JP PCT/JP2024/080221 2024-12-06 FA1535-24186 JP PCT/JP2023/044949 2023-12-08 Astellas Pharma Inc. COMBINATION THERAPY INVOLVING BISPECIFIC BINDING AGENTS BINDING TO CLDN18.2 AND CD3 AND AGENTS STABILIZING OR INCREASING EXPRESSION OF CLDN18.2 TERAPIA DE COMBINACIÓN QUE IMPLICA AGENTES DE UNIÓN BIESPECÍFICOS QUE SE UNEN A CLDN18.2 Y CD3 Y AGENTES QUE ESTABILIZAN O AUMENTAN LA EXPRESIÓN DE CLDN18.2 38 261 AA PAT source 1..261 mol_type protein organism Homo sapiens Homo sapiens MAVTACQGLGFVVSLIGIAGIIAATCMDQWSTQDLYNNPVTAVFNYQGLWRSCVRESSGFTECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAGGLTLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKIYDGGARTEDEVQSYPSKHDYV 20 AA PAT REGION 1..20 note Peptide linker Enlazador peptídico source 1..20 mol_type protein organism synthetic construct constructo sintético GKPGSGKPGSGKPGSGKPGS 9 AA PAT REGION 1..9 note Peptide linker Enlazador peptídico source 1..9 mol_type protein organism synthetic construct constructo sintético KTHTCPPCP 19 AA PAT REGION 1..19 note Peptide linker Enlazador peptídico source 1..19 mol_type protein organism synthetic construct constructo sintético GGGGSGGGGSKTHTCPPCP 10 AA PAT REGION 1..10 note Peptide linker Enlazador peptídico source 1..10 mol_type protein organism synthetic construct constructo sintético GGGGSGGGGS 15 AA PAT REGION 1..15 note Peptide linker Enlazador peptídico source 1..15 mol_type protein organism synthetic construct constructo sintético EPKSCDKTHTCPPCP 329 AA PAT REGION 1..329 note Immunoglobulin-derived sequence Secuencia derivada de inmunoglobulina source 1..329 mol_type protein organism synthetic construct constructo sintético ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSDTKVDKKVEPKSCDKTHTCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVKHEDPEVKFNWYVDGVEVHNAKTKPREEEYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCDVSGFYPSDIAVEWESDGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWEQGDVFSCSVMHEALHNHYTQKSLSLSPGK 216 AA PAT REGION 1..216 note Immunoglobulin-derived sequence Secuencia derivada de inmunoglobulina source 1..216 mol_type protein organism synthetic construct constructo sintético APPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVKHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREQMTKNQVKLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 107 AA PAT REGION 1..107 note Immunoglobulin-derived sequence Secuencia derivada de inmunoglobulina source 1..107 mol_type protein organism synthetic construct constructo sintético RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 5 AA PAT REGION 1..5 note CDR sequence Secuencia CDR source 1..5 mol_type protein organism synthetic construct constructo sintético SYWIN 17 AA PAT REGION 1..17 note CDR sequence Secuencia CDR source 1..17 mol_type protein organism synthetic construct constructo sintético NIYPSDSYTNYNQKFQG 9 AA PAT REGION 1..9 note CDR sequence Secuencia CDR source 1..9 mol_type protein organism synthetic construct constructo sintético SWRGNSFDY 17 AA PAT REGION 1..17 note CDR sequence Secuencia CDR source 1..17 mol_type protein organism synthetic construct constructo sintético KSSQSLLNSGNQKNYLT 7 AA PAT REGION 1..7 note CDR sequence Secuencia CDR source 1..7 mol_type protein organism synthetic construct constructo sintético WASTRES 9 AA PAT REGION 1..9 note CDR sequence Secuencia CDR source 1..9 mol_type protein organism synthetic construct constructo sintético QNDYSYPFT 118 AA PAT REGION 1..118 note Immunoglobulin-derived sequence Secuencia derivada de inmunoglobulina source 1..118 mol_type protein organism synthetic construct constructo sintético EVQLVQSGAEVKKPGESLRISCKASGYTFTSYWINWVRQMPGKGLEWMGNIYPSDSYTNYNQKFQGHVTISVDKSISTAYLQWSSLKASDTAMYYCTRSWRGNSFDYWGQGTLVTVSS 113 AA PAT REGION 1..113 note Immunoglobulin-derived sequence Secuencia derivada de inmunoglobulina source 1..113 mol_type protein organism synthetic construct constructo sintético DIVMTQSPDSLAVSLGERATINCKSSQSLLNSGNQKNYLTWYQQKPGQPPKLLIYWASTRESGVPDRFTGSGSGTDFTLTISSLQAEDVAVYYCQNDYSYPFTFGSGTKLEIK 5 AA PAT REGION 1..5 note CDR sequence Secuencia CDR source 1..5 mol_type protein organism synthetic construct constructo sintético TYAMN 14 AA PAT REGION 1..14 note CDR sequence Secuencia CDR source 1..14 mol_type protein organism synthetic construct constructo sintético HGNFGDSYVSWFAY 14 AA PAT REGION 1..14 note CDR sequence Secuencia CDR source 1..14 mol_type protein organism synthetic construct constructo sintético GSSTGAVTTSNYAN 7 AA PAT REGION 1..7 note CDR sequence Secuencia CDR source 1..7 mol_type protein organism synthetic construct constructo sintético GTNKRAP 9 AA PAT REGION 1..9 note CDR sequence Secuencia CDR source 1..9 mol_type protein organism synthetic construct constructo sintético ALWYSNHWV 19 AA PAT REGION 1..19 note CDR sequence Secuencia CDR source 1..19 mol_type protein organism synthetic construct constructo sintético RIRSKANNYATYYADSVKG 109 AA PAT REGION 1..109 note Immunoglobulin-derived sequence Secuencia derivada de inmunoglobulina source 1..109 mol_type protein organism synthetic construct constructo sintético QAVVTQEPSLTVSPGGTVTLTCGSSTGAVTTSNYANWVQQKPGKSPRGLIGGTNKRAPGVPARFSGSLLGGKAALTISGAQPEDEADYYCALWYSNHWVFGGGTKLTVL 125 AA PAT REGION 1..125 note Immunoglobulin-derived sequence Secuencia derivada de inmunoglobulina source 1..125 mol_type protein organism synthetic construct constructo sintético EVQLVESGGGLVQPGGSLRLSCAASGFTFSTYAMNWVRQAPGKGLEWVGRIRSKANNYATYYADSVKGRFTISRDDSKNTLYLQMNSLRAEDTAVYYCVRHGNFGDSYVSWFAYWGQGTLVTVSS 254 AA PAT REGION 1..254 note Immunoglobulin-derived sequence Secuencia derivada de inmunoglobulina source 1..254 mol_type protein organism synthetic construct constructo sintético QAVVTQEPSLTVSPGGTVTLTCGSSTGAVTTSNYANWVQQKPGKSPRGLIGGTNKRAPGVPARFSGSLLGGKAALTISGAQPEDEADYYCALWYSNHWVFGGGTKLTVLGKPGSGKPGSGKPGSGKPGSEVQLVESGGGLVQPGGSLRLSCAASGFTFSTYAMNWVRQAPGKGLEWVGRIRSKANNYATYYADSVKGRFTISRDDSKNTLYLQMNSLRAEDTAVYYCVRHGNFGDSYVSWFAYWGQGTLVTVSS 447 AA PAT REGION 1..447 note Immunoglobulin-derived sequence Secuencia derivada de inmunoglobulina source 1..447 mol_type protein organism synthetic construct constructo sintético EVQLVQSGAEVKKPGESLRISCKASGYTFTSYWINWVRQMPGKGLEWMGNIYPSDSYTNYNQKFQGHVTISVDKSISTAYLQWSSLKASDTAMYYCTRSWRGNSFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSDTKVDKKVEPKSCDKTHTCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVKHEDPEVKFNWYVDGVEVHNAKTKPREEEYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCDVSGFYPSDIAVEWESDGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWEQGDVFSCSVMHEALHNHYTQKSLSLSPGK 720 AA PAT REGION 1..720 note Immunoglobulin-derived sequence Secuencia derivada de inmunoglobulina source 1..720 mol_type protein organism synthetic construct constructo sintético EVQLVQSGAEVKKPGESLRISCKASGYTFTSYWINWVRQMPGKGLEWMGNIYPSDSYTNYNQKFQGHVTISVDKSISTAYLQWSSLKASDTAMYYCTRSWRGNSFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCGGGGSGGGGSQAVVTQEPSLTVSPGGTVTLTCGSSTGAVTTSNYANWVQQKPGKSPRGLIGGTNKRAPGVPARFSGSLLGGKAALTISGAQPEDEADYYCALWYSNHWVFGGGTKLTVLGKPGSGKPGSGKPGSGKPGSEVQLVESGGGLVQPGGSLRLSCAASGFTFSTYAMNWVRQAPGKGLEWVGRIRSKANNYATYYADSVKGRFTISRDDSKNTLYLQMNSLRAEDTAVYYCVRHGNFGDSYVSWFAYWGQGTLVTVSSGGGGSGGGGSKTHTCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVKHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREQMTKNQVKLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 220 AA PAT REGION 1..220 note Immunoglobulin-derived sequence Secuencia derivada de inmunoglobulina source 1..220 mol_type protein organism synthetic construct constructo sintético DIVMTQSPDSLAVSLGERATINCKSSQSLLNSGNQKNYLTWYQQKPGQPPKLLIYWASTRESGVPDRFTGSGSGTDFTLTISSLQAEDVAVYYCQNDYSYPFTFGSGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 1337 AA PAT source 1..1337 mol_type protein organism Homo sapiens Homo sapiens ASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV 116 AA PAT source 1..116 mol_type protein organism synthetic construct constructo sintético EVQLVQSGGGLVKPGGSLRLSCAASGFTFSSYSMNWVRQAPGKGLEWVSSISSSSSYIYYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARVTDAFDIWGQGTMVTVSS 107 AA PAT source 1..107 mol_type protein organism synthetic construct constructo sintético DIQMTQSPSSVSASIGDRVTITCRASQGIDNWLGWYQQKPGKAPKLLIYDASNLDTGVPSRFSGSGSGTYFTLTISSLQAEDFAVYFCQQAKAFPPTFGGGTKVDIK 446 AA PAT source 1..446 mol_type protein organism synthetic construct constructo sintético EVQLVQSGGGLVKPGGSLRLSCAASGFTFSSYSMNWVRQAPGKGLEWVSSISSSSSYIYYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARVTDAFDIWGQGTMVTVSSASTKGPSVLPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 214 AA PAT source 1..214 mol_type protein organism synthetic construct constructo sintético DIQMTQSPSSVSASIGDRVTITCRASQGIDNWLGWYQQKPGKAPKLLIYDASNLDTGVPSRFSGSGSGTYFTLTISSLQAEDFAVYFCQQAKAFPPTFGGGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 440 AA PAT source 1..440 mol_type protein organism synthetic construct constructo sintético QVQLVESGGGVVQPGRSLRLDCKASGITFSNSGMHWVRQAPGKGLEWVAVIWYDGSKRYYADSVKGRFTISRDNSKNTLFLQMNSLRAEDTAVYYCATNDDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK 214 AA PAT source 1..214 mol_type protein organism synthetic construct constructo sintético EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQSSNWPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 447 AA PAT source 1..447 mol_type protein organism synthetic construct constructo sintético QVQLVQSGVEVKKPGASVKVSCKASGYTFTNYYMYWVRQAPGQGLEWMGGINPSNGGTNFNEKFKNRVTLTTDSSTTTAYMELKSLQFDDTAVYYCARRDYRFDMGFDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK 218 AA PAT source 1..218 mol_type protein organism synthetic construct constructo sintético EIVLTQSPATLSLSPGERATLSCRASKGVSTSGYSYLHWYQQKPGQAPRLLIYLASYLESGVPARFSGSGSGTDFTLTISSLEPEDFAVYYCQHSRDLPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC