAVYYCARDHRYNEGVSFDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALAAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG 218 AA PAT source 1..218 mol_type protein organism synthetic construct constructo sintético DIQLTQSPSSLSASVGDRATITCRASESVDGFGNSFMNWYQQKPGKAPKLLIYLASNLESGVPSRFSGSGSGTDFTLTISSVQPEDFATYYCQQNNEDPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 1776 RNA PAT source 1..1776 mol_type other RNA organism synthetic construct constructo sintético agcataaaagtcacatttgcttctgacatagttgtgttgactcacaaccccagaaacagacatcgaattcgctgccaccatggccctgcccgtgaccgccctcctgctgcccctggccctgctcctgcacgccgcccggcccgagatcgtgctgacccagagccccggcaccctgagcctgagccccggcgagcgggccaccctgagctgccgggccagccagagcgtgagcagcagttacctggcctggtaccagcagaagcccggccaggccccacggctgctgatctacggcgccagcagccgggccaccggcatccccgaccggttcagcggctccggcagcggcaccgacttcaccctgaccatcagccggctggagcccgaggacttcgccgtgtactactgccagcagtacggcagcagccggttcaccttcggccccggcaccaaggtggacatcaagggcagcaccagcggcagcggcaagcccggcagcggcgagggcagcaccaagggccaggtgcagctggtgcagagcggcgccgaggtgaagaagcccggcagcagcgtgaaggtgagctgcaaggacagcggcggcaccttcagcagctacgccatcagctgggtgcggcaggccccaggccagggcctggagtggatgggcggcatcatccccatcttcggcaccaccaactacgcccagcagttccagggccgggtgaccatcaccgccgacgagagcaccagcaccgcctacatggagctgagcagcctgcggagcgaggacaccgccgtctactactgcgcccgggaggccgtggccgccgactggctggacccctggggccagggcaccctggtgaccgtgagcagcatcgaggtgatgtacccaccaccctacctggacaacgagaaaagcaacggcaccatcatccacgtgaagggcaagcacctgtgccccagcccactgttccccggccccagcaagcccttctgggtgctggtcgtggtgggcggcgtgctggcctgctacagcctgctggtgaccgtggccttcatcatcttctgggtgcggagcaagcggagccggctgctgcacagcgactacatgaacatgaccccacggcggcccggccccacccggaagcactaccagccctacgccccaccccgggacttcgccgcctaccggagccgggtgaagttcagccggagcgccgacgccccagcctaccagcagggccagaaccagctctacaacgagctgaacctgggccggcgggaggagtacgacgtgctggacaagcggcggggccgggaccccgagatgggcggcaagccccggcggaagaacccacaggagggcctctacaatgagctgcagaaggacaagatggccgaggcctacagcgagatcggcatgaagggcgagcggcggaggggcaagggccacgacggcctgtaccagggcctgagcaccgccaccaaggacacctacgacgccctgcacatgcaggccctgccaccccggtgataaaggatccgagactactgttatttgaccaatgaattgacttctaataaaatctagtggtgatgcagttcagacttcaaatagtggcaaataaaaagtgctatttgtgatggtttgcttctgtgtacaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa 1969 RNA PAT source 1..1969 mol_type other RNA organism synthetic construct constructo sintético agcataaaagtcacatttgcttctgacatagttgtgttgactcacaaccccagaaacagacatcgaattcgctgccaccatggaagacgccaaaaacataaagaaaggcccagcgccattctacccactcgaagacgggaccgccggcgagcagctgcacaaagccatgaagcgctacgccctggtgcccggcaccatcgcctttaccgacgcacatatcgaggtggacattacctacgccgagtacttcgagatgagcgttcggctggcagaagctatgaagcgctatgggctgaatacaaaccatcggatcgtggtgtgcagcgagaatagcttgcagttcttcatgcccgtgttgggtgccctgttcatcggtgtggctgtggccccagctaacgacatctacaacgagcgcgagctgctgaacagcatgggcatcagccagcccaccgtcgtattcgtgagcaagaaagggctgcaaaagatcctcaacgtgcaaaagaagctaccgatcatacaaaagatcatcatcatggatagcaagaccgactaccagggcttccaaagcatgtacaccttcgtgacttcccatttgccacccggcttcaacgagtacgacttcgtgcccgagagcttcgaccgggacaaaaccatcgccctgatcatgaacagtagtggcagtaccggattgcccaagggcgtagccctaccgcaccgcaccgcttgtgtccgattcagtcatgcccgcgaccccatcttcggcaaccagatcatccccgacaccgctatcctcagcgtggtgccatttcaccacggcttcggcatgttcaccacgctgggctacttgatctgcggctttcgggtcgtgctcatgtaccgcttcgaggaggagctattcttgcgcagcttgcaagactataagattcaatctgccctgctggtgcccacactatttagcttcttcgctaagagcactctcatcgacaagtacgacctaagcaacttgcacgagatcgccagcggcggggcgccgctcagcaaggaggtaggtgaggccgtggccaaacgcttccacctaccaggcatccgccagggctacggcctgacagaaacaaccagcgccattctgatcacccccgaaggggacgacaagcctggcgcagtaggcaaggtggtgcccttcttcgaggctaaggtggtggacttggacaccggtaagacactgggtgtgaaccagcgcggcgagctgtgcgtccgtggccccatgatcatgagcggctacgttaacaaccccgaggctacaaacgctctcatcgacaaggacggctggctgcacagcggcgacatcgcctactgggacgaggacgagcacttcttcatcgtggaccggctgaaaagcctgatcaaatacaagggctaccaggtagccccagccgaactggagagcatcctgctgcaacaccccaacatcttcgacgccggggtcgccggcctgcccgacgacgatgccggcgagctgcccgccgcagtcgtcgtgctggaacacggtaaaaccatgaccgagaaggagatcgtggactatgtggccagccaggttacaaccgccaagaagctgcgcggtggtgttgtgttcgtggacgaggtgcctaaaggactgaccggcaagttggacgcccgcaagatccgcgagattctcattaaggccaagaagggcggaaagatcgccgtgtgataaaggatccgctggagcctcggtggccatgcttcttgccccttgggcctccccccagcccctcctccccttcctgcacccgtacccccgtggtctttgaataaagtctgagtgggcggcatgtacaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa 1128 RNA PAT source 1..1128 mol_type other RNA organism synthetic construct constructo sintético agcataaaagtctcaacacaacatatacaaaacaaacgaatctcaagcaatcaagcattctacttctattgcagcaatttaaatcatttcttttaaagcaaaagcaattttctgaaaattttcaccatttacgaacgatagcgaattcgctgccaccatggtgtccaagggcgaggaagataatatggccatcatcaaggagttcatgaggttcaaggtgcacatggaaggcagcgttaacggccacgagttcgagatcgagggcgaaggagaaggaagaccctacgagggaacacagaccgctaaactgaaagtgacaaagggaggccctctgccattcgcctgggacatcctgtcccctcagttcatgtacggcagcaaggcctacgtcaagcatcctgccgacatccctgactacctgaagctgagctttcccgagggcttcaagtgggaacgggtgatgaacttcgaggacggcggcgtggtgaccgtgacacaagacagcagcctgcaggatggagagtttatttataaggtgaagctgagaggcaccaacttccccagcgacggccctgtgatgcagaaaaagaccatgggctgggaggcctctagcgagcggatgtatcctgaagatggcgccctgaagggcgagatcaagcagagactgaaactgaaggacggcggccactacgacgccgaggtgaaaaccacctacaaggccaagaagcctgtgcagctgcccggcgcttacaacgtgaatatcaagctcgatatcaccagccacaacgaggattacaccatcgtggaacagtacgagagagccgaaggcagacactctacaggaggcatggacgagctgtacaagtgaggatccagtgactgactaggatctggttaccactaaaccagcctcaagaacacccgaatggagtctctaagctacataataccaacttacacttacaaaatgttgtcccccaaaatgtagccattcgtatctgctcctaataaaaagaaagtttcttcacattctaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaatctag 5 AA PAT source 1..5 mol_type protein organism synthetic construct constructo sintético LPXTG