JP PCT/JP2024/080220 2024-12-06 FA1535-24185 JP PCT/JP2023/044950 2023-12-08 Astellas Pharma Inc. COMBINATION THERAPY INVOLVING BISPECIFIC BINDING AGENTS BINDING TO CLDN18.2 AND CD3 AND ANTI-VEGFR2 ANTIBODIES 34 261 AA PAT source 1..261 mol_type protein organism Homo sapiens Homo sapiens MAVTACQGLGFVVSLIGIAGIIAATCMDQWSTQDLYNNPVTAVFNYQGLWRSCVRESSGFTECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAGGLTLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKIYDGGARTEDEVQSYPSKHDYV 20 AA PAT REGION 1..20 note Peptide linker Enlazador peptídico source 1..20 mol_type protein organism synthetic construct constructo sintético GKPGSGKPGSGKPGSGKPGS 9 AA PAT REGION 1..9 note Peptide linker Enlazador peptídico source 1..9 mol_type protein organism synthetic construct constructo sintético KTHTCPPCP 19 AA PAT REGION 1..19 note Peptide linker Enlazador peptídico source 1..19 mol_type protein organism synthetic construct constructo sintético GGGGSGGGGSKTHTCPPCP 10 AA PAT REGION 1..10 note Peptide linker Enlazador peptídico source 1..10 mol_type protein organism synthetic construct constructo sintético GGGGSGGGGS 15 AA PAT REGION 1..15 note Peptide linker Enlazador peptídico source 1..15 mol_type protein organism synthetic construct constructo sintético EPKSCDKTHTCPPCP 329 AA PAT REGION 1..329 note Immunoglobulin-derived sequence Secuencia derivada de inmunoglobulina source 1..329 mol_type protein organism synthetic construct constructo sintético ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSDTKVDKKVEPKSCDKTHTCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVKHEDPEVKFNWYVDGVEVHNAKTKPREEEYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCDVSGFYPSDIAVEWESDGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWEQGDVFSCSVMHEALHNHYTQKSLSLSPGK 216 AA PAT REGION 1..216 note Immunoglobulin-derived sequence Secuencia derivada de inmunoglobulina source 1..216 mol_type protein organism synthetic construct constructo sintético APPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVKHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREQMTKNQVKLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 107 AA PAT REGION 1..107 note Immunoglobulin-derived sequence Secuencia derivada de inmunoglobulina source 1..107 mol_type protein organism synthetic construct constructo sintético RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 5 AA PAT REGION 1..5 note CDR sequence Secuencia CDR source 1..5 mol_type protein organism synthetic construct constructo sintético SYWIN 17 AA PAT REGION 1..17 note CDR sequence Secuencia CDR source 1..17 mol_type protein organism synthetic construct constructo sintético NIYPSDSYTNYNQKFQG 9 AA PAT REGION 1..9 note CDR sequence Secuencia CDR source 1..9 mol_type protein organism synthetic construct constructo sintético SWRGNSFDY 17 AA PAT REGION 1..17 note CDR sequence Secuencia CDR source 1..17 mol_type protein organism synthetic construct constructo sintético KSSQSLLNSGNQKNYLT 7 AA PAT REGION 1..7 note CDR sequence Secuencia CDR source 1..7 mol_type protein organism synthetic construct constructo sintético WASTRES 9 AA PAT REGION 1..9 note CDR sequence Secuencia CDR source 1..9 mol_type protein organism synthetic construct constructo sintético QNDYSYPFT 118 AA PAT REGION 1..118 note Immunoglobulin-derived sequence Secuencia derivada de inmunoglobulina source 1..118 mol_type protein organism synthetic construct constructo sintético EVQLVQSGAEVKKPGESLRISCKASGYTFTSYWINWVRQMPGKGLEWMGNIYPSDSYTNYNQKFQGHVTISVDKSISTAYLQWSSLKASDTAMYYCTRSWRGNSFDYWGQGTLVTVSS 113 AA PAT REGION 1..113 note Immunoglobulin-derived sequence Secuencia derivada de inmunoglobulina source 1..113 mol_type protein organism synthetic construct constructo sintético DIVMTQSPDSLAVSLGERATINCKSSQSLLNSGNQKNYLTWYQQKPGQPPKLLIYWASTRESGVPDRFTGSGSGTDFTLTISSLQAEDVAVYYCQNDYSYPFTFGSGTKLEIK 5 AA PAT REGION 1..5 note CDR sequence Secuencia CDR source 1..5 mol_type protein organism synthetic construct constructo sintético TYAMN 14 AA PAT REGION 1..14 note CDR sequence Secuencia CDR source 1..14 mol_type protein organism synthetic construct constructo sintético HGNFGDSYVSWFAY 14 AA PAT REGION 1..14 note CDR sequence Secuencia CDR source 1..14 mol_type protein organism synthetic construct constructo sintético GSSTGAVTTSNYAN 7 AA PAT REGION 1..7 note CDR sequence Secuencia CDR source 1..7 mol_type protein organism synthetic construct constructo sintético GTNKRAP 9 AA PAT REGION 1..9 note CDR sequence Secuencia CDR source 1..9 mol_type protein organism synthetic construct constructo sintético ALWYSNHWV 19 AA PAT REGION 1..19 note CDR sequence Secuencia CDR source 1..19 mol_type protein organism synthetic construct constructo sintético RIRSKANNYATYYADSVKG 109 AA PAT REGION 1..109 note Immunoglobulin-derived sequence Secuencia derivada de inmunoglobulina source 1..109 mol_type protein organism synthetic construct constructo sintético QAVVTQEPSLTVSPGGTVTLTCGSSTGAVTTSNYANWVQQKPGKSPRGLIGGTNKRAPGVPARFSGSLLGGKAALTISGAQPEDEADYYCALWYSNHWVFGGGTKLTVL 125 AA PAT REGION 1..125 note Immunoglobulin-derived sequence Secuencia derivada de inmunoglobulina source 1..125 mol_type protein organism synthetic construct constructo sintético EVQLVESGGGLVQPGGSLRLSCAASGFTFSTYAMNWVRQAPGKGLEWVGRIRSKANNYATYYADSVKGRFTISRDDSKNTLYLQMNSLRAEDTAVYYCVRHGNFGDSYVSWFAYWGQGTLVTVSS 254 AA PAT REGION 1..254 note Immunoglobulin-derived sequence Secuencia derivada de inmunoglobulina source 1..254 mol_type protein organism synthetic construct constructo sintético QAVVTQEPSLTVSPGGTVTLTCGSSTGAVTTSNYANWVQQKPGKSPRGLIGGTNKRAPGVPARFSGSLLGGKAALTISGAQPEDEADYYCALWYSNHWVFGGGTKLTVLGKPGSGKPGSGKPGSGKPGSEVQLVESGGGLVQPGGSLRLSCAASGFTFSTYAMNWVRQAPGKGLEWVGRIRSKANNYATYYADSVKGRFTISRDDSKNTLYLQMNSLRAEDTAVYYCVRHGNFGDSYVSWFAYWGQGTLVTVSS 447 AA PAT REGION 1..447 note Immunoglobulin-derived sequence Secuencia derivada de inmunoglobulina source 1..447 mol_type protein organism synthetic construct constructo sintético EVQLVQSGAEVKKPGESLRISCKASGYTFTSYWINWVRQMPGKGLEWMGNIYPSDSYTNYNQKFQGHVTISVDKSISTAYLQWSSLKASDTAMYYCTRSWRGNSFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSDTKVDKKVEPKSCDKTHTCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVKHEDPEVKFNWYVDGVEVHNAKTKPREEEYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCDVSGFYPSDIAVEWESDGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWEQGDVFSCSVMHEALHNHYTQKSLSLSPGK 720 AA PAT REGION 1..720 note Immunoglobulin-derived sequence Secuencia derivada de inmunoglobulina source 1..720 mol_type protein organism synthetic construct constructo sintético EVQLVQSGAEVKKPGESLRISCKASGYTFTSYWINWVRQMPGKGLEWMGNIYPSDSYTNYNQKFQGHVTISVDKSISTAYLQWSSLKASDTAMYYCTRSWRGNSFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCGGGGSGGGGSQAVVTQEPSLTVSPGGTVTLTCGSSTGAVTTSNYANWVQQKPGKSPRGLIGGTNKRAPGVPARFSGSLLGGKAALTISGAQPEDEADYYCALWYSNHWVFGGGTKLTVLGKPGSGKPGSGKPGSGKPGSEVQLVESGGGLVQPGGSLRLSCAASGFTFSTYAMNWVRQAPGKGLEWVGRIRSKANNYATYYADSVKGRFTISRDDSKNTLYLQMNSLRAEDTAVYYCVRHGNFGDSYVSWFAYWGQGTLVTVSSGGGGSGGGGSKTHTCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVKHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREQMTKNQVKLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 220 AA PAT REGION 1..220 note Immunoglobulin-derived sequence Secuencia derivada de inmunoglobulina source 1..220 mol_type protein organism synthetic construct constructo sintético DIVMTQSPDSLAVSLGERATINCKSSQSLLNSGNQKNYLTWYQQKPGQPPKLLIYWASTRESGVPDRFTGSGSGTDFTLTISSLQAEDVAVYYCQNDYSYPFTFGSGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 1337 AA PAT source 1..1337 mol_type protein organism Homo sapiens Homo sapiens ASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV 116 AA PAT source 1..116 mol_type protein organism synthetic construct constructo sintético EVQLVQSGGGLVKPGGSLRLSCAASGFTFSSYSMNWVRQAPGKGLEWVSSISSSSSYIYYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARVTDAFDIWGQGTMVTVSS 107 AA PAT source 1..107 mol_type protein organism synthetic construct constructo sintético DIQMTQSPSSVSASIGDRVTITCRASQGIDNWLGWYQQKPGKAPKLLIYDASNLDTGVPSRFSGSGSGTYFTLTISSLQAEDFAVYFCQQAKAFPPTFGGGTKVDIK 446 AA PAT source 1..446 mol_type protein organism synthetic construct constructo sintético EVQLVQSGGGLVKPGGSLRLSCAASGFTFSSYSMNWVRQAPGKGLEWVSSISSSSSYIYYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARVTDAFDIWGQGTMVTVSSASTKGPSVLPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 214 AA PAT source 1..214 mol_type protein organism synthetic construct constructo sintético DIQMTQSPSSVSASIGDRVTITCRASQGIDNWLGWYQQKPGKAPKLLIYDASNLDTGVPSRFSGSGSGTYFTLTISSLQAEDFAVYFCQQAKAFPPTFGGGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC